PubRank

John Kuriyan

Author PubWeight™ 191.32‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2002 13.03
2 The conformational plasticity of protein kinases. Cell 2002 11.21
3 An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 2006 10.28
4 Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell 2003 5.44
5 Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell 2009 4.78
6 Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex. Nature 2004 4.37
7 Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res 2002 4.19
8 Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature 2012 4.01
9 Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell 2003 3.66
10 A myristoyl/phosphotyrosine switch regulates c-Abl. Cell 2003 3.48
11 A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol 2006 3.40
12 Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat Struct Mol Biol 2008 3.18
13 Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell 2005 3.08
14 Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol 2008 2.82
15 Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature 2007 2.78
16 Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. Cell 2007 2.68
17 Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization. Cell 2012 2.67
18 The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2. Cell 2011 2.58
19 Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. Proc Natl Acad Sci U S A 2009 2.55
20 Conformational coupling across the plasma membrane in activation of the EGF receptor. Cell 2013 2.49
21 Structure of a sliding clamp on DNA. Cell 2008 2.42
22 Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proc Natl Acad Sci U S A 2004 2.41
23 Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell 2004 2.38
24 Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. Mol Cell 2011 2.35
25 High yield bacterial expression of active c-Abl and c-Src tyrosine kinases. Protein Sci 2005 2.32
26 Architecture and membrane interactions of the EGF receptor. Cell 2013 2.29
27 Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell 2006 2.28
28 A conserved protonation-dependent switch controls drug binding in the Abl kinase. Proc Natl Acad Sci U S A 2008 2.18
29 The structure, regulation, and function of ZAP-70. Immunol Rev 2009 2.01
30 Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res 2006 1.98
31 Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II. Mol Cell 2003 1.98
32 Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III. Cell 2006 1.94
33 c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty. Structure 2007 1.87
34 Molecular mechanisms in signal transduction at the membrane. Nat Struct Mol Biol 2010 1.86
35 Clamp loaders and sliding clamps. Curr Opin Struct Biol 2002 1.77
36 Motors and switches: AAA+ machines within the replisome. Nat Rev Mol Cell Biol 2002 1.74
37 Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal 2013 1.73
38 The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell 2009 1.72
39 Regulation of ras signaling dynamics by Sos-mediated positive feedback. Curr Biol 2006 1.70
40 Structural basis for the recognition of c-Src by its inactivator Csk. Cell 2008 1.66
41 Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations. Cancer Res 2009 1.64
42 A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci U S A 2006 1.57
43 A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell 2011 1.56
44 How a DNA polymerase clamp loader opens a sliding clamp. Science 2011 1.56
45 Protein-protein interactions in the allosteric regulation of protein kinases. Curr Opin Struct Biol 2006 1.49
46 Probing the function of heme distortion in the H-NOX family. ACS Chem Biol 2008 1.42
47 Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II. FEBS J 2006 1.40
48 A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol 2006 1.39
49 A reinterpretation of the dimerization interface of the N-terminal domains of STATs. Protein Sci 2003 1.39
50 Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases. Cancer Res 2002 1.34
51 Mechanism of proliferating cell nuclear antigen clamp opening by replication factor C. J Biol Chem 2006 1.32
52 DNA polymerase clamp loaders and DNA recognition. FEBS Lett 2005 1.28
53 Out-of-plane motions in open sliding clamps: molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen. Proc Natl Acad Sci U S A 2005 1.27
54 Regulation of the catalytic activity of the EGF receptor. Curr Opin Struct Biol 2011 1.26
55 The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. BMC Struct Biol 2008 1.26
56 Clamp loaders and replication initiation. Curr Opin Struct Biol 2006 1.25
57 Analysis of the role of PCNA-DNA contacts during clamp loading. BMC Struct Biol 2010 1.25
58 The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. J Biol Chem 2006 1.22
59 Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc Natl Acad Sci U S A 2010 1.22
60 Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1. Elife 2013 1.22
61 Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nat Struct Mol Biol 2010 1.21
62 Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex. Proc Natl Acad Sci U S A 2004 1.20
63 Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless. Proc Natl Acad Sci U S A 2005 1.20
64 The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2). BMC Struct Biol 2009 1.18
65 Crystal structure of the chi:psi sub-assembly of the Escherichia coli DNA polymerase clamp-loader complex. Eur J Biochem 2004 1.12
66 Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless. Structure 2003 1.12
67 Crenolanib is a selective type I pan-FLT3 inhibitor. Proc Natl Acad Sci U S A 2014 1.12
68 SAXS and the working protein. Structure 2005 1.08
69 Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response. Proc Natl Acad Sci U S A 2009 1.04
70 Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp. Proc Natl Acad Sci U S A 2008 1.04
71 A structural perspective on the regulation of the epidermal growth factor receptor. Annu Rev Biochem 2015 1.04
72 Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium. BMC Struct Biol 2006 1.03
73 Directed evolution of the epidermal growth factor receptor extracellular domain for expression in yeast. Proteins 2006 1.03
74 Modulating heme redox potential through protein-induced porphyrin distortion. J Am Chem Soc 2010 1.01
75 Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker. Mol Cell Biol 2013 0.99
76 Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex. Nat Struct Mol Biol 2005 0.98
77 Tuning a three-component reaction for trapping kinase substrate complexes. J Am Chem Soc 2008 0.96
78 Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity. Elife 2013 0.96
79 Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc Natl Acad Sci U S A 2011 0.95
80 Macromolecular juggling by ubiquitylation enzymes. BMC Biol 2013 0.95
81 Clamp loader ATPases and the evolution of DNA replication machinery. BMC Biol 2012 0.92
82 A structural role for the PHP domain in E. coli DNA polymerase III. BMC Struct Biol 2013 0.90
83 Structure and specificity of the SH2 domain. Cell 2004 0.90
84 Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II. Curr Opin Struct Biol 2013 0.90
85 Comparative analysis of mutant tyrosine kinase chemical rescue. Biochemistry 2009 0.89
86 The tyrosine kinase Csk dimerizes through Its SH3 domain. PLoS One 2009 0.88
87 Structural insights into the molecular mechanism of H-NOX activation. Protein Sci 2010 0.88
88 Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1. Structure 2009 0.88
89 Fluorescence measurements on the E.coli DNA polymerase clamp loader: implications for conformational changes during ATP and clamp binding. J Mol Biol 2004 0.88
90 Analysis of a multicomponent thermostable DNA polymerase III replicase from an extreme thermophile. J Biol Chem 2002 0.87
91 C2 can do it, too. Cell 2005 0.87
92 Nucleotide-induced conformational changes in an isolated Escherichia coli DNA polymerase III clamp loader subunit. Structure 2003 0.85
93 Efficient semisynthesis of a tetraphosphorylated analogue of the Type I TGFbeta receptor. Org Lett 2002 0.80
94 John T. Edsall and Advances in Protein Chemistry. Adv Protein Chem 2002 0.78
95 A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation. Biochem J 2013 0.77
96 Fixing a hole where the Ras gets in. Cell 2013 0.76
97 A MAPK scaffold lends a helping hand. Cell 2009 0.75
98 Correction: Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity. Elife 2014 0.75