Published in Bioorg Med Chem Lett on February 04, 2010
Challenges in β(3)-Adrenoceptor Agonist Drug Development. Ther Adv Endocrinol Metab (2011) 0.88
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites. Nature (2002) 9.62
Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases. Lancet (2013) 3.77
The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers. Cancer Res (2010) 3.16
Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120. Cell (2003) 3.03
Clinical genetic testing for patients with autism spectrum disorders. Pediatrics (2010) 2.87
Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein. J Virol (2002) 2.81
Substituted piperazines as novel dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett (2004) 2.80
Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120. Structure (2008) 2.74
Alfuzosin and symptoms of chronic prostatitis-chronic pelvic pain syndrome. N Engl J Med (2008) 2.66
Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins. Proc Natl Acad Sci U S A (2004) 2.44
Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer. Nat Struct Mol Biol (2012) 2.36
Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state. PLoS Pathog (2009) 2.34
Structure-based, targeted deglycosylation of HIV-1 gp120 and effects on neutralization sensitivity and antibody recognition. Virology (2003) 2.25
Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions. Mol Cell (2010) 2.22
Structural basis of J cochaperone binding and regulation of Hsp70. Mol Cell (2007) 2.14
Hand, foot, and mouth disease in China: patterns of spread and transmissibility. Epidemiology (2011) 2.13
Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer. Proc Natl Acad Sci U S A (2013) 2.05
Structure of the Hsp110:Hsc70 nucleotide exchange machine. Mol Cell (2008) 1.96
Leukotriene B4 strongly increases monocyte chemoattractant protein-1 in human monocytes. Arterioscler Thromb Vasc Biol (2004) 1.94
Spatial analysis of malaria in Anhui province, China. Malar J (2008) 1.92
Epitope mapping and characterization of a novel CD4-induced human monoclonal antibody capable of neutralizing primary HIV-1 strains. Virology (2003) 1.90
Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis. Glia (2006) 1.90
Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells. Cancer Res (2010) 1.78
Copy number variation plays an important role in clinical epilepsy. Ann Neurol (2014) 1.73
Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. Diabetes (2008) 1.72
Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer. Breast Cancer Res Treat (2012) 1.71
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes (2005) 1.70
Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem (2008) 1.66
Analysis of αSMA-labeled progenitor cell commitment identifies notch signaling as an important pathway in fracture healing. J Bone Miner Res (2014) 1.66
Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem (2005) 1.65
Oil and tocopherol content and composition of pumpkin seed oil in 12 cultivars. J Agric Food Chem (2007) 1.65
High-affinity peptide against MT1-MMP for in vivo tumor imaging. J Control Release (2011) 1.59
Primary care and urology patients with the male pelvic pain syndrome: symptoms and quality of life. J Urol (2002) 1.55
Characterization of the outer domain of the gp120 glycoprotein from human immunodeficiency virus type 1. J Virol (2004) 1.51
Breast cancer subpopulation with high risk of internal mammary lymph nodes metastasis: analysis of 2,269 Chinese breast cancer patients treated with extended radical mastectomy. Breast Cancer Res Treat (2007) 1.49
Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity. PLoS Pathog (2011) 1.47
In vivo fate mapping identifies mesenchymal progenitor cells. Stem Cells (2012) 1.44
Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes. Proc Natl Acad Sci U S A (2011) 1.43
Comparison of two and three-dimensional computerized polyethylene wear analysis after total hip arthroplasty. J Bone Joint Surg Am (2003) 1.38
Improving the performance of outbreak detection algorithms by classifying the levels of disease incidence. PLoS One (2013) 1.36
Osterix-cre labeled progenitor cells contribute to the formation and maintenance of the bone marrow stroma. PLoS One (2013) 1.34
Diversity and abundance of oil-degrading bacteria and alkane hydroxylase (alkB) genes in the subtropical seawater of Xiamen Island. Microb Ecol (2010) 1.33
Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus. Radiat Res (2006) 1.31
Genetic control of floral zygomorphy in pea (Pisum sativum L.). Proc Natl Acad Sci U S A (2008) 1.27
Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence. Proc Natl Acad Sci U S A (2002) 1.25
Crystallization of protein-ligand complexes. Acta Crystallogr D Biol Crystallogr (2006) 1.23
Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain. J Virol (2009) 1.23
Emergence of a tetracycline-resistant Campylobacter jejuni clone associated with outbreaks of ovine abortion in the United States. J Clin Microbiol (2008) 1.23
Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes. J Med Chem (2014) 1.22
Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors. Bioorg Med Chem Lett (2005) 1.20
Functional mimicry of a human immunodeficiency virus type 1 coreceptor by a neutralizing monoclonal antibody. J Virol (2005) 1.19
NEDD9 is a positive regulator of epithelial-mesenchymal transition and promotes invasion in aggressive breast cancer. PLoS One (2011) 1.19
The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg Med Chem Lett (2005) 1.18
Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors. J Med Chem (2007) 1.17
Human exposure to live poultry and psychological and behavioral responses to influenza A(H7N9), China. Emerg Infect Dis (2014) 1.17
Aggressive angiomyxoma: an unusual presentation. Korean J Radiol (2011) 1.16
A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects. Diabetes (2004) 1.16
Multi-modal magnetic resonance imaging alterations in two rat models of mild neurotrauma. J Neurotrauma (2007) 1.14
Strontium enhances osteogenic differentiation of mesenchymal stem cells and in vivo bone formation by activating Wnt/catenin signaling. Stem Cells (2011) 1.13
Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Curr Top Med Chem (2007) 1.12
Prognosis of patients with new prostatitis/pelvic pain syndrome episodes. J Urol (2004) 1.12
Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage. J Orthop Res (2010) 1.11
CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression. Sci Rep (2013) 1.11
Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity. Biochemistry (2004) 1.09
Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorg Med Chem Lett (2005) 1.08
Isolation and preliminary probiotic selection of lactobacilli from koumiss in Inner Mongolia. J Basic Microbiol (2009) 1.06
Post-junctional facilitation of Substance P signaling in a tibia fracture rat model of complex regional pain syndrome type I. Pain (2009) 1.05
Allosteric inhibition of human immunodeficiency virus integrase: late block during viral replication and abnormal multimerization involving specific protein domains. J Biol Chem (2014) 1.04
Effects of testosterone and levonorgestrel combined with a 5alpha-reductase inhibitor or gonadotropin-releasing hormone antagonist on spermatogenesis and intratesticular steroid levels in normal men. J Clin Endocrinol Metab (2005) 1.04
Thermomechanics of nanocrystalline nickel under high pressure-temperature conditions. Nano Lett (2007) 1.02
Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett (2006) 1.02
Severe acute pancreatitis in China: etiology and mortality in 1976 patients. Pancreas (2007) 1.01
Toward low friction in high vacuum for hydrogenated diamondlike carbon by tailoring sliding interface. ACS Appl Mater Interfaces (2013) 1.01
The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer. Oncotarget (2014) 1.01
Neuroprotective role of bradykinin because of the attenuation of pro-inflammatory cytokine release from activated microglia. J Neurochem (2007) 1.01
Phylogenetic diversity of the Bacillus pumilus group and the marine ecotype revealed by multilocus sequence analysis. PLoS One (2013) 1.00
Acupuncture for dysphagia in acute stroke. Cochrane Database Syst Rev (2008) 1.00
Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation. Cancer Res (2013) 1.00
Alcanivorax pacificus sp. nov., isolated from a deep-sea pyrene-degrading consortium. Int J Syst Evol Microbiol (2010) 0.98
Isolation of murine bone marrow derived mesenchymal stem cells using Twist2 Cre transgenic mice. Bone (2010) 0.98
Nitratireductor pacificus sp. nov., isolated from a pyrene-degrading consortium. Int J Syst Evol Microbiol (2010) 0.98
Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett (2004) 0.98
Corticosteroids reverse cytokine-induced block of survival and differentiation of oligodendrocyte progenitor cells from rats. J Neuroinflammation (2008) 0.98
Structural basis for calmodulin as a dynamic calcium sensor. Structure (2012) 0.97
Highly regioselective palladium-catalyzed direct arylation of oxazole at C-2 or C-5 with aryl bromides, chlorides, and triflates. Org Lett (2010) 0.97
Neuropeptides contribute to peripheral nociceptive sensitization by regulating interleukin-1β production in keratinocytes. Anesth Analg (2011) 0.96
Neuropeptide deficient mice have attenuated nociceptive, vascular, and inflammatory changes in a tibia fracture model of complex regional pain syndrome. Mol Pain (2012) 0.96
Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the nuclear factor erythroid 2-related factor 2 pathway. J Pharmacol Exp Ther (2012) 0.96
Tumor endothelial marker 1-specific DNA vaccination targets tumor vasculature. J Clin Invest (2014) 0.96
4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett (2004) 0.96