Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis.

PubWeight™: 1.57‹?› | Rank: Top 4%

🔗 View Article (PMC 2930080)

Published in Gastroenterology on May 24, 2010

Authors

Goo Lee1, Tatiana Goretsky, Elizabeth Managlia, Ramanarao Dirisina, Ajay Pal Singh, Jeffrey B Brown, Randal May, Guang-Yu Yang, Josette William Ragheb, B Mark Evers, Christopher R Weber, Jerrold R Turner, Xi C He, Rebecca B Katzman, Linheng Li, Terrence A Barrett

Author Affiliations

1: Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Articles citing this

Inflammation and colorectal cancer: colitis-associated neoplasia. Semin Immunopathol (2012) 1.61

MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell (2014) 1.59

The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair. Gastroenterology (2011) 1.39

Inducible progenitor-derived Wingless regulates adult midgut regeneration in Drosophila. EMBO J (2012) 1.18

Targeting disease through novel pathways of apoptosis and autophagy. Expert Opin Ther Targets (2012) 1.14

IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice. Gastroenterology (2013) 1.12

Cancer stem-like cell properties are regulated by EGFR/AKT/β-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma. FEBS J (2013) 1.12

TLR4 activates the β-catenin pathway to cause intestinal neoplasia. PLoS One (2013) 1.10

p53 mediates TNF-induced epithelial cell apoptosis in IBD. Am J Pathol (2012) 1.07

Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling. Mol Biol Cell (2011) 1.07

Transition from colitis to cancer: high Wnt activity sustains the tumor-initiating potential of colon cancer stem cell precursors. Cancer Res (2012) 1.06

Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL. Aging (Albany NY) (2012) 1.04

Epithelial phosphatidylinositol-3-kinase signaling is required for β-catenin activation and host defense against Citrobacter rodentium infection. Infect Immun (2011) 1.02

Genetics, diagnosis and management of colorectal cancer (Review). Oncol Rep (2015) 1.02

Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium. J Biol Chem (2011) 1.01

PTEN-mediated Akt/β-catenin/Foxo1 signaling regulates innate immune responses in mouse liver ischemia/reperfusion injury. Hepatology (2012) 1.01

Caught in the Akt: regulation of Wnt signaling in the intestine. Gastroenterology (2010) 0.99

Erythropoietin: new directions for the nervous system. Int J Mol Sci (2012) 0.95

M2 macrophages activate WNT signaling pathway in epithelial cells: relevance in ulcerative colitis. PLoS One (2013) 0.95

PI3K/AKT signaling is essential for communication between tissue-infiltrating mast cells, macrophages, and epithelial cells in colitis-induced cancer. Clin Cancer Res (2013) 0.91

A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR. Future Neurol (2012) 0.90

The Wnt/β-catenin signaling pathway controls the inflammatory response in infections caused by pathogenic bacteria. Mediators Inflamm (2014) 0.89

WISP1: Clinical insights for a proliferative and restorative member of the CCN family. Curr Neurovasc Res (2014) 0.88

Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1. Biochem Pharmacol (2012) 0.88

Beta catenin and cytokine pathway dysregulation in patients with manifestations of the "PTEN hamartoma tumor syndrome". BMC Med Genet (2012) 0.87

Lgr4 gene deficiency increases susceptibility and severity of dextran sodium sulfate-induced inflammatory bowel disease in mice. J Biol Chem (2013) 0.87

Enteric bacteria and cancer stem cells. Cancers (Basel) (2010) 0.87

Inflammatory cues acting on the adult intestinal stem cells and the early onset of cancer (review). Int J Oncol (2014) 0.86

Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD. Mucosal Immunol (2013) 0.86

Worms, flies and four-legged friends: the applicability of biological models to the understanding of intestinal inflammatory diseases. Dis Model Mech (2011) 0.85

Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/β-catenin signaling. Am J Physiol Gastrointest Liver Physiol (2013) 0.84

Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis. World J Gastroenterol (2013) 0.84

Regulation of Wnt4 in chronic obstructive pulmonary disease. FASEB J (2013) 0.84

Major signaling pathways in intestinal stem cells. Biochim Biophys Acta (2012) 0.83

Inhibition of Gsk3β activity improves β-cell function in c-KitWv/+ male mice. Lab Invest (2012) 0.82

Extracellular Calcium-Sensing Receptor Inhibition of Intestinal EpithelialTNF Signaling Requires CaSR-Mediated Wnt5a/Ror2 Interaction. Front Physiol (2011) 0.82

Novel methylxanthine derivative-mediated anti-inflammatory effects in inflammatory bowel disease. World J Gastroenterol (2014) 0.81

Distraction-induced intestinal growth: the role of mechanotransduction mechanisms in a mouse model of short bowel syndrome. Tissue Eng Part A (2013) 0.80

Erythropoietin and diabetes mellitus. World J Diabetes (2015) 0.80

Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis. Biochim Biophys Acta (2015) 0.80

Radiofrequency ablation for dysplasia in Barrett's esophagus restores β-catenin activation within esophageal progenitor cells. Dig Dis Sci (2011) 0.79

DDX3 enhances oncogenic KRAS‑induced tumor invasion in colorectal cancer via the β‑catenin/ZEB1 axis. Oncotarget (2016) 0.79

Neutrophil interactions with epithelial-expressed ICAM-1 enhances intestinal mucosal wound healing. Mucosal Immunol (2016) 0.79

Recent advancement in understanding colitis-associated tumorigenesis. Inflamm Bowel Dis (2014) 0.79

The architect who never sleeps: tumor-induced plasticity. FEBS Lett (2014) 0.78

EGFR kinase activity is required for TLR4 signaling and the septic shock response. EMBO Rep (2015) 0.78

A Cytosolic Multiprotein Complex Containing p85α Is Required for β-Catenin Activation in Colitis and Colitis-associated Cancer. J Biol Chem (2015) 0.77

Wnt signaling inhibits CTL memory programming. Mol Immunol (2013) 0.77

15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway. FASEB J (2015) 0.77

Immunohistochemical analysis of retinoblastoma and β-catenin as an assistant tool in the differential diagnosis between Crohn's disease and ulcerative colitis. PLoS One (2013) 0.77

Heparin-binding epidermal growth factor-like growth factor restores Wnt/β-catenin signaling in intestinal stem cells exposed to ischemia/reperfusion injury. Surgery (2014) 0.76

Clonal evolution of colorectal cancer in IBD. Nat Rev Gastroenterol Hepatol (2017) 0.75

Alcohol Injury Damages Intestinal Stem Cells. Alcohol Clin Exp Res (2017) 0.75

Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition. Cell Mol Gastroenterol Hepatol (2017) 0.75

β-catenin signaling is required for RAS-driven thyroid cancer through PI3K activation. Oncotarget (2016) 0.75

Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection. Am J Pathol (2016) 0.75

Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552. Am J Physiol Cell Physiol (2016) 0.75

Myo-inositol reduces β-catenin activation in colitis. World J Gastroenterol (2017) 0.75

Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease. J Immunol (2017) 0.75

Articles cited by this

Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32

Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25

Wnt signalling in stem cells and cancer. Nature (2005) 19.26

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet (2006) 17.19

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell (2002) 13.92

Wnt signalling and its impact on development and cancer. Nat Rev Cancer (2008) 8.37

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest (1996) 7.97

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet (2004) 7.37

Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol (2009) 7.29

Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem (2007) 4.60

HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. Oncogene (2008) 4.53

Clonal analysis of mouse intestinal epithelial progenitors. Gastroenterology (1999) 4.47

Wnt signaling controls the phosphorylation status of beta-catenin. J Biol Chem (2002) 4.40

The intestinal stem cell. Genes Dev (2008) 4.21

PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet (2007) 4.09

Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology (2005) 4.09

Current view: intestinal stem cells and signaling. Gastroenterology (2008) 3.46

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology (2004) 3.39

Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin. EMBO Rep (2001) 3.02

Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative. J Clin Pathol (1997) 2.98

Stem cells in gastrointestinal epithelium: numbers, characteristics and death. Philos Trans R Soc Lond B Biol Sci (1998) 2.92

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J Exp Med (1996) 2.79

Intestinal epithelial stem cells and progenitors. Methods Enzymol (2006) 2.43

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. Nat Genet (2000) 2.39

Rapid development of colitis in NSAID-treated IL-10-deficient mice. Gastroenterology (2002) 2.27

Isolation and characterization of a putative intestinal stem cell fraction from mouse jejunum. Gastroenterology (2005) 2.23

Cytokine-related syndrome following injection of anti-CD3 monoclonal antibody: further evidence for transient in vivo T cell activation. Eur J Immunol (1990) 1.96

beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev (2007) 1.96

Interaction of FOXO with beta-catenin inhibits beta-catenin/T cell factor activity. J Biol Chem (2008) 1.93

Gastrointestinal stem cells. II. Intestinal stem cells. Am J Physiol Gastrointest Liver Physiol (2005) 1.87

Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-catenin. Cell Signal (2008) 1.87

Live and let die in the intestinal epithelium. Curr Opin Cell Biol (2003) 1.85

Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma. Ann Surg (2006) 1.82

Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy. Mol Cell Biol (2005) 1.78

Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells. Gut (2003) 1.62

Regulation of Wnt signaling by protein-protein interaction and post-translational modifications. Exp Mol Med (2006) 1.60

Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade. J Biol Chem (2009) 1.57

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nat Genet (2008) 1.50

Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. J Biol Chem (2004) 1.43

Crypt production in normal and diseased human colonic epithelium. Anat Rec (1986) 1.38

Dietary iron supplementation enhances DSS-induced colitis and associated colorectal carcinoma development in mice. Dig Dis Sci (2002) 1.34

Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells. Endocrinology (2008) 1.28

Epithelial: lamina propria lymphocyte interactions promote epithelial cell differentiation. Gastroenterology (2007) 1.23

Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation. Gastroenterology (2005) 1.22

T-cell activation in the intestinal mucosa. Immunol Rev (2007) 1.20

Immunohistologic demonstration of abnormal colonic crypt cell kinetics in ulcerative colitis. Hum Pathol (1985) 1.17

Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis. Gastroenterology (2009) 1.15

Wnt pathway-related gene expression in inflammatory bowel disease. Dig Dis Sci (2007) 1.15

Isolation of intestinal epithelial cells for the study of differential gene expression along the crypt-villus axis. Am J Physiol (1991) 1.15

Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development. Carcinogenesis (2001) 1.14

Wnt pathway-related gene expression during malignant progression in ulcerative colitis. Acta Histochem (2007) 1.12

Neonatal co-infection with helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-) mice. Helicobacter (2007) 1.04

Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells. Cell Signal (2007) 0.95

Increased expression of proliferative Ki-67 nuclear antigen is correlated with dysplastic colorectal epithelium in ulcerative colitis. Int J Colorectal Dis (1999) 0.93

Cyclin D1 and p21 in ulcerative colitis-related inflammation and epithelial neoplasia: a study of aberrant expression and underlying mechanisms. Hum Pathol (2003) 0.93

Epithelial proliferation in response to gastrointestinal inflammation. Ann N Y Acad Sci (1992) 0.89

Articles by these authors

Identification of the haematopoietic stem cell niche and control of the niche size. Nature (2003) 18.17

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet (2004) 7.37

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature (2006) 7.35

Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell (2009) 4.73

The stem cell niches in bone. J Clin Invest (2006) 4.11

PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet (2007) 4.09

Detection of functional haematopoietic stem cell niche using real-time imaging. Nature (2008) 4.06

Current view: intestinal stem cells and signaling. Gastroenterology (2008) 3.46

Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5. Cell Host Microbe (2007) 3.34

Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell (2013) 3.32

Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors. Gastroenterology (2012) 3.29

Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am J Pathol (2005) 3.22

Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood (2002) 3.21

Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid. Proc Natl Acad Sci U S A (2011) 3.19

Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J Clin Invest (2005) 3.15

mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res (2011) 3.12

FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. J Biol Chem (2002) 2.90

Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res (2003) 2.86

Recognition of host immune activation by Pseudomonas aeruginosa. Science (2005) 2.84

Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. J Virol (2008) 2.84

Inflammation and the development of pancreatic cancer. Surg Oncol (2002) 2.83

A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest (2004) 2.75

Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. Lab Invest (2006) 2.67

A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology (2002) 2.66

Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J Cell Sci (2006) 2.59

Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. J Cell Biol (2010) 2.47

Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane. Mol Biol Cell (2005) 2.46

The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. J Cell Biol (2008) 2.42

Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology (2008) 2.42

CD95 promotes tumour growth. Nature (2010) 2.42

Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity (2010) 2.39

Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell (2012) 2.36

Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged. Circulation (2002) 2.32

Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. Mol Biol Cell (2005) 2.29

Increased incidence of well-differentiated thyroid cancer associated with Hashimoto thyroiditis and the role of the PI3k/Akt pathway. J Am Coll Surg (2007) 2.28

Epithelial barriers in homeostasis and disease. Annu Rev Pathol (2010) 2.28

Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence. Nature (2013) 2.22

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest (2012) 2.12

Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in mice. J Am Soc Nephrol (2003) 2.12

Dysplastic lesions in inflammatory bowel disease: molecular pathogenesis to morphology. Arch Pathol Lab Med (2013) 2.11

Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ Res (2004) 2.10

Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion. Stem Cells (2006) 2.09

Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest (2011) 2.09

Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. Proc Natl Acad Sci U S A (2008) 2.04

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J (2010) 2.04

PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway. Gastroenterology (2002) 2.03

Continuing attrition of physician-scientists (CAPS): a preventable syndrome? Gastroenterology (2012) 2.00

Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest (2006) 2.00

N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells. Cell Stem Cell (2008) 1.98

Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models. Carcinogenesis (2003) 1.98

Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Am J Clin Nutr (2005) 1.97

Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. Mol Cell Biol (2006) 1.96

Long-lived intestinal tuft cells serve as colon cancer-initiating cells. J Clin Invest (2014) 1.90

IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology (2006) 1.89

Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma. Ann Surg (2006) 1.82

Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis (2005) 1.77

Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: lessons learned of the EPR effect and image-guided drug delivery. J Control Release (2013) 1.77

BMP signaling and stem cell regulation. Dev Biol (2005) 1.77

Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol (2008) 1.76

Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis. Mech Ageing Dev (2003) 1.76

Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice. Hepatology (2015) 1.76

T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase. J Clin Invest (2002) 1.74

Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J Biol Chem (2010) 1.74

DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism. Cancer Res (2011) 1.73

Mechanism underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli. J Clin Invest (2007) 1.72

MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. Proc Natl Acad Sci U S A (2010) 1.70

LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology (2007) 1.70

Differential gene expression profiling of adult murine hematopoietic stem cells. Blood (2002) 1.69

Knockdown of RNA binding protein musashi-1 leads to tumor regression in vivo. Gastroenterology (2008) 1.68

Fractures of capitellum: a review of 14 cases treated by open reduction and internal fixation with Herbert screws. Int Orthop (2009) 1.67

Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt. Proc Natl Acad Sci U S A (2004) 1.66

A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. J Biol Chem (2004) 1.64

Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay. Gastroenterology (2013) 1.64

Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Invest (2008) 1.64

Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion. Genes Dev (2011) 1.63

Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer. Clin Cancer Res (2009) 1.61

A nomenclature for intestinal in vitro cultures. Am J Physiol Gastrointest Liver Physiol (2012) 1.61

Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa. PLoS Pathog (2007) 1.60

mTOR inhibitors in cancer therapy. Cancer Lett (2012) 1.59

Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter. J Biol Chem (2006) 1.59

Proapoptotic Bid is required for pulmonary fibrosis. Proc Natl Acad Sci U S A (2006) 1.59

Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol (2011) 1.58

Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients. Hepatology (2012) 1.56