Published in J Biol Chem on June 14, 2010
Chymotrypsin C mutations in chronic pancreatitis. J Gastroenterol Hepatol (2011) 1.12
Chymotrypsin C (caldecrin) is associated with enamel development. J Dent Res (2011) 0.89
Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway. Cell Commun Signal (2013) 0.88
Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-κB ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling pathway. J Biol Chem (2012) 0.83
Rhinacanthin C Inhibits Osteoclast Differentiation and Bone Resorption: Roles of TRAF6/TAK1/MAPKs/NF-κB/NFATc1 Signaling. PLoS One (2015) 0.75
Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function. World J Biol Chem (2015) 0.75
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell (1998) 17.76
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell (1997) 15.96
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A (1998) 12.61
Bone resorption by osteoclasts. Science (2000) 11.68
Calcium oscillations increase the efficiency and specificity of gene expression. Nature (1998) 9.19
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell (2002) 9.10
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature (1997) 8.59
Contingent genetic regulatory events in T lymphocyte activation. Science (1989) 8.03
Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations. Science (1998) 7.29
Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev (2000) 6.42
Calcineurin: form and function. Physiol Rev (2000) 5.26
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature (1998) 4.93
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature (2004) 4.92
TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J Biol Chem (1997) 4.61
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature (2002) 4.44
The molecular understanding of osteoclast differentiation. Bone (2006) 4.39
Modulation of osteoclast differentiation. Endocr Rev (1992) 4.27
Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. Cell (1998) 3.90
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med (2005) 3.70
Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Invest (2000) 3.15
The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A (2004) 3.15
Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. Nature (1996) 2.90
The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. J Biol Chem (1998) 2.80
The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J Cell Biol (1999) 2.78
Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. Arthritis Rheum (2000) 2.61
Intracellular calcium dependence of gene expression in single T lymphocytes. Proc Natl Acad Sci U S A (1994) 2.42
Resorption of bone by isolated rabbit osteoclasts. J Cell Sci (1984) 2.33
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol (2007) 2.27
NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation. EMBO J (2003) 2.24
A novel member of the leukocyte receptor complex regulates osteoclast differentiation. J Exp Med (2002) 2.04
DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features. J Exp Med (2003) 2.04
The calcineurin/nuclear factor of activated T cells signaling pathway regulates osteoclastogenesis in RAW264.7 cells. J Biol Chem (2004) 1.94
RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis. J Biol Chem (2010) 1.58
Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-kappa B and mitogen-activated protein kinase signaling. J Biol Chem (2001) 1.55
p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells. J Exp Med (1993) 1.40
Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis. Proc Natl Acad Sci U S A (2008) 1.35
Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus. BMC Cell Biol (2007) 1.32
IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-kappaB. J Clin Invest (2001) 1.31
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development. J Immunol (2008) 1.18
12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation. J Bone Miner Res (2003) 1.13
Free radicals and other reactive oxygen metabolites in inflammatory bowel disease: cause, consequence or epiphenomenon? Pharmacol Ther (1992) 1.11
Generation of bone-resorbing osteoclasts from B220+ cells: its role in accelerated osteoclastogenesis due to estrogen deficiency. J Bone Miner Res (2001) 1.10
Interleukin-10 selectively inhibits osteoclastogenesis by inhibiting differentiation of osteoclast progenitors into preosteoclast-like cells in rat bone marrow culture system. J Cell Physiol (1995) 1.07
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis. J Immunol (1999) 0.93
Determination of amino acid sequence responsible for suppression of bone resorption by serum calcium-decreasing factor (caldecrin). FEBS Lett (2001) 0.91
Molecular cloning and expression of serum calcium-decreasing factor (caldecrin). J Biol Chem (1995) 0.90
RANK-L induces the expression of NFATc1, but not of NFkappaB subunits during osteoclast formation. Biochem Biophys Res Commun (2005) 0.86
Serum calcium-decreasing factor (caldecrin) from porcine pancreas has proteolytic activity which has no clear connection with the calcium decrease. FEBS Lett (1992) 0.85
Molecular cloning and expression of human caldecrin. FEBS Lett (1996) 0.85
Osteoclast precursors in bone marrow and peritoneal cavity. J Cell Physiol (1997) 0.84
Caldecrin proform requires trypsin activation for the acquisition of serum calcium-decreasing activity. FEBS Lett (1993) 0.82
Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene. J Biochem (1998) 0.79
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Biological activity of persimmon (Diospyros kaki) peel extracts. Phytother Res (2003) 1.49
Cytotoxic 3,5-bis(benzylidene)piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells. Eur J Med Chem (2007) 1.45
Biological activity of barbados cherry (acerola fruits, fruit of Malpighia emarginata DC) extracts and fractions. Phytother Res (2004) 1.32
3-(3,4,5-Trimethoxyphenyl)-1-oxo-2-propene: a novel pharmacophore displaying potent multidrug resistance reversal and selective cytotoxicity. Bioorg Med Chem (2007) 1.21
The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones. Eur J Med Chem (2008) 1.20
Biological activity of 3-formylchromones and related compounds. In Vivo (2007) 1.15
Radical scavenging activity and cytotoxicity of ferulic acid. Anticancer Res (2003) 1.12
Cytotoxic potential of phenothiazines. Curr Drug Targets (2006) 1.09
3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells. Bioorg Med Chem Lett (2005) 1.05
Coumarin derivatives with tumor-specific cytotoxicity and multidrug resistance reversal activity. In Vivo (2005) 1.00
Tumor-specific cytotoxicity of 3,5-dibenzoyl-1,4-dihydropyridines. Anticancer Res (2005) 0.99
3,5-Bis(benzylidene)-1-[4-2-(morpholin-4-yl)ethoxyphenylcarbonyl]-4-piperidone hydrochloride: a lead tumor-specific cytotoxin which induces apoptosis and autophagy. Bioorg Med Chem Lett (2009) 0.99
Production of bioactive triterpenes by Eriobotrya japonica calli. Phytochemistry (2002) 0.99
Tumor-specificity and apoptosis-inducing activity of stilbenes and flavonoids. Anticancer Res (2005) 0.98
Antinephritis and radical scavenging activity of prenylflavonoids. Fitoterapia (2003) 0.98
Cytotoxicity and apoptosis induction by butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). Anticancer Res (2004) 0.98
Tumor-specific cytotoxicity and apoptosis-inducing activity of berberines. Anticancer Res (2005) 0.96
Preliminary evaluation of antinephritis and radical scavenging activities of glabridin from Glycyrrhiza glabra. Fitoterapia (2003) 0.95
LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner. J Neurosci (2012) 0.95
Antioxidant and prooxidant action of eugenol-related compounds and their cytotoxicity. Toxicology (2002) 0.94
Hypoxia and reoxygenation augment bone-resorbing factor production from human periodontal ligament cells. J Periodontol (2007) 0.93
3,5-dibenzoyl-1,4-dihydropyridines: synthesis and MDR reversal in tumor cells. Bioorg Med Chem (2002) 0.93
Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression by eugenol-related compounds. Anticancer Res (2005) 0.92
Characterization of the pigment produced by the planarian, Dugesia ryukyuensis. Pigment Cell Res (2006) 0.92
Structure-activity relationships of alpha, beta-unsaturated ketones as assessed by their cytotoxicity against oral tumor cells. Anticancer Res (2004) 0.91
The redox state of glutathione regulates the hypoxic induction of HIF-1. Eur J Pharmacol (2009) 0.91
EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland. Dev Dyn (2003) 0.91
Comparative analysis of apoptosis-inducing activity of codeine and codeinone. Anesthesiology (2003) 0.90
New diarylheptanoids and diarylheptanoid glucosides from the rhizomes of Tacca chantrieri and their cytotoxic activity. J Nat Prod (2002) 0.90
Cycloartane glycosides from the rhizomes of Cimicifuga racemosa and their cytotoxic activities. Chem Pharm Bull (Tokyo) (2002) 0.89
Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity. Mol Pain (2010) 0.89
A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice--as a mouse model for Parkinson's disease. Biochem Biophys Res Commun (2008) 0.88
Induction of apoptosis by beta-diketones in human tumor cells. Anticancer Res (2004) 0.88
Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain. Brain Res Mol Brain Res (2003) 0.87
Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwifruit extracts. J Ethnopharmacol (2002) 0.87
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells. Eur J Med Chem (2007) 0.87
Re-evaluation of anti-inflammatory activity of mastic using activated macrophages. In Vivo (2009) 0.86
Polyhydroxylated spirostanol saponins from the tubers of Dioscorea polygonoides. J Nat Prod (2005) 0.86
Bimodal effect of glycyrrhizin on macrophage nitric oxide and prostaglandin E2 production. In Vivo (2008) 0.86
Effect of anticancer agents on codeinone-induced apoptosis in human cancer cell lines. Anticancer Res (2005) 0.85
Cytotoxicity and apoptosis-inducing activity of bisphenol A and hydroquinone in HL-60 cells. Anticancer Res (2005) 0.85
Plasma pteridine concentrations in patients with chronic renal failure. Nephrol Dial Transplant (2002) 0.85
Induction of tumor-specific cytotoxicity and apoptosis by doxorubicin. Anticancer Res (2005) 0.84
Dimeric 3,5-bis(benzylidene)-4-piperidones: a novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties. Eur J Med Chem (2012) 0.84
Time-saving closing loops for anterior retraction. J Clin Orthod (2002) 0.84
Hydroquinone-induced apoptosis in HL-60 cells. Anticancer Res (2005) 0.84
3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones: a novel cluster of potent tumor-selective cytotoxins. J Med Chem (2011) 0.84
Cell death-inducing activity of opiates in human oral tumor cell lines. Anticancer Res (2002) 0.84
Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines. Anticancer Res (2007) 0.84
Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation. PLoS One (2010) 0.84
Inhibition by Moxa smoke of NO production and iNOS expression in mouse macrophage-like cells Raw 264.7. In Vivo (2005) 0.83
Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-κB ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling pathway. J Biol Chem (2012) 0.83
Induction of apoptosis by epigallocatechin gallate and autophagy inhibitors in a mouse macrophage-like cell line. Anticancer Res (2008) 0.83
Induction of apoptosis by morphine in human tumor cell lines in vitro. Anticancer Res (2007) 0.83
Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells. J Oral Sci (2005) 0.83
Cytotoxic activity of deferiprone, maltol and related hydroxyketones against human tumor cell lines. Anticancer Res (2004) 0.83
Tumor-specific cytotoxicity and type of cell death induced by gefitinib in oral squamous cell carcinoma cell lines. Anticancer Res (2009) 0.82
Triterpene glycosides from the whole plant of Anemone hupehensis var. japonica and their cytotoxic activity. Chem Pharm Bull (Tokyo) (2009) 0.82
Spontaneous disappearance of a renal arteriovenous malformation. Int J Urol (2003) 0.82
1-(3-aminomethyl-4-hydroxyphenyl)-3-pyridinyl-2-propen-1-ones: a novel group of tumour-selective cytotoxins. J Enzyme Inhib Med Chem (2012) 0.82
Rat brain expresses serum calcium-decreasing factor (caldecrin). Neurosci Lett (2002) 0.82
Changes in amino acid metabolism during activation of mouse macrophage-like cell lines. In Vivo (2010) 0.81
Platelet-derived growth factor exerts disparate effects on odontoblast differentiation depending on the dimers in rat dental pulp cells. Cell Tissue Res (2004) 0.81
1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: A quest for selective cytotoxicity for malignant cells. Bioorg Med Chem (2008) 0.81
Quantitative structure-cytotoxicity relationship of newly synthesized tropolones determined by a semiempirical molecular-orbital method (PM5). Anticancer Res (2010) 0.81
2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance. Bioorg Med Chem (2009) 0.81
Changes in fluoride sensitivity during in vitro senescence of normal human oral cells. Anticancer Res (2005) 0.81
Induction of prostaglandin E2 production by TiO2 nanoparticles in human gingival fibroblast. In Vivo (2014) 0.81
Changes of metabolic profiles in an oral squamous cell carcinoma cell line induced by eugenol. In Vivo (2013) 0.80
Inhibition of NO production by activated macrophages by phenolcarboxylic acid monomers and polymers with radical scavenging activity. Anticancer Res (2003) 0.80
Nicorandil enhances the effect of endothelial nitric oxide under hypoxia-reoxygenation: role of the KATP channel. Eur J Pharmacol (2007) 0.80
Apoptosis-inducing activity of cisplatin (CDDP) against human hepatoma and oral squamous cell carcinoma cell lines. Anticancer Res (2004) 0.80
Effect of Scutellariae radix ingredients on prostaglandin E(2) production and COX-2 expression by LPS-activated macrophage. In Vivo (2009) 0.80
AATYK1A phosphorylation by Cdk5 regulates the recycling endosome pathway. Genes Cells (2010) 0.80
Sulindac, a nonsteroidal anti-inflammatory drug, selectively inhibits interferon-gamma-induced expression of the chemokine CXCL9 gene in mouse macrophages. Biochem Biophys Res Commun (2006) 0.80
Induction of cell death by combination treatment with cisplatin and 5-fluorouracil in a human oral squamous cell carcinoma cell line. Anticancer Res (2007) 0.80
Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src. Genes Cells (2008) 0.80
Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives. In Vivo (2010) 0.80
Re-evaluation of cytotoxicity and iron chelation activity of three beta-diketones by semiempirical molecular orbital method. In Vivo (2005) 0.79
Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by Barbados cherry, a fruit of Malpighia emarginata DC. Anticancer Res (2003) 0.79
Induction of non-apoptotic cell death by morphinone in human promyelocytic leukemia HL-60 cells. Anticancer Res (2006) 0.79
Effect of two different groups of Chinese medicines on nitric oxide production by mouse macrophage-like cells. In Vivo (2005) 0.79
COX-2 as possible target for the inhibition of PGE2 production by Rikko-san in activated macrophage. In Vivo (2008) 0.79
Inhibition of NO production in LPS-stimulated mouse macrophage-like cells by trihaloacetylazulene derivatives. Anticancer Res (2008) 0.79
Localization of heat shock protein 27 (hsp27) in the rat gingiva and its changes with tooth eruption. Acta Histochem Cytochem (2011) 0.79
Application of semiempirical method to estimate the cytotoxic activity of gallic acid and its related compounds. Anticancer Res (2003) 0.79
New cardenolides from the seeds of Adonis aestivalis. Chem Pharm Bull (Tokyo) (2012) 0.79
Quest for anti-inflammatory substances using IL-1β-stimulated gingival fibroblasts. In Vivo (2011) 0.79
Systematizing and cloning of genes involved in the cerebellar cortex circuit development. Neurochem Res (2011) 0.79
Lanosterol and tetranorlanosterol glycosides from the bulbs of Muscari paradoxum. Phytochemistry (2003) 0.79
Cytotoxic activity of tropolones against human oral tumor cell lines. Anticancer Res (2004) 0.79
Effects of TiO2 nanoparticles on cytotoxic action of chemotherapeutic drugs against a human oral squamous cell carcinoma cell line. In Vivo (2014) 0.78
Amurensiosides A-K, 11 new pregnane glycosides from the roots of Adonis amurensis. Steroids (2009) 0.78
Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure. Anticancer Res (2013) 0.78
Anatomical and electrophysiological mechanisms for asymmetrical excitatory propagation in the rat insular cortex: in vivo optical imaging and whole-cell patch-clamp studies. J Comp Neurol (2013) 0.78
Type of cell death induced by seven metals in cultured mouse osteoblastic cells. In Vivo (2010) 0.78