Published in J Biol Chem on June 04, 2010
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Epithelial Na(+) channel regulation by cytoplasmic and extracellular factors. Exp Cell Res (2012) 1.08
Af17 deficiency increases sodium excretion and decreases blood pressure. J Am Soc Nephrol (2011) 1.00
Regulation of the renal Na+-Cl- cotransporter by phosphorylation and ubiquitylation. Am J Physiol Renal Physiol (2012) 0.90
Insulin resistance, obesity, hypertension, and renal sodium transport. Int J Hypertens (2011) 0.87
Exploring the intricate regulatory network controlling the thiazide-sensitive NaCl cotransporter (NCC). Pflugers Arch (2011) 0.84
WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination. Am J Physiol Renal Physiol (2013) 0.84
WNK kinases and the kidney. Exp Cell Res (2012) 0.83
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Kidney-specific WNK1 regulates sodium reabsorption and potassium secretion in mouse cortical collecting duct. Am J Physiol Renal Physiol (2012) 0.81
Serum and glucocorticoid-inducible kinase1 increases plasma membrane wt-CFTR in human airway epithelial cells by inhibiting its endocytic retrieval. PLoS One (2014) 0.80
Antagonistic regulation of cystic fibrosis transmembrane conductance regulator cell surface expression by protein kinases WNK4 and spleen tyrosine kinase. Mol Cell Biol (2011) 0.80
An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron. Am J Physiol Cell Physiol (2015) 0.79
The kidneys and aldosterone/mineralocorticoid receptor system in salt-sensitive hypertension. Curr Hypertens Rep (2011) 0.79
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Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis. Int J Mol Sci (2016) 0.78
Regulators of Slc4 bicarbonate transporter activity. Front Physiol (2015) 0.77
Hypertension: the missing WNKs. Am J Physiol Renal Physiol (2016) 0.76
Association Between Polymorphisms of ADRBK1 Gene and Plasma Renin Activity in Hypertensive Patients: A Case-Control Study. Med Sci Monit (2016) 0.75
WNK signalling pathways in blood pressure regulation. Cell Mol Life Sci (2016) 0.75
Cell-specific regulation of L-WNK1 by dietary K. Am J Physiol Renal Physiol (2015) 0.75
Emerging Targets of Diuretic Therapy. Clin Pharmacol Ther (2017) 0.75
Oncogenic MNK signalling regulates the metastasis suppressor NDRG1. Oncotarget (2017) 0.75
Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules. J Am Soc Nephrol (2017) 0.75
Human hypertension caused by mutations in WNK kinases. Science (2001) 8.71
Genome-wide detection of tissue-specific alternative splicing in the human transcriptome. Nucleic Acids Res (2002) 6.71
Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Nature (2005) 5.30
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A (2003) 4.70
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion. Nat Genet (2003) 4.08
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The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J (2005) 3.52
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci U S A (2003) 3.48
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem (2005) 3.26
Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4. Am J Physiol Cell Physiol (2005) 2.51
WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. Oncogene (2001) 2.48
Epithelial sodium channel and the control of sodium balance: interaction between genetic and environmental factors. Annu Rev Physiol (2002) 2.36
PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1). J Biol Chem (2003) 2.34
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. J Biol Chem (2002) 2.16
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci U S A (2006) 1.93
WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. Proc Natl Acad Sci U S A (2006) 1.90
Properties of WNK1 and implications for other family members. J Biol Chem (2005) 1.89
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure (2004) 1.82
WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. J Biol Chem (2003) 1.80
Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform. Mol Cell Biol (2003) 1.76
WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci U S A (2005) 1.76
Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. J Clin Invest (2009) 1.59
The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes. J Biol Chem (1999) 1.53
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo. Proc Natl Acad Sci U S A (2007) 1.46
Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3. Mol Endocrinol (2005) 1.46
WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. Biochem J (2004) 1.43
Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport. Am J Physiol Renal Physiol (2002) 1.42
WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. J Biol Chem (2005) 1.37
SLC26A9 is a Cl(-) channel regulated by the WNK kinases. J Physiol (2007) 1.33
The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo. J Biol Chem (1999) 1.33
Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1). J Biol Chem (2002) 1.24
Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel. Am J Physiol Renal Physiol (2002) 1.23
Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. J Biol Chem (2005) 1.23
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome. Pediatr Nephrol (2006) 1.11
WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron. Kidney Int (2006) 1.11
WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1). J Physiol (2005) 1.07
WNK1 and WNK4 modulate CFTR activity. Biochem Biophys Res Commun (2006) 1.06
WNK kinases: molecular regulators of integrated epithelial ion transport. Curr Opin Nephrol Hypertens (2004) 1.04
Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway. J Biol Chem (2007) 0.97
Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion. PLoS One (2009) 0.92
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell (2006) 11.38
Acetylation is indispensable for p53 activation. Cell (2008) 5.70
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell (2011) 5.27
Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell (2009) 5.26
RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. Cell (2006) 5.08
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol Cell Proteomics (2008) 4.36
Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic. J Biol Chem (2003) 3.90
Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science (2003) 3.59
JMJD6 is a histone arginine demethylase. Science (2007) 3.48
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell (2009) 2.99
CHD7 cooperates with PBAF to control multipotent neural crest formation. Nature (2010) 2.88
Identification of lysine succinylation as a new post-translational modification. Nat Chem Biol (2010) 2.87
The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics (2011) 2.83
Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation. J Proteome Res (2007) 2.76
A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. Proc Natl Acad Sci U S A (2004) 2.74
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol Cell (2002) 2.64
Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci U S A (2008) 2.62
Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol Cell (2002) 2.51
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature (2010) 2.47
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46
Integrated approach for manual evaluation of peptides identified by searching protein sequence databases with tandem mass spectra. J Proteome Res (2005) 2.27
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell (2013) 2.17
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. J Biol Chem (2002) 2.16
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction. Cell (2011) 2.10
An intimate collaboration between peroxisomes and lipid bodies. J Cell Biol (2006) 2.04
A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation. Genes Dev (2008) 2.01
Lysine succinylation and lysine malonylation in histones. Mol Cell Proteomics (2012) 1.95
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci U S A (2006) 1.93
DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN. J Am Soc Nephrol (2012) 1.93
WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. Proc Natl Acad Sci U S A (2006) 1.90
Properties of WNK1 and implications for other family members. J Biol Chem (2005) 1.89
Crystal structure of domain-swapped STE20 OSR1 kinase domain. Protein Sci (2009) 1.87
2D differential in-gel electrophoresis for the identification of esophageal scans cell cancer-specific protein markers. Mol Cell Proteomics (2002) 1.85
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure (2004) 1.82
Proteome-wide prediction of acetylation substrates. Proc Natl Acad Sci U S A (2009) 1.81
WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. J Biol Chem (2003) 1.80
Proteomic analysis of integral plasma membrane proteins. Anal Chem (2004) 1.78
WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci U S A (2005) 1.76
The roles of MAPKs in disease. Cell Res (2008) 1.76
Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Mol Pharmacol (2009) 1.75
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The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature (2013) 1.70
HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription. Mol Cell (2006) 1.67
Intersectin links WNK kinases to endocytosis of ROMK1. J Clin Invest (2007) 1.67
Proteomics of human breast ductal carcinoma in situ. Cancer Res (2002) 1.62
TAO kinases mediate activation of p38 in response to DNA damage. EMBO J (2007) 1.59
Myosin light chain kinase and myosin phosphorylation effect frequency-dependent potentiation of skeletal muscle contraction. Proc Natl Acad Sci U S A (2005) 1.59
Nonradioactive analysis of phosphatidylinositides and other anionic phospholipids by anion-exchange high-performance liquid chromatography with suppressed conductivity detection. Anal Biochem (2002) 1.57
Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54
ERK2 enters the nucleus by a carrier-independent mechanism. Proc Natl Acad Sci U S A (2002) 1.54
Early diagnosis of thyrotoxic periodic paralysis: spot urine calcium to phosphate ratio. Crit Care Med (2006) 1.51
Evaluation of ethanol-fixed, paraffin-embedded tissues for proteomic applications. Proteomics (2003) 1.50
Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1. J Biol Chem (2002) 1.49
ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter. J Biol Chem (2005) 1.48
An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. PLoS Biol (2009) 1.48
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell (2009) 1.47
Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells. J Biol Chem (2003) 1.46
PTMap--a sequence alignment software for unrestricted, accurate, and full-spectrum identification of post-translational modification sites. Proc Natl Acad Sci U S A (2009) 1.46
Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways. Mol Cell Biol (2004) 1.45
Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. Nucleic Acids Res (2004) 1.44
Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis. Kidney Int (2013) 1.44
A strategy for modulation of enzymes in the ubiquitin system. Science (2013) 1.43
The case: a young man with acute kidney injury after exercise. The diagnosis: exercise induced acute kidney injury in hereditary renal hypouricemia. Kidney Int (2010) 1.42
Tetrandrine inhibits Wnt/β-catenin signaling and suppresses tumor growth of human colorectal cancer. Mol Pharmacol (2010) 1.40
Global identification of O-GlcNAc-modified proteins. Anal Chem (2006) 1.40
14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J (2006) 1.40
Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway. J Biol Chem (2002) 1.39
Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex. Nucleic Acids Res (2008) 1.39
Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint. Proc Natl Acad Sci U S A (2007) 1.39
Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles. Am J Physiol Renal Physiol (2002) 1.39
Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. PLoS One (2011) 1.38
Hunting down a double gap metabolic acidosis. Ann Clin Biochem (2010) 1.38
WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. J Biol Chem (2005) 1.37
Phenotype and genotype analysis in Chinese patients with Gitelman's syndrome. J Clin Endocrinol Metab (2005) 1.37
WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. Mol Cell (2004) 1.35
PIP2 activates TRPV5 and releases its inhibition by intracellular Mg2+. J Gen Physiol (2005) 1.35