Genetics of early-onset obsessive-compulsive disorder.

Obsessive-compulsive disorder in children and adolescents. Dtsch Arztebl Int (2011) 2.10

Annual research review: The neurobehavioral development of multiple memory systems--implications for childhood and adolescent psychiatric disorders. J Child Psychol Psychiatry (2013) 1.46

GABA and Glutamate Transporters in Brain. Front Endocrinol (Lausanne) (2013) 1.06

Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. Neurosci Biobehav Rev (2011) 1.00

Glutamate as a neurotransmitter in the healthy brain. J Neural Transm (Vienna) (2014) 0.97

Environmental effects on compulsive tail chasing in dogs. PLoS One (2012) 0.97

High frequency of known copy number abnormalities and maternal duplication 15q11-q13 in patients with combined schizophrenia and epilepsy. BMC Med Genet (2011) 0.95

Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes. J Neurosci (2015) 0.93

Child and adolescent psychiatric genetics. Eur Child Adolesc Psychiatry (2010) 0.86

Pilot study on HTR2A promoter polymorphism, -1438G/A (rs6311) and a nearby copy number variation showed association with onset and severity in early onset obsessive-compulsive disorder. J Neural Transm (Vienna) (2011) 0.82

Circadian rhythms in obsessive-compulsive disorder. J Neural Transm (Vienna) (2012) 0.82

Pharmacogenomics in psychiatry: the relevance of receptor and transporter polymorphisms. Br J Clin Pharmacol (2014) 0.82

The role of the serotonergic and GABA system in translational approaches in drug discovery for anxiety disorders. Front Pharmacol (2013) 0.80

Neuroimaging of cognitive brain function in paediatric obsessive compulsive disorder: a review of literature and preliminary meta-analysis. J Neural Transm (Vienna) (2012) 0.80

Trio study and meta-analysis support the association of genetic variation at the serotonin transporter with early-onset obsessive-compulsive disorder. Neurosci Lett (2014) 0.79

The neurobiological link between OCD and ADHD. Atten Defic Hyperact Disord (2014) 0.79

Association between Obsessive Compulsive Disorder and Tumor Necrosis Factor-α Gene -308 (G>A) and -850 (C>T) Polymorphisms in Turkish Children. Balkan J Med Genet (2012) 0.78

A review of obsessive-compulsive disorder in children and adolescents. Dialogues Clin Neurosci (2011) 0.77

DNA Methylation at the Neonatal State and at the Time of Diagnosis: Preliminary Support for an Association with the Estrogen Receptor 1, Gamma-Aminobutyric Acid B Receptor 1, and Myelin Oligodendrocyte Glycoprotein in Female Adolescent Patients with OCD. Front Psychiatry (2016) 0.75

Increased decision thresholds enhance information gathering performance in juvenile Obsessive-Compulsive Disorder (OCD). PLoS Comput Biol (2017) 0.75

Cool and Hot Aspects of Executive Function in Childhood Obsessive-Compulsive Disorder. J Abnorm Child Psychol (2016) 0.75

Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry (2005) 58.92

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet (1995) 49.77

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science (1996) 16.04

Allelic variation of human serotonin transporter gene expression. J Neurochem (1996) 7.08

Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet (2006) 6.27

Meta-analysis of the symptom structure of obsessive-compulsive disorder. Am J Psychiatry (2008) 2.64

Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nat Neurosci (2005) 2.31

A family study of obsessive-compulsive disorder. Am J Psychiatry (1995) 2.24

Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder. Arch Gen Psychiatry (2006) 2.23

Targeting the murine serotonin transporter: insights into human neurobiology. Nat Rev Neurosci (2008) 2.21

Long-term outcome of pediatric obsessive-compulsive disorder: a meta-analysis and qualitative review of the literature. Acta Psychiatr Scand (2004) 2.05

A family study of obsessive-compulsive disorder. Arch Gen Psychiatry (2000) 2.03

Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder. Arch Gen Psychiatry (2006) 2.02

dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing. RNA (2000) 1.95

Obsessive compulsive disorder in adolescence: an epidemiological study. J Am Acad Child Adolesc Psychiatry (1988) 1.55

A twin study of anxiety-related behaviours in pre-school children. J Child Psychol Psychiatry (2003) 1.48

Obsessive-compulsive disorder phenotypes: implications for genetic studies. Mol Psychiatry (2005) 1.44

Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder. NeuroRx (2006) 1.43

Twin studies on obsessive-compulsive disorder: a review. Twin Res Hum Genet (2005) 1.41

Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. Psychopharmacology (Berl) (2004) 1.39

Frequency of obsessive-compulsive disorder in a community sample of young adolescents. J Am Acad Child Adolesc Psychiatry (1994) 1.39

Glutamatergic dysfunction in OCD. Neuropsychopharmacology (2005) 1.36

Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. Am J Med Genet (2002) 1.35

Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. Am J Hum Genet (2003) 1.32

Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet (2007) 1.27

Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q. Mol Psychiatry (2006) 1.24

A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder. Arch Gen Psychiatry (2009) 1.16

Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorder. Am J Hum Genet (2004) 1.13

A family study of early-onset obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet (2005) 1.13

Psychiatric disorders in first degree relatives of children and adolescents with obsessive compulsive disorder. J Am Acad Child Adolesc Psychiatry (1990) 1.12

A family study of obsessive-compulsive disorder with pediatric probands. Am J Med Genet B Neuropsychiatr Genet (2005) 1.10

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder. Int J Neuropsychopharmacol (2005) 1.08

A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder. Neuropsychopharmacology (2007) 1.07

Psychiatric disorders in the families of patients with obsessive-compulsive disorder. Psychiatry Res (1992) 1.06

Early-onset obsessive-compulsive disorder: a subgroup with a specific clinical and familial pattern? J Child Psychol Psychiatry (2005) 1.04

The genetics of obsessive compulsive disorder: a review of the evidence. Am J Med Genet C Semin Med Genet (2008) 1.04

Obsessive compulsive disorder in children and adolescents: phenomenology and family history. J Am Acad Child Adolesc Psychiatry (1990) 1.02

Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder. Mol Psychiatry (2001) 0.98

A family study of obsessive-compulsive disorder. Arch Gen Psychiatry (1992) 0.96

Genetic and environmental contributions to the Child Behavior Checklist Obsessive-Compulsive Scale: a cross-cultural twin study. Arch Gen Psychiatry (2004) 0.96

Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins. Psychol Med (2006) 0.96

Updated overview of the putative role of the serotoninergic system in obsessive-compulsive disorder. Neuropsychiatr Dis Treat (2005) 0.93

Symptom dimensions in obsessive-compulsive disorder: toward quantitative phenotypes. Am J Med Genet (2001) 0.92

Extensive genotyping of the BDNF and NTRK2 genes define protective haplotypes against obsessive-compulsive disorder. Biol Psychiatry (2007) 0.90

Evidence for a susceptibility locus on chromosome 10p15 in early-onset obsessive-compulsive disorder. Biol Psychiatry (2007) 0.90

Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system. J Neural Transm (Vienna) (2008) 0.89

Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder. Biol Psychiatry (2001) 0.86

Myelin oligodendrocyte glycoprotein (MOG) gene is associated with obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet (2004) 0.86

Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/A. Mol Psychiatry (1999) 0.83

Evidence for potential relationship between SLC1A1 and a putative genetic linkage region on chromosome 14q to obsessive-compulsive disorder with compulsive hoarding. Am J Med Genet B Neuropsychiatr Genet (2008) 0.83

Genetics of obsessive-compulsive disorder: a research update. Expert Rev Neurother (2007) 0.81

5-HT2A promoter polymorphism -1438G/A in children and adolescents with obsessive-compulsive disorders. Mol Psychiatry (2002) 0.81

Transmission disequilibrium studies in children and adolescents with obsessive-compulsive disorders pertaining to polymorphisms of genes of the serotonergic pathway. J Neural Transm (Vienna) (2004) 0.81

A family study of juvenile obsessive-compulsive disorder. Can J Psychiatry (2001) 0.81

Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes. Isr J Psychiatry Relat Sci (2008) 0.81

Family study of obsessive-compulsive disorder in a Mexican population. Arch Med Res (1993) 0.79

An exploratory study on obsessive-compulsive disorder with and without a familial component: are there any phenomenological differences? Psychopathology (2002) 0.78

Brain-derived neurotrophic factor V66M polymorphism in childhood-onset obsessive-compulsive disorder. Int J Neuropsychopharmacol (2005) 0.76

Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry (2010) 3.13

Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. Am J Psychiatry (2012) 2.48

Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. Nat Genet (2010) 2.46

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. J Neural Transm (Vienna) (2008) 2.43

Obsessive-compulsive disorder in children and adolescents. Dtsch Arztebl Int (2011) 2.10

Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. Am J Hum Genet (2005) 1.94

Case-control genome-wide association study of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry (2010) 1.86

Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys. Biol Psychiatry (2005) 1.81

Contribution of common genetic variants to antidepressant response. Biol Psychiatry (2012) 1.73

Gene expression and genetic variation data implicate PCLO in bipolar disorder. Biol Psychiatry (2010) 1.70

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet (2013) 1.68

Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nat Genet (2011) 1.63

How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology (2008) 1.56

Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet (2008) 1.48

Echogenicity of the substantia nigra: association with increased iron content and marker for susceptibility to nigrostriatal injury. Arch Neurol (2002) 1.45

A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia. Hum Mol Genet (2007) 1.32

Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation. J Neurochem (2009) 1.28

A common neural basis for receptive and expressive communication of pleasant facial affect. Neuroimage (2005) 1.24

Empathy in children with autism and conduct disorder: group-specific profiles and developmental aspects. J Child Psychol Psychiatry (2011) 1.23

Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis. PLoS Med (2012) 1.19

The history of attention deficit hyperactivity disorder. Atten Defic Hyperact Disord (2010) 1.16

Subthalamic nucleus stimulation affects a frontotemporal network: a PET study. Ann Neurol (2003) 1.15

Developmental comorbidity in attention-deficit/hyperactivity disorder. Atten Defic Hyperact Disord (2010) 1.13

Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants. Am J Med Genet B Neuropsychiatr Genet (2013) 1.11

Effects of methylphenidate on multiple components of attention in children with attention deficit hyperactivity disorder. Psychopharmacology (Berl) (2006) 1.11

High loading of polygenic risk for ADHD in children with comorbid aggression. Am J Psychiatry (2013) 1.10

Genome-wide association study in German patients with attention deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet (2011) 1.09

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder. Int J Neuropsychopharmacol (2005) 1.08

Effects of gum chewing on memory and attention: reply to Scholey (2004). Appetite (2004) 1.08

Executive functions in children with dyslexia. Dyslexia (2005) 1.07

Further evidence for DYX1C1 as a susceptibility factor for dyslexia. Psychiatr Genet (2009) 1.06

Long-term outcome and prognosis of dissociative disorder with onset in childhood or adolescence. Child Adolesc Psychiatry Ment Health (2008) 1.04

Diminished cooperativeness of psychopaths in a prisoner's dilemma game yields higher rewards. J Abnorm Psychol (2008) 1.04

Altered response control and anterior cingulate function in attention-deficit/hyperactivity disorder boys. Clin Neurophysiol (2004) 1.04

Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample. J Neural Transm (Vienna) (2008) 1.00

Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sample. Psychiatr Genet (2008) 1.00

A systematic eQTL study of cis-trans epistasis in 210 HapMap individuals. Eur J Hum Genet (2011) 1.00

Risky behavior in gambling tasks in individuals with ADHD--a systematic literature review. PLoS One (2013) 1.00

The extent of social anxiety in combination with mental disorders. Eur Child Adolesc Psychiatry (2006) 0.99

Vigilance and sustained attention in children and adults with ADHD. J Atten Disord (2008) 0.99

Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling. Mol Cell Neurosci (2007) 0.98

Association of attention-deficit/hyperactivity disorder and atopic eczema modified by sleep disturbance in a large population-based sample. J Epidemiol Community Health (2009) 0.96

Novel mutations of the extraneuronal monoamine transporter gene in children and adolescents with obsessive-compulsive disorder. Int J Neuropsychopharmacol (2007) 0.96

Human prefrontal and sensory cortical activity during divided attention tasks. Hum Brain Mapp (2003) 0.96

Elevated physical activity and low leptin levels co-occur in patients with anorexia nervosa. J Clin Endocrinol Metab (2003) 0.95

miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells. Int J Neuropsychopharmacol (2012) 0.94

A pharmacological analysis of mice with a targeted disruption of the serotonin transporter. Psychopharmacology (Berl) (2007) 0.94

A systematic review on olfaction in child and adolescent psychiatric disorders. J Neural Transm (Vienna) (2012) 0.94

Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity. Philos Trans R Soc Lond B Biol Sci (2013) 0.94

Preoperative and postoperative cognitive functioning in patients with frontal meningiomas. J Neurosurg (2003) 0.92

Chewing gum differentially affects aspects of attention in healthy subjects. Appetite (2004) 0.91

Echogenicity of the substantia nigra in relatives of patients with sporadic Parkinson's disease. Neuroimage (2003) 0.90

Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. Am J Psychiatry (2014) 0.90

Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21. Am J Med Genet B Neuropsychiatr Genet (2010) 0.90

Does methylphenidate cause a cytogenetic effect in children with attention deficit hyperactivity disorder? Environ Health Perspect (2007) 0.89

Clinical drug monitoring in child and adolescent psychiatry: side effects of atypical neuroleptics. J Child Adolesc Psychopharmacol (2006) 0.89

Neural networks of response shifting: influence of task speed and stimulus material. Brain Res (2006) 0.89

Animal models of attention deficit/hyperactivity disorder (ADHD): a critical review. Atten Defic Hyperact Disord (2010) 0.89

Brain dopamine and kinematics of graphomotor functions. Hum Mov Sci (2006) 0.89

Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system. J Neural Transm (Vienna) (2008) 0.89

Improved odor sensitivity in attention-deficit/hyperactivity disorder. Biol Psychiatry (2008) 0.88

Weight gain in children and adolescents during 45 weeks treatment with clozapine, olanzapine and risperidone. J Neural Transm (Vienna) (2008) 0.88

Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet (2013) 0.88

The genetics of panic disorder. J Med Genet (2011) 0.88

Biomarkers for attention-deficit/hyperactivity disorder (ADHD). A consensus report of the WFSBP task force on biological markers and the World Federation of ADHD. World J Biol Psychiatry (2012) 0.87

Evidence for the late MMN as a neurophysiological endophenotype for dyslexia. PLoS One (2012) 0.87

Is moderate substance use associated with altered executive functioning in a population-based sample of young adults? Hum Psychopharmacol (2009) 0.87

Developmental dyslexia--recurrence risk estimates from a german bi-center study using the single proband sib pair design. Hum Hered (2005) 0.87

A double-blind, randomized, placebo/active controlled crossover evaluation of the efficacy and safety of Ritalin ® LA in children with attention-deficit/hyperactivity disorder in a laboratory classroom setting. J Child Adolesc Psychopharmacol (2010) 0.87

The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sample. Schizophr Res (2010) 0.87

Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice. BMC Pharmacol (2011) 0.87

Increased gene expression of diacylglycerol kinase η in bipolar disorder. Int J Neuropsychopharmacol (2010) 0.86

Multicenter P300 brain mapping of impaired attention to cues in hyperkinetic children. J Am Acad Child Adolesc Psychiatry (2002) 0.86

Influence of a genetic variant of the neuronal growth associated protein Stathmin 1 on cognitive and affective control processes: an event-related potential study. Am J Med Genet B Neuropsychiatr Genet (2011) 0.86

Measurement of stigmatization towards adults with attention deficit hyperactivity disorder. PLoS One (2012) 0.86

SNP variations in the 7q33 region containing DGKI are associated with dyslexia in the Finnish and German populations. Behav Genet (2011) 0.86

Cognitive behavioral therapy of socially phobic children focusing on cognition: a randomised wait-list control study. Child Adolesc Psychiatry Ment Health (2011) 0.85

Abnormal affective responsiveness in attention-deficit/hyperactivity disorder: subtype differences. Biol Psychiatry (2008) 0.85

Training of attention functions in children with attention deficit hyperactivity disorder. Atten Defic Hyperact Disord (2011) 0.85

Increased mRNA levels of the mitochondrial complex I 75-kDa subunit. A potential peripheral marker of early onset schizophrenia? Eur Child Adolesc Psychiatry (2006) 0.84

Proteomic research in psychiatry. J Psychopharmacol (2010) 0.84

Functional neuroanatomy of perceiving surprised faces. Hum Brain Mapp (2004) 0.84

The psychopathological and psychosocial outcome of early-onset schizophrenia: preliminary data of a 13-year follow-up. Child Adolesc Psychiatry Ment Health (2008) 0.83

Executive functioning in daily life in Parkinson's disease: initiative, planning and multi-task performance. PLoS One (2011) 0.83

Clustering and switching on verbal and figural fluency functions in adults with attention deficit hyperactivity disorder. Cogn Neuropsychiatry (2005) 0.83

A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry. Schizophr Res (2010) 0.83

Differential effects of methylphenidate on problem solving in adults with ADHD. J Atten Disord (2010) 0.83

Evaluation of the efficacy and effectiveness of a structured disorder tailored psychotherapy in ADHD in adults: study protocol of a randomized controlled multicentre trial. Atten Defic Hyperact Disord (2010) 0.83

Prefrontal oxygenation during working memory in ADHD. J Psychiatr Res (2009) 0.83

Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder. Mov Disord (2013) 0.83