Published in Cancer Res on February 23, 2010
Current views on the function of the lymphatic vasculature in health and disease. Genes Dev (2010) 1.84
Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses. J Exp Med (2013) 1.77
Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer. Cell Res (2011) 1.06
Tumor lymphangiogenesis as a potential therapeutic target. J Oncol (2012) 0.97
Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period. Circ Res (2014) 0.90
Role of lymphatic vasculature in regional and distant metastases. Microvasc Res (2014) 0.83
Serum somatostatin and neuron-specific enolase might be biochemical markers of vascular dementia in the early stage. Int J Clin Exp Med (2015) 0.75
Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer (2009) 14.17
Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med (2001) 7.78
Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science (1997) 6.37
Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest (2006) 6.12
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J (1996) 5.33
Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J (2001) 4.70
Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am J Pathol (1998) 4.41
Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nat Med (2000) 4.36
Functionally specialized junctions between endothelial cells of lymphatic vessels. J Exp Med (2007) 4.10
Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell (2002) 3.11
A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging. Eur J Nucl Med Mol Imaging (2004) 3.07
Pulmonary tumor thrombotic microangiopathy with pulmonary hypertension. Cancer (1990) 2.91
Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4. Proc Natl Acad Sci U S A (1996) 2.77
Halting angiogenesis suppresses carcinoma cell invasion. Nat Med (1997) 2.61
Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2. Cancer Res (2006) 2.40
Incidence and clinical significance of tumor embolization to the lungs. Am J Med (1968) 2.32
Lymphangitis carcinomatosa: a literature review. J R Coll Surg Edinb (1996) 2.00
VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors. Int J Cancer (2002) 1.80
Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor. Cancer Res (2005) 1.73
Prognostic significance of vascular endothelial cell growth factors -A, -C and -D in breast cancer and their relationship with angio- and lymphangiogenesis. Br J Cancer (2007) 1.66
Lymphangiogenesis and tumor metastasis. Cell Tissue Res (2003) 1.50
Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis. Cancer Res (2008) 1.38
Modulating metastasis by a lymphangiogenic switch in prostate cancer. Int J Cancer (2007) 1.30
Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats. Cancer Res (2003) 1.22
Abnormal lymphangiogenesis in idiopathic pulmonary fibrosis with insights into cellular and molecular mechanisms. Proc Natl Acad Sci U S A (2009) 1.21
Clinical significance of vascular endothelial growth factor C expression and angiogenesis at the deepest invasive site of advanced colorectal carcinoma. Oncology (2002) 1.14
Pulmonary lymphangitic carcinomatosis as a primary manifestation of colon cancer in a young adult. CMAJ (2008) 1.11
Cancer invasion and metastasis: positive and negative regulatory elements. Cancer Invest (1991) 1.06
Distinct roles of VEGF-A and VEGF-C in tumour metastasis of gastric carcinoma. Oncol Rep (2007) 0.91
Vascular endothelial growth factor C promotes human gastric carcinoma lymph node metastasis in mice. J Exp Clin Cancer Res (2001) 0.90
Lymphangitic spread of metastatic cancer to the lung. A radiologic-pathologic classification. Radiology (1971) 0.88
Clinical significance of plasma level of vascular endothelial growth factor-C in patients with colorectal cancer. Jpn J Clin Oncol (2008) 0.85
Vascular endothelial growth factor C promotes lymph node metastasis in a rectal cancer orthotopic model. Surg Today (2005) 0.85
Vascular endothelial growth factor C (VEGF-C) expression in pT2 gastric cancer. Hepatogastroenterology (2005) 0.82
Lymphangitic carcinomatosis of the lungs. The clinical significance of its roentgenologic classification. Chest (1972) 0.81
Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Invest (2005) 6.10
B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity (2006) 4.04
Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody. J Natl Cancer Inst (2005) 3.58
T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection. Nat Med (2007) 3.07
Molecular characterization of lymphatic endothelial cells. Proc Natl Acad Sci U S A (2002) 2.68
Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2. Cancer Res (2006) 2.40
Overexpression of VEGF-C causes transient lymphatic hyperplasia but not increased lymphangiogenesis in regenerating skin. Circ Res (2005) 2.08
CCR2 deficiency decreases intimal hyperplasia after arterial injury. Arterioscler Thromb Vasc Biol (2002) 1.92
Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes. Nat Biotechnol (2003) 1.87
Cardiac microvascular pathology in Fabry disease: evaluation of endomyocardial biopsies before and after enzyme replacement therapy. Circulation (2009) 1.84
Immunohistochemical detection of p53 homolog p63 in solid cell nests, papillary thyroid carcinoma, and hashimoto's thyroiditis: A stem cell hypothesis of papillary carcinoma oncogenesis. Hum Pathol (2004) 1.83
MRI to detect atherosclerosis with gadolinium-containing immunomicelles targeting the macrophage scavenger receptor. Magn Reson Med (2006) 1.79
Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses. J Exp Med (2013) 1.77
Therapeutic lymphangiogenesis with human recombinant VEGF-C. FASEB J (2002) 1.67
EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury. Am J Pathol (2005) 1.62
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest (2007) 1.60
Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living mice. Cancer Res (2004) 1.59
Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance imaging. Circulation (2004) 1.57
NF-kappaB is essential for the progression of KSHV- and EBV-infected lymphomas in vivo. Blood (2005) 1.56
A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture. Am J Physiol Heart Circ Physiol (2012) 1.55
PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment. Mol Cell Biol (2011) 1.52
Lymphangiogenesis and tumor metastasis. Cell Tissue Res (2003) 1.50
Heterogeneity of EAE mediated by multiple distinct T-effector subsets. J Neuroimmunol (2007) 1.46
Monitoring the efficacy of adoptively transferred prostate cancer-targeted human T lymphocytes with PET and bioluminescence imaging. J Nucl Med (2008) 1.35
Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. Am J Pathol (2002) 1.35
Cell-graph mining for breast tissue modeling and classification. Conf Proc IEEE Eng Med Biol Soc (2007) 1.35
Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo. Nat Biotechnol (2008) 1.33
Human reporter genes: potential use in clinical studies. Nucl Med Biol (2007) 1.33
Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism. J Immunol (2009) 1.33
In vivo noninvasive detection and age definition of arterial thrombus by MRI. J Am Coll Cardiol (2002) 1.33
Lymphatic endothelium: morphological, molecular and functional properties. J Cell Biol (2003) 1.31
Dietary glycotoxins promote diabetic atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis (2003) 1.31
Chronic thrombus detection with in vivo magnetic resonance imaging and a fibrin-targeted contrast agent. Circulation (2005) 1.31
High-density lipoproteins retard the progression of atherosclerosis and favorably remodel lesions without suppressing indices of inflammation or oxidation. Arterioscler Thromb Vasc Biol (2004) 1.30
Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosis. Mol Pharm (2010) 1.28
Serial studies of mouse atherosclerosis by in vivo magnetic resonance imaging detect lesion regression after correction of dyslipidemia. Arterioscler Thromb Vasc Biol (2004) 1.27
2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology. Cardiovasc Pathol (2011) 1.24
Lowering of dietary advanced glycation endproducts (AGE) reduces neointimal formation after arterial injury in genetically hypercholesterolemic mice. Atherosclerosis (2002) 1.21
Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid. Proc Natl Acad Sci U S A (2007) 1.18
Zoledronic acid inhibits both the osteolytic and osteoblastic components of osteosarcoma lesions in a mouse model. Clin Cancer Res (2009) 1.18
Caspase-3 and tissue factor expression in lipid-rich plaque macrophages: evidence for apoptosis as link between inflammation and atherothrombosis. Circulation (2004) 1.09
Progression and regression of atherosclerotic lesions: monitoring with serial noninvasive magnetic resonance imaging. Circulation (2002) 1.09
Intravascular epithelioid hemangioendothelioma of the inferior vena cava: case report of an unusual and unpredictable vascular tumor. Cardiovasc Pathol (2008) 1.09
The synergism of age and db/db genotype impairs wound healing. Exp Gerontol (2007) 1.07
The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis: in vivo study by high-resolution magnetic resonance imaging. J Am Coll Cardiol (2004) 1.05
Haptoglobin genotype is a major determinant of the amount of iron in the human atherosclerotic plaque. J Am Coll Cardiol (2008) 1.03
Quantification of human atherosclerotic plaques using spatially enhanced cluster analysis of multicontrast-weighted magnetic resonance images. Magn Reson Med (2004) 1.01
Apomab, a fully human agonistic antibody to DR5, exhibits potent antitumor activity against primary and metastatic breast cancer. Mol Cancer Ther (2009) 1.00
A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs. J Nucl Med (2010) 1.00
Multimodality in vivo molecular-genetic imaging. Bioconjug Chem (2004) 1.00
Lymphatic vessel activation in cancer. Ann N Y Acad Sci (2008) 0.99
Fibrin-targeted contrast agent for improvement of in vivo acute thrombus detection with magnetic resonance imaging. Atherosclerosis (2005) 0.98
Excision is indicated for intraductal papilloma of the breast diagnosed on core needle biopsy. Cancer (2009) 0.97
Imaging transgene activity in vivo. Cancer Res (2008) 0.97
Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter. Blood (2004) 0.97
In vivo bioluminescence tomography with a blocking-off finite-difference SP3 method and MRI/CT coregistration. Med Phys (2010) 0.97
Heart allograft rejection: detection with breath alkanes in low levels (the HARDBALL study). J Heart Lung Transplant (2004) 0.96
Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity. J Clin Invest (2013) 0.96
Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. Blood (2003) 0.94
MCP-1 deficiency is associated with reduced intimal hyperplasia after arterial injury. Biochem Biophys Res Commun (2003) 0.93
Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells. Am J Pathol (2006) 0.93
Apo2L/TRAIL inhibits tumor growth and bone destruction in a murine model of multiple myeloma. Clin Cancer Res (2009) 0.93
Prediction of heart transplant rejection with a breath test for markers of oxidative stress. Am J Cardiol (2004) 0.92
Optical bioluminescence imaging of human ES cell progeny in the rodent CNS. J Neurochem (2007) 0.92
Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice. J Invest Dermatol (2003) 0.92
Non-invasive molecular and functional imaging of cytosine deaminase and uracil phosphoribosyltransferase fused with red fluorescence protein. Acta Oncol (2008) 0.91
Hydrogel-embedded endothelial progenitor cells evade LPS and mitigate endotoxemia. Am J Physiol Renal Physiol (2011) 0.91
Imaging expression of cytosine deaminase-herpes virus thymidine kinase fusion gene (CD/TK) expression with [124I]FIAU and PET. Mol Imaging (2003) 0.90
A novel nonobstructive intravascular MRI coil: in vivo imaging of experimental atherosclerosis. Arterioscler Thromb Vasc Biol (2003) 0.90
Subphysiologic apolipoprotein E (ApoE) plasma levels inhibit neointimal formation after arterial injury in ApoE-deficient mice. Arterioscler Thromb Vasc Biol (2004) 0.90
Anticancer efficacy of Apo2L/TRAIL is retained in the presence of high and biologically active concentrations of osteoprotegerin in vivo. J Bone Miner Res (2011) 0.90
Lymphatic vessel activation in cancer. Ann N Y Acad Sci (2002) 0.90
Splitting vessels: keeping lymph apart from blood. Nat Med (2003) 0.89
Decreased reendothelialization and increased neointima formation with endostatin overexpression in a mouse model of arterial injury. Circulation (2003) 0.88
Imaging of hypoxia-driven gene expression in an orthotopic liver tumor model. Mol Cancer Ther (2007) 0.88
High frequency of TERT promoter mutation in small cell carcinoma of bladder, but not in small cell carcinoma of other origins. J Hematol Oncol (2014) 0.87
Platelet-derived growth factor-B normalizes micromorphology and vessel function in vascular endothelial growth factor-A-induced squamous cell carcinomas. Am J Pathol (2009) 0.87
Remodeling of small intramyocardial coronary arteries distal to a severe epicardial coronary artery stenosis. Arterioscler Thromb Vasc Biol (2002) 0.87
Effects of simvastatin on plasma lipoproteins and response to arterial injury in wild-type and apolipoprotein-E-deficient mice. J Vasc Res (2004) 0.86
Hepatocyte growth factor is a survival factor for endothelial cells and is expressed in human atherosclerotic plaques. Atherosclerosis (2002) 0.86
Serial, noninvasive, in vivo magnetic resonance microscopy detects the development of atherosclerosis in apolipoprotein E-deficient mice and its progression by arterial wall remodeling. J Magn Reson Imaging (2003) 0.86
Primary pulmonary artery leiomyosarcoma. Cardiovasc Pathol (2003) 0.85
Near-infrared fluorescence energy transfer imaging of nanoparticle accumulation and dissociation kinetics in tumor-bearing mice. ACS Nano (2013) 0.84
Effects of abciximab on the acute pathology of blood vessels after arterial stenting in nonhuman primates. J Am Coll Cardiol (2002) 0.83
TFE3-Fusion Variant Analysis Defines Specific Clinicopathologic Associations Among Xp11 Translocation Cancers. Am J Surg Pathol (2016) 0.83
Fenofibrate induces plaque regression in hypercholesterolemic atherosclerotic rabbits: in vivo demonstration by high-resolution MRI. Atherosclerosis (2006) 0.83
The p17 cleaved form of caspase-3 is present within viable macrophages in vitro and in atherosclerotic plaque. Arterioscler Thromb Vasc Biol (2003) 0.83
PET imaging of HSV1-tk mutants with acquired specificity toward pyrimidine- and acycloguanosine-based radiotracers. Eur J Nucl Med Mol Imaging (2009) 0.83
Incidental intraductal papillomas (<2 mm) of the breast diagnosed on needle core biopsy do not need to be excised. Breast J (2013) 0.82
Atypical ductal hyperplasia at margin of breast biopsy--is re-excision indicated? Ann Surg Oncol (2007) 0.82
Intraductal carcinoma arising in intraductal papilloma in an axillary lymph node: review of the literature and proposed theories of evolution. Arch Pathol Lab Med (2008) 0.81
In situ localization of tissue factor in human thrombi. Blood (2002) 0.81
Mechanism of cell death mediated by a BF2-chelated tetraaryl-azadipyrromethene photodynamic therapeutic: dissection of the apoptotic pathway in vitro and in vivo. Int J Cancer (2011) 0.81
Localization of BRCA1 protein in breast cancer tissue and cell lines with mutations. Cancer Cell Int (2013) 0.81