Published in Nat Neurosci on June 06, 2010
GSK-3: Functional Insights from Cell Biology and Animal Models. Front Mol Neurosci (2011) 1.99
Ultrafast endocytosis at Caenorhabditis elegans neuromuscular junctions. Elife (2013) 1.74
What Are the bona fide GSK3 Substrates? Int J Alzheimers Dis (2011) 1.65
Protein scaffolds in the coupling of synaptic exocytosis and endocytosis. Nat Rev Neurosci (2011) 1.61
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission. Nat Neurosci (2012) 1.30
The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3). J Biol Chem (2013) 1.14
Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I. EMBO J (2011) 1.11
Synaptic vesicle recycling: steps and principles. EMBO J (2014) 1.08
Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2. Trends Neurosci (2012) 1.08
A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis. Elife (2014) 1.00
Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses. Proc Natl Acad Sci U S A (2012) 0.94
The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma. Neuro Oncol (2012) 0.94
Key physiological parameters dictate triggering of activity-dependent bulk endocytosis in hippocampal synapses. PLoS One (2012) 0.93
The role of Cdk5 in cognition and neuropsychiatric and neurological pathology. Brain Res Bull (2010) 0.93
Crosstalk between Akt/GSK3β signaling and dynamin-1 regulates clathrin-mediated endocytosis. EMBO J (2015) 0.92
Clathrin-mediated endocytosis at the synaptic terminal: bridging the gap between physiology and molecules. Traffic (2010) 0.92
Calcineurin selectively docks with the dynamin Ixb splice variant to regulate activity-dependent bulk endocytosis. J Biol Chem (2011) 0.91
GSK3 as a Sensor Determining Cell Fate in the Brain. Front Mol Neurosci (2012) 0.90
Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase. Nat Commun (2014) 0.86
Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase. Front Mol Neurosci (2012) 0.86
Synaptic release at mammalian bipolar cell terminals. Vis Neurosci (2011) 0.85
Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1. J Neurosci (2015) 0.85
GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation. Elife (2014) 0.84
Dynamin photoinactivation blocks Clathrin and α-adaptin recruitment and induces bulk membrane retrieval. J Cell Biol (2014) 0.84
Prediction of functional phosphorylation sites by incorporating evolutionary information. Protein Cell (2012) 0.84
Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa. J Biol Chem (2012) 0.83
Inhibition of glycogen synthase kinase-3β prevents remifentanil-induced hyperalgesia via regulating the expression and function of spinal N-methyl-D-aspartate receptors in vivo and vitro. PLoS One (2013) 0.83
Phosphorylation by Dyrk1A of clathrin coated vesicle-associated proteins: identification of the substrate proteins and the effects of phosphorylation. PLoS One (2012) 0.82
Akt/PKB controls the activity-dependent bulk endocytosis of synaptic vesicles. Traffic (2012) 0.82
Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase. Mol Brain (2013) 0.82
The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol (2013) 0.82
Increased dynamin-1 and -2 protein expression in the aged gerbil hippocampus. Cell Mol Neurobiol (2014) 0.80
VAMP4 Is an Essential Cargo Molecule for Activity-Dependent Bulk Endocytosis. Neuron (2015) 0.80
Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation. Sci Rep (2015) 0.79
Control of synaptic vesicle endocytosis by an extracellular signalling molecule. Nat Commun (2013) 0.79
Phosphorylation Regulates the Endocytic Function of the Yeast Dynamin-Related Protein Vps1. Mol Cell Biol (2015) 0.78
Quantitative analysis of BDNF/TrkB protein and mRNA in cortical and striatal neurons using α-tubulin as a normalization factor. Cytometry A (2012) 0.78
Synucleins Have Multiple Effects on Presynaptic Architecture. Cell Rep (2017) 0.77
GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation. Front Mol Neurosci (2017) 0.76
Bulk-like endocytosis plays an important role in the recycling of insulin granules in pancreatic beta cells. Protein Cell (2012) 0.76
Protein interactions of the vesicular glutamate transporter VGLUT1. PLoS One (2014) 0.76
Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis. EMBO Rep (2015) 0.76
Synaptic vesicle exocytosis and increased cytosolic calcium are both necessary but not sufficient for activity-dependent bulk endocytosis. J Neurochem (2015) 0.76
Cholesterol regulates multiple forms of vesicle endocytosis at a mammalian central synapse. J Neurochem (2015) 0.76
Dynamin 2 is essential for mammalian spermatogenesis. Sci Rep (2016) 0.75
Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in Neurons. Front Mol Neurosci (2017) 0.75
Studying synaptic efficiency by post-hoc immunolabelling. BMC Neurosci (2013) 0.75
TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation. Proc Natl Acad Sci U S A (2017) 0.75
Roles of GSK3β in odor habituation and spontaneous neural activity of the mouse olfactory bulb. PLoS One (2013) 0.75
Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets. Pharmacol Rev (2017) 0.75
Phosphatidylinositol 3-Kinase Couples Localised Calcium Influx to Activation of Akt in Central Nerve Terminals. Neurochem Res (2015) 0.75
Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell. J Cell Biol (2017) 0.75
Putting a brake on synaptic vesicle endocytosis. Cell Mol Life Sci (2017) 0.75
The Calcineurin-Binding, Activity-Dependent Splice Variant Dynamin1xb Is Highly Enriched in Synapses in Various Regions of the Central Nervous System. Front Mol Neurosci (2017) 0.75
The selectivity of protein kinase inhibitors: a further update. Biochem J (2007) 15.73
GSK3 takes centre stage more than 20 years after its discovery. Biochem J (2001) 7.74
Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns. Mol Cell Proteomics (2005) 6.34
Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J (1990) 6.23
Clathrin-mediated endocytosis is the dominant mechanism of vesicle retrieval at hippocampal synapses. Neuron (2006) 5.70
A decade of CDK5. Nat Rev Mol Cell Biol (2001) 5.24
Synaptic vesicle endocytosis impaired by disruption of dynamin-SH3 domain interactions. Science (1997) 3.59
LTP inhibits LTD in the hippocampus via regulation of GSK3beta. Neuron (2007) 3.17
The GSK3 hypothesis of Alzheimer's disease. J Neurochem (2007) 3.16
Cdk5 is essential for synaptic vesicle endocytosis. Nat Cell Biol (2003) 3.11
The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis. Trends Neurosci (2001) 2.76
Two endocytic recycling routes selectively fill two vesicle pools in frog motor nerve terminals. Neuron (2000) 2.73
Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J Biol Chem (2003) 2.65
Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc Natl Acad Sci U S A (2006) 2.61
Two pathways of synaptic vesicle retrieval revealed by single-vesicle imaging. Neuron (2009) 2.38
Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron (2008) 2.20
Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Nat Neurosci (2006) 1.99
Bulk membrane retrieval in the synaptic terminal of retinal bipolar cells. J Neurosci (2003) 1.99
Glycogen synthase kinase 3: an emerging therapeutic target. Trends Mol Med (2002) 1.85
Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release. J Cell Biol (2006) 1.85
The phospho-dependent dynamin-syndapin interaction triggers activity-dependent bulk endocytosis of synaptic vesicles. J Neurosci (2009) 1.73
Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development. J Cell Biol (2007) 1.64
Bulk synaptic vesicle endocytosis is rapidly triggered during strong stimulation. J Neurosci (2008) 1.55
Formation of an endophilin-Ca2+ channel complex is critical for clathrin-mediated synaptic vesicle endocytosis. Cell (2003) 1.48
Activity-dependent control of slow synaptic vesicle endocytosis by cyclin-dependent kinase 5. J Neurosci (2007) 1.47
Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. J Biol Chem (2006) 1.33
Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes. Curr Pharm Des (2004) 1.30
Macroendocytosis and endosome processing in snake motor boutons. J Physiol (2007) 1.24
Perturbation of syndapin/PACSIN impairs synaptic vesicle recycling evoked by intense stimulation. J Neurosci (2008) 1.22
The in vivo phosphorylation sites of rat brain dynamin I. J Biol Chem (2007) 1.07
The Wnt pool of glycogen synthase kinase 3beta is critical for trophic-deprivation-induced neuronal death. Mol Cell Biol (2008) 0.92
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42
Protein composition of catalytically active human telomerase from immortal cells. Science (2007) 3.53
Cdk5 is essential for synaptic vesicle endocytosis. Nat Cell Biol (2003) 3.11
Filaggrin in the frontline: role in skin barrier function and disease. J Cell Sci (2009) 2.71
Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. Cell (2011) 2.56
Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Dev Cell (2005) 2.40
A rapid Percoll gradient procedure for preparation of synaptosomes. Nat Protoc (2008) 2.02
Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Nat Neurosci (2006) 1.99
SIMAC (sequential elution from IMAC), a phosphoproteomics strategy for the rapid separation of monophosphorylated from multiply phosphorylated peptides. Mol Cell Proteomics (2007) 1.98
Involvement of novel autophosphorylation sites in ATM activation. EMBO J (2006) 1.94
GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons. J Biol Chem (2004) 1.91
Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells. J Cell Biol (2010) 1.84
Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation. BMC Neurosci (2004) 1.81
Bradykinin-induced microglial migration mediated by B1-bradykinin receptors depends on Ca2+ influx via reverse-mode activity of the Na+/Ca2+ exchanger. J Neurosci (2007) 1.74
The phospho-dependent dynamin-syndapin interaction triggers activity-dependent bulk endocytosis of synaptic vesicles. J Neurosci (2009) 1.73
A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo. J Biol Chem (2008) 1.72
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol (2008) 1.63
Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells. Diabetes (2007) 1.57
Bulk synaptic vesicle endocytosis is rapidly triggered during strong stimulation. J Neurosci (2008) 1.55
Cystic fibrosis in Australia, 2009: results from a data registry. Med J Aust (2011) 1.53
The molecular physiology of activity-dependent bulk endocytosis of synaptic vesicles. J Neurochem (2009) 1.49
Label-free quantitation of phosphopeptide changes during rat sperm capacitation. J Proteome Res (2010) 1.49
Activity-dependent control of slow synaptic vesicle endocytosis by cyclin-dependent kinase 5. J Neurosci (2007) 1.47
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc Natl Acad Sci U S A (2010) 1.46
Enriched monolayer precursor cell cultures from micro-dissected adult mouse dentate gyrus yield functional granule cell-like neurons. PLoS One (2007) 1.45
Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report. Pharm Res (2005) 1.44
Suppression of the intrinsic apoptosis pathway by synaptic activity. J Neurosci (2010) 1.40
Differential proteomics analysis of synaptic proteins identifies potential cellular targets and protein mediators of synaptic neuroprotection conferred by the slow Wallerian degeneration (Wlds) gene. Mol Cell Proteomics (2007) 1.35
Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. J Biol Chem (2006) 1.33
Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Mol Pharmacol (2007) 1.33
AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line. J Biol Chem (2004) 1.30
Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. J Med Chem (2009) 1.30
Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism. J Biol Chem (2011) 1.27
Neuromodulation of circuits with variable parameters: single neurons and small circuits reveal principles of state-dependent and robust neuromodulation. Annu Rev Neurosci (2014) 1.27
Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells. J Biol Chem (2005) 1.23
Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure. Biochem J (2005) 1.23
Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. J Neurochem (2007) 1.20
Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. J Neurochem (2007) 1.19
Synaptophysin is required for synaptobrevin retrieval during synaptic vesicle endocytosis. J Neurosci (2011) 1.19
Synapsin I-associated phosphatidylinositol 3-kinase mediates synaptic vesicle delivery to the readily releasable pool. J Biol Chem (2003) 1.18
Molecular connexions between dementia and diabetes. Neurosci Biobehav Rev (2007) 1.18
Properties of doublecortin-(DCX)-expressing cells in the piriform cortex compared to the neurogenic dentate gyrus of adult mice. PLoS One (2011) 1.17
Mammalian septins nomenclature. Mol Biol Cell (2002) 1.16
Multiple mechanisms switch an electrically coupled, synaptically inhibited neuron between competing rhythmic oscillators. Neuron (2013) 1.16
5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men. Diabetes (2007) 1.15
Activity-dependent bulk endocytosis and clathrin-dependent endocytosis replenish specific synaptic vesicle pools in central nerve terminals. J Neurosci (2010) 1.15
Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain. J Neurochem (2010) 1.15
Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif. J Biol Chem (2004) 1.15
Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic (2013) 1.14
GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4. J Neurosci (2010) 1.14
Improved detection of hydrophilic phosphopeptides using graphite powder microcolumns and mass spectrometry: evidence for in vivo doubly phosphorylated dynamin I and dynamin III. Mol Cell Proteomics (2004) 1.13
Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity. J Biol Chem (2002) 1.12
Protein-protein interactions identified by pull-down experiments and mass spectrometry. Curr Protoc Cell Biol (2004) 1.12
Ral: mediator of membrane trafficking. Int J Biochem Cell Biol (2006) 1.12
A differential role for macropinocytosis in mediating entry of the two forms of vaccinia virus into dendritic cells. PLoS Pathog (2010) 1.11
C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation. J Neurosci Res (2009) 1.10
Autophosphorylation and ATM activation: additional sites add to the complexity. J Biol Chem (2010) 1.07
The in vivo phosphorylation sites of rat brain dynamin I. J Biol Chem (2007) 1.07
Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element. BMC Mol Biol (2004) 1.05
Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase. Int J Biochem Cell Biol (2009) 1.05
Modulation of fate determinants Olig2 and Pax6 in resident glia evokes spiking neuroblasts in a model of mild brain ischemia. Stroke (2010) 1.04
Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes. Hum Mol Genet (2014) 1.04
Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals. J Neurochem (2004) 1.03
Dynamin I phosphorylation and the control of synaptic vesicle endocytosis. Biochem Soc Symp (2005) 1.01
The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Mol Cancer Ther (2010) 1.01
Rapid purification of native dynamin I and colorimetric GTPase assay. Methods Enzymol (2005) 1.01
CRMP2 hyperphosphorylation is characteristic of Alzheimer's disease and not a feature common to other neurodegenerative diseases. J Alzheimers Dis (2011) 1.01
Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission. Mol Cell Biol (2008) 1.00
The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. Exp Cell Res (2007) 0.99
Activity-dependent control of bulk endocytosis by protein dephosphorylation in central nerve terminals. J Physiol (2007) 0.99
Identification of the 49-kDa autoantigen associated with lymphocytic hypophysitis as alpha-enolase. J Clin Endocrinol Metab (2002) 0.97
Multisite phosphorylation of doublecortin by cyclin-dependent kinase 5. Biochem J (2004) 0.96
Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels. J Biol Chem (2009) 0.95
Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. Bioorg Med Chem Lett (2004) 0.95
Analysis of synaptic vesicle endocytosis in synaptosomes by high-content screening. Nat Protoc (2012) 0.94
Calcineurin activity is required for the completion of cytokinesis. Cell Mol Life Sci (2010) 0.94
Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors. Trends Cell Biol (2012) 0.94
Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2. Proc Natl Acad Sci U S A (2010) 0.94
Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3. Biochem J (2005) 0.94
Key physiological parameters dictate triggering of activity-dependent bulk endocytosis in hippocampal synapses. PLoS One (2012) 0.93
Adaptor protein complexes 1 and 3 are essential for generation of synaptic vesicles from activity-dependent bulk endosomes. J Neurosci (2012) 0.93
Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Mol Cancer Ther (2011) 0.93
A systematic review of randomized controlled trials on exercise parameters in the treatment of patellofemoral pain: what works? J Multidiscip Healthc (2011) 0.93
High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task. Behav Brain Res (2010) 0.92
A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene causing, respectively, nonclassic and classic 3beta-HSD deficiency congenital adrenal hyperplasia. J Clin Endocrinol Metab (2002) 0.92
Distinction between human cytochrome P450 (CYP) isoforms and identification of new phosphorylation sites by mass spectrometry. J Proteome Res (2008) 0.92
Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin. J Biol Chem (2012) 0.92