CTLA-4 blockade: therapeutic potential in cancer treatments.

PubWeight™: 1.33‹?› | Rank: Top 10%

🔗 View Article (PMC 2895779)

Published in Onco Targets Ther on June 24, 2010

Authors

Ahmad A Tarhini1, Fatima Iqbal

Author Affiliations

1: University of Pittsburgh School of Medicine, Melanoma and Skin Cancer Program, Pittsburgh, PA, USA.

Associated clinical trials:

Phase I Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma | NCT01703507

Articles citing this

Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma. Ann N Y Acad Sci (2013) 2.03

Antibody-based therapeutics to watch in 2011. MAbs (2011) 2.00

Metastasectomy for distant metastatic melanoma: analysis of data from the first Multicenter Selective Lymphadenectomy Trial (MSLT-I). Ann Surg Oncol (2012) 1.92

Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. J Immunol (2011) 1.77

CTLA-4 blockade in tumor models: an overview of preclinical and translational research. Cancer Immun (2013) 1.71

Prospects of immune checkpoint modulators in the treatment of glioblastoma. Nat Rev Neurol (2015) 1.50

A new understanding in the epidemiology of melanoma. Expert Rev Anticancer Ther (2010) 1.30

Immune-mediated adverse events associated with ipilimumab ctla-4 blockade therapy: the underlying mechanisms and clinical management. Scientifica (Cairo) (2013) 1.28

Cancer/testis (CT) antigens, carcinogenesis and spermatogenesis. Spermatogenesis (2011) 1.16

New insights into the role of the immune microenvironment in breast carcinoma. Clin Dev Immunol (2013) 1.01

Adverse events to monoclonal antibodies used for cancer therapy: Focus on hypersensitivity responses. Oncoimmunology (2013) 1.01

Immune modulation by chemotherapy or immunotherapy to enhance cancer vaccines. Cancers (Basel) (2011) 0.99

Induced regulatory T cells in inhibitory microenvironments created by cancer. Expert Opin Biol Ther (2014) 0.93

Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in adjuvant with PF-3512676 and GM-CSF in metastatic melanoma. J Immunother (2012) 0.89

Immune microenvironment in colorectal cancer: a new hallmark to change old paradigms. Clin Dev Immunol (2011) 0.83

Metastatic melanoma - a review of current and future drugs. Drugs Context (2012) 0.83

Severe meningo-radiculo-neuritis associated with ipilimumab. Invest New Drugs (2012) 0.82

Malignant melanoma of the urethra: a rare histologic subdivision of vulvar cancer with a poor prognosis. Case Rep Obstet Gynecol (2012) 0.81

Immunotherapy of malignant gliomas using autologous and allogeneic tissue cells. Anticancer Agents Med Chem (2010) 0.78

A phase I study of intratumoral ipilimumab and interleukin-2 in patients with advanced melanoma. Oncotarget (2016) 0.78

Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy. Oncoimmunology (2016) 0.75

Ipilimumab: Melanoma and beyond. J Pharm Bioallied Sci (2011) 0.75

Articles cited by this

Enhancement of antitumor immunity by CTLA-4 blockade. Science (1996) 17.94

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (1995) 16.19

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity (1995) 14.90

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci U S A (2003) 10.71

CD28/B7 system of T cell costimulation. Annu Rev Immunol (1996) 10.48

CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med (1991) 9.94

Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol (2005) 9.72

CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol (2001) 9.19

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med (2001) 8.60

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med (1995) 8.31

Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials. J Clin Oncol (2008) 8.09

Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med (1999) 7.94

Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ann Surg Oncol (2005) 5.36

Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov (2006) 5.19

Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206. J Clin Oncol (2005) 4.77

CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat Immunol (2002) 4.48

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci U S A (2008) 4.43

Antibody pharmacokinetics and pharmacodynamics. J Pharm Sci (2004) 4.28

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity (1994) 3.73

Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade. J Immunol (2005) 3.53

Metabolic properties of IgG subclasses in man. J Clin Invest (1970) 3.48

Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother (2007) 3.32

Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. J Immunother (2005) 2.84

A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer. Clin Cancer Res (2007) 2.71

Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity (2002) 2.71

Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer. Proc Natl Acad Sci U S A (1997) 2.53

Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma. Clin Cancer Res (2010) 2.20

Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma. J Exp Med (2002) 1.95

Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma. J Immunother (2006) 1.66

Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy. Proc Natl Acad Sci U S A (1999) 1.61

The role of CTLA-4 in the regulation of T cell immune responses. Immunol Cell Biol (1999) 1.59

Detailed analysis of immunologic effects of the cytotoxic T lymphocyte-associated antigen 4-blocking monoclonal antibody tremelimumab in peripheral blood of patients with melanoma. J Transl Med (2008) 1.56

Disease stage variation in CD4+ and CD8+ T-cell reactivity to the receptor tyrosine kinase EphA2 in patients with renal cell carcinoma. Cancer Res (2003) 1.48

Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses. J Immunol (1999) 1.44

Expression and function of CTLA-4 in Th1 and Th2 cells. J Immunol (1998) 1.31

SnapShot: B7/CD28 costimulation. Cell (2009) 0.92

Surveillance of the eye and vision in clinical trials of CP-675,206 for metastatic melanoma. Am J Ophthalmol (2007) 0.86

The clinical utility of cytotoxic T lymphocyte antigen 4 abrogation by human antibodies. Melanoma Res (2006) 0.79

Early development of the Toll-like receptor 9 agonist, PF-3512676, for the treatment of patients with advanced cancers. Expert Opin Drug Discov (2009) 0.79

Articles by these authors

Depressive symptoms and spiritual wellbeing in asymptomatic heart failure patients. J Behav Med (2014) 1.38

Novel biomarkers for heart failure. Expert Rev Cardiovasc Ther (2013) 0.82

Liaison psychiatry and depression in medical inpatients. J Pak Med Assoc (2007) 0.79