Published in J Struct Biol on June 10, 2010
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4. J Mol Biol (2012) 1.69
DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature (2015) 1.50
Improving the chances of successful protein structure determination with a random forest classifier. Acta Crystallogr D Biol Crystallogr (2014) 1.50
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases. J Biol Chem (2013) 1.46
Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases. J Biol Chem (2011) 1.42
A new class of small molecule inhibitor of BMP signaling. PLoS One (2013) 1.36
Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases. J Biol Chem (2011) 1.03
Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis. Mol Cell (2016) 1.01
Crystal structures of the catalytic domain of human soluble guanylate cyclase. PLoS One (2013) 1.01
Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases. J Biol Chem (2012) 1.00
Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures. Nat Commun (2014) 0.97
Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I. Haematologica (2013) 0.95
Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains. Biochem J (2012) 0.95
Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases. J Mol Biol (2013) 0.94
Recent advances in mammalian protein production. FEBS Lett (2013) 0.93
Bacillus anthracis thioredoxin systems, characterization and role as electron donors for ribonucleotide reductase. J Biol Chem (2012) 0.92
Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles. Antimicrob Agents Chemother (2015) 0.90
Structural insights into functional overlapping and differentiation among myosin V motors. J Biol Chem (2013) 0.90
Environment sensing and response mediated by ABC transporters. BMC Genomics (2011) 0.89
EXD2 promotes homologous recombination by facilitating DNA end resection. Nat Cell Biol (2016) 0.88
Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes. Biochemistry (2015) 0.88
High-performance liquid chromatography separation and intact mass analysis of detergent-solubilized integral membrane proteins. Anal Biochem (2010) 0.87
Crystal structure of human aurora B in complex with INCENP and VX-680. J Med Chem (2012) 0.87
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J Med Chem (2016) 0.86
X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor. J Med Chem (2013) 0.86
Biochemical and structural characterization of a thermostable β-glucosidase from Halothermothrix orenii for galacto-oligosaccharide synthesis. Appl Microbiol Biotechnol (2014) 0.85
Analysis of conditions affecting auto-phosphorylation of human kinases during expression in bacteria. Protein Expr Purif (2011) 0.85
Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation. N Biotechnol (2011) 0.85
Crystal structure of reduced MsAcg, a putative nitroreductase from Mycobacterium smegmatis and a close homologue of Mycobacterium tuberculosis Acg. J Biol Chem (2012) 0.84
A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases. Nucleic Acids Res (2013) 0.83
Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION. J Biol Chem (2015) 0.83
Crystal Structure of Sphingosine Kinase 1 with PF-543. ACS Med Chem Lett (2014) 0.83
The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factor. Nucleic Acids Res (2013) 0.83
Panoramic view of a superfamily of phosphatases through substrate profiling. Proc Natl Acad Sci U S A (2015) 0.83
Expression platforms for producing eukaryotic proteins: a comparison of E. coli cell-based and wheat germ cell-free synthesis, affinity and solubility tags, and cloning strategies. J Struct Funct Genomics (2015) 0.82
Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes. Nucleic Acids Res (2015) 0.82
The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities. Nucleic Acids Res (2015) 0.81
Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme. IUCrJ (2013) 0.81
Lessons from ten years of crystallization experiments at the SGC. Acta Crystallogr D Struct Biol (2016) 0.81
ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel d-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58. J Biol Chem (2015) 0.80
Crystal structures of the human Dysferlin inner DysF domain. BMC Struct Biol (2014) 0.80
Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin. Cell Rep (2016) 0.80
Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding. PLoS One (2016) 0.79
Fragment screening of cyclin G-associated kinase by weak affinity chromatography. Anal Bioanal Chem (2012) 0.79
Guidelines for the successful generation of protein-ligand complex crystals. Acta Crystallogr D Struct Biol (2017) 0.79
Site-selective (13)C labeling of proteins using erythrose. J Biomol NMR (2017) 0.78
Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2. J Biol Chem (2015) 0.78
Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa. Acta Crystallogr D Biol Crystallogr (2015) 0.78
Structural insights into the DNA-binding specificity of E2F family transcription factors. Nat Commun (2015) 0.77
High-throughput structural biology of metabolic enzymes and its impact on human diseases. J Inherit Metab Dis (2011) 0.77
l-Galactose metabolism in Bacteroides vulgatus from the human gut microbiota. Biochemistry (2014) 0.77
Crystal structures of Phanerochaete chrysosporium pyranose 2-oxidase suggest that the N-terminus acts as a propeptide that assists in homotetramer assembly. FEBS Open Bio (2013) 0.77
The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex. Biochem J (2014) 0.77
Dimeric Structure of the Bacterial Extracellular Foldase PrsA. J Biol Chem (2014) 0.77
Engineering a thermostable Halothermothrix orenii β-glucosidase for improved galacto-oligosaccharide synthesis. Appl Microbiol Biotechnol (2015) 0.76
Structure of the stationary phase survival protein YuiC from B.subtilis. BMC Struct Biol (2015) 0.76
High-resolution crystal structure of a polyextreme GH43 glycosidase from Halothermothrix orenii with α-L-arabinofuranosidase activity. Acta Crystallogr F Struct Biol Commun (2015) 0.76
Functional Evolution in Orthologous Cell-encoded RNA-dependent RNA Polymerases. J Biol Chem (2016) 0.76
Unraveling the B. pseudomallei Heptokinase WcbL: From Structure to Drug Discovery. Chem Biol (2015) 0.75
Stilbene epoxidation and detoxification in a Photorhabdus luminescens-nematode symbiosis. J Biol Chem (2017) 0.75
A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA. J Mol Biol (2015) 0.75
PAT: predictor for structured units and its application for the optimization of target molecules for the generation of synthetic antibodies. BMC Bioinformatics (2016) 0.75
Structure of the opening reading frame 49 protein encoded by Kaposi's sarcoma associated herpesvirus (KSHV). J Virol (2016) 0.75
Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease. Nucleic Acids Res (2016) 0.75
Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps. PLoS One (2016) 0.75
Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II. J Biol Chem (2016) 0.75
Another look at the mechanism involving trimeric dUTPases in Staphylococcus aureus pathogenicity island induction involves novel players in the party. Nucleic Acids Res (2016) 0.75
Complete Genome Sequence of the Autographa californica Multiple Nucleopolyhedrovirus Strain E2. Genome Announc (2014) 0.75
Discovery of a novel L-lyxonate degradation pathway in Pseudomonas aeruginosa PAO1. Biochemistry (2014) 0.75
Structure of an ABC transporter solute-binding protein specific for the amino sugars glucosamine and galactosamine. Acta Crystallogr F Struct Biol Commun (2016) 0.75
Structural basis for dolichylphosphate mannose biosynthesis. Nat Commun (2017) 0.75
Structural Characterization of Maize SIRK1 Kinase Domain Reveals an Unusual Architecture of the Activation Segment. Front Plant Sci (2017) 0.75
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Sci Rep (2017) 0.75
Mutations of Bacteria from Virus Sensitivity to Virus Resistance. Genetics (1943) 165.64
NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res (2006) 48.10
SMART, a simple modular architecture research tool: identification of signaling domains. Proc Natl Acad Sci U S A (1998) 36.83
Protein secondary structure prediction based on position-specific scoring matrices. J Mol Biol (1999) 33.07
The Pfam protein families database. Nucleic Acids Res (2007) 30.53
The PSIPRED protein structure prediction server. Bioinformatics (2000) 20.58
CD-Search: protein domain annotations on the fly. Nucleic Acids Res (2004) 16.76
Ligation-independent cloning of PCR products (LIC-PCR). Nucleic Acids Res (1990) 12.16
The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics (1996) 11.71
GlobPlot: Exploring protein sequences for globularity and disorder. Nucleic Acids Res (2003) 5.90
A new vector for high-throughput, ligation-independent cloning encoding a tobacco etch virus protease cleavage site. Protein Expr Purif (2002) 5.72
FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded. Bioinformatics (2005) 5.44
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. Proc Natl Acad Sci U S A (2006) 4.45
Protein production and purification. Nat Methods (2008) 3.97
Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. J Exp Biol (2005) 3.76
Improvement of the GenTHREADER method for genomic fold recognition. Bioinformatics (2003) 3.70
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A (2007) 3.21
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Cell (2008) 2.46
Open access chemical and clinical probes to support drug discovery. Nat Chem Biol (2009) 2.28
XtalPred: a web server for prediction of protein crystallizability. Bioinformatics (2007) 2.26
High throughput methods for gene cloning and expression. Protein Expr Purif (2002) 2.26
The completion of the Mammalian Gene Collection (MGC). Genome Res (2009) 2.21
The use of systematic N- and C-terminal deletions to promote production and structural studies of recombinant proteins. Protein Expr Purif (2007) 2.10
In vivo and in vitro protein solubility assays using split GFP. Nat Methods (2006) 1.92
Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study. Protein Expr Purif (2008) 1.82
Hsp90 and Cdc37 -- a chaperone cancer conspiracy. Curr Opin Genet Dev (2005) 1.78
Recombinant protein expression and solubility screening in Escherichia coli: a comparative study. Acta Crystallogr D Biol Crystallogr (2006) 1.65
Medium-scale structural genomics: strategies for protein expression and crystallization. Acc Chem Res (2003) 1.53
Protein structures hint at the shape of things to come. Nature (2005) 1.42
First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value. Acta Crystallogr D Biol Crystallogr (2006) 1.40
Baculovirus expression vector system: an emerging host for high-throughput eukaryotic protein expression. Methods Mol Biol (2008) 1.29
Strategies for structural proteomics of prokaryotes: Quantifying the advantages of studying orthologous proteins and of using both NMR and X-ray crystallography approaches. Proteins (2003) 1.27
Large-scale structural biology of the human proteome. Annu Rev Biochem (2009) 1.25
Enabling IMAC purification of low abundance recombinant proteins from E. coli lysates. Nat Methods (2009) 1.23
A pilot project to generate affinity reagents to human proteins. Nat Methods (2008) 1.16
High throughput production of recombinant human proteins for crystallography. Methods Mol Biol (2008) 1.08
Scalable high-throughput micro-expression device for recombinant proteins. Biotechniques (2004) 1.05
An efficient and generic strategy for producing soluble human proteins and domains in E. coli by screening construct libraries. Proteins (2006) 0.95
Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications. Protein Sci (2006) 0.92
Combinatorial library approaches for improving soluble protein expression in Escherichia coli. Acta Crystallogr D Biol Crystallogr (2005) 0.91
Z(basic)--a novel purification tag for efficient protein recovery. J Chromatogr A (2007) 0.83
Creating a structural genomics consortium. Nat Struct Biol (2000) 0.82
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. Proc Natl Acad Sci U S A (2006) 4.45
Protein production and purification. Nat Methods (2008) 3.97
Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell (2009) 3.51
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature (2007) 3.05
MicroRNA expression distinguishes between germinal center B cell-like and activated B cell-like subtypes of diffuse large B cell lymphoma. Int J Cancer (2007) 2.94
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol Biochem Parasitol (2006) 2.39
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. J Med Chem (2005) 2.34
Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study. Protein Expr Purif (2008) 1.82
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4. J Mol Biol (2012) 1.69
Structural basis of fumarate hydratase deficiency. J Inherit Metab Dis (2011) 1.58
Scanning electron microscopy of cells and tissues under fully hydrated conditions. Proc Natl Acad Sci U S A (2004) 1.57
Disseminating structural genomics data to the public: from a data dump to an animated story. Trends Biochem Sci (2006) 1.55
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Proc Natl Acad Sci U S A (2013) 1.54
Structure of the human RECQ1 helicase reveals a putative strand-separation pin. Proc Natl Acad Sci U S A (2009) 1.52
Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria. J Biol Chem (2006) 1.50
SPARC is a key Schwannian-derived inhibitor controlling neuroblastoma tumor angiogenesis. Cancer Res (2002) 1.47
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases. J Biol Chem (2013) 1.46
Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. Genes Dev (2011) 1.46
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. Hum Mol Genet (2009) 1.44
The structural basis of ZMPSTE24-dependent laminopathies. Science (2013) 1.43
Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases. J Biol Chem (2011) 1.42
Task-oriented processes in care (TOPIC): a proven model for teaching ambulatory care. Fam Med (2003) 1.38
Baculovirus expression vector system: an emerging host for high-throughput eukaryotic protein expression. Methods Mol Biol (2008) 1.29
A new method for publishing three-dimensional content. PLoS One (2009) 1.23
Assessing strategies for improved superfamily recognition. Protein Sci (2005) 1.21
Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired. Proc Natl Acad Sci U S A (2010) 1.20
The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary. Chem Biol Interact (2008) 1.13
A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression. J Biol Chem (2002) 1.13
A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation. Nucleic Acids Res (2010) 1.09
High throughput production of recombinant human proteins for crystallography. Methods Mol Biol (2008) 1.08
The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins. J Struct Funct Genomics (2007) 1.07
Target selection and determination of function in structural genomics. IUBMB Life (2003) 1.05
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. Chem Biol (2013) 1.04
Probing the structural basis of RecQ helicase function. Biophys Chem (2010) 1.04
Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases. J Biol Chem (2011) 1.03
SGC--structural biology and human health: a new approach to publishing structural biology results. PLoS One (2009) 1.02
Crystal structures of the catalytic domain of human soluble guanylate cyclase. PLoS One (2013) 1.01
[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains. J Med Chem (2013) 1.01
ChromoHub: a data hub for navigators of chromatin-mediated signalling. Bioinformatics (2012) 1.00
Structural comparison of human mammalian ste20-like kinases. PLoS One (2010) 1.00
Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases. J Biol Chem (2012) 1.00
P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. Mol Cancer Ther (2007) 0.98
Direct observation of RuvAB-catalyzed branch migration of single Holliday junctions. Proc Natl Acad Sci U S A (2004) 0.97
MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas. Br J Haematol (2007) 0.96
Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I. Haematologica (2013) 0.95
Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. Angew Chem Int Ed Engl (2012) 0.94
Structural insights into functional overlapping and differentiation among myosin V motors. J Biol Chem (2013) 0.90
Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase. FEBS Lett (2010) 0.90
Sodium bicarbonate supplementation and ingestion timing: does it matter? J Strength Cond Res (2012) 0.90
Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization. Am J Hum Genet (2012) 0.89
High-performance liquid chromatography separation and intact mass analysis of detergent-solubilized integral membrane proteins. Anal Biochem (2010) 0.87
Lymphadenopathy resulting from acute toxoplasmosis mimicking relapse of non-Hodgkin's lymphoma on fluorodeoxyglucose positron emission tomography/computed tomography. J Cancer Res Ther (2012) 0.85
Composite adrenal medullary tumor: A rare cause of hypertension in a young male. Urol Ann (2011) 0.85
Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation. N Biotechnol (2011) 0.85
Aberrant expression of microRNA biosynthetic pathway components is a common feature of haematological malignancy. Br J Haematol (2008) 0.83
PASD1 is a potential multiple myeloma-associated antigen. Blood (2006) 0.83
OOMMPPAA: a tool to aid directed synthesis by the combined analysis of activity and structural data. J Chem Inf Model (2014) 0.81
Interactive JIMD articles using the iSee concept: turning a new page on structural biology data. J Inherit Metab Dis (2011) 0.80
A novel method for "Wet" SEM. Ultrastruct Pathol (2004) 0.80
Mutations in the RING domain of TFB3, a subunit of yeast transcription factor IIH, reveal a role in cell cycle progression. J Biol Chem (2002) 0.80
Electron microscopy of wet tissues: a case study in renal pathology. Toxicol Pathol (2004) 0.80
Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations. Structure (2013) 0.78
Dietary outcomes of the healthy dads healthy kids randomised controlled trial. J Pediatr Gastroenterol Nutr (2012) 0.78
Gas phase characterization of the noncovalent quaternary structure of cholera toxin and the cholera toxin B subunit pentamer. Biophys J (2006) 0.78
Medium-throughput production of recombinant human proteins: ligation-independent cloning. Methods Mol Biol (2014) 0.76
Medium-throughput production of recombinant human proteins: protein production in insect cells. Methods Mol Biol (2014) 0.76
Correction: Biofilm Morphotypes and Population Structure among Staphylococcus epidermidis from Commensal and Clinical Samples. PLoS One (2016) 0.75
Aspartame in conjunction with carbohydrate reduces insulin levels during endurance exercise. J Int Soc Sports Nutr (2012) 0.75
Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites. Struct Dyn (2017) 0.75
Medium-throughput production of recombinant human proteins: protein production in E. coli. Methods Mol Biol (2014) 0.75