Published in J Biol Chem on February 17, 2010
Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J Clin Invest (2012) 2.67
Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters. Proc Natl Acad Sci U S A (2011) 2.10
MicroRNA in TLR signaling and endotoxin tolerance. Cell Mol Immunol (2011) 1.86
Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro. Brain Behav Immun (2013) 1.66
Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes. J Virol (2011) 1.32
Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice. Cell Res (2011) 1.26
Lactation-related microRNA expression profiles of porcine breast milk exosomes. PLoS One (2012) 1.24
MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells. Oncogene (2011) 1.14
MicroRNAs: new regulators of Toll-like receptor signalling pathways. Biomed Res Int (2014) 1.11
MicroRNA regulation of innate immune responses in epithelial cells. Cell Mol Immunol (2011) 1.11
Transcriptome microRNA profiling of bovine mammary epithelial cells challenged with Escherichia coli or Staphylococcus aureus bacteria reveals pathogen directed microRNA expression profiles. BMC Genomics (2014) 1.09
Next generation sequencing reveals the expression of a unique miRNA profile in response to a gram-positive bacterial infection. PLoS One (2013) 1.07
Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-γ. Cell Mol Gastroenterol Hepatol (2015) 1.03
PPARs in Liver Diseases and Cancer: Epigenetic Regulation by MicroRNAs. PPAR Res (2012) 1.03
Vascular PPARδ protects against stroke-induced brain injury. Arterioscler Thromb Vasc Biol (2011) 1.01
Hypoxia mediates mutual repression between microRNA-27a and PPARγ in the pulmonary vasculature. PLoS One (2013) 0.97
NMDA mediated contextual conditioning changes miRNA expression. PLoS One (2011) 0.96
MicroRNAs in the regulation of TLR and RIG-I pathways. Cell Mol Immunol (2012) 0.92
miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program. Nat Commun (2015) 0.91
MicroRNAs in Breastmilk and the Lactating Breast: Potential Immunoprotectors and Developmental Regulators for the Infant and the Mother. Int J Environ Res Public Health (2015) 0.88
Antagonism of betulinic acid on LPS-mediated inhibition of ABCA1 and cholesterol efflux through inhibiting nuclear factor-kappaB signaling pathway and miR-33 expression. PLoS One (2013) 0.87
miRNAs as potential therapeutic targets for age-related macular degeneration. Future Med Chem (2012) 0.87
MicroRNA expression profiles of bovine milk exosomes in response to Staphylococcus aureus infection. BMC Genomics (2015) 0.86
MicroRNA-140 promotes adipocyte lineage commitment of C3H10T1/2 pluripotent stem cells via targeting osteopetrosis-associated transmembrane protein 1. J Biol Chem (2013) 0.85
miR-15a/16 regulates macrophage phagocytosis after bacterial infection. J Immunol (2014) 0.84
Emerging role of microRNAs in lipid metabolism. Acta Pharm Sin B (2015) 0.84
hCG-induced down-regulation of PPARγ and liver X receptors promotes periovulatory progesterone synthesis by macaque granulosa cells. Endocrinology (2010) 0.82
The role of peroxisome proliferator-activated receptors in the esophageal, gastric, and colorectal cancer. PPAR Res (2012) 0.82
Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells. J Transl Med (2014) 0.81
The effects of microRNA on the absorption, distribution, metabolism and excretion of drugs. Br J Pharmacol (2014) 0.81
Therapeutic manipulation of angiogenesis with miR-27b. Vasc Cell (2015) 0.80
Peroxisome proliferator-activated receptor-γ agonists attenuate biofilm formation by Pseudomonas aeruginosa. FASEB J (2017) 0.79
MicroRNA-27a promotes renal tubulointerstitial fibrosis via suppressing PPARγ pathway in diabetic nephropathy. Oncotarget (2016) 0.79
MicroRNAs in the Host-Apicomplexan Parasites Interactions: A Review of Immunopathological Aspects. Front Cell Infect Microbiol (2016) 0.79
Pathways involved in the synergistic activation of macrophages by lipoteichoic acid and hemoglobin. PLoS One (2012) 0.79
MicroRNA-27a Negatively Modulates the Inflammatory Response in Lipopolysaccharide-Stimulated Microglia by Targeting TLR4 and IRAK4. Cell Mol Neurobiol (2016) 0.78
MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers. PPAR Res (2017) 0.78
miR-27a attenuates adipogenesis and promotes osteogenesis in steroid-induced rat BMSCs by targeting PPARγ and GREM1. Sci Rep (2016) 0.77
Down-regulation of a host microRNA by a viral noncoding RNA. Cold Spring Harb Symp Quant Biol (2010) 0.77
MicroRNAs Involved in Anti-Tumour Immunity. Int J Mol Sci (2013) 0.77
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PPARs: Protectors or Opponents of Myocardial Function? PPAR Res (2015) 0.77
Identification of TLR2 and TLR4‑induced microRNAs in human mesenchymal stem cells and their possible roles in regulating TLR signals. Mol Med Rep (2016) 0.76
MicroRNA profiling of the intestinal tissue of Kazakh sheep after experimental Echinococcus granulosus infection, using a high-throughput approach. Parasite (2016) 0.76
Increased Wnt5a in squamous cell lung carcinoma inhibits endothelial cell motility. BMC Cancer (2016) 0.75
Aging and serum exomiR content in women-effects of estrogenic hormone replacement therapy. Sci Rep (2017) 0.75
Peroxisome proliferator-activated receptor-γ is downregulated in ulcerative colitis and is involved in experimental colitis-associated neoplasia. Oncol Lett (2015) 0.75
Identification of the microRNA networks contributing to macrophage differentiation and function. Oncotarget (2016) 0.75
Analysis of miRNAs and their target genes associated with lipid metabolism in duck liver. Sci Rep (2016) 0.75
The regulation roles of miR-125b, miR-221 and miR-27b in porcine Salmonella infection signalling pathway. Biosci Rep (2016) 0.75
Naproxcinod shows significant advantages over naproxen in the mdx model of Duchenne Muscular Dystrophy. Orphanet J Rare Dis (2015) 0.75
Comparative analysis of hepatic miRNA levels in male marathon mice reveals a link between obesity and endurance exercise capacities. J Comp Physiol B (2016) 0.75
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Database for mRNA half-life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells. DNA Res (2008) 3.29
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Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology (2003) 2.59
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Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids. BMC Genomics (2007) 2.49
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PPARgamma as a new therapeutic target in inflammatory bowel diseases. Gut (2006) 1.99
microRNA miR-27b impairs human adipocyte differentiation and targets PPARgamma. Biochem Biophys Res Commun (2009) 1.98
Adding fuel to fire: microRNAs as a new class of mediators of inflammation. Ann Rheum Dis (2008) 1.96
Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc Natl Acad Sci U S A (2006) 1.81
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Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor gamma and nuclear factor-kappaB in macrophages. Immunology (2008) 1.22
Peroxisome proliferator-activated receptors (PPARs) and the human skin: importance of PPARs in skin physiology and dermatologic diseases. Am J Clin Dermatol (2008) 1.16
PPARgamma1 attenuates cytosol to membrane translocation of PKCalpha to desensitize monocytes/macrophages. J Cell Biol (2007) 1.10
Microarray analyses of the effects of NF-kappaB or PI3K pathway inhibitors on the LPS-induced gene expression profile in RAW264.7 cells: synergistic effects of rapamycin on LPS-induced MMP9-overexpression. Cell Signal (2009) 1.07
Therapeutic use of agonists of the nuclear receptor PPARgamma in Alzheimer's disease. Curr Alzheimer Res (2007) 1.06
The regulation of elongation by eukaryotic RNA polymerase II: a recent view. Mol Cells (2001) 1.05
Delayed activation of PPARgamma by LPS and IFN-gamma attenuates the oxidative burst in macrophages. FASEB J (2001) 1.03
Endotoxin downregulates peroxisome proliferator-activated receptor-gamma via the increase in TNF-alpha release. Am J Physiol Regul Integr Comp Physiol (2007) 1.01
Recognition of apoptotic cells by macrophages activates the peroxisome proliferator-activated receptor-gamma and attenuates the oxidative burst. Cell Death Differ (2005) 0.98
An inverse relationship between peroxisome proliferator-activated receptor gamma and allergic airway inflammation in an allergen challenge model. Ann Allergy Asthma Immunol (2005) 0.98
PPAR-gamma: Therapeutic Potential for Multiple Sclerosis. PPAR Res (2008) 0.86
The content of PPAR, LXR, and RXR and the PPAR DNA-binding activity in macrophages over the course of inflammation in mice. Bull Exp Biol Med (2009) 0.78
Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages. Int J Cancer (2012) 2.80
Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases. Mol Biol Cell (2003) 2.11
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Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. Blood (2006) 1.40
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Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants. Mol Biol Cell (2009) 1.31
Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate. Mol Biol Cell (2007) 1.30
Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1alpha through a nuclear factor-kappaB-dependent pathway. Mol Biol Cell (2003) 1.30
Nitric oxide, apoptosis and macrophage polarization during tumor progression. Nitric Oxide (2008) 1.26
PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation. J Biol Chem (2004) 1.25
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HIF-1 and p53: communication of transcription factors under hypoxia. J Cell Mol Med (2004) 1.20
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Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms. Blood (2003) 1.15
Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids. Hepatology (2010) 1.13
Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells. Mol Cancer Res (2009) 1.13
PPARgamma1 attenuates cytosol to membrane translocation of PKCalpha to desensitize monocytes/macrophages. J Cell Biol (2007) 1.10
Cytokines and hormones in the regulation of hypoxia inducible factor-1alpha (HIF-1alpha). Cardiovasc Hematol Agents Med Chem (2006) 1.10
Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity. Cytokine (2010) 1.10
Regulation of macrophage function by sphingosine-1-phosphate. Immunobiology (2009) 1.08
Role of sestrin2 in peroxide signaling in macrophages. FEBS Lett (2009) 1.08
Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses. Carcinogenesis (2010) 1.07
NO and TNF-alpha released from activated macrophages stabilize HIF-1alpha in resting tubular LLC-PK1 cells. Am J Physiol Cell Physiol (2002) 1.07
Reactive oxygen species attenuate nitric-oxide-mediated hypoxia-inducible factor-1alpha stabilization. Free Radic Biol Med (2006) 1.07
Activation of peroxisome proliferator-activated receptor gamma by nitric oxide in monocytes/macrophages down-regulates p47phox and attenuates the respiratory burst. J Immunol (2002) 1.06
Inhibition of GSK3beta by indirubins restores HIF-1alpha accumulation under prolonged periods of hypoxia/anoxia. FEBS Lett (2005) 1.04
NO restores HIF-1alpha hydroxylation during hypoxia: role of reactive oxygen species. Free Radic Biol Med (2005) 1.04
Peroxisome proliferator-activated receptor gamma as a molecular target of resveratrol-induced modulation of polyamine metabolism. Cancer Res (2006) 1.01
Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation. Carcinogenesis (2011) 1.01
Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600. J Nat Prod (2011) 1.00
miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target. PLoS One (2012) 1.00
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Development of a high-throughput cell-based reporter assay to identify stabilizers of tumor suppressor Pdcd4. J Biomol Screen (2009) 0.98
HIF-1alpha and p53 as targets of NO in affecting cell proliferation, death and adaptation. Curr Mol Med (2004) 0.98
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A23187, ionomycin and thapsigargin upregulate mRNA of HIF-1alpha via endoplasmic reticulum stress rather than a rise in intracellular calcium. J Cell Physiol (2008) 0.97
Calpain mediates a von Hippel-Lindau protein-independent destruction of hypoxia-inducible factor-1alpha. Mol Biol Cell (2006) 0.97
Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation. J Biol Chem (2010) 0.97
Critical role for classical PKC in activating Akt by phospholipase A2-modified LDL in monocytic cells. Cardiovasc Res (2006) 0.96
Peroxisome proliferator-activated receptor gamma contributes to T lymphocyte apoptosis during sepsis. J Leukoc Biol (2006) 0.95
Interleukin-10-induced neutrophil gelatinase-associated lipocalin production in macrophages with consequences for tumor growth. Mol Cell Biol (2012) 0.95
Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation--implications for prolyl hydroxylase activity and iron. Exp Cell Res (2005) 0.95
Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1. PLoS One (2012) 0.95
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Apoptotic cells induce arginase II in macrophages, thereby attenuating NO production. FASEB J (2007) 0.94
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Nitric oxide donors inhibit formation of the Apaf-1/caspase-9 apoptosome and activation of caspases. Biochem J (2003) 0.92
Casein-kinase-II-dependent phosphorylation of PPARgamma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytosol. J Cell Sci (2009) 0.91
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Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration. J Pathol (2011) 0.90
Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity. Eur J Immunol (2012) 0.89
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Nitric oxide induces phosphorylation of p53 and impairs nuclear export. Oncogene (2003) 0.88
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Nitric oxide prevents oxidised LDL-induced p53 accumulation, cytochrome c translocation, and apoptosis in macrophages via guanylate cyclase stimulation. Atherosclerosis (2002) 0.88
Crosstalk between the peroxisome proliferator-activated receptor γ (PPARγ) and the vitamin D receptor (VDR) in human breast cancer cells: PPARγ binds to VDR and inhibits 1α,25-dihydroxyvitamin D3 mediated transactivation. Exp Cell Res (2012) 0.87
Peroxisome proliferator-activated receptor gamma (PPAR gamma) and sepsis. Arch Immunol Ther Exp (Warsz) (2007) 0.87
Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1. Free Radic Biol Med (2009) 0.87
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NO and transcriptional regulation: from signaling to death. Toxicology (2005) 0.87
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