Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells.

PubWeight™: 1.18‹?› | Rank: Top 10%

🔗 View Article (PMC 2871473)

Published in J Biol Chem on March 26, 2010

Authors

In Ohk Lee1, Jie Hyun Kim, Yeun Jung Choi, Michael H Pillinger, Seok-Yong Kim, Martin J Blaser, Yong Chan Lee

Author Affiliations

1: Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seodaemunku Shinchondong 134, Seoul 120-752, Korea.

Articles citing this

Beyond the stomach: an updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment. World J Gastroenterol (2014) 1.51

Microbiome and malignancy. Cell Host Microbe (2011) 1.45

A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease. Front Microbiol (2010) 1.00

Chronic inflammation and oxidative stress: the smoking gun for Helicobacter pylori-induced gastric cancer? Gut Microbes (2013) 0.95

Helicobacter pylori CagA triggers expression of the bactericidal lectin REG3γ via gastric STAT3 activation. PLoS One (2012) 0.94

Helicobacter pylori Eradication in Patients with Immune Thrombocytopenic Purpura: A Review and the Role of Biogeography. Helicobacter (2015) 0.93

Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways. Cell Commun Signal (2015) 0.92

At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer. J Leukoc Biol (2014) 0.91

Helicobacter pylori CagA: From Pathogenic Mechanisms to Its Use as an Anti-Cancer Vaccine. Front Immunol (2013) 0.91

Helicobacter pylori colonization ameliorates glucose homeostasis in mice through a PPAR γ-dependent mechanism. PLoS One (2012) 0.90

Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells. Gut Microbes (2013) 0.89

A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactions. PLoS Pathog (2015) 0.88

MicroRNAs up-regulated by CagA of Helicobacter pylori induce intestinal metaplasia of gastric epithelial cells. PLoS One (2012) 0.88

Functions of Shp2 in cancer. J Cell Mol Med (2015) 0.88

Enteric bacteria and cancer stem cells. Cancers (Basel) (2010) 0.87

Helicobacter pylori-Induced Signaling Pathways Contribute to Intestinal Metaplasia and Gastric Carcinogenesis. Biomed Res Int (2015) 0.87

MMP-2 mediates mesenchymal stem cell tropism towards medulloblastoma tumors. Gene Ther (2011) 0.86

Helicobacter pylori with stronger intensity of CagA phosphorylation lead to an increased risk of gastric intestinal metaplasia and cancer. BMC Microbiol (2011) 0.84

Role of Helicobacter pylori infection in pathogenesis of gastric carcinoma. World J Gastrointest Pathophysiol (2016) 0.84

The Jeremiah Metzger Lecture: Global warming redux: the disappearing microbiota and epidemic obesity. Trans Am Clin Climatol Assoc (2012) 0.83

Repressed TGF-β signaling through CagA-Smad3 interaction as pathogenic mechanisms of Helicobacter pylori-associated gastritis. J Clin Biochem Nutr (2015) 0.82

rs744166 polymorphism of the STAT3 gene is associated with risk of gastric cancer in a Chinese population. Biomed Res Int (2014) 0.82

Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer. Nat Rev Microbiol (2017) 0.81

Epigenetic silencing of the NR4A3 tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer. Sci Rep (2016) 0.80

Regulation of RKIP function by Helicobacter pylori in gastric cancer. PLoS One (2012) 0.80

16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, human papilloma virus infection and surgical treatment. Oncotarget (2016) 0.79

Dynamic Expansion and Contraction of cagA Copy Number in Helicobacter pylori Impact Development of Gastric Disease. MBio (2017) 0.78

Helicobacter pylori CagA: a critical destroyer of the gastric epithelial barrier. Dig Dis Sci (2013) 0.78

Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models. Dis Model Mech (2017) 0.78

Sequence analysis of East Asian cagA of Helicobacter pylori isolated from asymptomatic healthy Japanese and Thai individuals. Curr Microbiol (2010) 0.78

Jak1/Stat3 is an upstream signaling of NF-κB activation in Helicobacter pylori-induced IL-8 production in gastric epithelial AGS cells. Yonsei Med J (2015) 0.77

The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter. Open Biol (2014) 0.77

Osteopontin depletion decreases inflammation and gastric epithelial proliferation during Helicobacter pylori infection in mice. Lab Invest (2015) 0.76

New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract. Cell Mol Gastroenterol Hepatol (2015) 0.76

Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis. Cancers (Basel) (2011) 0.76

Impact of Helicobacter pylori on the healing process of the gastric barrier. World J Gastroenterol (2016) 0.76

Aberrant JAK/STAT Signaling Suppresses TFF1 and TFF2 through Epigenetic Silencing of GATA6 in Gastric Cancer. Int J Mol Sci (2016) 0.75

Dietary factors modulate Helicobacter-associated gastric cancer in rodent models. Toxicol Pathol (2013) 0.75

Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3. Int J Mol Sci (2017) 0.75

STAT3 activation in infection and infection-associated cancer. Mol Cell Endocrinol (2017) 0.75

Type IV Secretion and Signal Transduction of Helicobacter pylori CagA through Interactions with Host Cell Receptors. Toxins (Basel) (2017) 0.75

SOX2 Inhibition Promotes Promoter Demethylation of CDX2 to Facilitate Gastric Intestinal Metaplasia. Dig Dis Sci (2016) 0.75

Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer. Proc Jpn Acad Ser B Phys Biol Sci (2017) 0.75

Petri Net-Based Model of Helicobacter pylori Mediated Disruption of Tight Junction Proteins in Stomach Lining during Gastric Carcinoma. Front Microbiol (2017) 0.75

Articles cited by this

Helicobacter pylori infection and the development of gastric cancer. N Engl J Med (2001) 17.13

STATs and gene regulation. Science (1997) 16.55

Helicobacter pylori infection. N Engl J Med (2002) 14.81

Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci U S A (1993) 11.85

Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res (1995) 11.07

Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J (2003) 10.77

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem (1995) 8.52

c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol (1999) 8.17

Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science (2000) 7.99

Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. Infect Immun (1993) 7.75

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J (1998) 7.15

Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc Natl Acad Sci U S A (1999) 6.34

STATs: signal transducers and activators of transcription. Cell (1996) 6.10

SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science (2001) 5.49

Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol (1997) 5.38

Helicobacter pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology (1998) 5.15

Cytokine signal transduction. Cell (1994) 5.14

Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation. Proc Natl Acad Sci U S A (2000) 5.07

Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut (1997) 4.70

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med (2002) 4.28

Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology (1998) 4.13

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev (1995) 4.11

Helicobacter exploits integrin for type IV secretion and kinase activation. Nature (2007) 4.02

Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med (2000) 3.74

Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J Biol Chem (2002) 3.47

SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science (1993) 3.30

IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol (2003) 3.26

Coadaptation of Helicobacter pylori and humans: ancient history, modern implications. J Clin Invest (2009) 3.26

c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol (2002) 3.20

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J (1999) 3.19

STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol Cell Biol (1997) 3.18

Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus. Cell Microbiol (2000) 2.91

Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science (1993) 2.89

Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc Natl Acad Sci U S A (1989) 2.87

The equilibria that allow bacterial persistence in human hosts. Nature (2007) 2.45

Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. Proc Natl Acad Sci U S A (1992) 2.37

STAT3 is required for the gp130-mediated full activation of the c-myc gene. J Exp Med (1999) 2.36

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci U S A (2004) 2.36

Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet? Immunity (1997) 2.18

Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. J Biol Chem (2004) 2.01

Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity (2000) 1.92

Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases. Proc Natl Acad Sci U S A (1998) 1.56

A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc Natl Acad Sci U S A (1993) 1.56

Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease. Am J Epidemiol (2002) 1.53

Mutational analysis of acute-phase response factor/Stat3 activation and dimerization. Mol Cell Biol (1997) 1.51

Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK). Oncogene (1998) 1.48

Cloning and characterization of a human c-myc promoter-binding protein. Mol Cell Biol (1991) 1.47

Bacterial populations as perfect gases: genomic integrity and diversification tensions in Helicobacter pylori. Nat Rev Microbiol (2006) 1.44

Helicobacter pylori CagA transfection of gastric epithelial cells induces interleukin-8. Cell Microbiol (2006) 1.33

Marked stimulation of growth and motility of human keratinocytes by hepatocyte growth factor. Exp Cell Res (1991) 1.28

Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo. Cancer Res (2009) 1.28

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression. Biochem J (1998) 1.28

Natural variation in populations of persistently colonizing bacteria affect human host cell phenotype. J Infect Dis (2003) 1.16

In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway. Blood (2002) 1.15

Helicobacter pylori CagA seropositivity and gastric carcinoma risk in a Japanese American population. J Infect Dis (2002) 1.14

The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression. Curr Biol (1997) 1.14

The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa. J Infect Dis (2002) 1.13

Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs. Mol Cell Biol (1997) 1.08

Conditional gene silencing utilizing the lac repressor reveals a role of SHP-2 in cagA-positive Helicobacter pylori pathogenicity. Cancer Sci (2004) 1.03

Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation. J Biol Chem (2007) 0.98

Differential normalization of mucosal interleukin-8 and interleukin-6 activity after Helicobacter pylori eradication. Infect Immun (1998) 0.97

Inflammation intersection: gp130 balances gut irritation and stomach cancer. Nat Med (2002) 0.87

TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex. J Immunol (2003) 0.86

Articles by these authors

Traces of human migrations in Helicobacter pylori populations. Science (2003) 11.92

Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer (2002) 10.19

Molecular analysis of human forearm superficial skin bacterial biota. Proc Natl Acad Sci U S A (2007) 9.73

Molecular analysis of the bacterial microbiota in the human stomach. Proc Natl Acad Sci U S A (2006) 7.77

The human microbiome: at the interface of health and disease. Nat Rev Genet (2012) 7.54

Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications. Nat Biotechnol (2011) 7.53

Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature (2012) 6.37

Bacterial biota in the human distal esophagus. Proc Natl Acad Sci U S A (2004) 5.64

2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken) (2012) 5.22

Helicobacter pylori colonization is inversely associated with childhood asthma. J Infect Dis (2008) 3.95

Helicobacter pylori in health and disease. Gastroenterology (2009) 3.84

Substantial alterations of the cutaneous bacterial biota in psoriatic lesions. PLoS One (2008) 3.56

Inverse associations of Helicobacter pylori with asthma and allergy. Arch Intern Med (2007) 3.48

Coadaptation of Helicobacter pylori and humans: ancient history, modern implications. J Clin Invest (2009) 3.26

Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science (2004) 3.06

Long-term persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pylori. Ann Intern Med (2003) 3.04

Evolutionary implications of microbial genome tetranucleotide frequency biases. Genome Res (2003) 3.02

Molecular analysis of fungal microbiota in samples from healthy human skin and psoriatic lesions. J Clin Microbiol (2006) 3.01

Opposing risks of gastric cardia and noncardia gastric adenocarcinomas associated with Helicobacter pylori seropositivity. J Natl Cancer Inst (2006) 2.97

2012 American College of Rheumatology guidelines for management of gout. Part 2: therapy and antiinflammatory prophylaxis of acute gouty arthritis. Arthritis Care Res (Hoboken) (2012) 2.83

Decreased risk of celiac disease in patients with Helicobacter pylori colonization. Am J Epidemiol (2013) 2.58

Prevalence of contraindications and prescription of pharmacologic therapies for gout. Am J Med (2011) 2.57

Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum (2012) 2.24

Saturnine gout, redux: a review. Am J Med (2013) 2.09

Asthma is inversely associated with Helicobacter pylori status in an urban population. PLoS One (2008) 2.04

Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation. Microbiome (2013) 1.98

Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases. Clin Immunol (2006) 1.96

East Asian genotypes of Helicobacter pylori strains in Amerindians provide evidence for its ancient human carriage. Proc Natl Acad Sci U S A (2002) 1.92

15d-PGJ2: the anti-inflammatory prostaglandin? Clin Immunol (2005) 1.92

Mechanisms of disease: Inflammation and the origins of cancer. Nat Clin Pract Oncol (2005) 1.88

The fibroblast-like synovial cell in rheumatoid arthritis: a key player in inflammation and joint destruction. Clin Immunol (2005) 1.86

Association between gastric Helicobacter pylori colonization and glycated hemoglobin levels. J Infect Dis (2012) 1.84

Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis. Br J Pharmacol (2006) 1.79

Mailborne transmission of anthrax: Modeling and implications. Proc Natl Acad Sci U S A (2002) 1.74

Association between Helicobacter pylori and mortality in the NHANES III study. Gut (2013) 1.74

Early gastric cancer of signet ring cell carcinoma is more amenable to endoscopic treatment than is early gastric cancer of poorly differentiated tubular adenocarcinoma in select tumor conditions. Surg Endosc (2011) 1.71

Development of the human gastrointestinal microbiota and insights from high-throughput sequencing. Gastroenterology (2011) 1.70

Concerted evolution between duplicated genetic elements in Helicobacter pylori. J Mol Biol (2002) 1.68

Reproducibility of musculoskeletal ultrasound for determining monosodium urate deposition: concordance between readers. Arthritis Care Res (Hoboken) (2011) 1.68

Use of an open-reading frame-specific Campylobacter jejuni DNA microarray as a new genotyping tool for studying epidemiologically related isolates. J Infect Dis (2003) 1.67

Preliminary study of enteroscopy-guided, self-expandable metal stent placement for malignant small bowel obstruction. J Gastroenterol Hepatol (2012) 1.66

De minimis risk: a proposal for a new category of research risk. Am J Bioeth (2011) 1.65

Extensive repetitive DNA facilitates prokaryotic genome plasticity. Proc Natl Acad Sci U S A (2003) 1.59

Molecular analysis of sarcoidosis tissues for mycobacterium species DNA. Emerg Infect Dis (2002) 1.59

Structure of the human gastric bacterial community in relation to Helicobacter pylori status. ISME J (2010) 1.58

Narrative review: the pathophysiology of fibromyalgia. Ann Intern Med (2007) 1.56

Responses of endoscopy patients in Ladakh, India, to Helicobacter pylori whole-cell and Cag A antigens. Clin Diagn Lab Immunol (2002) 1.55

Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease. Am J Epidemiol (2002) 1.53

Role of luxS in Bacillus anthracis growth and virulence factor expression. Virulence (2010) 1.52

Pathways in microbe-induced obesity. Cell Metab (2013) 1.51

Evidence of host-virus co-evolution in tetranucleotide usage patterns of bacteriophages and eukaryotic viruses. BMC Genomics (2006) 1.51

Telomere length in peripheral leukocyte DNA and gastric cancer risk. Cancer Epidemiol Biomarkers Prev (2009) 1.48

Statins as antiinflammatory and immunomodulatory agents: a future in rheumatologic therapy? Arthritis Rheum (2006) 1.48

Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor. J Immunol (2008) 1.45

The anti-inflammatory effects of prostaglandins. J Investig Med (2009) 1.45

Microbiome and malignancy. Cell Host Microbe (2011) 1.45

Bacterial populations as perfect gases: genomic integrity and diversification tensions in Helicobacter pylori. Nat Rev Microbiol (2006) 1.44

Community differentiation of the cutaneous microbiota in psoriasis. Microbiome (2013) 1.44

Metabolic syndrome is an independent risk factor for synchronous colorectal neoplasm in patients with gastric neoplasm. J Gastroenterol Hepatol (2012) 1.41

The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin. BMC Gastroenterol (2011) 1.40

Participation and conflict in the decision-making process for endoscopic resection or surgical gastrectomy for early gastric cancer. J Surg Oncol (2012) 1.40

The seroprevalence of Helicobacter pylori and its relationship to malaria in Ugandan children. Trans R Soc Trop Med Hyg (2011) 1.39

Incidence and predictive factors of irritable bowel syndrome after acute diverticulitis in Korea. Int J Colorectal Dis (2014) 1.39

[Massive gastrointestinal bleeding due to aneurysmal rupture of ileo-colic artery in a patient with Behcet's disease]. Korean J Gastroenterol (2007) 1.38

Quantitation of major human cutaneous bacterial and fungal populations. J Clin Microbiol (2010) 1.37

Natural transformation of helicobacter pylori involves the integration of short DNA fragments interrupted by gaps of variable size. PLoS Pathog (2009) 1.35

Tooth loss, pancreatic cancer, and Helicobacter pylori. Am J Clin Nutr (2003) 1.35

Development and application of a reverse genetics system for Japanese encephalitis virus. J Virol (2003) 1.34

Helicobacter pylori CagA transfection of gastric epithelial cells induces interleukin-8. Cell Microbiol (2006) 1.33

Resolution of inflammation: prostaglandin E2 dissociates nuclear trafficking of individual NF-kappaB subunits (p65, p50) in stimulated rheumatoid synovial fibroblasts. J Immunol (2005) 1.31

Clinicopathological aspects and prognostic value with respect to age: an analysis of 3,362 consecutive gastric cancer patients. J Surg Oncol (2009) 1.30

Long-term outcome of early gastric cancer after endoscopic submucosal dissection: expanded indication is comparable to absolute indication. Dig Liver Dis (2013) 1.28

Campylobacter fetus of reptile origin as a human pathogen. J Clin Microbiol (2004) 1.27

The ecology of height: the effect of microbial transmission on human height. Perspect Biol Med (2002) 1.25

Bacterial biota in reflux esophagitis and Barrett's esophagus. World J Gastroenterol (2005) 1.24

Microbiomic signatures of psoriasis: feasibility and methodology comparison. Sci Rep (2013) 1.24

Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans. BMC Microbiol (2012) 1.24

Antibiotics in animal feed and spread of resistant Campylobacter from poultry to humans. Emerg Infect Dis (2004) 1.23

Biphasic assembly of the murine intestinal microbiota during early development. ISME J (2013) 1.23

Pre-treatment neutrophil to lymphocyte ratio as a prognostic marker to predict chemotherapeutic response and survival outcomes in metastatic advanced gastric cancer. Gastric Cancer (2014) 1.23

Plasticity of repetitive DNA sequences within a bacterial (Type IV) secretion system component. J Exp Med (2003) 1.19

Inhibition of Bacillus anthracis growth and virulence-gene expression by inhibitors of quorum-sensing. J Infect Dis (2005) 1.19

Clinicopathologic factors influence accurate endosonographic assessment for early gastric cancer. Gastrointest Endosc (2007) 1.18

Distinctive epidermal growth factor receptor/extracellular regulated kinase-independent and -dependent signaling pathways in the induction of airway mucin 5B and mucin 5AC expression by phorbol 12-myristate 13-acetate. Am J Pathol (2007) 1.17

Natural variation in populations of persistently colonizing bacteria affect human host cell phenotype. J Infect Dis (2003) 1.16

Structural and functional divergence of MutS2 from bacterial MutS1 and eukaryotic MSH4-MSH5 homologs. J Bacteriol (2005) 1.16

Predictive factors for local recurrence after endoscopic resection for early gastric cancer: long-term clinical outcome in a single-center experience. Surg Endosc (2010) 1.16

Risk factors and prognosis of pulmonary complications after endoscopic submucosal dissection for gastric neoplasia. Dig Dis Sci (2012) 1.16

Endoscopic resection for undifferentiated early gastric cancer. Gastrointest Endosc (2009) 1.15

Retinal ganglion cell death induced by endoplasmic reticulum stress in a chronic glaucoma model. Brain Res (2009) 1.15

[Guidelines for the diagnosis and treatment of Helicobacter pylori infection in Korea, 2013 revised edition]. Korean J Gastroenterol (2013) 1.15

Helicobacter pylori seropositivity and colorectal cancer risk: a prospective study of male smokers. Cancer Epidemiol Biomarkers Prev (2002) 1.14

Anti-inflammatory effect of capsaicin in Helicobacter pylori-infected gastric epithelial cells. Helicobacter (2007) 1.14

Transient and persistent Helicobacter pylori colonization in Native American children. J Clin Microbiol (2003) 1.14

Helicobacter pylori CagA seropositivity and gastric carcinoma risk in a Japanese American population. J Infect Dis (2002) 1.14

Clinical application of self-expandable metallic stent for treatment of colorectal obstruction caused by extrinsic invasive tumors. Dis Colon Rectum (2008) 1.14

Helicobacter pylori and overweight status in the United States: data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol (2005) 1.13

Helicobacter pylori interstrain restriction-modification diversity prevents genome subversion by chromosomal DNA from competing strains. Nucleic Acids Res (2002) 1.13