The contribution of dynamic stromal remodeling during mammary development to breast carcinogenesis.

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Published in Breast Cancer Res on June 17, 2010

Authors

Jessica McCready1, Lisa M Arendt, Jenny A Rudnick, Charlotte Kuperwasser

Author Affiliations

1: Department of Anatomy and Cellular Biology, Sackler School, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA. jessica.mccready@tufts.edu

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Inflammation and cancer. Nature (2002) 53.78

Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med (2003) 35.39

Inflammation and metabolic disorders. Nature (2006) 33.33

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01

Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19

Mammographic density and the risk and detection of breast cancer. N Engl J Med (2007) 14.32

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest (2006) 12.32

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res (2005) 11.88

Stromal fibroblasts in cancer initiation and progression. Nature (2004) 11.69

CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science (2004) 10.23

Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A (2004) 7.96

Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res (2006) 6.52

Mammographic features and breast cancer risk: effects with time, age, and menopause status. J Natl Cancer Inst (1995) 5.35

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev (1996) 5.17

Matrix metalloproteinases: they're not just for matrix anymore! Curr Opin Cell Biol (2001) 4.99

Breast patterns as an index of risk for developing breast cancer. AJR Am J Roentgenol (1976) 4.98

Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol (2000) 4.83

Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr (2006) 4.72

Risk factors for breast cancer according to estrogen and progesterone receptor status. J Natl Cancer Inst (2004) 4.57

Transient increase in the risk of breast cancer after giving birth. N Engl J Med (1994) 4.08

Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J Cell Biol (1994) 3.68

Risk for breast cancer development determined by mammographic parenchymal pattern. Cancer (1976) 3.37

Adiponectin--journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med (2005) 3.29

Body mass index as a prognostic feature in operable breast cancer: the International Breast Cancer Study Group experience. Ann Oncol (2004) 3.29

Postnatal mammary gland development requires macrophages and eosinophils. Development (2000) 3.10

Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J Biol Chem (2004) 3.01

Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC). Int J Cancer (2004) 2.96

Source of estrogen production in postmenopausal women. J Clin Endocrinol Metab (1973) 2.91

Tumor-associated macrophages in breast cancer. J Mammary Gland Biol Neoplasia (2002) 2.90

Minireview: Obesity and breast cancer: the estrogen connection. Endocrinology (2009) 2.57

Oestrogen receptor expression in the normal and pre-cancerous breast. J Pathol (1999) 2.52

Pregnancy-associated breast cancer and metastasis. Nat Rev Cancer (2006) 2.52

Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3. Breast Cancer Res (2003) 2.48

Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocr Relat Cancer (2007) 2.45

Molecular links between obesity and breast cancer. Endocr Relat Cancer (2006) 2.44

The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Curr Biol (2000) 2.42

Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. J Clin Invest (2005) 2.38

Mammographic density is related to stroma and stromal proteoglycan expression. Breast Cancer Res (2003) 2.37

Growth factors and stromal matrix proteins associated with mammographic densities. Cancer Epidemiol Biomarkers Prev (2001) 2.35

Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene (2003) 2.27

Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors. J Leukoc Biol (2001) 2.26

Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. Cancer Res (2009) 2.25

Plasma adiponectin concentrations and risk of incident breast cancer. J Clin Endocrinol Metab (2007) 2.07

Stromelysin-1 regulates adipogenesis during mammary gland involution. J Cell Biol (2001) 2.03

Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP. Diabetes (2002) 2.00

Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status--a meta-analysis. Int J Cancer (2009) 1.88

Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis. Am J Pathol (2006) 1.83

A longitudinal study of the effects of menopause on mammographic features. Cancer Epidemiol Biomarkers Prev (2002) 1.78

White adipose tissue cells are recruited by experimental tumors and promote cancer progression in mouse models. Cancer Res (2009) 1.78

Tamoxifen and mammographic breast densities. Cancer Epidemiol Biomarkers Prev (2000) 1.72

Human breast development. J Mammary Gland Biol Neoplasia (2000) 1.71

In vivo regulation of lipolysis in humans. J Lipid Res (1994) 1.70

Transforming growth factor beta3 induces cell death during the first stage of mammary gland involution. Development (2000) 1.70

Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue. Cancer Res (1985) 1.70

Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers. Cancer Res (2007) 1.66

Age at any birth and breast cancer risk. Int J Cancer (1983) 1.65

Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. J Biol Chem (2000) 1.65

Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development. Am J Pathol (1998) 1.64

Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1(op)/Csf1(op)) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis. Blood (2001) 1.64

Height and weight, mammographic features of breast tissue, and breast cancer risk. Am J Epidemiol (1984) 1.62

Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo. Clin Cancer Res (2009) 1.58

Cloning of cell-specific secreted and surface proteins by subtractive antibody screening. Nat Biotechnol (1998) 1.58

Persistent parity-induced changes in growth factors, TGF-beta3, and differentiation in the rodent mammary gland. Mol Endocrinol (2002) 1.56

Pregnancy and breast cancer: when they collide. J Mammary Gland Biol Neoplasia (2009) 1.55

Body mass and stage of breast cancer at diagnosis. Int J Cancer (2002) 1.54

Pregnancy-associated breast cancer. Isr Med Assoc J (2008) 1.53

Involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ. Breast Cancer Res (2006) 1.51

Mammary gland architecture as a determining factor in the susceptibility of the human breast to cancer. Breast J (2002) 1.51

Breast cancer in adolescents and young women. Eur J Cancer (2003) 1.49

Evidence for a crossover in breast cancer risk factors. Am J Epidemiol (1982) 1.49

A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland. Development (2003) 1.48

Mammary ECM composition and function are altered by reproductive state. Mol Carcinog (2004) 1.48

Evidence of poorer survival in pregnancy-associated breast cancer. Obstet Gynecol (2008) 1.36

Adipocyte differentiation induces dynamic changes in NF-kappaB expression and activity. Am J Physiol Endocrinol Metab (2004) 1.35

Vascular remodelling during the normal and malignant life cycle of the mammary gland. Microsc Res Tech (2001) 1.35

Aromatase expression in health and disease. Recent Prog Horm Res (1997) 1.35

Mammary involution and breast cancer risk: transgenic models and clinical studies. J Mammary Gland Biol Neoplasia (2009) 1.32

Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice. Oncogene (1997) 1.30

Leptin receptor expression and cell signaling in breast cancer. Int J Oncol (2006) 1.27

Worse survival in breast cancer among women with recent childbirth: results from a Swedish population-based register study. Clin Breast Cancer (2003) 1.27

The short-term and long-term effect of a pregnancy on breast cancer risk: a prospective study of 802,457 parous Norwegian women. Br J Cancer (1995) 1.27

Adverse effects of obesity on breast cancer prognosis, and the biological actions of leptin (review). Int J Oncol (2002) 1.25

Morphometric studies of age related changes in normal human breast and their significance for evolution of mammary cancer. J Clin Pathol (1985) 1.25

Delayed involution of the mammary epithelium in BALB/c-p53null mice. Oncogene (1998) 1.25

Differences in breast cancer risk factors according to the estrogen receptor level of the tumor. J Natl Cancer Inst (1983) 1.23

Risk factors for breast carcinoma in situ versus invasive breast cancer in a prospective study of pre- and post-menopausal women. Breast Cancer Res Treat (2006) 1.21

Body mass index and post-menopausal breast cancer: an age-specific analysis. Br J Cancer (1997) 1.19

Epidemiology of breast cancer. Findings from the nurses' health study. Cancer (1993) 1.18

Roles of Fas and Fas ligand during mammary gland remodeling. J Clin Invest (2000) 1.18

Clinicopathologic characteristics and prognosis of breast cancer patients associated with pregnancy and lactation: analysis of case-control study in Japan. Jpn J Cancer Res (1992) 1.17

Increased lymph node metastases at mastectomy for breast cancer associated with host obesity, cigarette smoking, age, and large tumor size. Cancer (1988) 1.14

Tumor biology of breast cancer in young women. Breast Dis (2006) 1.13

Tumour-stromal interactions. Role of the stroma in mammary development. Breast Cancer Res (2001) 1.10

Obesity hormone leptin: a new target in breast cancer? Breast Cancer Res (2007) 1.10

Age-dependent changes in breast cancer hormone receptors and oxidant stress markers. Breast Cancer Res Treat (2002) 1.05

Loss of interleukin 6 results in delayed mammary gland involution: a possible role for mitogen-activated protein kinase and not signal transducer and activator of transcription 3. Mol Endocrinol (2002) 1.03

Postmenopausal hormone therapy and changes in mammographic density. J Clin Oncol (2007) 1.01

Dual effect of parity on breast cancer risk. Eur J Cancer (1994) 1.01

Relation of time since last birth and parity to survival of young women with breast cancer. Epidemiology (1998) 1.01

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