Published in Int J Environ Res Public Health on February 26, 2010
Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet (2014) 2.58
Identifying the odds ratio estimated by a two-stage instrumental variable analysis with a logistic regression model. Stat Med (2013) 1.14
Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways. Int J Epidemiol (2014) 0.96
Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approach. PLoS One (2012) 0.94
Circulating interleukin-6 and cancer: A meta-analysis using Mendelian randomization. Sci Rep (2015) 0.80
Genomics and metabolomics of muscular mass in a community-based sample of UK females. Eur J Hum Genet (2015) 0.78
Model selection approach suggests causal association between 25-hydroxyvitamin D and colorectal cancer. PLoS One (2013) 0.78
Role of Vitamin D deficiency in extraskeletal complications: predictor of health outcome or marker of health status? Biomed Res Int (2015) 0.78
C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects. Inflamm Res (2011) 0.77
Genetically lowered concentrations of circulating sRAGE might cause an increased risk of cancer: Meta-analysis using Mendelian randomization. J Int Med Res (2016) 0.77
Evaluation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis. BMC Med Genet (2015) 0.76
Mendelian randomization: potential use of genetics to enable causal inferences regarding HIV-associated biomarkers and outcomes. Curr Opin HIV AIDS (2010) 0.76
Circulating interleukin-6 and rheumatoid arthritis: A Mendelian randomization meta-analysis. Medicine (Baltimore) (2016) 0.75
AMD Genetics in India: The Missing Links. Front Aging Neurosci (2016) 0.75
A significant causal association between C-reactive protein levels and schizophrenia. Sci Rep (2016) 0.75
A comparison of three methods of Mendelian randomization when the genetic instrument, the risk factor and the outcome are all binary. PLoS One (2012) 0.75
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA (2002) 80.37
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med (2006) 23.83
Causal diagrams for epidemiologic research. Epidemiology (1999) 19.48
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol (2003) 16.71
Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med (2008) 9.39
MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet (2002) 7.41
Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med (1993) 6.37
When are observational studies as credible as randomised trials? Lancet (2004) 6.19
An introduction to instrumental variables for epidemiologists. Int J Epidemiol (2000) 6.17
Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med (2009) 6.16
C-reactive protein and its role in metabolic syndrome: mendelian randomisation study. Lancet (2005) 5.51
The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome. BMC Cardiovasc Disord (2008) 5.33
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA (2009) 5.32
Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol (2004) 5.07
Genetically elevated lipoprotein(a) and increased risk of myocardial infarction. JAMA (2009) 4.42
Mendelian randomization as an instrumental variable approach to causal inference. Stat Methods Med Res (2007) 4.04
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Homocysteine and stroke: evidence on a causal link from mendelian randomisation. Lancet (2005) 3.60
Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev Med (1991) 3.53
Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? Hum Genet (2007) 3.13
Insight into the nature of the CRP-coronary event association using Mendelian randomization. Int J Epidemiol (2006) 2.70
Fibrinogen and coronary heart disease: test of causality by 'Mendelian randomization'. Int J Epidemiol (2006) 2.68
Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality. Arterioscler Thromb Vasc Biol (2005) 2.42
Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study. PLoS One (2008) 2.37
Commentary: the concept of 'Mendelian Randomization'. Int J Epidemiol (2004) 2.35
Apolipoprotein E isoforms, serum cholesterol, and cancer. Lancet (1986) 2.05
Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype. Hypertension (2009) 2.01
How does body fat influence bone mass in childhood? A Mendelian randomization approach. J Bone Miner Res (2009) 2.01
Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream. PLoS Med (2008) 1.95
Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures. J Bone Miner Res (2004) 1.93
Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype. Int J Epidemiol (2009) 1.87
Evidence for extensive transmission distortion in the human genome. Am J Hum Genet (2003) 1.86
Re: Estimation of bias in nongenetic observational studies using "Mendelian triangulation" by Bautista et al. Ann Epidemiol (2007) 1.86
Alcohol, ALDH2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach. Cancer Epidemiol Biomarkers Prev (2005) 1.84
'Mendelian randomization' equals instrumental variable analysis with genetic instruments. Stat Med (2008) 1.77
Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study. Eur Heart J (2008) 1.76
Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos. Eur J Hum Genet (2002) 1.73
Meta-analysis of genetic studies using Mendelian randomization--a multivariate approach. Stat Med (2005) 1.72
Vitamin C and risk of coronary heart disease in women. J Am Coll Cardiol (2003) 1.65
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet (2009) 1.61
Adjusting for bias and unmeasured confounding in Mendelian randomization studies with binary responses. Int J Epidemiol (2008) 1.45
Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002. Diabetologia (2007) 1.45
Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations. Am J Hum Genet (2000) 1.41
The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. PLoS One (2008) 1.28
An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. J Gerontol A Biol Sci Med Sci (2007) 1.27
Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach. J Clin Endocrinol Metab (2009) 1.27
An integrated approach to the meta-analysis of genetic association studies using Mendelian randomization. Am J Epidemiol (2004) 1.26
Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study. PLoS One (2008) 1.09
Apolipoprotein e genotype, plasma cholesterol, and cancer: a Mendelian randomization study. Am J Epidemiol (2009) 1.07
Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendelian randomization approach. Cancer Epidemiol Biomarkers Prev (2009) 1.05
Mendelian randomization suggests no causal association between C-reactive protein and carotid intima-media thickness in the young Finns study. Arterioscler Thromb Vasc Biol (2007) 1.04
A cautionary note on the use of Mendelian randomization to infer causation in observational epidemiology. Int J Epidemiol (2007) 1.01
Association between C-reactive protein and adiposity in women. J Clin Endocrinol Metab (2009) 0.98
Challenges and novel approaches in the epidemiological study of early life influences on later disease. Adv Exp Med Biol (2009) 0.98
Polymorphisms of the insulin receptor and the insulin receptor substrates genes in polycystic ovary syndrome: a Mendelian randomization meta-analysis. Mol Genet Metab (2009) 0.97
Relationship between leptin and C-reactive protein in young Finnish adults. J Clin Endocrinol Metab (2007) 0.95
Systemic inflammation, genetic susceptibility and lung function. Eur Respir J (2008) 0.93
Associations between lactase persistence and the metabolic syndrome in a cross-sectional study in the Canary Islands. Eur J Nutr (2009) 0.92
Circulating beta-carotene levels and type 2 diabetes-cause or effect? Diabetologia (2009) 0.89
RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans. J Lipid Res (2009) 0.89
Relation of age-related cataract with obesity and obesity genes in an Asian population. Am J Epidemiol (2009) 0.86
Stillbirth and slow metabolizers of caffeine: comparison by genotypes. Int J Epidemiol (2006) 0.81
The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies. Int J Epidemiol (2009) 0.76
Evidence-based value of prophylactic drainage in gastrointestinal surgery: a systematic review and meta-analyses. Ann Surg (2004) 2.49
A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning. Ann Surg (2003) 2.48
Limited diagnostic value of laryngopharyngeal lesions in patients with gastroesophageal reflux during routine upper gastrointestinal endoscopy. Am J Gastroenterol (2007) 2.26
The effect of ductal diameter on surgical and medical closure of patent ductus arteriosus in preterm neonates: size matters. J Thorac Cardiovasc Surg (2008) 2.24
Evidence-based treatment of acute pancreatitis: a look at established paradigms. Ann Surg (2006) 1.79
Spontaneous closure of small residual ventricular septal defects after surgical repair. Ann Thorac Surg (2007) 1.79
Delayed referral and gram-negative organisms increase the conversion thoracotomy rate in patients undergoing video-assisted thoracoscopic surgery for empyema. Ann Thorac Surg (2005) 1.65
Hemodynamic and neurohumoral effects of selective endothelin A (ET(A)) receptor blockade in chronic heart failure: the Heart Failure ET(A) Receptor Blockade Trial (HEAT). Circulation (2002) 1.64
Risk factors for reoperation after relief of congenital subaortic stenosis. Eur J Cardiothorac Surg (2008) 1.46
Increased EEG power and slowed dominant frequency in patients with neurogenic pain. Brain (2005) 1.37
The contribution of rectangularization to the secular increase of life expectancy: an empirical study. Int J Epidemiol (2012) 1.36
Incidence and management of complications after neoadjuvant chemotherapy followed by extrapleural pneumonectomy for malignant pleural mesothelioma. Eur J Cardiothorac Surg (2006) 1.28
Effects of promyelocytic leukemia protein on virus-host balance. J Virol (2002) 1.28
Survival of zirconia- and metal-supported fixed dental prostheses: a systematic review. Int J Prosthodont (2011) 1.26
Morbidity and recurrence after completion lymph node dissection following sentinel lymph node biopsy in cutaneous malignant melanoma. Ann Surg (2008) 1.18
Morbidity, survival, and site of recurrence after mediastinal lymph-node dissection versus systematic sampling after complete resection for non-small cell lung cancer. Ann Thorac Surg (2005) 1.17
Associations between body mass, leptin, IGF-I and circulating adrenal androgens in children with obesity and premature adrenarche. Eur J Endocrinol (2002) 1.10
Early insertion of a pulmonary valve for chronic regurgitation helps restoration of ventricular dimensions. Ann Thorac Surg (2005) 1.09
WHO 2004 criteria and CK19 are reliable prognostic markers in pancreatic endocrine tumors. Am J Surg Pathol (2007) 1.06
Clinical performance of cervical restorations--a meta-analysis. Dent Mater (2010) 1.05
Gender, age, and body surface area are the major determinants of ascending aorta dimensions in subjects with apparently normal echocardiograms. J Am Soc Echocardiogr (2009) 1.02
Reference values and factors associated with renal resistive index in a family-based population study. Hypertension (2013) 1.00
Analysis of risk factors for low bone mineral density in inflammatory bowel disease. Digestion (2006) 1.00
Exercise dose and insulin sensitivity: relevance for diabetes prevention. Med Sci Sports Exerc (2012) 0.98
Association between C-reactive protein and adiposity in women. J Clin Endocrinol Metab (2009) 0.98
Hypothalamic and gonadal components of hypogonadism in boys with Prader-Labhart- Willi syndrome. J Clin Endocrinol Metab (2005) 0.94
Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approach. PLoS One (2012) 0.94
Clinical effectiveness of direct class II restorations - a meta-analysis. J Adhes Dent (2012) 0.93
Combined thalidomide and temozolomide treatment in patients with glioblastoma multiforme. J Neurooncol (2004) 0.92
EEG power and coherence in children with educational problems. J Clin Neurophysiol (2003) 0.91
Routine stenting reduces urologic complications as compared with stenting "on demand" in adult kidney transplantation. Urology (2007) 0.88
Gender and socioeconomic disparities in BMI trajectories in the Seychelles: a cohort analysis based on serial population-based surveys. BMC Public Health (2011) 0.87
Use of a human-like low-grade bacteremia model of experimental endocarditis to study the role of Staphylococcus aureus adhesins and platelet aggregation in early endocarditis. Infect Immun (2012) 0.87
Association between substance use and psychosocial characteristics among adolescents of the Seychelles. BMC Pediatr (2011) 0.87
Local recurrence model of malignant pleural mesothelioma for investigation of intrapleural treatment. Eur J Cardiothorac Surg (2007) 0.86
Growth hormone and body composition in children younger than 2 years with Prader-Willi syndrome. J Pediatr (2004) 0.86
Development of motor speed and associated movements from 5 to 18 years. Dev Med Child Neurol (2009) 0.86
Brain natriuretic peptide and magnetic resonance imaging in tetralogy with right ventricular dilatation. Ann Thorac Surg (2006) 0.85
Impaired motor performance and movement quality in very-low-birthweight children at 6 years of age. Dev Med Child Neurol (2006) 0.85
Developmental profiles in young children with Prader-Labhart-Willi syndrome: effects of weight and therapy with growth hormone or coenzyme Q10. Am J Med Genet A (2008) 0.84
Chromosomal translocations t(4;14), t(11;14) and proliferation rate stratify patients with mature plasma cell myelomas into groups with different survival probabilities: a molecular epidemiologic study on tissue microarrays. Am J Surg Pathol (2007) 0.84
Fracture rates of IPS Empress all-ceramic crowns--a systematic review. Int J Prosthodont (2010) 0.84
Neuromotor development in children. Part 3: motor performance in 3- to 5-year-olds. Dev Med Child Neurol (2012) 0.84
Extended donor lungs: eleven years experience in a consecutive series. Eur J Cardiothorac Surg (2005) 0.83
Stability of cognitive performance in children with mild intellectual disability. Dev Med Child Neurol (2014) 0.83
Prognostic value of plasma N-terminal pro-brain natriuretic peptide in children with congenital heart defects and open-heart surgery. J Pediatr (2006) 0.83
Correlations between motor and intellectual functions in normally developing children between 7 and 18 years. Dev Neuropsychol (2013) 0.82
Patients' preferences on information and involvement in decision making for gastrointestinal surgery. World J Surg (2013) 0.82
Abnormalities of the lesser tuberosity on radiography and MRI: association with subscapularis tendon lesions. AJR Am J Roentgenol (2008) 0.81
Use of a Mendelian randomization approach to assess the causal relation of gamma-Glutamyltransferase with blood pressure and serum insulin levels. Am J Epidemiol (2010) 0.80
Infant motor milestones: poor predictive value for outcome of healthy children. Acta Paediatr (2013) 0.80
Outcomes and reoperations after total correction of complete atrio-ventricular septal defect. Eur J Cardiothorac Surg (2008) 0.80
Delayed cyclic activity development on early amplitude-integrated EEG in the preterm infant with brain lesions. Neonatology (2012) 0.80
Low-molecular-weight heparin for prevention of restenosis after femoropopliteal percutaneous transluminal angioplasty: a randomized controlled trial. J Vasc Surg (2006) 0.79
Quantitative reference curves for associated movements in children and adolescents. Dev Med Child Neurol (2007) 0.79
High-dose atorvastatin in peripheral arterial disease (PAD): effect on endothelial function, intima-media-thickness and local progression of PAD. An open randomized controlled pilot trial. Thromb Haemost (2008) 0.79
Alzheimer disease versus mixed dementias: an EEG perspective. Clin Neurophysiol (2008) 0.79
Wear of two artificial tooth materials in vivo: a 12-month pilot study. J Prosthet Dent (2009) 0.79
Homemade thermometry instruments in the field. Wilderness Environ Med (2012) 0.78
Association between short sleeping hours and physical activity in boys playing ice hockey. J Pediatr (2008) 0.78
Modelling neuromotor ratings with floor-effects. Stat Med (2004) 0.78
Increased adrenal androgen levels in patients with Prader-Willi syndrome are associated with insulin, IGF-I, and leptin, but not with measures of obesity. Horm Res (2002) 0.78
Serum cholesterol levels do not influence outcome or recovery in acute ischemic stroke. Neurol Res (2008) 0.78
Monocyte function-associated antigen expression during and after pediatric cardiac surgery. J Thorac Cardiovasc Surg (2005) 0.78
Serological evidence for the association of Bartonella henselae infection with arrhythmogenic right ventricular cardiomyopathy. Clin Cardiol (2008) 0.78
Trisomy 18: changes in sex ratio during intrauterine life. Am J Med Genet A (2006) 0.77
Pooling of dentin microtensile bond strength data improves clinical correlation. J Adhes Dent (2011) 0.77
Weight status, body image and bullying among adolescents in the Seychelles. Int J Environ Res Public Health (2013) 0.77
Meta-Analysis of the Influence of Bonding Parameters on the Clinical Outcome of Tooth-colored Cervical Restorations. J Adhes Dent (2015) 0.77
Decreased wall shear stress in the common carotid artery of patients with peripheral arterial disease or abdominal aortic aneurysm: relation to blood rheology, vascular risk factors, and intima-media thickness. J Vasc Surg (2006) 0.77
Association between foot growth and musculoskeletal loading in children with Prader-Willi syndrome before and during growth hormone treatment. J Pediatr (2008) 0.76
Perioperative diclofenac application during video-assisted thoracic surgery pleurodesis modulates early inflammatory and fibrinolytic processes in an experimental model. Eur Surg Res (2013) 0.76
C-reactive protein and red cell aggregation correlate with late venous function after acute deep venous thrombosis. J Vasc Surg (2004) 0.76
Authors' response to 'Limitless longevity': the contribution of rectangularization to the secular increase in life expectancy: an empirical study. Int J Epidemiol (2013) 0.75
Methadone treatments in a Swiss region, 2001-2008: a registry-based analysis. BMC Psychiatry (2012) 0.75
A comparison of three methods of Mendelian randomization when the genetic instrument, the risk factor and the outcome are all binary. PLoS One (2012) 0.75
Intra-individual stability of neuromotor tasks from 6 to 18 years: a longitudinal study. Hum Mov Sci (2011) 0.75
The marginal quality of luted ceramic inserts in bovine teeth and ceramic inlays in extracted molars after occlusal loading. J Adhes Dent (2005) 0.75
Clinical markers of hypoxia and other predictive factors of survival in conservative therapy of squamous-cell carcinoma of the esophagus. Int J Colorectal Dis (2002) 0.75
Blood fluidity and outcome after femoropopliteal percutaneous transluminal angioplasty (PTA): role of plasma viscosity and low platelet count in predicting restenosis. Clin Hemorheol Microcirc (2005) 0.75
Parametric modeling of reaction time experiment data. Biometrics (2003) 0.75
A computerized analysis-by-synthesis algorithm improves precision of linear wear measurements in total hip replacements. J Orthop Res (2008) 0.75
Plasma homocysteine and restenosis after femoropopliteal angioplasty. J Endovasc Ther (2004) 0.75
Patient-reported toxicity correlated to dose-volume histograms of the rectum in radiotherapy of the prostate. Am J Clin Oncol (2003) 0.75
Wear of two denture teeth materials in vivo-2-year results. Dent Mater (2013) 0.75
Functional outcome and prevalence of recurrent ischemic events in patients with acute ischemic stroke due to aortic plaques. Cerebrovasc Dis (2007) 0.75
Late morbidity during childhood and adolescence in previously premature neonates after patent ductus arteriosus closure. Pediatr Cardiol (2009) 0.75