Published in J Natl Cancer Inst on June 14, 2010
Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet (2012) 5.99
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Predictive accuracy of the Liverpool Lung Project risk model for stratifying patients for computed tomography screening for lung cancer: a case-control and cohort validation study. Ann Intern Med (2012) 3.45
Attributing effects to interactions. Epidemiology (2014) 2.63
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26
Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction. Am J Epidemiol (2012) 2.16
Current status of genome-wide association studies in cancer. Hum Genet (2011) 2.14
The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing. Clin Cancer Res (2011) 2.09
The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet (2010) 1.90
Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis. J Natl Cancer Inst (2012) 1.82
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. Hum Mol Genet (2012) 1.77
A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation. Nat Genet (2012) 1.73
Genetics of leukocyte telomere length and its role in atherosclerosis. Mutat Res (2011) 1.44
Significance testing in ridge regression for genetic data. BMC Bioinformatics (2011) 1.37
From men to mice: CHRNA5/CHRNA3, smoking behavior and disease. Nicotine Tob Res (2012) 1.31
A unification of mediation and interaction: a 4-way decomposition. Epidemiology (2014) 1.28
The genetics of substance dependence. Annu Rev Genomics Hum Genet (2012) 1.25
Test for interactions between a genetic marker set and environment in generalized linear models. Biostatistics (2013) 1.20
Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk. Carcinogenesis (2011) 1.14
Two novel BRM insertion promoter sequence variants are associated with loss of BRM expression and lung cancer risk. Oncogene (2011) 1.12
Chapter 6: Lung cancer in never smokers: epidemiology and risk prediction models. Risk Anal (2012) 1.09
Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. Carcinogenesis (2012) 1.05
Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk. PLoS One (2011) 1.03
DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative. Aging (Albany NY) (2015) 1.03
Genetic susceptibility to lung cancer and co-morbidities. J Thorac Dis (2013) 1.02
Genetic susceptibility to lung cancer--light at the end of the tunnel? Carcinogenesis (2013) 1.00
Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era. BMC Med (2013) 0.96
A risk model for lung cancer incidence. Cancer Prev Res (Phila) (2012) 0.95
Inflammation in chronic obstructive pulmonary disease and its role in cardiovascular disease and lung cancer. Clin Transl Med (2015) 0.95
TERT-CLPTM1L polymorphism rs401681 contributes to cancers risk: evidence from a meta-analysis based on 29 publications. PLoS One (2012) 0.94
Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors. Neuropharmacology (2012) 0.93
Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report. COPD (2011) 0.93
Using prior information from the medical literature in GWAS of oral cancer identifies novel susceptibility variant on chromosome 4--the AdAPT method. PLoS One (2012) 0.90
Linkage analyses of stimulant dependence, craving, and heavy use in American Indians. Am J Med Genet B Neuropsychiatr Genet (2011) 0.89
Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers. Cancer Causes Control (2011) 0.89
Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer--a case-control study in a Chinese population. Lung Cancer (2013) 0.88
Smoking related cancers and loci at chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish population. PLoS One (2011) 0.88
Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. Cancer Epidemiol Biomarkers Prev (2012) 0.88
TERT Polymorphism rs2736100-C Is Associated with EGFR Mutation-Positive Non-Small Cell Lung Cancer. Clin Cancer Res (2015) 0.86
Explorations of lung cancer stigma for female long-term survivors. Nurs Inq (2013) 0.86
Molecular epidemiology of lung cancer and geographic variations with special reference to EGFR mutations. Transl Lung Cancer Res (2014) 0.86
Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56,307 individuals from the HUNT study in Norway. Eur J Hum Genet (2013) 0.85
Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia. J Natl Cancer Inst (2014) 0.85
Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer. J Natl Cancer Inst (2015) 0.85
A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk. Cancer Epidemiol Biomarkers Prev (2011) 0.84
A cloud-based workflow to quantify transcript-expression levels in public cancer compendia. Sci Rep (2016) 0.84
Translational genetic approaches to substance use disorders: bridging the gap between mice and humans. Hum Genet (2011) 0.83
Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS). J Thorac Oncol (2012) 0.83
Natural and orthogonal interaction framework for modeling gene-environment interactions with application to lung cancer. Hum Hered (2012) 0.82
Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study. Int J Cancer (2016) 0.82
Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci. Carcinogenesis (2015) 0.81
The SNP rs402710 in 5p15.33 is associated with lung cancer risk: a replication study in Chinese population and a meta-analysis. PLoS One (2013) 0.81
Early lung cancer detection using the self-evaluation scoring questionnaire and chest digital radiography: a 3-year follow-up study in China. J Digit Imaging (2013) 0.81
Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies. BMC Med Res Methodol (2012) 0.81
Genome-wide association study of lung cancer in Korean non-smoking women. J Korean Med Sci (2013) 0.80
Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung. Carcinogenesis (2014) 0.80
Review of the Gene-Environment Interaction Literature in Cancer: What Do We Know? Genet Epidemiol (2016) 0.79
Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants. Mol Neurobiol (2013) 0.79
Association between CLPTM1L polymorphisms (rs402710 and rs401681) and lung cancer susceptibility: evidence from 27 case-control studies. Mol Genet Genomics (2014) 0.77
Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations. Am J Hum Genet (2015) 0.77
A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer. Sci Rep (2016) 0.77
A risky business--identifying susceptibility loci for lung cancer. J Natl Cancer Inst (2010) 0.77
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nat Genet (2017) 0.76
No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects. PLoS One (2014) 0.76
A resequence analysis of genomic loci on chromosomes 1q32.1, 5p15.33, and 13q22.1 associated with pancreatic cancer risk. Pancreas (2013) 0.76
Heritability of radiation response in lung cancer families. Genes (Basel) (2012) 0.75
Nervous System and Intracranial Tumour Incidence by Ethnicity in England, 2001-2007: A Descriptive Epidemiological Study. PLoS One (2016) 0.75
Serum biomarkers of polyomavirus infection and risk of lung cancer in never smokers. Br J Cancer (2016) 0.75
Incorporating epistasis interaction of genetic susceptibility single nucleotide polymorphisms in a lung cancer risk prediction model. Int J Oncol (2016) 0.75
Gene-set meta-analysis of lung cancer identifies pathway related to systemic lupus erythematosus. PLoS One (2017) 0.75
Association Between the Telomerase rs2736098_TT Genotype and a Lower Risk of Chronic Hepatitis B and Cirrhosis in Chinese Males. Clin Transl Gastroenterol (2017) 0.75
Bayesian variable selection for hierarchical gene-environment and gene-gene interactions. Hum Genet (2014) 0.75
The SNP rs931794 in 15q25.1 Is Associated with Lung Cancer Risk: A Hospital-Based Case-Control Study and Meta-Analysis. PLoS One (2015) 0.75
Germline genetic variants and lung cancer survival in African Americans. Cancer Epidemiol Biomarkers Prev (2017) 0.75
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature (2008) 18.21
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet (2008) 16.17
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet (2006) 13.16
KORA-gen--resource for population genetics, controls and a broad spectrum of disease phenotypes. Gesundheitswesen (2005) 7.93
Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet (2006) 7.90
Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet (2009) 7.62
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet (2009) 6.91
Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. Mol Psychiatry (2008) 6.37
Lung cancer susceptibility locus at 5p15.33. Nat Genet (2008) 5.99
Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat Genet (2008) 5.43
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nat Genet (2009) 5.13
Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst (2003) 5.09
The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. J Natl Cancer Inst (2008) 3.67
A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet (2008) 3.25
Genome-wide and candidate gene association study of cigarette smoking behaviors. PLoS One (2009) 3.00
Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B Neuropsychiatr Genet (2009) 2.86
A prospective study of telomere length and the risk of skin cancer. J Invest Dermatol (2008) 2.75
Short telomere length and breast cancer risk: a study in sister sets. Cancer Res (2007) 2.70
Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. Carcinogenesis (2005) 2.50
Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. Cancer Res (2008) 2.47
Leukocyte telomere length predicts cancer risk in Barrett's esophagus. Cancer Epidemiol Biomarkers Prev (2007) 2.39
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. Genes Dev (2007) 2.32
A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis. J Med Genet (2008) 2.15
Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations. Cancer Res (2009) 1.94
EPIC-Germany--A source for studies into diet and risk of chronic diseases. European Investigation into Cancer and Nutrition. Ann Nutr Metab (1999) 1.87
Lung cancer in a U.S. population with low to moderate arsenic exposure. Environ Health Perspect (2009) 1.77
Genetic polymorphisms of ataxia telangiectasia mutated affect lung cancer risk. Hum Mol Genet (2006) 1.75
On the road to immortality: hTERT upregulation in cancer cells. FEBS Lett (2004) 1.66
Polymorphism of Xeroderma Pigmentosum group G and the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagus. Int J Cancer (2006) 1.65
Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer. Cancer Epidemiol Biomarkers Prev (2008) 1.58
Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese. Carcinogenesis (2008) 1.57
Short telomeres in aggressive non-Hodgkin's lymphoma as a risk factor in lymphomagenesis. Exp Hematol (2007) 1.55
International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways. Cancer Epidemiol Biomarkers Prev (2008) 1.51
Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population. Carcinogenesis (2009) 1.48
The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer. Cancer Epidemiol Biomarkers Prev (2007) 1.47
Telomerase expression in lung preneoplasia and neoplasia. Int J Cancer (2007) 1.45
Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer. Br J Cancer (2006) 1.44
Loss of telomerase activity may be a potential favorable prognostic marker in lung carcinomas. Lung Cancer (2003) 1.34
Real-time RT-PCR quantification of human telomerase reverse transcriptase splice variants in tumor cell lines and non-small cell lung cancer. Clin Chem (2006) 1.31
Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study. Carcinogenesis (2007) 1.19
Increased lung cancer risk due to residential radon in a pooled and extended analysis of studies in Germany. Health Phys (2005) 1.17
MutS homologues hMSH4 and hMSH5: diverse functional implications in humans. Front Biosci (2007) 1.03
Synergism between smoking and alcohol consumption with respect to serum gamma-glutamyltransferase. Hepatology (2009) 1.02
CYP1A1 variants and smoking-related lung cancer in San Francisco Bay area Latinos and African Americans. Int J Cancer (2005) 0.96
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
A high-resolution recombination map of the human genome. Nat Genet (2002) 28.66
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol (2012) 22.04
Genetics of gene expression and its effect on disease. Nature (2008) 21.35
International network of cancer genome projects. Nature (2010) 20.35
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet (2007) 19.18
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Characterizing the cancer genome in lung adenocarcinoma. Nature (2007) 16.48
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet (2008) 16.17
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet (2004) 13.71
A common inversion under selection in Europeans. Nat Genet (2005) 13.66
A common variant associated with prostate cancer in European and African populations. Nat Genet (2006) 13.47
Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med (2009) 13.47
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Many sequence variants affecting diversity of adult human height. Nat Genet (2008) 12.80
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet (2008) 12.43
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med (2007) 12.24
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Rate of de novo mutations and the importance of father's age to disease risk. Nature (2012) 11.92
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell (2012) 11.69
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet (2007) 10.81
Common variants conferring risk of schizophrenia. Nature (2009) 10.37
Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34
Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med (2012) 10.16
Ceritinib in ALK-rearranged non-small-cell lung cancer. N Engl J Med (2014) 9.94
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet (2007) 9.88
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med (2007) 9.80
Detection of sharing by descent, long-range phasing and haplotype imputation. Nat Genet (2008) 9.69
Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. Lancet (2011) 9.49
DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics (2012) 9.31