Published in Nat Chem Biol on July 01, 2010
Perceiving the epigenetic landscape through histone readers. Nat Struct Mol Biol (2012) 2.76
A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction. Cell (2014) 1.99
CHARMM-GUI Membrane Builder toward realistic biological membrane simulations. J Comput Chem (2014) 1.89
Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy. Nat Chem Biol (2011) 1.58
Conditional peripheral membrane proteins: facing up to limited specificity. Structure (2011) 1.55
High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine. J Cell Biol (2011) 1.49
Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs, a β-propeller protein family. Proc Natl Acad Sci U S A (2012) 1.29
Endoplasmic reticulum PI(3)P lipid binding targets malaria proteins to the host cell. Cell (2012) 1.26
A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion. Cell Res (2012) 1.24
Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain. J Biol Chem (2011) 1.21
Phosphoinositides in cell architecture. Cold Spring Harb Perspect Biol (2011) 1.13
The Toxoplasma gondii calcium-dependent protein kinase 7 is involved in early steps of parasite division and is crucial for parasite survival. Cell Microbiol (2013) 1.08
Rous sarcoma virus gag has no specific requirement for phosphatidylinositol-(4,5)-bisphosphate for plasma membrane association in vivo or for liposome interaction in vitro. J Virol (2011) 1.02
The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes. Mol Cell Biol (2012) 1.00
Small-molecule inhibitors of the PI3K signaling network. Future Med Chem (2011) 0.98
Plasma membrane localization of Solanum tuberosum remorin from group 1, homolog 3 is mediated by conformational changes in a novel C-terminal anchor and required for the restriction of potato virus X movement]. Plant Physiol (2012) 0.95
PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions. J Cell Biol (2015) 0.94
A PtdIns(4)P-driven electrostatic field controls cell membrane identity and signalling in plants. Nat Plants (2016) 0.93
The cation-π box is a specific phosphatidylcholine membrane targeting motif. J Biol Chem (2013) 0.92
Emerging methodologies to investigate lipid-protein interactions. Integr Biol (Camb) (2012) 0.92
Defining the membrane-associated state of the PTEN tumor suppressor protein. Biophys J (2013) 0.92
Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes. Epigenetics (2013) 0.91
Essential role of class II phosphatidylinositol-3-kinase-C2α in sphingosine 1-phosphate receptor-1-mediated signaling and migration in endothelial cells. J Biol Chem (2012) 0.90
Synthesis of densely phosphorylated bis-1,5-diphospho-myo-inositol tetrakisphosphate and its enantiomer by bidirectional P-anhydride formation. Angew Chem Int Ed Engl (2014) 0.90
Expanding proteostasis by membrane trafficking networks. Cold Spring Harb Perspect Biol (2013) 0.89
Cellular and molecular interactions of phosphoinositides and peripheral proteins. Chem Phys Lipids (2014) 0.89
Finding a needle in a haystack: the role of electrostatics in target lipid recognition by PH domains. PLoS Comput Biol (2012) 0.89
Role of PI(4,5)P(2) in vesicle exocytosis and membrane fusion. Subcell Biochem (2012) 0.87
Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function. Nat Struct Mol Biol (2016) 0.87
Cooperative phosphoinositide and peptide binding by PSD-95/discs large/ZO-1 (PDZ) domain of polychaetoid, Drosophila zonulin. J Biol Chem (2011) 0.87
Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic. EMBO J (2016) 0.87
IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold. J Biol Chem (2012) 0.85
Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO. PLoS One (2012) 0.85
An immunity-triggering effector from the Barley smut fungus Ustilago hordei resides in an Ustilaginaceae-specific cluster bearing signs of transposable element-assisted evolution. PLoS Pathog (2014) 0.84
Guidelines for the Use of Protein Domains in Acidic Phospholipid Imaging. Methods Mol Biol (2016) 0.83
Regulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiae. J Biol Chem (2013) 0.83
TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. PLoS Biol (2013) 0.83
Infectious bursal disease virus VP5 polypeptide: a phosphoinositide-binding protein required for efficient cell-to-cell virus dissemination. PLoS One (2015) 0.82
Multiscale computational models in physical systems biology of intracellular trafficking. IET Syst Biol (2014) 0.82
Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage. Sci Rep (2013) 0.82
Qualitative and quantitative characterization of protein-phosphoinositide interactions with liposome-based methods. Autophagy (2013) 0.82
Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments. PLoS One (2013) 0.81
The molecular basis of ceramide-1-phosphate recognition by C2 domains. J Lipid Res (2012) 0.81
Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling. Mol Biol Cell (2015) 0.81
Structure-function analysis of vaccinia virus H7 protein reveals a novel phosphoinositide binding fold essential for poxvirus replication. J Virol (2014) 0.80
Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase. J Biol Chem (2012) 0.80
Molecular analysis of protein-phosphoinositide interactions. Curr Top Microbiol Immunol (2012) 0.80
The late endosomal HOPS complex anchors active G-protein signaling essential for pathogenesis in magnaporthe oryzae. PLoS Pathog (2013) 0.79
Phosphoinositide 5-phosphatases: How do they affect tumourigenesis? J Biochem (2012) 0.79
Regulation of polar auxin transport by protein and lipid kinases. J Exp Bot (2016) 0.79
Biochemical characterization of a Pseudomonas aeruginosa phospholipase D. Biochemistry (2015) 0.78
Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis. Proc Natl Acad Sci U S A (2015) 0.78
Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun (2015) 0.78
Combined treatment with Myo-inositol and selenium ensures euthyroidism in subclinical hypothyroidism patients with autoimmune thyroiditis. J Thyroid Res (2013) 0.78
Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection. Traffic (2014) 0.78
Myo-inositol therapy for poor-responders during IVF: a prospective controlled observational trial. J Ovarian Res (2015) 0.78
Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms. Proc Natl Acad Sci U S A (2016) 0.77
Fluorinated Aromatic Amino Acids Distinguish Cation-π Interactions from Membrane Insertion. J Biol Chem (2015) 0.77
Folate protection from congenital heart defects linked with canonical Wnt signaling and epigenetics. Curr Opin Pediatr (2010) 0.77
The Dictyostelium discoideum RACK1 orthologue has roles in growth and development. Cell Commun Signal (2014) 0.77
Eukaryotic virulence determinants utilize phosphoinositides at the ER and host cell surface. Trends Microbiol (2013) 0.77
Sphingolipid transfer proteins defined by the GLTP-fold. Q Rev Biophys (2015) 0.76
How PI3K-derived lipids control cell division. Front Cell Dev Biol (2015) 0.76
PI3K/SHIP2/PTEN pathway in cell polarity and hepatitis C virus pathogenesis. World J Hepatol (2017) 0.75
The emerging role of phosphoinositide clustering in intracellular trafficking and signal transduction. F1000Res (2016) 0.75
Histone deacetylation: IP4 is an epigenetic coregulator. Nat Chem Biol (2012) 0.75
Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes. Proc Natl Acad Sci U S A (2017) 0.75
Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy Cells. Mol Cell Biol (2016) 0.75
Structural, thermodynamic, and phosphatidylinositol 3-phosphate binding properties of Phafin2. Protein Sci (2017) 0.75
Treatment with Myo-Inositol and Selenium Ensures Euthyroidism in Patients with Autoimmune Thyroiditis. Int J Endocrinol (2017) 0.75
The unexpected role of Drosophila OCRL during cytokinesis. Commun Integr Biol (2012) 0.75
Class C ABC transporters and Saccharomyces cerevisiae vacuole fusion. Cell Logist (2014) 0.75
Deciphering the roles of phosphoinositide lipids in phagolysosome biogenesis. Commun Integr Biol (2016) 0.75
Clostridium Perfringens Epsilon Toxin Binds to Membrane Lipids and Its Cytotoxic Action Depends on Sulfatide. PLoS One (2015) 0.75
Spectrin βV adaptive mutations and changes in subcellular location correlate with emergence of hair cell electromotility in mammalians. Proc Natl Acad Sci U S A (2017) 0.75
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet (2006) 17.19
Phosphoinositides in cell regulation and membrane dynamics. Nature (2006) 14.00
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature (2007) 10.98
Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem (2001) 8.47
Curvature of clathrin-coated pits driven by epsin. Nature (2002) 8.03
Membrane recognition by phospholipid-binding domains. Nat Rev Mol Cell Biol (2008) 7.43
Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes. Science (2001) 5.45
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol (2001) 4.64
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature (1994) 4.49
Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem J (2000) 4.26
Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains. Mol Cell (1998) 4.01
Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science (1997) 3.91
FYVE fingers bind PtdIns(3)P. Nature (1998) 3.91
BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane-cytosol interfaces and membrane curvature. Biochim Biophys Acta (2006) 3.83
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell (1995) 3.65
G-protein signaling through tubby proteins. Science (2001) 3.59
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. J Cell Biol (2000) 3.39
Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Nat Cell Biol (2001) 3.14
Pleckstrin domain homology. Nature (1993) 3.03
The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase C. Science (1990) 3.02
High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate. Curr Biol (2002) 2.92
A putative modular domain present in diverse signaling proteins. Cell (1993) 2.90
Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Mol Cell (2000) 2.86
Structure of the binding site for inositol phosphates in a PH domain. EMBO J (1995) 2.71
GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding. Cell (2009) 2.54
Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J (2000) 2.49
The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate. Mol Cell (2001) 2.47
Phosphoinositides in constitutive membrane traffic. Physiol Rev (2004) 2.45
Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains? Protein Sci (1996) 2.40
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol (2001) 2.39
A functional PtdIns(3)P-binding motif. Nature (1998) 2.38
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci (2004) 2.35
SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Nat Cell Biol (2001) 2.33
The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization. J Biol Chem (2000) 2.28
Membrane binding and subcellular targeting of C2 domains. Biochim Biophys Acta (2006) 2.20
Pleckstrin homology domains: not just for phosphoinositides. Biochem Soc Trans (2004) 2.20
New EMBO members' review: actin cytoskeleton regulation through modulation of PI(4,5)P(2) rafts. EMBO J (2001) 2.15
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. Biochem J (2003) 2.15
Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains. Mol Cell (2000) 2.13
The effector domain of myristoylated alanine-rich C kinase substrate binds strongly to phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2000) 2.12
Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction. EMBO J (2002) 2.09
Multivalent endosome targeting by homodimeric EEA1. Mol Cell (2001) 2.03
Membrane-targeting sequences on AKAP79 bind phosphatidylinositol-4, 5-bisphosphate. EMBO J (1998) 2.01
All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate. J Biol Chem (2001) 1.96
Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p. Cell (1999) 1.92
The Phox (PX) domain proteins and membrane traffic. Biochim Biophys Acta (2006) 1.87
Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function. Biochem J (2009) 1.78
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. EMBO J (2004) 1.77
Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. Mol Cell (2007) 1.76
Membrane and juxtamembrane targeting by PH and PTB domains. Biochim Biophys Acta (2006) 1.74
Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. Structure (1999) 1.74
Phosphatidylinositol 3-phosphate induces the membrane penetration of the FYVE domains of Vps27p and Hrs. J Biol Chem (2002) 1.74
Membrane binding domains. Biochim Biophys Acta (2006) 1.67
Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins. Biochem J (2001) 1.62
Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction. Cell (2000) 1.59
The PX-BAR membrane-remodeling unit of sorting nexin 9. EMBO J (2007) 1.59
Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity. J Biol Chem (1996) 1.58
PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking. J Cell Biol (2009) 1.58
Structural mechanism of endosome docking by the FYVE domain. Science (2001) 1.56
Mutations in phosphoinositide metabolizing enzymes and human disease. Physiology (Bethesda) (2009) 1.56
Solution structure of the PX domain, a target of the SH3 domain. Nat Struct Biol (2001) 1.53
FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. J Cell Sci (2001) 1.52
Structural basis for endosomal targeting by FYVE domains. J Biol Chem (2003) 1.50
Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch. Proc Natl Acad Sci U S A (2005) 1.47
Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox. J Biol Chem (2003) 1.46
Single-molecule fluorescence studies of a PH domain: new insights into the membrane docking reaction. Biophys J (2009) 1.44
Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. EMBO J (2004) 1.43
Multivalent mechanism of membrane insertion by the FYVE domain. J Biol Chem (2003) 1.38
Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains. J Biol Chem (2007) 1.37
Phosphatidylinositol 3-phosphate recognition and membrane docking by the FYVE domain. Biochim Biophys Acta (2006) 1.37
Phosphoinositide signaling; from affinity probes to pharmaceutical targets. Chem Biol (2004) 1.33
Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9. J Biol Chem (2007) 1.32
High-affinity binding of a FYVE domain to phosphatidylinositol 3-phosphate requires intact phospholipid but not FYVE domain oligomerization. Biochemistry (2001) 1.32
Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study. BMC Cell Biol (2009) 1.31
The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer. Biochem J (1999) 1.30
Phox homology domains specifically bind phosphatidylinositol phosphates. Biochemistry (2001) 1.24
The molecular basis of the differential subcellular localization of FYVE domains. J Biol Chem (2004) 1.23
Structural and membrane binding analysis of the Phox homology domain of Bem1p: basis of phosphatidylinositol 4-phosphate specificity. J Biol Chem (2007) 1.22
Crystal structure of the yeast Phox homology (PX) domain protein Grd19p complexed to phosphatidylinositol-3-phosphate. J Biol Chem (2003) 1.20
Structural basis of membrane targeting by the Phox homology domain of cytokine-independent survival kinase (CISK-PX). J Biol Chem (2004) 1.16
Determinants of the endosomal localization of sorting nexin 1. Mol Biol Cell (2005) 1.15
Mechanism of membrane binding of the phospholipase D1 PX domain. J Biol Chem (2004) 1.14
Molecular mechanism of membrane docking by the Vam7p PX domain. J Biol Chem (2006) 1.12
Computer modeling of the membrane interaction of FYVE domains. J Mol Biol (2003) 1.12
Solution structure of the Vam7p PX domain. Biochemistry (2002) 1.10
Molecular mechanism of membrane targeting by the GRP1 PH domain. J Lipid Res (2008) 1.09
Molecular modeling of the membrane targeting of phospholipase C pleckstrin homology domains. Protein Sci (2003) 1.08
Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha. J Biol Chem (2006) 1.05
Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranes. Prog Lipid Res (2007) 1.02
Membrane insertion of the FYVE domain is modulated by pH. Proteins (2009) 1.01
The prevalence and significance of PDZ domain-phosphoinositide interactions. Biochim Biophys Acta (2006) 1.00
Membrane activity of the phospholipase C-delta1 pleckstrin homology (PH) domain. Biochem J (2005) 0.98
Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding. EMBO J (2007) 0.96
Structural analysis of the carboxy terminal PH domain of pleckstrin bound to D-myo-inositol 1,2,3,5,6-pentakisphosphate. BMC Struct Biol (2007) 0.93
Investigation of the binding geometry of a peripheral membrane protein. Biochemistry (2005) 0.90
Orientation and penetration depth of monolayer-bound p40phox-PX. Biochemistry (2006) 0.88
The structural basis of novel endosome anchoring activity of KIF16B kinesin. EMBO J (2007) 0.86
Solution structure of human sorting nexin 22. Protein Sci (2007) 0.83
A high-resolution solution structure of a trypanosomatid FYVE domain. Protein Sci (2007) 0.81
Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding. BMC Struct Biol (2008) 0.78