Published in J Biol Chem on April 16, 2010
The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis. J Neuroimmunol (2010) 1.07
New paradigms in sepsis: from prevention to protection of failing microcirculation. J Thromb Haemost (2015) 0.89
Lethality in a murine model of pulmonary anthrax is reduced by combining nuclear transport modifier with antimicrobial therapy. PLoS One (2012) 0.81
Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver. J Am Heart Assoc (2013) 0.81
Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expression. Cells (2014) 0.79
Regulation of Macrophage, Dendritic Cell, and Microglial Phenotype and Function by the SOCS Proteins. Front Immunol (2015) 0.78
The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli. J Biol Chem (2014) 0.78
Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer's disease brains and human microglia. Neuroscience (2014) 0.76
Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol (2005) 9.70
Proinflammatory cytokines. Chest (2000) 5.89
SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol (2003) 4.90
Anti-inflammatory cytokines. Chest (2000) 4.74
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev (1998) 4.29
The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol (2004) 3.76
Suppressors of cytokine signaling and immunity. Nat Immunol (2003) 3.68
SOCS3 regulates the plasticity of gp130 signaling. Nat Immunol (2003) 3.45
A20: central gatekeeper in inflammation and immunity. J Biol Chem (2008) 2.83
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J (1999) 2.80
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc Natl Acad Sci U S A (2000) 2.58
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells (1999) 2.28
Mutational switch of an IL-6 response to an interferon-gamma-like response. Proc Natl Acad Sci U S A (2002) 1.96
Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis. Nat Med (2005) 1.88
Innate immunity and inflammation: a transcriptional paradigm. Immunol Res (2001) 1.73
Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins. Immunol Rev (2008) 1.53
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability. Mol Cell (2006) 1.41
The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase. J Mol Biol (2008) 1.39
Controlling cytokine signaling by constitutive inhibitors. Biochem Pharmacol (2005) 1.37
The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression. J Mol Biol (2009) 1.35
Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction. J Immunol (2002) 1.29
Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol Endocrinol (2004) 1.22
Calmodulin binds and stabilizes the regulatory enzyme, CTP: phosphocholine cytidylyltransferase. J Biol Chem (2007) 1.20
Noninvasive intracellular delivery of functional peptides and proteins. Curr Opin Chem Biol (1999) 1.13
A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. Eur J Biochem (2002) 1.12
Different protein turnover of interleukin-6-type cytokine signalling components. Eur J Biochem (1999) 1.09
The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6. J Biol Chem (2002) 1.03
PEST sequences do not influence substrate susceptibility to calpain proteolysis. J Biol Chem (1995) 1.01
Receptor/transporter-independent targeting of functional peptides across the plasma membrane. J Biol Chem (2003) 1.00
Intracellular delivery of a cell-penetrating SOCS1 that targets IFN-gamma signaling. Sci Signal (2009) 0.90
PEST sequences in calmodulin-binding proteins. Mol Cell Biochem (1996) 0.89
Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2. Growth Factors (2009) 0.89
Intracellular ANKRD1 protein levels are regulated by 26S proteasome-mediated degradation. FEBS Lett (2009) 0.83
Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis. Nat Med (2005) 1.88
Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Immunity (2006) 1.82
Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway. J Biol Chem (2005) 1.70
Nuclear import of proinflammatory transcription factors is required for massive liver apoptosis induced by bacterial lipopolysaccharide. J Biol Chem (2004) 1.49
Suppression of acute lung inflammation by intracellular peptide delivery of a nuclear import inhibitor. Mol Ther (2009) 1.03
Receptor/transporter-independent targeting of functional peptides across the plasma membrane. J Biol Chem (2003) 1.00
Suppression of Staphylococcal Enterotoxin B-induced Toxicity by a Nuclear Import Inhibitor. J Biol Chem (2004) 0.94
A novel oxidized low-density lipoprotein-binding protein from Pseudomonas aeruginosa. Microbiology (2008) 0.90
Intracellular delivery of a cell-penetrating SOCS1 that targets IFN-gamma signaling. Sci Signal (2009) 0.90
In vivo islet protection by a nuclear import inhibitor in a mouse model of type 1 diabetes. PLoS One (2010) 0.88
Fractalkine and CX3CR1 mediate leukocyte capture by endothelium in response to Shiga toxin. J Immunol (2008) 0.87
Targeting nuclear import shuttles, importins/karyopherins alpha by a peptide mimicking the NFκB1/p50 nuclear localization sequence. J Am Heart Assoc (2013) 0.85
Lethality in a murine model of pulmonary anthrax is reduced by combining nuclear transport modifier with antimicrobial therapy. PLoS One (2012) 0.81
Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver. J Am Heart Assoc (2013) 0.81
The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling. PLoS One (2013) 0.81
Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes. J Immunol (2012) 0.80
Host derived inflammatory phospholipids regulate rahU (PA0122) gene, protein, and biofilm formation in Pseudomonas aeruginosa. Cell Immunol (2011) 0.80
Lipopolysaccharide O-antigen chain length regulation in Pseudomonas aeruginosa serogroup O11 strain PA103. J Bacteriol (2007) 0.80
Epitope mapping of monoclonal antibodies using synthetic oligosaccharides uncovers novel aspects of immune recognition of the Psl exopolysaccharide of Pseudomonas aeruginosa. Chemistry (2013) 0.77