Published in Am J Respir Crit Care Med on June 03, 2010
Lactobacillus GG in the Prophylaxis of Ventilator Associated Pneumonia | NCT00613795
Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis. Crit Care (2016) 2.01
An update on the use and investigation of probiotics in health and disease. Gut (2013) 1.62
The role of the bacterial microbiome in lung disease. Expert Rev Respir Med (2013) 1.62
Towards an ecology of the lung: new conceptual models of pulmonary microbiology and pneumonia pathogenesis. Lancet Respir Med (2014) 1.36
The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia. Gut (2015) 1.23
Effects of probiotics on serum levels of Th1/Th2 cytokine and clinical outcomes in severe traumatic brain-injured patients: a prospective randomized pilot study. Crit Care (2011) 1.14
Antibiotics or probiotics as preventive measures against ventilator-associated pneumonia: a literature review. Crit Care (2011) 1.08
Probiotics' effects on the incidence of nosocomial pneumonia in critically ill patients: a systematic review and meta-analysis. Crit Care (2012) 1.03
Clostridium difficile in the ICU: the struggle continues. Chest (2011) 1.01
Probiotics for preventing ventilator-associated pneumonia. Cochrane Database Syst Rev (2014) 0.93
Towards a better understanding of Lactobacillus rhamnosus GG--host interactions. Microb Cell Fact (2014) 0.93
Hospitalization Type and Subsequent Severe Sepsis. Am J Respir Crit Care Med (2015) 0.93
Prevention of ventilator-associated pneumonia in the intensive care unit: a review of the clinically relevant recent advancements. Indian J Med Res (2014) 0.92
Challenges in the culture-independent analysis of oral and respiratory samples from intubated patients. Front Cell Infect Microbiol (2014) 0.91
Probiotic/synbiotic therapy for treating critically ill patients from a gut microbiota perspective. Dig Dis Sci (2012) 0.90
The endogenous bacteria alter gut epithelial apoptosis and decrease mortality following Pseudomonas aeruginosa pneumonia. Shock (2012) 0.89
Respiratory viral infections in children with asthma: do they matter and can we prevent them? BMC Pediatr (2012) 0.89
Treating critically ill patients with probiotics: Beneficial or dangerous? Gut Pathog (2011) 0.87
Effect of probiotics on the incidence of ventilator-associated pneumonia in critically ill patients: a randomized controlled multicenter trial. Intensive Care Med (2016) 0.86
Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections. World J Gastroenterol (2016) 0.86
Probiotic-associated aspiration pneumonia due to Lactobacillus rhamnosus. J Clin Microbiol (2014) 0.81
Probiotics for preventing ventilator-associated pneumonia: a systematic review and meta-analysis of high-quality randomized controlled trials. PLoS One (2013) 0.81
Clinical practice guideline: management of acute pancreatitis. Can J Surg (2016) 0.80
Prevention of ventilator-associated pneumonia: bugs or drugs? Am J Respir Crit Care Med (2010) 0.79
Lactobacillus rhamnosus GG and Bifidobacterium longum attenuate lung injury and inflammatory response in experimental sepsis. PLoS One (2014) 0.79
Update in pulmonary infections 2010. Am J Respir Crit Care Med (2011) 0.77
Probiotics in the management of lung diseases. Mediators Inflamm (2013) 0.77
Probiotics for the Primary and Secondary Prevention of C. difficile Infections: A Meta-analysis and Systematic Review. Antibiotics (Basel) (2015) 0.77
Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial-PROSPECT: protocol for a feasibility randomized pilot trial. Pilot Feasibility Stud (2015) 0.77
Survey and Systematic Literature Review of Probiotics Stocked in Academic Medical Centers within the United States. Hosp Pharm (2013) 0.76
Probiotics for severe trauma patients. Crit Care (2011) 0.75
Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial-PROSPECT: a pilot trial. Trials (2016) 0.75
Respiratory Microbiome of New-Born Infants. Front Pediatr (2016) 0.75
Effect of probiotic administration in the therapy of pediatric thermal burn. Ann Burns Fire Disasters (2016) 0.75
An analysis of microbiota-targeted therapies in patients with avian influenza virus subtype H7N9 infection. BMC Infect Dis (2014) 0.75
The Effect of Probiotic Treatment on Patients Infected with the H7N9 Influenza Virus. PLoS One (2016) 0.75
Gut microbiome, surgical complications and probiotics. Ann Gastroenterol (2016) 0.75
Preoperative Staphylococcus aureus Carriage and Risk of Surgical Site Infection After Cardiac Surgery in Children Younger than 1 year: A Pilot Cohort Study. Pediatr Cardiol (2016) 0.75
Influence of a probiotic Lactobacillus casei strain on the colonisation with potential pathogenic streptococci and Staphylococcus aureus in the nasopharyngeal space of healthy men with a low baseline NK cell activity. Med Microbiol Immunol (2014) 0.75
Evidence in the eye of the beholder: about probiotics and VAP prevention. Intensive Care Med (2016) 0.75
Impact of selective digestive decontamination on respiratory tract Candida among patients with suspected ventilator-associated pneumonia. A meta-analysis. Eur J Clin Microbiol Infect Dis (2016) 0.75
A multiple testing procedure for clinical trials. Biometrics (1979) 26.80
Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med (2005) 23.85
Concern Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet (2008) 10.70
Nosocomial infections in medical intensive care units in the United States. National Nosocomial Infections Surveillance System. Crit Care Med (1999) 7.90
Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest (2002) 6.13
Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia. Chest (2005) 5.91
Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med (1998) 4.01
Guidelines for preventing health-care--associated pneumonia, 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR Recomm Rep (2004) 3.84
Impact of the administration of probiotics on the incidence of ventilator-associated pneumonia: a meta-analysis of randomized controlled trials. Crit Care Med (2010) 3.43
Silver-coated endotracheal tubes and incidence of ventilator-associated pneumonia: the NASCENT randomized trial. JAMA (2008) 3.01
Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial. BMJ (2001) 2.91
A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. J Biol Chem (2002) 2.61
The safety and diagnostic accuracy of minibronchoalveolar lavage in patients with suspected ventilator-associated pneumonia. Ann Intern Med (1995) 2.23
Preventing ventilator-associated pneumonia in adults: sowing seeds of change. Chest (2006) 2.15
Probiotics: effects on immunity. Am J Clin Nutr (2001) 2.10
Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation--a randomized, double-blind trial. Am J Transplant (2005) 2.08
Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia. Ann Intern Med (2004) 1.97
Prevention of hospital-associated pneumonia and ventilator-associated pneumonia. Crit Care Med (2004) 1.92
What is ventilator-associated pneumonia and why is it important? Respir Care (2005) 1.58
The occurrence of ventilator-associated pneumonia in a community hospital: risk factors and clinical outcomes. Chest (2001) 1.48
Expression of concern--Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet (2010) 1.46
Benefits of a synbiotic formula (Synbiotic 2000Forte) in critically Ill trauma patients: early results of a randomized controlled trial. World J Surg (2006) 1.42
A prospective randomised study of the probiotic Lactobacillus plantarum 299V on indices of gut barrier function in elective surgical patients. Gut (2002) 1.36
Mechanisms of action of probiotics. Clin Infect Dis (2008) 1.27
Humoral immune response patterns of human mucosae: induction and relation to bacterial respiratory tract infections. J Infect Dis (1992) 1.25
An educational intervention to reduce ventilator-associated pneumonia in an integrated health system: a comparison of effects. Chest (2004) 1.16
Lactobacillus casei reduces CD8+ T cell-mediated skin inflammation. Eur J Immunol (2004) 1.14
Guidance for substantiating the evidence for beneficial effects of probiotics: prevention and management of infections by probiotics. J Nutr (2010) 1.13
Ventilator associated pneumonia: perspectives on the burden of illness. Intensive Care Med (2000) 1.10
Use of the probiotic Lactobacillus plantarum 299 to reduce pathogenic bacteria in the oropharynx of intubated patients: a randomised controlled open pilot study. Crit Care (2008) 1.10
Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients. JPEN J Parenter Enteral Nutr (2007) 1.07
Oral probiotic and prevention of Pseudomonas aeruginosa infections: a randomized, double-blind, placebo-controlled pilot study in intensive care unit patients. Crit Care (2008) 1.06
Effect of synbiotic therapy on the incidence of ventilator associated pneumonia in critically ill patients: a randomised, double-blind, placebo-controlled trial. Intensive Care Med (2008) 1.00
Benefits of early enteral nutrition with glutamine and probiotics in brain injury patients. Clin Sci (Lond) (2004) 1.00
Probiotics in inflammatory bowel disease: is it all gut flora modulation? Gut (2004) 0.99
Does the use of probiotics/synbiotics prevent postoperative infections in patients undergoing abdominal surgery? A meta-analysis of randomized controlled trials. Eur J Clin Pharmacol (2009) 0.95
Ingested probiotics reduce nasal colonization with pathogenic bacteria (Staphylococcus aureus, Streptococcus pneumoniae, and beta-hemolytic streptococci). Am J Clin Nutr (2003) 0.91
Probiotics in surgery. Surgery (2007) 0.87
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med (2009) 9.38
Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study. Clin Infect Dis (2012) 7.97
Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest (2002) 6.13
Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol (2010) 5.80
Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia. Chest (2003) 5.64
Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality. Antimicrob Agents Chemother (2005) 5.35
Before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med (2006) 4.10
Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest (2002) 3.98
Increase in adult Clostridium difficile-related hospitalizations and case-fatality rate, United States, 2000-2005. Emerg Infect Dis (2008) 3.88
Validation of a clinical score for assessing the risk of resistant pathogens in patients with pneumonia presenting to the emergency department. Clin Infect Dis (2011) 3.78
The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections. Drugs (2007) 3.63
Pseudomonas aeruginosa bloodstream infection: importance of appropriate initial antimicrobial treatment. Antimicrob Agents Chemother (2005) 3.49
Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol (2011) 3.35
Telavancin versus vancomycin for hospital-acquired pneumonia due to gram-positive pathogens. Clin Infect Dis (2011) 3.20
Pneumonia caused by methicillin-resistant Staphylococcus aureus. Clin Infect Dis (2008) 3.13
Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol (2010) 3.12
The importance of fluid management in acute lung injury secondary to septic shock. Chest (2009) 2.92
Impact of Sepsis Classification and Multidrug-Resistance Status on Outcome Among Patients Treated With Appropriate Therapy. Crit Care Med (2015) 2.87
Time to Appropriate Antibiotic Therapy Is an Independent Determinant of Postinfection ICU and Hospital Lengths of Stay in Patients With Sepsis. Crit Care Med (2015) 2.86
Fluconazole prophylaxis in critically ill surgical patients: a meta-analysis. Crit Care Med (2005) 2.70
Outcome and attributable cost of ventilator-associated pneumonia among intensive care unit patients in a suburban medical center. Crit Care Med (2003) 2.59
Hospital-wide impact of a standardized order set for the management of bacteremic severe sepsis. Crit Care Med (2009) 2.57
Healthcare-associated bloodstream infection: A distinct entity? Insights from a large U.S. database. Crit Care Med (2006) 2.51
Health care-associated pneumonia and community-acquired pneumonia: a single-center experience. Antimicrob Agents Chemother (2007) 2.49
Implementation of a real-time computerized sepsis alert in nonintensive care unit patients. Crit Care Med (2011) 2.35
Short- vs long-duration antibiotic regimens for ventilator-associated pneumonia: a systematic review and meta-analysis. Chest (2013) 2.32
A randomized controlled trial of an antibiotic discontinuation policy for clinically suspected ventilator-associated pneumonia. Chest (2004) 2.26
Long-acting β2-agonist step-off in patients with controlled asthma. Arch Intern Med (2012) 2.24
Endotracheal tube intraluminal volume loss among mechanically ventilated patients. Crit Care Med (2004) 2.20
Inappropriate antibiotic therapy in Gram-negative sepsis increases hospital length of stay. Crit Care Med (2011) 2.16
Early versus late enteral feeding of mechanically ventilated patients: results of a clinical trial. JPEN J Parenter Enteral Nutr (2002) 2.15
Occurrence of co-colonization or co-infection with vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus in a medical intensive care unit. Infect Control Hosp Epidemiol (2004) 2.13
Pneumonia Pathogen Characterization Is an Independent Determinant of Hospital Readmission. Chest (2015) 2.09
Association between a silver-coated endotracheal tube and reduced mortality in patients with ventilator-associated pneumonia. Chest (2009) 2.09
Treatment-related risk factors for hospital mortality in Candida bloodstream infections. Crit Care Med (2008) 2.06
A retrospective analysis of possible renal toxicity associated with vancomycin in patients with health care-associated methicillin-resistant Staphylococcus aureus pneumonia. Clin Ther (2007) 2.05
Attitudes of respiratory therapists and nurses about measures to prevent ventilator-associated pneumonia: a multicenter, cross-sectional survey study. Respir Care (2007) 2.03
Delirium as detected by the CAM-ICU predicts restraint use among mechanically ventilated medical patients. Crit Care Med (2005) 1.92
Economic implications of an evidence-based sepsis protocol: can we improve outcomes and lower costs? Crit Care Med (2007) 1.88
Methicillin-resistant Staphylococcus aureus sterile-site infection: The importance of appropriate initial antimicrobial treatment. Crit Care Med (2006) 1.86
A comparison of ventilator-associated pneumonia rates as identified according to the National Healthcare Safety Network and American College of Chest Physicians criteria. Crit Care Med (2012) 1.82
Omalizumab treatment downregulates dendritic cell FcepsilonRI expression. J Allergy Clin Immunol (2003) 1.82
Diagnostic implications of soluble triggering receptor expressed on myeloid cells-1 in BAL fluid of patients with pulmonary infiltrates in the ICU. Chest (2008) 1.81
Methicillin-resistant Staphylococcus aureus prolongs intensive care unit stay in ventilator-associated pneumonia, despite initially appropriate antibiotic therapy. Crit Care Med (2006) 1.80
Effect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia. Crit Care Med (2002) 1.72
Inappropriate therapy for methicillin-resistant Staphylococcus aureus: resource utilization and cost implications. Crit Care Med (2008) 1.72
Antimicrobial stewardship in the intensive care unit: advances and obstacles. Am J Respir Crit Care Med (2009) 1.71
Silver-coated endotracheal tubes associated with reduced bacterial burden in the lungs of mechanically ventilated dogs. Chest (2002) 1.63
Use of adjunctive aerosolized antimicrobial therapy in the treatment of Pseudomonas aeruginosa and Acinetobacter baumannii ventilator-associated pneumonia. Respir Care (2012) 1.62
Clostridium difficile in the intensive care unit: epidemiology, costs, and colonization pressure. Infect Control Hosp Epidemiol (2007) 1.61
Nursing adherence with evidence-based guidelines for preventing ventilator-associated pneumonia. Crit Care Med (2003) 1.61
Identifying critically ill patients at risk for inappropriate antibiotic therapy: a pilot study of a point-of-care decision support alert. Crit Care Med (2014) 1.60
Readmission following hospitalization for pneumonia: the impact of pneumonia type and its implication for hospitals. Clin Infect Dis (2013) 1.60
A prospective evaluation of ventilator-associated conditions and infection-related ventilator-associated conditions. Chest (2015) 1.59
Prediction of infection due to antibiotic-resistant bacteria by select risk factors for health care-associated pneumonia. Arch Intern Med (2008) 1.58
Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients: frequency, outcomes, and risk factors. Crit Care Med (2006) 1.57
Use of a handheld computer by respiratory care practitioners to improve the efficiency of weaning patients from mechanical ventilation. Crit Care Med (2002) 1.56
Omalizumab rapidly decreases nasal allergic response and FcepsilonRI on basophils. J Allergy Clin Immunol (2004) 1.53
A randomized trial of conventional chest physical therapy versus high frequency chest wall compressions in intubated and non-intubated adults. Respir Care (2011) 1.51
Patient safety event reporting in critical care: a study of three intensive care units. Crit Care Med (2007) 1.51
Linezolid for treatment of ventilator-associated pneumonia: a cost-effective alternative to vancomycin. Crit Care Med (2004) 1.49
Antimicrobial therapy escalation and hospital mortality among patients with health-care-associated pneumonia: a single-center experience. Chest (2008) 1.47
Non-invasive stroke volume measurement and passive leg raising predict volume responsiveness in medical ICU patients: an observational cohort study. Crit Care (2009) 1.47
Epidemiology and outcomes of clostridium difficile-associated disease among patients on prolonged acute mechanical ventilation. Chest (2009) 1.47
Physicians' estimates of cardiac index and intravascular volume based on clinical assessment versus transesophageal Doppler measurements obtained by critical care nurses. Am J Crit Care (2003) 1.46
Hospital mortality for patients with bacteremia due to Staphylococcus aureus or Pseudomonas aeruginosa. Chest (2004) 1.45
Diagnostic utility of plasma procalcitonin for nosocomial pneumonia in the intensive care unit setting. Respir Care (2011) 1.45
Prevention of hospital infection. Microbes Infect (2005) 1.45
Secular trends in candidemia-related hospitalization in the United States, 2000-2005. Infect Control Hosp Epidemiol (2008) 1.42
Ambulatory care-sensitive conditions: clinical outcomes and impact on intensive care unit resource use. South Med J (2003) 1.42
Activity of a silver-coated endotracheal tube in preclinical models of ventilator-associated pneumonia and a study after extubation. Crit Care Med (2010) 1.42
Levofloxacin for treatment of ventilator-associated pneumonia: a subgroup analysis from a randomized trial. Clin Infect Dis (2005) 1.40
Addition of vasopressin to norepinephrine as independent predictor of mortality in patients with refractory septic shock: an observational study. Surg Infect (Larchmt) (2007) 1.39
Morbidity and cost burden of methicillin-resistant Staphylococcus aureus in early onset ventilator-associated pneumonia. Crit Care (2006) 1.37
Staphylococcus aureus nasal colonization and subsequent infection in intensive care unit patients: does methicillin resistance matter? Infect Control Hosp Epidemiol (2010) 1.34
Cost and mortality prediction using polymerase chain reaction pathogen detection in sepsis: evidence from three observational trials. Crit Care (2010) 1.33
Continuation of a randomized, double-blind, multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumonia. Clin Ther (2003) 1.33
Grading local side effects of sublingual immunotherapy for respiratory allergy: speaking the same language. J Allergy Clin Immunol (2013) 1.33
Analysis of 30-day mortality for clostridium difficile-associated disease in the ICU setting. Chest (2007) 1.30
Multiple-allergen and single-allergen immunotherapy strategies in polysensitized patients: looking at the published evidence. J Allergy Clin Immunol (2012) 1.29
Inappropriate empiric antifungal therapy for candidemia in the ICU and hospital resource utilization: a retrospective cohort study. BMC Infect Dis (2010) 1.29
Empiric combination antibiotic therapy is associated with improved outcome against sepsis due to Gram-negative bacteria: a retrospective analysis. Antimicrob Agents Chemother (2010) 1.27
Allergen-specific immunotherapy for respiratory allergies: from meta-analysis to registration and beyond. J Allergy Clin Immunol (2010) 1.27
Hospital resource utilization and costs of inappropriate treatment of candidemia. Pharmacotherapy (2010) 1.25
The role of vitamin D in asthma. Ann Allergy Asthma Immunol (2010) 1.25
Deep vein thrombosis during prolonged mechanical ventilation despite prophylaxis. Crit Care Med (2002) 1.25
The effect of an education program on the incidence of central venous catheter-associated bloodstream infection in a medical ICU. Chest (2004) 1.24
Cultured lung fibroblasts from ovalbumin-challenged "asthmatic" mice differ functionally from normal. Am J Respir Cell Mol Biol (2007) 1.22
Increase in Clostridium difficile-related hospitalizations among infants in the United States, 2000-2005. Pediatr Infect Dis J (2008) 1.20
Transfusion practice and blood stream infections in critically ill patients. Chest (2005) 1.19
A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilator-associated pneumonia. Crit Care (2012) 1.18
Unmet needs in severe chronic upper airway disease (SCUAD). J Allergy Clin Immunol (2009) 1.16
An educational intervention to reduce ventilator-associated pneumonia in an integrated health system: a comparison of effects. Chest (2004) 1.16
CD4+ T-cell-directed antibody responses are maintained in patients with psoriasis receiving alefacept: results of a randomized study. J Am Acad Dermatol (2003) 1.16
Red blood cell transfusion and ventilator-associated pneumonia: A potential link? Crit Care Med (2004) 1.15