Published in Nat Protoc on March 25, 2010
Comparative protein structure modeling using Modeller. Curr Protoc Bioinformatics (2006) 8.72
The Phyre2 web portal for protein modeling, prediction and analysis. Nat Protoc (2015) 8.53
The I-TASSER Suite: protein structure and function prediction. Nat Methods (2015) 6.17
Protein 3D structure computed from evolutionary sequence variation. PLoS One (2011) 4.71
Template-based protein structure modeling using the RaptorX web server. Nat Protoc (2012) 3.68
A bright monomeric green fluorescent protein derived from Branchiostoma lanceolatum. Nat Methods (2013) 3.32
A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator. Mol Microbiol (2010) 3.23
Atomic-level protein structure refinement using fragment-guided molecular dynamics conformation sampling. Structure (2011) 2.97
Ab initio protein structure assembly using continuous structure fragments and optimized knowledge-based force field. Proteins (2012) 2.94
The Protein Model Portal--a comprehensive resource for protein structure and model information. Database (Oxford) (2013) 2.76
COFACTOR: an accurate comparative algorithm for structure-based protein function annotation. Nucleic Acids Res (2012) 2.75
X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men. N Engl J Med (2015) 2.71
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature (2015) 2.64
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc (2010) 2.50
Protein-ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment. Bioinformatics (2013) 2.43
Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat Genet (2014) 2.34
Improving the physical realism and structural accuracy of protein models by a two-step atomic-level energy minimization. Biophys J (2011) 2.24
T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26. Nat Immunol (2015) 2.24
Positional cloning and characterization reveal the molecular basis for soybean maturity locus E1 that regulates photoperiodic flowering. Proc Natl Acad Sci U S A (2012) 2.11
Interplay of I-TASSER and QUARK for template-based and ab initio protein structure prediction in CASP10. Proteins (2013) 2.09
Mutant alcohol dehydrogenase leads to improved ethanol tolerance in Clostridium thermocellum. Proc Natl Acad Sci U S A (2011) 1.96
Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir. J Virol (2011) 1.95
Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA. Proc Natl Acad Sci U S A (2011) 1.90
Terpene biosynthesis: modularity rules. Angew Chem Int Ed Engl (2011) 1.73
Sequential evolution of bacterial morphology by co-option of a developmental regulator. Nature (2014) 1.71
Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine. Elife (2014) 1.66
Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification. J Bone Miner Res (2013) 1.60
TNXB mutations can cause vesicoureteral reflux. J Am Soc Nephrol (2013) 1.59
I-TASSER server: new development for protein structure and function predictions. Nucleic Acids Res (2015) 1.59
Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations. J Virol (2011) 1.58
Automated protein structure modeling in CASP9 by I-TASSER pipeline combined with QUARK-based ab initio folding and FG-MD-based structure refinement. Proteins (2011) 1.58
Proteomic analysis of skeletal organic matrix from the stony coral Stylophora pistillata. Proc Natl Acad Sci U S A (2013) 1.57
Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity (2015) 1.57
Ecogenomics and potential biogeochemical impacts of globally abundant ocean viruses. Nature (2016) 1.57
Crystal structure of the CusBA heavy-metal efflux complex of Escherichia coli. Nature (2011) 1.56
Structural changes enable start codon recognition by the eukaryotic translation initiation complex. Cell (2014) 1.55
Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. Nat Med (2013) 1.49
Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus. PLoS Genet (2015) 1.46
The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing. Cell (2014) 1.45
Homology of SMP domains to the TULIP superfamily of lipid-binding proteins provides a structural basis for lipid exchange between ER and mitochondria. Bioinformatics (2010) 1.44
Recognizing protein-ligand binding sites by global structural alignment and local geometry refinement. Structure (2012) 1.42
CRHR1 genotypes, neural circuits and the diathesis for anxiety and depression. Mol Psychiatry (2012) 1.42
Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia. Genome Res (2014) 1.42
Characterization of CRISPR RNA processing in Clostridium thermocellum and Methanococcus maripaludis. Nucleic Acids Res (2012) 1.41
Molecular architecture and mechanism of the anaphase-promoting complex. Nature (2014) 1.36
Spatiotemporal control of opioid signaling and behavior. Neuron (2015) 1.32
An essential role of antibodies in the control of Chikungunya virus infection. J Immunol (2013) 1.31
A novel hepacivirus with an unusually long and intrinsically disordered NS5A protein in a wild Old World primate. J Virol (2013) 1.30
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. Nat Neurosci (2013) 1.30
Mechanism of eIF6 release from the nascent 60S ribosomal subunit. Nat Struct Mol Biol (2015) 1.29
Comparative evolution of GII.3 and GII.4 norovirus over a 31-year period. J Virol (2011) 1.28
Structural basis for a reciprocal regulation between SCF and CSN. Cell Rep (2012) 1.28
Evaluation of residue-residue contact predictions in CASP9. Proteins (2011) 1.26
Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication. Proc Natl Acad Sci U S A (2015) 1.26
Cross-domain inhibition of TACE ectodomain. Proc Natl Acad Sci U S A (2011) 1.26
DNA variations in oculocutaneous albinism: an updated mutation list and current outstanding issues in molecular diagnostics. Hum Mutat (2013) 1.25
Improving protein structure prediction using multiple sequence-based contact predictions. Structure (2011) 1.24
Variants affecting exon skipping contribute to complex traits. PLoS Genet (2012) 1.24
The IntFOLD server: an integrated web resource for protein fold recognition, 3D model quality assessment, intrinsic disorder prediction, domain prediction and ligand binding site prediction. Nucleic Acids Res (2011) 1.23
Calreticulin in the immune system: ins and outs. Trends Immunol (2012) 1.23
A protocol for computer-based protein structure and function prediction. J Vis Exp (2011) 1.23
Atomic structure of the APC/C and its mechanism of protein ubiquitination. Nature (2015) 1.22
Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. J Am Chem Soc (2011) 1.22
High incidence of unrecognized visceral/neurological late-onset Niemann-Pick disease, type C1, predicted by analysis of massively parallel sequencing data sets. Genet Med (2015) 1.22
Longitudinal analysis of the human antibody response to Chikungunya virus infection: implications for serodiagnosis and vaccine development. J Virol (2012) 1.21
A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension. J Clin Endocrinol Metab (2012) 1.20
Physics-based protein structure refinement through multiple molecular dynamics trajectories and structure averaging. Proteins (2013) 1.20
Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genet (2011) 1.19
Reversible high affinity inhibition of phosphofructokinase-1 by acyl-CoA: a mechanism integrating glycolytic flux with lipid metabolism. J Biol Chem (2011) 1.18
Accelerating the design of biomimetic materials by integrating RNA-seq with proteomics and materials science. Nat Biotechnol (2013) 1.18
Structure and mechanism of the trans-acting acyltransferase from the disorazole synthase. Biochemistry (2011) 1.18
Molecular architecture and subunit organization of TRPA1 ion channel revealed by electron microscopy. J Biol Chem (2011) 1.17
Plastid gene expression and plant development require a plastidic protein of the mitochondrial transcription termination factor family. Proc Natl Acad Sci U S A (2011) 1.16
The VgrG proteins are "à la carte" delivery systems for bacterial type VI effectors. J Biol Chem (2014) 1.16
Mutations in the gene encoding IFT dynein complex component WDR34 cause Jeune asphyxiating thoracic dystrophy. Am J Hum Genet (2013) 1.16
Functional implications of structural predictions for alternative splice proteins expressed in Her2/neu-induced breast cancers. J Proteome Res (2011) 1.16
Turning catalytically inactive human Argonaute proteins into active slicer enzymes. Nat Struct Mol Biol (2013) 1.14
Molecular mechanism of photoactivation and structural location of the cyanobacterial orange carotenoid protein. Biochemistry (2013) 1.13
Unusual heme-binding PAS domain from YybT family proteins. J Bacteriol (2011) 1.12
Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid. Am J Hum Genet (2011) 1.12
Real-time visualization of assembling of a sphingomyelin-specific toxin on planar lipid membranes. Biophys J (2013) 1.12
Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges. Structure (2014) 1.12
The emerging era of genomic data integration for analyzing splice isoform function. Trends Genet (2014) 1.11
Proteome of Hydra nematocyst. J Biol Chem (2012) 1.11
Functional identification of a hydroxyproline-o-galactosyltransferase specific for arabinogalactan protein biosynthesis in Arabidopsis. J Biol Chem (2013) 1.09
A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions. Mol Biol Cell (2011) 1.09
The platform protein is essential for type IV pilus biogenesis. J Biol Chem (2013) 1.08
BSP-SLIM: a blind low-resolution ligand-protein docking approach using predicted protein structures. Proteins (2011) 1.08
Template-based structure modeling of protein-protein interactions. Curr Opin Struct Biol (2013) 1.08
Combined NGS approaches identify mutations in the intraflagellar transport gene IFT140 in skeletal ciliopathies with early progressive kidney Disease. Hum Mutat (2013) 1.07
Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575. Mol Cell Biol (2012) 1.07
A short PPR protein required for the splicing of specific group II introns in angiosperm chloroplasts. RNA (2012) 1.07
Arabidopsis CURVATURE THYLAKOID1 proteins modify thylakoid architecture by inducing membrane curvature. Plant Cell (2013) 1.07
GalaxyRefine: Protein structure refinement driven by side-chain repacking. Nucleic Acids Res (2013) 1.06
Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes. J Biol Chem (2012) 1.06
Natural zinc ribbon HNH endonucleases and engineered zinc finger nicking endonuclease. Nucleic Acids Res (2012) 1.06
RsfA (YbeB) proteins are conserved ribosomal silencing factors. PLoS Genet (2012) 1.06
The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses. J Virol (2014) 1.05
Structure of a bacterial type IV secretion core complex at subnanometre resolution. EMBO J (2013) 1.05
Fructo-oligosaccharide synthesis by mutant versions of Saccharomyces cerevisiae invertase. Appl Environ Microbiol (2011) 1.05
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
The Protein Data Bank. Nucleic Acids Res (2000) 187.10
Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol (1993) 64.61
Protein secondary structure prediction based on position-specific scoring matrices. J Mol Biol (1999) 33.07
Protein structure prediction on the Web: a case study using the Phyre server. Nat Protoc (2009) 32.64
Protein homology detection by HMM-HMM comparison. Bioinformatics (2004) 21.92
Hidden Markov models for detecting remote protein homologies. Bioinformatics (1998) 21.29
I-TASSER server for protein 3D structure prediction. BMC Bioinformatics (2008) 18.28
Comparative protein structure modeling of genes and genomes. Annu Rev Biophys Biomol Struct (2000) 17.81
TM-align: a protein structure alignment algorithm based on the TM-score. Nucleic Acids Res (2005) 14.15
A method to identify protein sequences that fold into a known three-dimensional structure. Science (1991) 14.08
Scoring function for automated assessment of protein structure template quality. Proteins (2004) 10.99
The PredictProtein server. Nucleic Acids Res (2004) 10.89
Assembly of protein tertiary structures from fragments with similar local sequences using simulated annealing and Bayesian scoring functions. J Mol Biol (1997) 10.38
FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties. J Mol Biol (2001) 10.02
A new approach to protein fold recognition. Nature (1992) 8.17
3D-Jury: a simple approach to improve protein structure predictions. Bioinformatics (2003) 7.99
Protein structure prediction and analysis using the Robetta server. Nucleic Acids Res (2004) 7.39
Template-based modeling and free modeling by I-TASSER in CASP7. Proteins (2007) 6.45
Automated structure prediction of weakly homologous proteins on a genomic scale. Proc Natl Acad Sci U S A (2004) 5.44
LOMETS: a local meta-threading-server for protein structure prediction. Nucleic Acids Res (2007) 5.30
Ab initio modeling of small proteins by iterative TASSER simulations. BMC Biol (2007) 5.07
SPICKER: a clustering approach to identify near-native protein folds. J Comput Chem (2004) 4.87
TOUCHSTONE II: a new approach to ab initio protein structure prediction. Biophys J (2003) 4.62
Improvement of the GenTHREADER method for genomic fold recognition. Bioinformatics (2003) 3.70
Assessment of CASP7 predictions for template-based modeling targets. Proteins (2007) 3.50
Progress and challenges in protein structure prediction. Curr Opin Struct Biol (2008) 3.48
Automated server predictions in CASP7. Proteins (2007) 3.40
MUSTER: Improving protein sequence profile-profile alignments by using multiple sources of structure information. Proteins (2008) 3.38
Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases. Protein Sci (1993) 3.25
Critical assessment of methods of protein structure prediction-Round VII. Proteins (2007) 3.23
I-TASSER: fully automated protein structure prediction in CASP8. Proteins (2009) 3.21
A threading-based method (FINDSITE) for ligand-binding site prediction and functional annotation. Proc Natl Acad Sci U S A (2007) 3.15
Local energy landscape flattening: parallel hyperbolic Monte Carlo sampling of protein folding. Proteins (2002) 3.09
Structure prediction for CASP7 targets using extensive all-atom refinement with Rosetta@home. Proteins (2007) 3.01
3D-SHOTGUN: a novel, cooperative, fold-recognition meta-predictor. Proteins (2003) 2.91
On the origin and highly likely completeness of single-domain protein structures. Proc Natl Acad Sci U S A (2006) 2.85
Fold recognition by combining sequence profiles derived from evolution and from depth-dependent structural alignment of fragments. Proteins (2005) 2.72
Identification and analysis of deleterious human SNPs. J Mol Biol (2005) 2.67
Protein structure prediction by global optimization of a potential energy function. Proc Natl Acad Sci U S A (1999) 2.66
Protein structure prediction: when is it useful? Curr Opin Struct Biol (2009) 2.52
Evaluation of template-based models in CASP8 with standard measures. Proteins (2009) 2.46
The other 90% of the protein: assessment beyond the Calphas for CASP8 template-based and high-accuracy models. Proteins (2009) 2.43
Structure modeling of all identified G protein-coupled receptors in the human genome. PLoS Comput Biol (2006) 2.40
Assessment of predictions submitted for the CASP6 comparative modeling category. Proteins (2005) 2.27
Protein threading using PROSPECT: design and evaluation. Proteins (2000) 2.26
Universal similarity measure for comparing protein structures. Biopolymers (2001) 2.24
Large-scale assessment of the utility of low-resolution protein structures for biochemical function assignment. Bioinformatics (2004) 2.17
Single-body residue-level knowledge-based energy score combined with sequence-profile and secondary structure information for fold recognition. Proteins (2004) 2.16
Tertiary structure predictions on a comprehensive benchmark of medium to large size proteins. Biophys J (2004) 2.13
A comprehensive assessment of sequence-based and template-based methods for protein contact prediction. Bioinformatics (2008) 2.08
Assessment of predictions submitted for the CASP7 function prediction category. Proteins (2007) 1.98
Assessment of CASP7 structure predictions for template free targets. Proteins (2007) 1.98
Prediction of solvent accessibility and sites of deleterious mutations from protein sequence. Nucleic Acids Res (2005) 1.95
REMO: A new protocol to refine full atomic protein models from C-alpha traces by optimizing hydrogen-bonding networks. Proteins (2009) 1.89
Analysis of TASSER-based CASP7 protein structure prediction results. Proteins (2007) 1.85
In silico pharmacology for drug discovery: applications to targets and beyond. Br J Pharmacol (2007) 1.78
Pcons5: combining consensus, structural evaluation and fold recognition scores. Bioinformatics (2005) 1.71
Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). Enzyme Nomenclature. Recommendations 1992. Supplement 4: corrections and additions (1997). Eur J Biochem (1997) 1.67
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression. J Med Chem (2006) 1.58
Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol (2007) 1.53
Modeling and analyzing three-dimensional structures of human disease proteins. Pac Symp Biocomput (2006) 1.39
Assessment of predictions submitted for the CASP7 domain prediction category. Proteins (2007) 1.39
Q-Dock: Low-resolution flexible ligand docking with pocket-specific threading restraints. J Comput Chem (2008) 1.34
Comparative modeling in structural genomics. Structure (2008) 1.31
A random mutagenesis approach to isolate dominant-negative yeast sec1 mutants reveals a functional role for domain 3a in yeast and mammalian Sec1/Munc18 proteins. Genetics (2008) 1.29
Application of sparse NMR restraints to large-scale protein structure prediction. Biophys J (2004) 1.28
Molecular and structural basis of drift in the functions of closely-related homologous enzyme domains: implications for function annotation based on homology searches and structural genomics. In Silico Biol (2009) 1.04
Multi-platform next-generation sequencing of the domestic turkey (Meleagris gallopavo): genome assembly and analysis. PLoS Biol (2010) 5.39
LOMETS: a local meta-threading-server for protein structure prediction. Nucleic Acids Res (2007) 5.30
Ab initio modeling of small proteins by iterative TASSER simulations. BMC Biol (2007) 5.07
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med (2010) 4.04
Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet (2010) 4.01
RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. J Clin Oncol (2012) 3.72
MUSTER: Improving protein sequence profile-profile alignments by using multiple sources of structure information. Proteins (2008) 3.38
How significant is a protein structure similarity with TM-score = 0.5? Bioinformatics (2010) 3.22
Atomic-level protein structure refinement using fragment-guided molecular dynamics conformation sampling. Structure (2011) 2.97
Ab initio protein structure assembly using continuous structure fragments and optimized knowledge-based force field. Proteins (2012) 2.94
Three-field or two-field resection for thoracic esophageal cancer: a meta-analysis. Ann Thorac Surg (2013) 2.92
COFACTOR: an accurate comparative algorithm for structure-based protein function annotation. Nucleic Acids Res (2012) 2.75
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes. J Biol Chem (2010) 2.72
Long noncoding RNAs with snoRNA ends. Mol Cell (2012) 2.71
BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions. Nucleic Acids Res (2012) 2.56
Protein-ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment. Bioinformatics (2013) 2.43
Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. Nature (2003) 2.42
Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation (2010) 2.39
Arsenic detoxification and evolution of trimethylarsine gas by a microbial arsenite S-adenosylmethionine methyltransferase. Proc Natl Acad Sci U S A (2006) 2.37
MicroRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene/transforming growth factor-β1 pathway. Circulation (2012) 2.36
Development and large scale benchmark testing of the PROSPECTOR_3 threading algorithm. Proteins (2004) 2.34
Improving the physical realism and structural accuracy of protein models by a two-step atomic-level energy minimization. Biophys J (2011) 2.24
Large-scale assessment of the utility of low-resolution protein structures for biochemical function assignment. Bioinformatics (2004) 2.17
HAb18G/CD147 promotes activation of hepatic stellate cells and is a target for antibody therapy of liver fibrosis. J Hepatol (2012) 2.15
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat Genet (2011) 2.13
A comprehensive assessment of sequence-based and template-based methods for protein contact prediction. Bioinformatics (2008) 2.08
Pattern of lymphatic spread in thoracic esophageal squamous cell carcinoma: A single-institution experience. J Thorac Cardiovasc Surg (2012) 2.08
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily. Nat Chem Biol (2008) 1.96
REMO: A new protocol to refine full atomic protein models from C-alpha traces by optimizing hydrogen-bonding networks. Proteins (2009) 1.89
The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. Cell (2012) 1.88
The role of concurrent chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma among endemic population: a meta-analysis of the phase III randomized trials. BMC Cancer (2010) 1.68
Gram-scale synthesis of submicrometer-long polythiophene wires in mesoporous silica matrices. Angew Chem Int Ed Engl (2003) 1.64
Outcomes of the POG 9340/9341/9342 trials for children with high-risk neuroblastoma: a report from the Children's Oncology Group. Pediatr Blood Cancer (2008) 1.60
Control of autophagy maturation by acid sphingomyelinase in mouse coronary arterial smooth muscle cells: protective role in atherosclerosis. J Mol Med (Berl) (2014) 1.59
Automated protein structure modeling in CASP9 by I-TASSER pipeline combined with QUARK-based ab initio folding and FG-MD-based structure refinement. Proteins (2011) 1.58
A novel side-chain orientation dependent potential derived from random-walk reference state for protein fold selection and structure prediction. PLoS One (2010) 1.56
FGF21 and the late adaptive response to starvation in humans. J Clin Invest (2015) 1.55
Palladium-catalyzed enantioselective addition of two distinct nucleophiles across alkenes capable of quinone methide formation. J Am Chem Soc (2009) 1.54
Generating triangulated macromolecular surfaces by Euclidean Distance Transform. PLoS One (2009) 1.54
Retrotransposons control fruit-specific, cold-dependent accumulation of anthocyanins in blood oranges. Plant Cell (2012) 1.52
TRAIL death receptor 4 signaling via lysosome fusion and membrane raft clustering in coronary arterial endothelial cells: evidence from ASM knockout mice. J Mol Med (Berl) (2012) 1.52
HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma. Mol Cancer Res (2007) 1.48
HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection. Histopathology (2009) 1.45
Potential role of human visceral pleura in pleural fluid turnover. Chin Med J (Engl) (2006) 1.44
Recognizing protein-ligand binding sites by global structural alignment and local geometry refinement. Structure (2012) 1.42
Infant speech perception activates Broca's area: a developmental magnetoencephalography study. Neuroreport (2006) 1.40
Toxicity and cellular responses of intestinal cells exposed to titanium dioxide. Cell Biol Toxicol (2009) 1.38
Protein-protein complex structure predictions by multimeric threading and template recombination. Structure (2011) 1.34
Ab initio protein structure prediction on a genomic scale: application to the Mycoplasma genitalium genome. Proc Natl Acad Sci U S A (2002) 1.33
National survey of the medical treatment status for non-small cell lung cancer (NSCLC) in China. Lung Cancer (2012) 1.30
Critical role of lipid raft redox signaling platforms in endostatin-induced coronary endothelial dysfunction. Arterioscler Thromb Vasc Biol (2007) 1.29
Application of sparse NMR restraints to large-scale protein structure prediction. Biophys J (2004) 1.28
Improving protein structure prediction using multiple sequence-based contact predictions. Structure (2011) 1.24
Identification of near-native structures by clustering protein docking conformations. Proteins (2007) 1.23
A protocol for computer-based protein structure and function prediction. J Vis Exp (2011) 1.23
Lipid raft redox signaling platforms in endothelial dysfunction. Antioxid Redox Signal (2007) 1.22
Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) in Mycobacterium tuberculosis leads to reduced virulence in a mouse model of infection. Mol Microbiol (2014) 1.22
The use of quantitative real-time reverse transcriptase PCR for 5' and 3' portions of ALK transcripts to detect ALK rearrangements in lung cancers. Clin Cancer Res (2012) 1.21
TOUCHSTONE: a unified approach to protein structure prediction. Proteins (2003) 1.20
A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy of paclitaxel-carboplatin alone or with endostar for advanced non-small cell lung cancer. J Thorac Oncol (2011) 1.19
Uncoupling protein-2 protects endothelial function in diet-induced obese mice. Circ Res (2012) 1.19
Significance of MYCN amplification in international neuroblastoma staging system stage 1 and 2 neuroblastoma: a report from the International Neuroblastoma Risk Group database. J Clin Oncol (2008) 1.18
Lung adenocarcinomas with HER2-activating mutations are associated with distinct clinical features and HER2/EGFR copy number gains. J Thorac Oncol (2012) 1.17
Lysin motif-containing proteins LYP4 and LYP6 play dual roles in peptidoglycan and chitin perception in rice innate immunity. Plant Cell (2012) 1.16
Functional implications of structural predictions for alternative splice proteins expressed in Her2/neu-induced breast cancers. J Proteome Res (2011) 1.16
Cyclic di-AMP impairs potassium uptake mediated by a cyclic di-AMP binding protein in Streptococcus pneumoniae. J Bacteriol (2013) 1.16
miR-1 exacerbates cardiac ischemia-reperfusion injury in mouse models. PLoS One (2012) 1.15
Comparison of exposure estimation methods for air pollutants: ambient monitoring data and regional air quality simulation. Environ Res (2012) 1.15
MM-align: a quick algorithm for aligning multiple-chain protein complex structures using iterative dynamic programming. Nucleic Acids Res (2009) 1.14
Mechanistic studies of Ce(IV)-mediated oxidation of beta-dicarbonyls: solvent-dependent behavior of radical cation intermediates. J Org Chem (2007) 1.14
Genetic variants in cyclooxygenase-2: Expression and risk of gastric cancer and its precursors in a Chinese population. Gastroenterology (2006) 1.14
Toward optimal fragment generations for ab initio protein structure assembly. Proteins (2012) 1.13
Frequency of well-identified oncogenic driver mutations in lung adenocarcinoma of smokers varies with histological subtypes and graduated smoking dose. Lung Cancer (2012) 1.12
iTRAQ-2DLC-ESI-MS/MS based identification of a new set of immunohistochemical biomarkers for classification of dysplastic nodules and small hepatocellular carcinoma. J Proteome Res (2011) 1.11
TOUCHSTONEX: protein structure prediction with sparse NMR data. Proteins (2003) 1.10
A genetic linkage map of Pacific white shrimp (Litopenaeus vannamei): sex-linked microsatellite markers and high recombination rates. Genetica (2006) 1.09
Corneal nerve structure and function in patients with non-sjogren dry eye: clinical correlations. Invest Ophthalmol Vis Sci (2013) 1.09
TASSER-based refinement of NMR structures. Proteins (2006) 1.09
Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus. J Infect Dis (2005) 1.09
BSP-SLIM: a blind low-resolution ligand-protein docking approach using predicted protein structures. Proteins (2011) 1.08
Enhancement of autophagy by simvastatin through inhibition of Rac1-mTOR signaling pathway in coronary arterial myocytes. Cell Physiol Biochem (2013) 1.08
Analysis of major known driver mutations and prognosis in resected adenosquamous lung carcinomas. J Thorac Oncol (2014) 1.08
Bridging small-gap peripheral nerve defects using acellular nerve allograft implanted with autologous bone marrow stromal cells in primates. Brain Res (2007) 1.08
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector? Antioxid Redox Signal (2015) 1.07
Abnormal junctions and permeability of myelin in PMP22-deficient nerves. Ann Neurol (2014) 1.06
Negative Differential Resistance in ZnO Nanowires Bridging Two Metallic Electrodes. Nanoscale Res Lett (2010) 1.06
Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors. Mol Endocrinol (2004) 1.06
A theory of germinal center B cell selection, division, and exit. Cell Rep (2012) 1.06
A novel probe for the non-invasive detection of tumor-associated inflammation. Oncoimmunology (2013) 1.05
Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant. Biochemistry (2003) 1.05
[Chemical constituents of Ligularia duciformis]. Yao Xue Xue Bao (2007) 1.05
ThreaDom: extracting protein domain boundary information from multiple threading alignments. Bioinformatics (2013) 1.05
Genome-wide identification and analysis of MAPK and MAPKK gene families in Brachypodium distachyon. PLoS One (2012) 1.05
Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells. Exp Cell Res (2006) 1.04
TASSER-Lite: an automated tool for protein comparative modeling. Biophys J (2006) 1.03
Controllable synthesis of silver nanoparticle-decorated reduced graphene oxide hybrids for ammonia detection. Analyst (2013) 1.03
Modulation of CD147-induced matrix metalloproteinase activity: role of CD147 N-glycosylation. Biochem J (2013) 1.02
A comparative study on screw loosening in osteoporotic lumbar spine fusion between expandable and conventional pedicle screws. Arch Orthop Trauma Surg (2011) 1.02
Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer. J Cancer Res Clin Oncol (2010) 1.02