Published in Future Oncol on March 01, 2010
CC3/TIP30 regulates metabolic adaptation of tumor cells to glucose limitation. Cell Cycle (2010) 2.26
AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. J Mol Med (Berl) (2011) 2.26
Autophagy and cancer. Exp Mol Med (2012) 1.57
SnRK2 protein kinases--key regulators of plant response to abiotic stresses. OMICS (2011) 1.40
Inositols in the Treatment of Insulin-Mediated Diseases. Int J Endocrinol (2016) 1.40
Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1. Eur J Cancer Prev (2016) 1.39
Dual blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) pathways synergistically inhibits rhabdomyosarcoma cell growth in vitro and in vivo. Clin Cancer Res (2013) 1.37
Suppression of AMPK activation via S485 phosphorylation by IGF-I during hyperglycemia is mediated by AKT activation in vascular smooth muscle cells. Endocrinology (2011) 1.21
Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Mol Cell (2014) 1.21
Radiation metabolomics and its potential in biodosimetry. Int J Radiat Biol (2011) 1.20
The proline regulatory axis and cancer. Front Oncol (2012) 1.10
The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. J Clin Invest (2014) 1.10
Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition. J Biol Chem (2012) 1.08
Cancer cell signaling pathways targeted by spice-derived nutraceuticals. Nutr Cancer (2011) 1.07
The antidiabetic drug metformin inhibits the proliferation of bladder cancer cells in vitro and in vivo. Int J Mol Sci (2013) 1.05
Targeting AMPK for cardiac protection: opportunities and challenges. J Mol Cell Cardiol (2010) 1.04
LITAF and TNFSF15, two downstream targets of AMPK, exert inhibitory effects on tumor growth. Oncogene (2011) 1.03
Reversing the Warburg effect as a treatment for glioblastoma. J Biol Chem (2013) 1.02
Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis. Proc Natl Acad Sci U S A (2013) 1.02
AMP-activated protein kinase inhibits vascular smooth muscle cell proliferation and migration and vascular remodeling following injury. Am J Physiol Heart Circ Physiol (2012) 1.00
Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies. Mol Cancer Res (2015) 0.97
Role of AMPK in UVB-induced DNA damage repair and growth control. Oncogene (2012) 0.96
Metabolic alterations in cancer cells and therapeutic implications. Chin J Cancer (2011) 0.96
AMPKα2 Suppresses Murine Embryonic Fibroblast Transformation and Tumorigenesis. Genes Cancer (2012) 0.94
AMP-Activated Protein Kinase α 2 Isoform Suppression in Primary Breast Cancer Alters AMPK Growth Control and Apoptotic Signaling. Genes Cancer (2013) 0.94
Surviving change: the metabolic journey of hematopoietic stem cells. Trends Cell Biol (2014) 0.93
Yeast and cancer cells - common principles in lipid metabolism. Biochim Biophys Acta (2012) 0.92
Use of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation. PLoS One (2014) 0.92
Metformin Induced AMPK Activation, G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal Squamous Cell Carcinomas In Vitro and In Vivo. PLoS One (2015) 0.91
Natural compounds as regulators of the cancer cell metabolism. Int J Cell Biol (2013) 0.91
5-Aminoimidazole-4-carboxyamide ribonucleoside induces G(1)/S arrest and Nanog downregulation via p53 and enhances erythroid differentiation. Stem Cells (2012) 0.90
Negative regulation of AMP-activated protein kinase (AMPK) activity by macrophage migration inhibitory factor (MIF) family members in non-small cell lung carcinomas. J Biol Chem (2012) 0.90
Mitochondrial dysfunction in some triple-negative breast cancer cell lines: role of mTOR pathway and therapeutic potential. Breast Cancer Res (2014) 0.90
NUAK2: an emerging acral melanoma oncogene. Oncotarget (2011) 0.90
Multifaceted roles of adiponectin in cancer. Best Pract Res Clin Endocrinol Metab (2013) 0.89
Control of Glycolytic Flux by AMP-Activated Protein Kinase in Tumor Cells Adapted to Low pH. Transl Oncol (2012) 0.89
ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis. Cancer Lett (2012) 0.89
Metformin effects revisited. Diabetes Res Clin Pract (2011) 0.88
CYP1A1 regulates breast cancer proliferation and survival. Mol Cancer Res (2013) 0.88
AMPK isoform expression in the normal and failing hearts. J Mol Cell Cardiol (2012) 0.87
Chemical metabolic inhibitors for the treatment of blood-borne cancers. Anticancer Agents Med Chem (2014) 0.87
Heterogeneity of glycolysis in cancers and therapeutic opportunities. Biochem Pharmacol (2014) 0.86
Long-term use of metformin and colorectal cancer risk in type II diabetics: a population-based case-control study. Cancer Med (2014) 0.85
Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity. Cell Death Differ (2015) 0.84
Emerging glycolysis targeting and drug discovery from chinese medicine in cancer therapy. Evid Based Complement Alternat Med (2012) 0.84
Mechanistic and pharmacological issues of aspirin as an anticancer agent. Pharmaceuticals (Basel) (2012) 0.84
Metformin inhibits leptin-induced growth and migration of glioblastoma cells. Oncol Lett (2012) 0.83
Astrocyte elevated gene-1 mediates glycolysis and tumorigenesis in colorectal carcinoma cells via AMPK signaling. Mediators Inflamm (2014) 0.82
AMPK as a potential anticancer target - friend or foe? Curr Pharm Des (2014) 0.82
The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells. PLoS One (2012) 0.82
Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets. Front Oncol (2015) 0.82
Diabetes medications and cancer risk: review of the literature. Am Health Drug Benefits (2012) 0.81
AMPK Inhibits the Stimulatory Effects of TGF-β on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal Transition. Mol Pharmacol (2015) 0.81
Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway. J Anim Sci Biotechnol (2012) 0.81
Pharmacologic regulation of AMPK in breast cancer affects cytoskeletal properties involved with microtentacle formation and re-attachment. Oncotarget (2015) 0.80
Glycolytic switch in response to betulinic acid in non-cancer cells. PLoS One (2014) 0.79
AMPK-activated protein kinase activation by Impatiens balsamina L. is related to apoptosis in HSC-2 human oral cancer cells. Pharmacogn Mag (2015) 0.79
AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts. Biochim Biophys Acta (2014) 0.79
Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment. Drug Des Devel Ther (2014) 0.79
MLK3 phophorylates AMPK independently of LKB1. PLoS One (2015) 0.79
Implication of transcriptional repression in compound C-induced apoptosis in cancer cells. Cell Death Dis (2013) 0.79
CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells. J Exp Clin Cancer Res (2016) 0.78
AMPK activity is down-regulated in endothelial cells of GHS-R(-/-) mice. Int J Clin Exp Pathol (2013) 0.78
Fluorinated N,N'-diarylureas as AMPK activators. Bioorg Med Chem Lett (2013) 0.78
Metabolic syndrome-breast cancer link varies by intrinsic molecular subtype. Diabetol Metab Syndr (2014) 0.78
Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action. J Med Chem (2012) 0.77
AMPK promotes tolerance to Ras pathway inhibition by activating autophagy. Oncogene (2016) 0.77
LKB1/AMPK inhibits TGF-β1 production and the TGF-β signaling pathway in breast cancer cells. Tumour Biol (2015) 0.77
Adiponectin and colorectal cancer. Surg Today (2016) 0.77
TMP21 modulates cell growth in papillary thyroid cancer cells by inducing autophagy through activation of the AMPK/mTOR pathway. Int J Clin Exp Pathol (2015) 0.76
Vitamin D mitigates the adverse effects of obesity on breast cancer in mice. Endocr Relat Cancer (2016) 0.76
Caffeic Acid Expands Anti-Tumor Effect of Metformin in Human Metastatic Cervical Carcinoma HTB-34 Cells: Implications of AMPK Activation and Impairment of Fatty Acids De Novo Biosynthesis. Int J Mol Sci (2017) 0.75
Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Sci Rep (2017) 0.75
Co-inhibition of EGFR and IGF1R synergistically impacts therapeutically on adrenocortical carcinoma. Oncotarget (2016) 0.75
Grape seed extract targets mitochondrial electron transport chain complex III and induces oxidative and metabolic stress leading to cytoprotective autophagy and apoptotic death in human head and neck cancer cells. Mol Carcinog (2014) 0.75
Negative regulation of Bmi-1 by AMPK and implication in cancer progression. Oncotarget (2016) 0.75
Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment. Oncotarget (2016) 0.75
Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway. Oncotarget (2017) 0.75
Anti-Obesity Effects of Spiramycin In Vitro and In Vivo. PLoS One (2016) 0.75
Cryptolepine inhibits melanoma cell growth through coordinated changes in mitochondrial biogenesis, dynamics and metabolic tumor suppressor AMPKα1/2-LKB1. Sci Rep (2017) 0.75
Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer. Biosci Rep (2014) 0.75
AMPKα1 deletion in fibroblasts promotes tumorigenesis in athymic nude mice by p52-mediated elevation of erythropoietin and CDK2. Oncotarget (2016) 0.75
AMPK downregulates ALK2 via increasing the interaction between Smurf1 and Smad6, leading to inhibition of in vitro osteogenic differentiation. Biochim Biophys Acta (2017) 0.75
The imidazoline compound RX871024 promotes insulinoma cell death independent of AMP-activated protein kinase inhibition. Invest New Drugs (2016) 0.75
MicroRNA Regulation of Glycolytic Metabolism in Glioblastoma. Biomed Res Int (2017) 0.75
Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK4/6 independent manner. Mol Oncol (2017) 0.75
Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities. Cell Discov (2017) 0.75
Cancer: Linking Powerhouses to Suicidal Bags. Front Oncol (2017) 0.75
Similarities in the Metabolic Reprogramming of Immune System and Endothelium. Front Immunol (2017) 0.75
Mutations of the BRAF gene in human cancer. Nature (2002) 65.42
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med (2003) 35.39
Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21
ras oncogenes in human cancer: a review. Cancer Res (1989) 22.03
Defining the role of mTOR in cancer. Cancer Cell (2007) 21.63
TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol (2007) 15.30
On respiratory impairment in cancer cells. Science (1956) 14.07
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell (2008) 13.49
Metformin and reduced risk of cancer in diabetic patients. BMJ (2005) 13.04
Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer (2009) 12.92
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol (2003) 12.91
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A (2004) 12.30
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell (2005) 11.19
Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell (2008) 11.18
Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol (2009) 10.18
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol (2003) 9.14
p53 regulates mitochondrial respiration. Science (2006) 9.06
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature (2002) 8.77
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer (2009) 8.43
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab (2005) 8.30
LKB1 modulates lung cancer differentiation and metastasis. Nature (2007) 7.80
The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell (2004) 7.77
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature (2004) 7.64
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell (2006) 7.49
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res (2007) 7.42
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab (2005) 7.15
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res (2002) 7.09
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell (2008) 6.88
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab (2008) 6.60
Glycolysis inhibition for anticancer treatment. Oncogene (2006) 6.55
AMPK in Health and Disease. Physiol Rev (2009) 6.38
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol (2007) 6.22
New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care (2009) 6.17
LKB1-dependent signaling pathways. Annu Rev Biochem (2006) 5.91
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res (2007) 5.45
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc Natl Acad Sci U S A (2003) 4.87
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J (2008) 4.51
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J (2007) 4.48
AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab (2009) 4.30
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem (2007) 4.22
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set. Mol Cancer Ther (2006) 4.09
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell (2009) 3.85
Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes (2006) 3.85
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem (2002) 3.81
Metformin in breast cancer: time for action. J Clin Oncol (2009) 3.81
Glycolytic enzymes can modulate cellular life span. Cancer Res (2005) 3.78
Glucose metabolism and cancer. Curr Opin Cell Biol (2006) 3.75
Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition (2000) 3.58
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res (2007) 3.55
The association between statins and cancer incidence in a veterans population. J Natl Cancer Inst (2008) 3.40
Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J Biol Chem (2006) 3.31
An E2F1-dependent gene expression program that determines the balance between proliferation and cell death. Cancer Cell (2008) 3.07
AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci (2005) 3.04
Mitochondria in cancer cells: what is so special about them? Trends Cell Biol (2008) 2.97
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells. EMBO J (2009) 2.88
Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun (2001) 2.86
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr Biol (2002) 2.73
Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro. J Biol Chem (2006) 2.69
p53: new roles in metabolism. Trends Cell Biol (2007) 2.69
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem (2005) 2.57
AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat Rev Drug Discov (2004) 2.46
Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am J Clin Nutr (2007) 2.40
Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study. Diabetes (2007) 2.26
Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. J Biol Chem (2005) 2.24
Somatic LKB1 mutations promote cervical cancer progression. PLoS One (2009) 2.21
AMPK: Lessons from transgenic and knockout animals. Front Biosci (Landmark Ed) (2009) 2.09
AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J (2009) 2.09
mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci U S A (2009) 2.08
Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF. PLoS One (2009) 2.03
Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. J Biol Chem (2007) 2.03
A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Proc Natl Acad Sci U S A (2006) 2.03
Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem J (2003) 2.02
The regulation of AMP-activated protein kinase by upstream kinases. Int J Obes (Lond) (2008) 1.98
RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. Cancer Res (2003) 1.97
AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochem Biophys Res Commun (2004) 1.95
LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. Physiol Rev (2009) 1.93
Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence. Exp Clin Endocrinol Diabetes (2008) 1.93
Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer. Oncogene (2006) 1.88
The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells. Mol Cell Biol (2004) 1.86
p53 and metabolism: Inside the TIGAR. Cell (2006) 1.84
The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. J Biol Chem (2002) 1.78
Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J (2003) 1.77
AMP-activated protein kinase: a universal regulator of autophagy? Autophagy (2007) 1.75
Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver. Cancer Res (2008) 1.73
Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. Cancer Res (2008) 1.67
Fatty acid synthase: a metabolic oncogene in prostate cancer? J Cell Biochem (2004) 1.64
Phenotypes of the tuberous sclerosis complex with a revision of diagnostic criteria. Ann N Y Acad Sci (1991) 1.64
AMP-activated protein kinase and cancer. Acta Physiol (Oxf) (2009) 1.64
Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors. J Biol Chem (2001) 1.61
KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. Cell Metab (2009) 1.53
Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells. Cancer Res (2007) 1.51
KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. Oncogene (2007) 1.48
Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones. Endocrinology (2006) 1.44
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. Cancer Res (2008) 1.42
Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun (2001) 1.40
KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals. Mol Cell (2009) 1.39
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem (2008) 4.16
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab (2011) 3.98
Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes. Am J Physiol Regul Integr Comp Physiol (2002) 2.23
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. J Biol Chem (2010) 2.20
Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family. J Lipid Res (2004) 2.08
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J (2011) 1.65
Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1. J Biol Chem (2002) 1.48
Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet (2003) 1.40
The Lip lipoprotein from Neisseria gonorrhoeae stimulates cytokine release and NF-kappaB activation in epithelial cells in a Toll-like receptor 2-dependent manner. J Biol Chem (2003) 1.35
Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2012) 1.29
High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy. Am J Pathol (2010) 1.24
Erbin suppresses the MAP kinase pathway. J Biol Chem (2002) 1.23
Metabolic partitioning of endogenous fatty acid in adipocytes. Obes Res (2003) 1.17
Impact of D2 receptor internalization on binding affinity of neuroimaging radiotracers. Neuropsychopharmacology (2009) 1.15
The thromboxane A2 receptor antagonist S18886 prevents enhanced atherogenesis caused by diabetes mellitus. Circulation (2005) 1.13
Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes. Mol Cell Endocrinol (2008) 1.12
CD40 ligand binds to alpha5beta1 integrin and triggers cell signaling. J Biol Chem (2006) 1.08
Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart. FASEB J (2010) 1.05
AMPK exerts dual regulatory effects on the PI3K pathway. J Mol Signal (2010) 1.05
Mechanism of cellular uptake of long-chain fatty acids: Do we need cellular proteins? Mol Cell Biochem (2002) 1.04
Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. J Biol Chem (2013) 0.99
Rapid flip-flop of oleic acid across the plasma membrane of adipocytes. J Biol Chem (2002) 0.98
Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs. PLoS One (2013) 0.97
The role of human papillomavirus infection in breast cancer. Med Oncol (2011) 0.97
Respiration in adipocytes is inhibited by reactive oxygen species. Obesity (Silver Spring) (2009) 0.94
Acyl coenzyme a synthetase regulation: putative role in long-chain acyl coenzyme a partitioning. Obes Res (2004) 0.94
Fenofibric acid reduces fibronectin and collagen type IV overexpression in human retinal pigment epithelial cells grown in conditions mimicking the diabetic milieu: functional implications in retinal permeability. Invest Ophthalmol Vis Sci (2011) 0.93
Medium-chain oil reduces fat mass and down-regulates expression of adipogenic genes in rats. Obes Res (2003) 0.92
Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice. Diabetes (2009) 0.92
Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects. Metabolism (2007) 0.91
Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes. J Nutr (2002) 0.89
Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus. Mol Endocrinol (2002) 0.87
Regulation of acetyl CoA carboxylase and carnitine palmitoyl transferase-1 in rat adipocytes. Obes Res (2005) 0.86
High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice. J Cardiovasc Pharmacol (2011) 0.86
Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes. Am J Physiol Endocrinol Metab (2005) 0.85
Absence of human papillomavirus in patients with breast cancer in north-west China. Med Oncol (2011) 0.85
Fluorescent chemosensors for toxic organophosphorus pesticides: a review. Sensors (Basel) (2010) 0.84
Oleate-induced formation of fat cells with impaired insulin sensitivity. Lipids (2006) 0.83
Effect of treatment of rosacea in females by Chibixiao Recipe in combination with minocycline and spironolactone. Chin J Integr Med (2006) 0.82
Medium-chain Fatty acids attenuate agonist-stimulated lipolysis, mimicking the effects of starvation. Obes Res (2004) 0.81
Assessment of the dining environment on and near the campuses of fifteen post-secondary institutions. Public Health Nutr (2012) 0.81
Identification of three genes encoding for the late acyltransferases of lipid A in Cronobacter sakazakii. Mar Drugs (2013) 0.80
The effects of testosterone deprivation and supplementation on proteasomal and autophagy activity in the skeletal muscle of the male mouse: differential effects on high-androgen responder and low-androgen responder muscle groups. Endocrinology (2013) 0.79
L-Serine overproduction with minimization of by-product synthesis by engineered Corynebacterium glutamicum. Appl Microbiol Biotechnol (2014) 0.78
Controlling the reactivity of chlorinated ethylenes with flavin mononucleotide hydroquinone. Environ Sci Technol (2009) 0.78
Quantitative assay for the colonization ability of heterogeneous bacteria on controlled nanopillar structures. Nanotechnology (2015) 0.78
Role of caveolin-1 and caveolae signaling in endotoxemia and sepsis. Life Sci (2013) 0.78
[Expression of heat-shock transcription factor 1 and X-linked inhibitor of apoptosis protein-associated factor-1 in gastrointestinal cancer]. Nan Fang Yi Ke Da Xue Xue Bao (2008) 0.77
Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy. Aging Cell (2013) 0.77
Effects of vanadate on leptin production from isolated rat adipocytes. Biol Trace Elem Res (2002) 0.77
Investigation on the temperature difference method for producing nanobubbles and their physical properties. Chemphyschem (2012) 0.77
Topical androgen antagonism promotes cutaneous wound healing without systemic androgen deprivation by blocking β-catenin nuclear translocation and cross-talk with TGF-β signaling in keratinocytes. Wound Repair Regen (2012) 0.76
MoS2 hierarchical hollow cubic cages assembled by bilayers: one-step synthesis and their electrochemical hydrogen storage properties. Chem Commun (Camb) (2006) 0.76
[Flavonoids in leaves of Alstonia scholaris]. Zhongguo Zhong Yao Za Zhi (2009) 0.76
Mustard seeds (Sinapis Alba Linn) attenuate azoxymethane-induced colon carcinogenesis. Redox Rep (2011) 0.75
[Relationship between the chronic periodontitis and the depression anxiety psychological factor]. Zhong Nan Da Xue Xue Bao Yi Xue Ban (2011) 0.75
Precursor B-cell lymphoblastic leukemia of the arm mimicking neurogenic tumor: case report. World J Surg Oncol (2012) 0.75
Influence of survivin-targeted siRNA on the biological features of colorectal carcinoma cells. Front Med China (2007) 0.75
[Expression of HSF1 and XAF1 in gastro-intestinal cancer]. Nan Fang Yi Ke Da Xue Xue Bao (2007) 0.75
Synthesis and transverse electromechanical characterization of single crystalline ZnO nanoleaves. Phys Chem Chem Phys (2009) 0.75
Dietary mustard seeds (Sinapis alba Linn) suppress 1,2-dimethylhydrazine-induced immuno-imbalance and colonic carcinogenesis in rats. Nutr Cancer (2012) 0.75
[Detection of QRS complexes using wavelet transformation and golden section search algorithm]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi (2009) 0.75
Imidapril inhibits right ventricular remodeling induced by low ambient temperature in broiler chickens. Poult Sci (2013) 0.75
Novel strategies for improving physical function. Horm Res Paediatr (2011) 0.75
Laser detection of electrical service safety in a single ZnO nanowire. J Nanosci Nanotechnol (2012) 0.75
[Relationship of serum iron and ferritin with the indicators for hepatic fibrosis]. Di Yi Jun Yi Da Xue Xue Bao (2003) 0.75
Max-confidence boosting with uncertainty for visual tracking. IEEE Trans Image Process (2015) 0.75
Study on nanobubble generation: saline solution/water exchange method. Chemphyschem (2013) 0.75
Size dependence of dielectric constant in a single pencil-like ZnO nanowire. Nano Lett (2012) 0.75
Transverse piezoelectric field-effect transistor based on single ZnO nanobelts. Phys Chem Chem Phys (2010) 0.75