Published in J Biol Chem on May 07, 2010
The presynaptic active zone. Neuron (2012) 2.35
Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia. PLoS One (2012) 1.07
RIM genes differentially contribute to organizing presynaptic release sites. Proc Natl Acad Sci U S A (2012) 1.07
Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones. J Neurosci (2011) 1.02
Pushing synaptic vesicles over the RIM. Cell Logist (2011) 0.93
Active zone protein Bassoon co-localizes with presynaptic calcium channel, modifies channel function, and recovers from aging related loss by exercise. PLoS One (2012) 0.91
RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse. J Neurophysiol (2014) 0.88
Presynaptic Active Zone Density during Development and Synaptic Plasticity. Front Mol Neurosci (2012) 0.88
Role of exercise in maintaining the integrity of the neuromuscular junction. Muscle Nerve (2013) 0.86
ELKS1 and Ca(2+) channel subunit β4 interact and colocalize at cerebellar synapses. Neuroreport (2012) 0.86
Active zones of mammalian neuromuscular junctions: formation, density, and aging. Ann N Y Acad Sci (2012) 0.83
Molecular mechanism of active zone organization at vertebrate neuromuscular junctions. Mol Neurobiol (2011) 0.82
Functional coupling of Rab3-interacting molecule 1 (RIM1) and L-type Ca2+ channels in insulin release. J Biol Chem (2011) 0.81
Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice. Front Behav Neurosci (2015) 0.78
Atomoxetine affects transcription/translation of the NMDA receptor and the norepinephrine transporter in the rat brain--an in vivo study. Drug Des Devel Ther (2013) 0.78
Transsynaptic channelosomes: non-conducting roles of ion channels in synapse formation. Channels (Austin) (2011) 0.77
The role of laminins in the organization and function of neuromuscular junctions. Matrix Biol (2016) 0.76
A novel region in the CaV2.1 α1 subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone. Elife (2017) 0.75
The synaptic vesicle cycle. Annu Rev Neurosci (2004) 12.25
Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices. J Physiol (1980) 7.20
Vesicle pools and Ca2+ microdomains: new tools for understanding their roles in neurotransmitter release. Neuron (1998) 5.96
The postsynaptic architecture of excitatory synapses: a more quantitative view. Annu Rev Biochem (2007) 4.75
Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission. Science (1994) 4.38
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature (2002) 4.37
Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature (1991) 3.77
Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Nature (1997) 3.63
Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons. Neuron (1989) 3.45
RIM1alpha is required for presynaptic long-term potentiation. Nature (2002) 3.28
Calcium channel regulation and presynaptic plasticity. Neuron (2008) 3.28
Nomenclature of voltage-gated calcium channels. Neuron (2000) 3.09
Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons. J Neurosci (1995) 3.07
Different types of calcium channels mediate central synaptic transmission. Nature (1993) 2.86
cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol (2000) 2.83
The I-II loop of the Ca2+ channel alpha1 subunit contains an endoplasmic reticulum retention signal antagonized by the beta subunit. Neuron (2000) 2.72
Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison. Proc Natl Acad Sci U S A (1989) 2.64
Inactivation of presynaptic calcium current contributes to synaptic depression at a fast central synapse. Neuron (1998) 2.56
Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming. Neuron (2001) 2.49
Functional impact of syntaxin on gating of N-type and Q-type calcium channels. Nature (1995) 2.46
Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle. Science (1989) 2.40
The coupling between synaptic vesicles and Ca2+ channels determines fast neurotransmitter release. Neuron (2007) 2.39
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem. Nature (2001) 2.28
Molecular diversity of voltage-dependent Ca2+ channels. Trends Pharmacol Sci (1991) 2.25
Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit. Proc Natl Acad Sci U S A (1999) 2.23
Molecular organization of the presynaptic active zone. Cell Tissue Res (2006) 2.22
Acceleration of activation and inactivation by the beta subunit of the skeletal muscle calcium channel. Nature (1991) 2.18
Distinctive biophysical and pharmacological properties of class A (BI) calcium channel alpha 1 subunits. Neuron (1993) 2.14
Single calcium channels and acetylcholine release at a presynaptic nerve terminal. Neuron (1993) 2.12
Identification of a syntaxin-binding site on N-type calcium channels. Neuron (1994) 2.09
Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel. Nature (1991) 2.09
The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. J Biol Chem (2000) 1.96
RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nat Neurosci (2007) 1.95
Ca2+ channel regulation by a conserved beta subunit domain. Neuron (1994) 1.92
Calcium channel beta subunit heterogeneity: functional expression of cloned cDNA from heart, aorta and brain. EMBO J (1992) 1.92
Regulation of membrane fusion in synaptic excitation-secretion coupling: speed and accuracy matter. Neuron (2007) 1.89
A synaptic laminin-calcium channel interaction organizes active zones in motor nerve terminals. Nature (2004) 1.89
Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin. J Biol Chem (2001) 1.86
The architecture of the active zone in the presynaptic nerve terminal. Physiology (Bethesda) (2004) 1.84
RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels. Neuron (2002) 1.81
Cloning and expression of a third calcium channel beta subunit. J Biol Chem (1993) 1.77
Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release. Cell Calcium (1999) 1.75
Association of neuronal calcium channels with modular adaptor proteins. J Biol Chem (1999) 1.75
Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. Neuron (2004) 1.74
Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis. J Biol Chem (2003) 1.66
Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1. J Cell Biol (2002) 1.65
UNC-13 and UNC-10/rim localize synaptic vesicles to specific membrane domains. J Neurosci (2006) 1.65
Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells. J Cell Sci (2006) 1.62
Alternative splicing of the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell-specific expression in the cerebellar cortex. J Neurosci (2006) 1.61
Localization of Ca2+ channel subtypes on rat spinal motor neurons, interneurons, and nerve terminals. J Neurosci (1998) 1.59
Cloning and expression of a neuronal calcium channel beta subunit. J Biol Chem (1993) 1.54
Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. EMBO J (2006) 1.53
Synaptic targeting of N-type calcium channels in hippocampal neurons. J Neurosci (2002) 1.53
Reciprocal regulation of P/Q-type Ca2+ channels by SNAP-25, syntaxin and synaptotagmin. Nat Neurosci (1999) 1.49
Design of siRNAs producing unstructured guide-RNAs results in improved RNA interference efficiency. Nat Biotechnol (2005) 1.47
Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel. J Biol Chem (1998) 1.35
Characterization of a calcium current in a vertebrate cholinergic presynaptic nerve terminal. J Neurosci (1991) 1.35
mRNA and 18S-RNA coapplication-reverse transcription for quantitative gene expression analysis. Anal Biochem (2005) 1.30
Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene. Neuron (1994) 1.30
Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins. Genomics (2003) 1.27
cAMP/PKA signaling and RIM1alpha mediate presynaptic LTP in the lateral amygdala. Proc Natl Acad Sci U S A (2008) 1.26
Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit. Proc Natl Acad Sci U S A (2002) 1.24
Transfection analysis of functional roles of complexin I and II in the exocytosis of two different types of secretory vesicles. Biochem Biophys Res Commun (1999) 1.23
Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity. FASEB J (2001) 1.21
RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions. J Neurosci (2008) 1.21
Genomic organisation and alternative splicing of human RIM1, a gene implicated in autosomal dominant cone-rod dystrophy (CORD7). Genomics (2003) 1.20
Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density. Neurosci Lett (2008) 1.18
Functional interactions between presynaptic calcium channels and the neurotransmitter release machinery. Curr Opin Neurobiol (2003) 1.16
Expression and subunit interaction of voltage-dependent Ca2+ channels in PC12 cells. J Neurosci (1996) 1.12
Exocytosis and endocytosis of small vesicles in PC12 cells studied with TEPIQ (two-photon extracellular polar-tracer imaging-based quantification) analysis. J Physiol (2005) 1.04
Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells. Mol Cell Neurosci (2006) 1.02
Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule. Mol Cell Neurosci (2010) 1.01
Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function. J Biol Chem (2000) 0.95
The HOOK-domain between the SH3 and the GK domains of Cavbeta subunits contains key determinants controlling calcium channel inactivation. Channels (Austin) (2007) 0.94
Glutamatergic modulation of cerebellar interneuron activity is mediated by an enhancement of GABA release and requires protein kinase A/RIM1alpha signaling. J Neurosci (2009) 0.90
Mutation associated with an autosomal dominant cone-rod dystrophy CORD7 modifies RIM1-mediated modulation of voltage-dependent Ca2+ channels. Channels (Austin) (2007) 0.89
A functional AMPA receptor-calcium channel complex in the postsynaptic membrane. Proc Natl Acad Sci U S A (2006) 0.88
Rab3a interacting molecule (RIM) and the tethering of pre-synaptic transmitter release site-associated CaV2.2 calcium channels. J Neurochem (2009) 0.88
Subcellular distribution of high-voltage-activated calcium channel subtypes in rat globus pallidus neurons. J Comp Neurol (2002) 0.85
Stable expression of the neuronal BI (class A) calcium channel in baby hamster kidney cells. Biochem Biophys Res Commun (1994) 0.84
Distribution of the voltage-dependent calcium channel alpha(1A) subunit throughout the mature rat brain and its relationship to neurotransmitter pathways. J Comp Neurol (1998) 0.83
Activation of Rac1 increases c-Jun NH(2)-terminal kinase activity and DNA fragmentation in a calcium-dependent manner in rat myoblast cell line H9c2. Biochem Biophys Res Commun (1999) 0.82
RIM3gamma is a postsynaptic protein in the rat central nervous system. J Comp Neurol (2007) 0.81
Exocytotic release of alanine from cultured cerebellar neurons. Brain Res (2002) 0.79
Defective membrane repair in dysferlin-deficient muscular dystrophy. Nature (2003) 6.50
Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies. Nature (2002) 5.21
Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy. Nature (2002) 3.96
Dystroglycan: from biosynthesis to pathogenesis of human disease. J Cell Sci (2006) 3.92
Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol (2006) 3.66
Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2006) 3.47
LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell (2002) 3.36
Cell therapy of alpha-sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblasts. Science (2003) 3.21
Muscular dystrophies involving the dystrophin-glycoprotein complex: an overview of current mouse models. Curr Opin Genet Dev (2002) 3.15
Auxiliary subunits: essential components of the voltage-gated calcium channel complex. Curr Opin Neurobiol (2003) 3.10
Structural analysis of the voltage-dependent calcium channel beta subunit functional core and its complex with the alpha 1 interaction domain. Neuron (2004) 3.05
LARGE can functionally bypass alpha-dystroglycan glycosylation defects in distinct congenital muscular dystrophies. Nat Med (2004) 3.00
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding. Science (2010) 2.98
Sarcolemma-localized nNOS is required to maintain activity after mild exercise. Nature (2008) 2.87
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes Dev (2007) 2.79
TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med (2008) 2.77
Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell (2011) 2.62
The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev (2006) 2.62
Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity (2011) 2.60
Dystrophin-glycoprotein complex: post-translational processing and dystroglycan function. J Biol Chem (2003) 2.56
Dysferlin and the plasma membrane repair in muscular dystrophy. Trends Cell Biol (2004) 2.41
Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone? Am J Physiol Heart Circ Physiol (2007) 2.41
New World arenavirus clade C, but not clade A and B viruses, utilizes alpha-dystroglycan as its major receptor. J Virol (2002) 2.35
Molecular recognition by LARGE is essential for expression of functional dystroglycan. Cell (2004) 2.33
TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy. EMBO J (2006) 2.28
ORL1 receptor-mediated internalization of N-type calcium channels. Nat Neurosci (2005) 2.24
Dystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGE. Science (2012) 2.22
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J (2006) 2.21
TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc Natl Acad Sci U S A (2009) 2.20
Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding. J Virol (2005) 2.17
Upregulation of TRPC1 in the development of cardiac hypertrophy. J Mol Cell Cardiol (2006) 2.17
Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A (2009) 2.08
Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. Science (2003) 2.05
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab (2011) 2.02
Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration. Cell (2002) 2.01
Mutations in EFHC1 cause juvenile myoclonic epilepsy. Nat Genet (2004) 1.98
RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nat Neurosci (2007) 1.95
ISPD loss-of-function mutations disrupt dystroglycan O-mannosylation and cause Walker-Warburg syndrome. Nat Genet (2012) 1.93
Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol (2004) 1.91
Dysferlin-mediated membrane repair protects the heart from stress-induced left ventricular injury. J Clin Invest (2007) 1.88
Dysferlin and muscle membrane repair. Curr Opin Cell Biol (2007) 1.82
Unique role of dystroglycan in peripheral nerve myelination, nodal structure, and sodium channel stabilization. Neuron (2003) 1.80
Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nat Neurosci (2009) 1.75
Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes. J Exp Med (2002) 1.73
Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle. J Gen Physiol (2010) 1.73
TRPM2 functions as a lysosomal Ca2+-release channel in beta cells. Sci Signal (2009) 1.71
STIM protein coupling in the activation of Orai channels. Proc Natl Acad Sci U S A (2009) 1.70
A dystroglycan mutation associated with limb-girdle muscular dystrophy. N Engl J Med (2011) 1.67
Limb-girdle muscular dystrophy in the United States. J Neuropathol Exp Neurol (2006) 1.59
FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation. Blood (2009) 1.59
Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. Channels (Austin) (2008) 1.59
The CACNA1F gene encodes an L-type calcium channel with unique biophysical properties and tissue distribution. J Neurosci (2004) 1.57
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function. Science (2013) 1.57
Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells. J Pharmacol Sci (2004) 1.56
Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices. Proc Natl Acad Sci U S A (2006) 1.55
The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas. J Mol Biol (2006) 1.54
Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy. J Neurosci (2008) 1.54
Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of α-dystroglycan. Am J Hum Genet (2013) 1.50
Dystroglycan loss disrupts polarity and beta-casein induction in mammary epithelial cells by perturbing laminin anchoring. J Cell Sci (2006) 1.49
The prognostic nutritional index can be a prognostic indicator in colorectal carcinoma. Surg Today (2011) 1.49
Long-term low-dose spironolactone therapy is safe in oligoanuric hemodialysis patients. Cardiology (2009) 1.49
TRPA1 underlies a sensing mechanism for O2. Nat Chem Biol (2011) 1.47
C-terminal titin deletions cause a novel early-onset myopathy with fatal cardiomyopathy. Ann Neurol (2007) 1.47
Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence. Proc Natl Acad Sci U S A (2011) 1.47
Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of alpha-dystroglycan. Proc Natl Acad Sci U S A (2009) 1.47
Mutations in B3GALNT2 cause congenital muscular dystrophy and hypoglycosylation of α-dystroglycan. Am J Hum Genet (2013) 1.47
Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE. J Biol Chem (2009) 1.46
Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling. Sci Signal (2010) 1.44
Exercise-induced left ventricular systolic dysfunction in women heterozygous for dystrophinopathy. J Am Soc Echocardiogr (2010) 1.43
TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci U S A (2007) 1.37
The Ca(v)3.2 T-type Ca(2+) channel is required for pressure overload-induced cardiac hypertrophy in mice. Circ Res (2009) 1.34
Fukutin gene mutations cause dilated cardiomyopathy with minimal muscle weakness. Ann Neurol (2006) 1.34
The voltage-dependent calcium channel beta subunit contains two stable interacting domains. J Biol Chem (2003) 1.33
Dystroglycan is selectively associated with inhibitory GABAergic synapses but is dispensable for their differentiation. J Neurosci (2002) 1.33
Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells. Cancer Res (2004) 1.33
Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival. J Immunol (2008) 1.32
TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat Commun (2013) 1.32
Glycomic analyses of mouse models of congenital muscular dystrophy. J Biol Chem (2011) 1.32
Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection. Proc Natl Acad Sci U S A (2011) 1.32
A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J Pharmacol Sci (2006) 1.31