Published in Chem Res Toxicol on August 16, 2010
On the formation and properties of interstrand DNA-DNA cross-links forged by reaction of an abasic site with the opposing guanine residue of 5'-CAp sequences in duplex DNA. J Am Chem Soc (2013) 1.17
The role of oxidative stress in menopause. J Midlife Health (2013) 0.98
Should autism be considered a canary bird telling that Homo sapiens may be on its way to extinction? Microb Ecol Health Dis (2012) 0.86
Dietary γ-Tocopherol-Rich Mixture Inhibits Estrogen-Induced Mammary Tumorigenesis by Modulating Estrogen Metabolism, Antioxidant Response, and PPARγ. Cancer Prev Res (Phila) (2015) 0.83
Oxidant/antioxidant status, paraoxonase activity, and lipid profile in plasma of ovariectomized rats under the influence of estrogen, estrogen combined with progesterone, and genistein. Drug Des Devel Ther (2015) 0.78
Oxidative Stress: An Effective Prognostic Tool for an Early Detection of Cardiovascular Disease in Menopausal Women. Biochem Res Int (2016) 0.77
Effects of Oxidative Stress and Testosterone on Pro-Inflammatory Signaling in a Female Rat Dopaminergic Neuronal Cell Line. Endocrinology (2016) 0.76
SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites. Cancer Prev Res (Phila) (2014) 0.76
Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects. Chem Res Toxicol (2016) 0.75
In this issue. Estrogen double whammy. Chem Res Toxicol (2010) 0.75
Estrogen- and stress-induced DNA damage in breast cancer and chemoprevention with dietary flavonoid. Genes Environ (2017) 0.75
The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med (1995) 11.08
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Postmenopausal hormone therapy and mortality. N Engl J Med (1997) 4.96
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Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. Proc Natl Acad Sci U S A (1997) 3.53
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Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention. Biochim Biophys Acta (2006) 2.76
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Potential mechanisms of estrogen quinone carcinogenesis. Chem Res Toxicol (2007) 1.56
Copper and zinc levels in normal and malignant tissues. Cancer (1983) 1.48
Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengers. Biochemistry (2005) 1.39
The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone. Chem Res Toxicol (1999) 1.26
Evidence from ESI-MS for NQO1-catalyzed reduction of estrogen ortho-quinones. Free Radic Biol Med (2007) 1.23
The effects of catechol-O-methyltransferase inhibition on estrogen metabolite and oxidative DNA damage levels in estradiol-treated MCF-7 cells. Cancer Res (2001) 1.20
Microsome-mediated 8-hydroxylation of guanine bases of DNA by steroid estrogens: correlation of DNA damage by free radicals with metabolic activation to quinones. Carcinogenesis (1995) 1.18
Depurinating estrogen-DNA adducts in the etiology and prevention of breast and other human cancers. Future Oncol (2010) 1.18
Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling. Chem Res Toxicol (2005) 1.15
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Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity. Carcinogenesis (1997) 1.10
Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases. Chem Res Toxicol (2001) 1.09
DNA damage resulting from the oxidation of hydroquinone by copper: role for a Cu(II)/Cu(I) redox cycle and reactive oxygen generation. Carcinogenesis (1993) 1.08
Hydroxyl free radical is not the main active species in site-specific DNA damage induced by copper (II) ion and hydrogen peroxide. J Biol Chem (1989) 1.06
A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines. Chem Res Toxicol (2000) 1.06
Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogens. Toxicology (2002) 1.06
Carcinogenic activities of various steroidal and nonsteroidal estrogens in the hamster kidney: relation to hormonal activity and cell proliferation. Cancer Res (1995) 1.05
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Oxidized apurinic/apyrimidinic sites formed in DNA by oxidative mutagens. Mutat Res (1989) 1.02
Hormones and hormone antagonists: mechanisms of action in carcinogenesis of endometrial and breast cancer. Horm Metab Res (2001) 1.01
DNA damage caused by reactive oxygen species originating from a copper-dependent oxidation of the 2-hydroxy catechol of estradiol. Carcinogenesis (1994) 1.01
Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus. J Biol Chem (2009) 0.99
4-hydroxyestradiol induces anchorage-independent growth of human mammary epithelial cells via activation of IkappaB kinase: potential role of reactive oxygen species. Cancer Res (2009) 0.99
Estrogen use and cancer incidence: a review. Cancer Invest (1995) 0.98
Evidence that a metabolite of equine estrogens, 4-hydroxyequilenin, induces cellular transformation in vitro. Chem Res Toxicol (2001) 0.95
Oxidative DNA damage induced by equine estrogen metabolites: role of estrogen receptor alpha. Chem Res Toxicol (2002) 0.95
Mutagenic events induced by 4-hydroxyequilin in supF shuttle vector plasmid propagated in human cells. Carcinogenesis (2003) 0.93
Exogenous and endogenous hormones and breast cancer. Best Pract Res Clin Endocrinol Metab (2008) 0.91
Metabolism of equilenin in MCF-7 and MDA-MB-231 human breast cancer cells. Chem Res Toxicol (2001) 0.90
Oxidative DNA damage in XPC-knockout and its wild mice treated with equine estrogen. Chem Res Toxicol (2008) 0.89
Problematic detoxification of estrogen quinones by NAD(P)H-dependent quinone oxidoreductase and glutathione-S-transferase. Chem Res Toxicol (2008) 0.87
DNA damage induced by catecholestrogens in the presence of copper (II): generation of reactive oxygen species and enhancement by NADH. Free Radic Biol Med (1999) 0.87
4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-kappaB and ERK/MAPK. Toxicol Appl Pharmacol (2005) 0.86
Clinical management of women at increased risk for breast cancer. Breast Cancer Res Treat (1993) 0.85
Increasing the DNA damage threshold in breast cancer cells. Toxicol Appl Pharmacol (2002) 0.84
Mechanism of cytochrome P450-catalyzed aromatic hydroxylation of estrogens. Chem Res Toxicol (1997) 0.84
Interaction of copper(I) with nucleic acids. Int J Radiat Biol (1990) 0.84
Surveying the damage: the challenges of developing nucleic acid biomarkers of inflammation. Mol Biosyst (2008) 0.83
Oxidative DNA adducts after Cu(2+)-mediated activation of dihydroxy PCBs: role of reactive oxygen species. Free Radic Biol Med (2009) 0.83
NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells. J Steroid Biochem Mol Biol (2009) 0.83
Differential effects of redox-cycling and arylating quinones on trans-plasma membrane electron transport. Biofactors (2008) 0.82
Estrogen carcinogenesis: specific identification of estrogen-modified nucleobase in breast tissue from women. Chem Res Toxicol (2008) 0.81
Measurement of oxidative DNA damage by catechol estrogens and analogues in vitro. Chem Res Toxicol (1999) 0.80
Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells. Chem Res Toxicol (2009) 0.80
Effects of naphthalene quinonoids on the induction of oxidative DNA damage and cytotoxicity in calf thymus DNA and in human cultured cells. Chem Res Toxicol (2005) 0.79
Aldehydic DNA lesions induced by catechol estrogens in calf thymus DNA. Carcinogenesis (2003) 0.78
Induction of cytotoxicity, aldehydic DNA lesions, and poly(ADP-ribose) polymerase-1 activation by catechol derivatives of pentachlorophenol in calf thymus DNA and in human breast cancer cells. Chem Res Toxicol (2005) 0.76
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc Natl Acad Sci U S A (2005) 2.92
A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environ Health (2014) 1.88
Bisphenol A promotes human prostate stem-progenitor cell self-renewal and increases in vivo carcinogenesis in human prostate epithelium. Endocrinology (2014) 1.81
Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex. Nat Protoc (2012) 1.79
Human, rat, and mouse metabolism of resveratrol. Pharm Res (2002) 1.62
Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. J Agric Food Chem (2003) 1.56
Potential mechanisms of estrogen quinone carcinogenesis. Chem Res Toxicol (2007) 1.56
Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent. Chem Res Toxicol (2007) 1.53
Effects of lycopene on protein expression in human primary prostatic epithelial cells. Cancer Prev Res (Phila) (2013) 1.53
Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause (2009) 1.45
Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem (2010) 1.41
The burden borne by urease. J Am Chem Soc (2005) 1.40
Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance. Autophagy (2013) 1.39
Sites of alkylation of human Keap1 by natural chemoprevention agents. J Am Soc Mass Spectrom (2007) 1.36
Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). J Agric Food Chem (2005) 1.32
An improved LC-MS/MS method for the quantification of prostaglandins E(2) and D(2) production in biological fluids. Anal Biochem (2007) 1.25
Estrogens and congeners from spent hops (Humulus lupulus). J Nat Prod (2004) 1.24
Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. J Nat Prod (2006) 1.23
Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase. Chem Res Toxicol (2005) 1.20
An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice, and in wine. J Agric Food Chem (2002) 1.20
Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Mol Nutr Food Res (2011) 1.20
Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles. J Agric Food Chem (2002) 1.19
Modification of keap1 cysteine residues by sulforaphane. Chem Res Toxicol (2011) 1.17
Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors. J Am Soc Mass Spectrom (2005) 1.15
Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance. Mol Pharmacol (2003) 1.12
Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice. Cancer Prev Res (Phila) (2010) 1.11
Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay. J Agric Food Chem (2013) 1.10
Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats. J Nutr (2002) 1.09
Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration. Hum Genomics (2011) 1.08
MicroRNA-98 and microRNA-214 post-transcriptionally regulate enhancer of zeste homolog 2 and inhibit migration and invasion in human esophageal squamous cell carcinoma. Mol Cancer (2012) 1.08
From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters. J Med Chem (2009) 1.06
Great majority of recombination events in Arabidopsis are gene conversion events. Proc Natl Acad Sci U S A (2012) 1.05
Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes. J Mass Spectrom (2005) 1.04
Altered baseline brain activity in type 2 diabetes: a resting-state fMRI study. Psychoneuroendocrinology (2013) 1.04
Quantitative analysis of lycopene isomers in human plasma using high-performance liquid chromatography-tandem mass spectrometry. Anal Chem (2003) 1.04
Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation. Chem Res Toxicol (2005) 1.04
Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones. Chem Res Toxicol (2004) 1.04
Up-regulation of neurotrophic factors by cinnamon and its metabolite sodium benzoate: therapeutic implications for neurodegenerative disorders. J Neuroimmune Pharmacol (2013) 1.02
Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents. Mar Drugs (2012) 1.01
Isotopic tracer techniques for studying the bioavailability and bioefficacy of dietary carotenoids, particularly beta-carotene, in humans: a review. Am J Clin Nutr (2003) 1.01
In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin. Chem Biol Interact (2008) 1.01
Nr2e3-directed transcriptional regulation of genes involved in photoreceptor development and cell-type specific phototransduction. Exp Eye Res (2009) 1.01
Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor design. J Mol Biol (2007) 1.01
Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms. PLoS One (2013) 1.01
Impact of temperature on the time required for the establishment of primordial biochemistry, and for the evolution of enzymes. Proc Natl Acad Sci U S A (2010) 1.00
Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone. Chem Res Toxicol (2011) 1.00
Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus. J Biol Chem (2009) 0.99
Applications of pulsed ultrafiltration-mass spectrometry. Mass Spectrom Rev (2002) 0.99
Identification of caffeic acid derivatives in Actea racemosa (Cimicifuga racemosa, black cohosh) by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom (2003) 0.99
Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity. J Agric Food Chem (2006) 0.99
Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study. Chem Res Toxicol (2005) 0.98
Measurement of cyclooxygenase inhibition using liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal (2010) 0.98
Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa. J Nat Prod (2005) 0.98
Self-renewal and chemotherapy resistance of p75NTR positive cells in esophageal squamous cell carcinomas. BMC Cancer (2009) 0.98
Therapeutic potential of angiogenin modified mesenchymal stem cells: angiogenin improves mesenchymal stem cells survival under hypoxia and enhances vasculogenesis in myocardial infarction. Microvasc Res (2008) 0.97
In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent. J Agric Food Chem (2008) 0.97
Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1. Anal Chem (2005) 0.97
Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation. Pharmacol Res (2010) 0.96
Orally active multi-functional antioxidants are neuroprotective in a rat model of light-induced retinal damage. PLoS One (2011) 0.96
The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract. J Altern Complement Med (2006) 0.96
Quinone formation as a chemoprevention strategy for hybrid drugs: balancing cytotoxicity and cytoprotection. Chem Res Toxicol (2007) 0.96
Quinoids formed from estrogens and antiestrogens. Methods Enzymol (2004) 0.96
Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: a systems biology based approach. Vision Res (2009) 0.95
Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation. Chem Res Toxicol (2010) 0.95
The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours. Eur J Cancer (2005) 0.95
Genetic variations strongly influence phenotypic outcome in the mouse retina. PLoS One (2011) 0.95
Oxidative DNA damage induced by equine estrogen metabolites: role of estrogen receptor alpha. Chem Res Toxicol (2002) 0.95
Identification of novel electrophilic metabolites of piper methysticum Forst (Kava). Chem Res Toxicol (2003) 0.94
Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1. Chem Res Toxicol (2008) 0.94
Absorption and subcellular localization of lycopene in human prostate cancer cells. Mol Cancer Ther (2006) 0.94
Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo. Mol Cancer Ther (2007) 0.94
Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes. Drug Metab Dispos (2004) 0.94
Disposition of hop prenylflavonoids in human breast tissue. Mol Nutr Food Res (2010) 0.94