Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning.

PubWeight™: 0.92‹?›

🔗 View Article (PMC 2851812)

Published in Proc Natl Acad Sci U S A on March 08, 2010

Authors

Cortney M Bouldin1, Amel Gritli-Linde, Sohyun Ahn, Brian D Harfe

Author Affiliations

1: Department of Molecular Genetics and Microbiology, The Genetics Institute, University of Florida, Gainesville, FL 32610, USA.

Articles cited by this

Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet (1999) 55.63

A series of normal stages in the development of the chick embryo. J Morphol (1951) 17.89

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46

Altered neural cell fates and medulloblastoma in mouse patched mutants. Science (1997) 11.44

Sonic hedgehog mediates the polarizing activity of the ZPA. Cell (1993) 8.67

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev (1999) 8.43

Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell (2004) 7.01

Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol (1993) 6.38

Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol (1995) 5.36

Communicating with Hedgehogs. Nat Rev Mol Cell Biol (2005) 5.01

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development (1995) 4.65

Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell (2004) 3.33

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell (1994) 2.98

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev (2008) 2.66

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development (2007) 2.60

Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat Genet (2000) 2.59

Fgf8 signalling from the AER is essential for normal limb development. Nat Genet (2000) 2.44

Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development (2004) 2.39

Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev (2003) 2.34

Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat Genet (2003) 2.31

Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud. Dev Cell (2008) 2.25

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proc Natl Acad Sci U S A (1999) 2.04

The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev Biol (2001) 1.98

Image averaging of flexible fibrous macromolecules: the clathrin triskelion has an elastic proximal segment. J Struct Biol (1991) 1.94

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell (2001) 1.88

Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev Biol (1996) 1.85

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development (1997) 1.82

Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development (1996) 1.80

Sonic hedgehog signaling by the patched-smoothened receptor complex. Curr Biol (1999) 1.79

Integration of growth and specification in chick wing digit-patterning. Nature (2008) 1.70

A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning. Science (2009) 1.58

An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth. Nature (2008) 1.55

FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev Cell (2009) 1.53

Apoptosis and morphology in mouse embryos by confocal laser scanning microscopy. Methods (1999) 1.41

The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science (2004) 1.40

Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell (2009) 1.38

Sonic hedgehog function in chondrichthyan fins and the evolution of appendage patterning. Nature (2006) 1.32

Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: dorsal signals regulate anteroposterior patterning. Cell (1995) 1.31

Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis. Dev Biol (2001) 1.29

A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Curr Biol (1995) 1.26

Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function. Development (2005) 1.24

Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling. Development (2006) 1.22

Regulation of Gremlin expression in the posterior limb bud. Dev Biol (2006) 1.12

Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development. Development (2000) 1.12

Interplay between the molecular signals that control vertebrate limb development. Int J Dev Biol (2002) 1.07

Sonic Hedgehog as a mediator of long-range signaling. Bioessays (2002) 0.97

The smoothened gene and hedgehog signal transduction in Drosophila and vertebrate development. Cold Spring Harb Symp Quant Biol (1997) 0.94

Retinoic acid and pattern formation in the developing chick wing: SEM and quantitative studies of early effects on the apical ectodermal ridge and bud outgrowth. J Embryol Exp Morphol (1985) 0.90

Shh signaling in limb bud ectoderm: potential role in teratogen-induced postaxial ectrodactyly. Dev Dyn (2005) 0.86

Aberrant FGF signaling, independent of ectopic hedgehog signaling, initiates preaxial polydactyly in Dorking chickens. Dev Biol (2009) 0.82

Development of the apical ectodermal ridge in the chick wing bud. J Embryol Exp Morphol (1984) 0.79

Disrupting the establishment of polarizing activity by teratogen exposure. Mech Dev (1999) 0.76

Articles by these authors

MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11

Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87

Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev Cell (2005) 3.98

BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet (2006) 3.79

The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature (2005) 3.78

Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron (2003) 3.76

Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci (2008) 3.33

Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet (2006) 3.27

Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. J Physiol (2009) 3.02

Cell behaviors and genetic lineages of the mesencephalon and rhombomere 1. Neuron (2004) 2.93

Epidermal stem cells arise from the hair follicle after wounding. FASEB J (2007) 2.81

MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes (2007) 2.80

Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol (2004) 2.77

Essential role for Dicer during skeletal muscle development. Dev Biol (2007) 2.76

Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest (2004) 2.72

Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol (2008) 2.69

The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol (2008) 2.61

Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways. J Biol Chem (2009) 2.59

Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci (2008) 2.50

Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A (2009) 2.33

Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A (2008) 2.32

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28

Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem (2009) 2.07

LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J (2009) 1.99

TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res (2012) 1.98

Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells. J Biol Chem (2010) 1.93

Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation. Dev Dyn (2008) 1.91

TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A. J Biol Chem (2009) 1.89

Degeneration and regeneration of the intervertebral disc: lessons from development. Dis Model Mech (2010) 1.69

The microRNA-processing enzyme dicer maintains juxtaglomerular cells. J Am Soc Nephrol (2010) 1.60

Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate. Nat Genet (2012) 1.60

Lrp4 modulates extracellular integration of cell signaling pathways in development. PLoS One (2008) 1.60

Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice. Dev Biol (2009) 1.55

Dicer1 is required for differentiation of the mouse male germline. Biol Reprod (2008) 1.52

Cell lineage analysis demonstrates an endodermal origin of the distal urethra and perineum. Dev Biol (2008) 1.51

Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons. Neuron (2012) 1.50

Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae. Mol Cell Biol (2002) 1.49

A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning. Dev Cell (2003) 1.48

The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science (2004) 1.40

Sertoli cell Dicer is essential for spermatogenesis in mice. Dev Biol (2008) 1.37

Ano1 as a regulator of proliferation. Am J Physiol Gastrointest Liver Physiol (2011) 1.32

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell (2007) 1.31

Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract. Mamm Genome (2009) 1.31

Expression of TMEM16 paralogs during murine embryogenesis. Dev Dyn (2008) 1.30

Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans. FASEB J (2004) 1.28

Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development (2005) 1.27

Multiphasic and tissue-specific roles of sonic hedgehog in cloacal septation and external genitalia development. Development (2009) 1.23

PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis. Dev Dyn (2002) 1.21

BMP4 is dispensable for skeletogenesis and fracture-healing in the limb. J Bone Joint Surg Am (2008) 1.20

Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs. Proc Natl Acad Sci U S A (2011) 1.15

Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development (2004) 1.13

Characterization of a novel ectodermal signaling center regulating Tbx2 and Shh in the vertebrate limb. Dev Biol (2006) 1.13

Fate-mapping of the epithelial seam during palatal fusion rules out epithelial-mesenchymal transformation. Dev Biol (2005) 1.11

Expression patterns of the Tmem16 gene family during cephalic development in the mouse. Gene Expr Patterns (2008) 1.04

In the limb AER Bmp2 and Bmp4 are required for dorsal-ventral patterning and interdigital cell death but not limb outgrowth. Dev Biol (2009) 1.01

Structural basis for activation of fibroblast growth factor signaling by sucrose octasulfate. Mol Cell Biol (2002) 1.00

Analysis of the regulation of lin-41 during chick and mouse limb development. Dev Dyn (2005) 1.00

The molecular profiles of neural stem cell niche in the adult subventricular zone. PLoS One (2012) 0.97

MicroRNAs in mammalian development and tumorigenesis. Birth Defects Res C Embryo Today (2006) 0.97

Needle puncture injury causes acute and long-term mechanical deficiency in a mouse model of intervertebral disc degeneration. J Orthop Res (2013) 0.97

Timing of Sonic hedgehog and Gli1 expression segregates midbrain dopamine neurons. J Comp Neurol (2011) 0.95

Electrical slow waves in the mouse oviduct are dependent upon a calcium activated chloride conductance encoded by Tmem16a. Biol Reprod (2012) 0.95

Gli3 is required for maintenance and fate specification of cortical progenitors. J Neurosci (2011) 0.94

Avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: implications for evolution of the vertebrate disc. Dev Dyn (2012) 0.93

The transmembrane protein 16A Ca(2+)-activated Cl- channel in airway smooth muscle contributes to airway hyperresponsiveness. Am J Respir Crit Care Med (2012) 0.93

Organization of the Indian hedgehog--parathyroid hormone-related protein system in the postnatal growth plate. J Mol Endocrinol (2011) 0.92

Foxa1 and Foxa2 are required for formation of the intervertebral discs. PLoS One (2013) 0.92

Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet (2012) 0.89

Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Genes Dev (2012) 0.89

The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol (2011) 0.89

Identification of genes expressed in the mouse limb using a novel ZPA microarray approach. Gene Expr Patterns (2007) 0.88

Depth-variant deconvolution of 3D widefield fluorescence microscopy using the penalized maximum likelihood estimation method. Opt Express (2013) 0.87

Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala. Neural Dev (2010) 0.87

Duration of Shh signaling contributes to mDA neuron diversity. Dev Biol (2012) 0.86

Genetic deletion of sonic hedgehog causes hemiagenesis and ectopic development of the thyroid in mouse. Am J Pathol (2004) 0.86

Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs. Mech Dev (2012) 0.85

Notochord to Nucleus Pulposus Transition. Curr Osteoporos Rep (2015) 0.84

Aberrant FGF signaling, independent of ectopic hedgehog signaling, initiates preaxial polydactyly in Dorking chickens. Dev Biol (2009) 0.82

Developmental changes in cellular and extracellular structural macromolecules in the secondary palate and in the nasal cavity of the mouse. Eur J Oral Sci (2010) 0.82

Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish. Genesis (2014) 0.81

The sonic hedgehog pathway in chordoid tumours. Histopathology (2010) 0.80

Bmp2, Bmp4 and Bmp7 are co-required in the mouse AER for normal digit patterning but not limb outgrowth. PLoS One (2012) 0.80

Retracted Phylogenetic, expression, and functional analyses of anoctamin homologs in Caenorhabditis elegans. Am J Physiol Regul Integr Comp Physiol (2013) 0.79

Nuclear factor 1-C2 is regulated by prolactin and shows a distinct expression pattern in the mouse mammary epithelial cells during development. Mol Endocrinol (2005) 0.79

Nuclei pulposi formation from the embryonic notochord occurs normally in GDF-5-deficient mice. Spine (Phila Pa 1976) (2011) 0.76

Expression of Pit2 sodium-phosphate cotransporter during murine odontogenesis is developmentally regulated. Eur J Oral Sci (2006) 0.75

Estimation of particle size distribution using photon autocorrelation function from dynamic light scattering considering unknown baseline. Opt Lett (2013) 0.75

Rapid Electroformation of Biopolymer Gels in Prescribed Shapes and Patterns: A Simpler Alternative to 3-D Printing. ACS Appl Mater Interfaces (2019) 0.75