Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy.

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Published in Br J Cancer on June 08, 2010

Authors

K H T Paraiso1, I V Fedorenko, L P Cantini, A C Munko, M Hall, V K Sondak, J L Messina, K T Flaherty, K S M Smalley

Author Affiliations

1: Department of Molecular Oncology, The Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.

Associated clinical trials:

Clinical Trial to Evaluate the Efficacy of Vemurafenib in Combination With Cobimetinib (Continuous and Intermittent) in BRAFV600-mutation Positive Patients With Unresectable Locally Advanced or Metastatic Melanoma | NCT02583516

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