Emerging drugs to treat squamous cell carcinomas of the head and neck.

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Published in Expert Opin Emerg Drugs on September 01, 2010

Authors

Christopher Fung1, Jennifer R Grandis

Author Affiliations

1: University of Pittsburgh and University of Pittsburgh Cancer Institute, Department of Otolaryngology, Pittsburgh, Pennsylvania, USA.

Associated clinical trials:

First-line Treatment of Participants With Stage IV Squamous Non-Small Cell Lung Cancer With Necitumumab and Gemcitabine-Cisplatin (SQUIRE) | NCT00981058

Study Of Adjuvant Lapatinib In High-Risk Head And Neck Cancer Subjects After Surgery | NCT00424255

STAT3 DECOY in Head and Neck Cancer | NCT00696176

Erlotinib Prevention of Oral Cancer (EPOC) | NCT00402779

Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With Stage III or Stage IV Head and Neck Cancer | NCT00265941

MAGE-A3/HPV 16 Vaccine for Squamous Cell Carcinoma of the Head and Neck | NCT00257738

Lapatinib Versus Placebo Given Concurrently With Cisplatin And Radiotherapy In Patients With Unresected Head And Neck Cancer | NCT00387127

Study of Post-Op Adjuvant Concurrent Chemo-RT With or Without Nimotuzumab for Head & Neck Cancer | NCT00957086

DAHANCA 19: The Importance of the EGFr-inhibitor Zalutumumab for the Outcome After Curative Radiotherapy for HNSCC | NCT00496652

ASPECCT: A Study of Panitumumab Efficacy and Safety Compared to Cetuximab in Patients With KRAS Wild-Type Metastatic Colorectal Cancer | NCT01001377

Radiation Therapy and Cisplatin or Panitumumab in Treating Patients With Locally Advanced Stage III or Stage IV Head and Neck Cancer | NCT00820248

Nimotuzumab in Combination With Chemoradiation for Nasopharyngeal Cancer | NCT01074021

Four Doses of MAGE Vaccine for Patients With Squamous Cell Carcinoma of the Head and Neck (MAGE) | NCT00704041

Zalutumumab in Patients With Non-curable Head and Neck Cancer | NCT00382031

Study of Panitumumab Efficacy in Patients With Recurrent and/or Metastatic Head and Neck Cancer (SPECTRUM) | NCT00460265

Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma | NCT00588770

A Study of Erlotinib (Tarceva) in Participants With Resected Head and Neck Squamous Cell Cancer | NCT00412217

Phase II Randomized Trial of the Combination of Cetuximab and Sorafenib or Single Agent Cetuximab | NCT00939627

Erlotinib (Tarceva) During First Line Standard Platinum Containing Chemo for Advanced Squamous Cell Head and Neck Cancer | NCT00448240

Sorafenib Plus Carboplatin and Paclitaxel in Head and Neck Squamous Cell Cancer | NCT00494182

Chemotherapy and Radiation Therapy (RT) With or Without Vandetanib in Treating Patients With High-Risk Stage III or Stage IV Head and Neck Cancer | NCT00720083

Docetaxel in Combination With Zactima (ZD6474) in Patients With Locally Advanced Squamous Cell Carcinoma of the the Head and Neck | NCT00459043

TPF Plus Cisplatin and Radiotherapy vs TPF Plus Cetuximab and Radiotherapy to Treat Head and Neck Cancer. | NCT00716391

Study of Sorafenib/Cetuximab in Head and Neck Cancer | NCT00815295

Induction Chemotherapy Followed by Cetuximab Plus Definitive Radiotherapy Versus Radiation Plus Cisplatin (INTERCEPTOR) | NCT00999700

Radiation Therapy With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer | NCT00956007

Cetuximab With Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck in Chinese Subjects (CHANCE) | NCT01012258

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