Published in Genome Res on July 20, 2010
Spatio-temporal transcriptome of the human brain. Nature (2011) 9.19
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83
Temporal dynamics and genetic control of transcription in the human prefrontal cortex. Nature (2011) 5.01
Evolutionary dynamics of gene and isoform regulation in Mammalian tissues. Science (2012) 4.52
Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease. Nat Rev Neurosci (2012) 2.52
MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates. PLoS Biol (2011) 1.57
miR-186 is decreased in aged brain and suppresses BACE1 expression. J Neurochem (2016) 1.49
Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53. EMBO J (2011) 1.42
Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. RNA Biol (2011) 1.40
Accelerated recruitment of new brain development genes into the human genome. PLoS Biol (2011) 1.39
Analysis of alternative splicing associated with aging and neurodegeneration in the human brain. Genome Res (2011) 1.35
Identification of differentially expressed microRNAs across the developing human brain. Mol Psychiatry (2013) 1.30
The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Clin Chem (2014) 1.26
Widespread splicing changes in human brain development and aging. Mol Syst Biol (2013) 1.23
Novel microRNAs differentially expressed during aging in the mouse brain. PLoS One (2012) 1.20
MicroRNAs in age-related diseases. EMBO Mol Med (2013) 1.20
A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls. J Alzheimers Dis (2013) 1.18
Human brain evolution: transcripts, metabolites and their regulators. Nat Rev Neurosci (2013) 1.16
Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome. Age (Dordr) (2012) 1.15
The Impact of MicroRNAs on Brain Aging and Neurodegeneration. Curr Gerontol Geriatr Res (2012) 1.14
A plasma microRNA signature of acute lentiviral infection: biomarkers of central nervous system disease. AIDS (2011) 1.10
Analysis of epigenetic changes in survivors of preterm birth reveals the effect of gestational age and evidence for a long term legacy. Genome Med (2013) 1.06
A highly expressed miR-101 isomiR is a functional silencing small RNA. BMC Genomics (2013) 1.05
Genome-wide identification of microRNA expression quantitative trait loci. Nat Commun (2015) 1.04
GO-Module: functional synthesis and improved interpretation of Gene Ontology patterns. Bioinformatics (2011) 1.02
XenomiRs and miRNA homeostasis in health and disease: evidence that diet and dietary miRNAs directly and indirectly influence circulating miRNA profiles. RNA Biol (2012) 1.02
Influence of sex differences on microRNA gene regulation in disease. Biol Sex Differ (2014) 1.00
Programmatic features of aging originating in development: aging mechanisms beyond molecular damage? FASEB J (2012) 1.00
Human brain evolution: harnessing the genomics (r)evolution to link genes, cognition, and behavior. Neuron (2010) 0.99
PROmiRNA: a new miRNA promoter recognition method uncovers the complex regulation of intronic miRNAs. Genome Biol (2013) 0.99
Systems biology in aging: linking the old and the young. Curr Genomics (2012) 0.97
Evolution of the let-7 microRNA family. RNA Biol (2012) 0.97
MicroRNAs in opioid pharmacology. J Neuroimmune Pharmacol (2011) 0.96
Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate. BMC Genomics (2012) 0.96
Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Res (2014) 0.94
Roles of the developmental regulator unc-62/Homothorax in limiting longevity in Caenorhabditis elegans. PLoS Genet (2013) 0.94
Next-generation sequencing-based mRNA and microRNA expression profiling analysis revealed pathways involved in the rapid growth of developing culms in Moso bamboo. BMC Plant Biol (2013) 0.94
Comparative genomic analysis of Drosophila melanogaster and vector mosquito developmental genes. PLoS One (2011) 0.93
Transcription factors are targeted by differentially expressed miRNAs in primates. Genome Biol Evol (2012) 0.93
The Cellular and Molecular Landscapes of the Developing Human Central Nervous System. Neuron (2016) 0.93
Human brain evolution: from gene discovery to phenotype discovery. Proc Natl Acad Sci U S A (2012) 0.92
Comparative analysis of human and mouse expression data illuminates tissue-specific evolutionary patterns of miRNAs. Nucleic Acids Res (2012) 0.92
Converging evidence implicates the abnormal microRNA system in schizophrenia. Schizophr Bull (2014) 0.91
Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes. Aging Cell (2016) 0.91
New Neurons in Aging Brains: Molecular Control by Small Non-Coding RNAs. Front Neurosci (2012) 0.91
Prediction of C. elegans longevity genes by human and worm longevity networks. PLoS One (2012) 0.90
Characterization of the rainbow trout egg microRNA transcriptome. PLoS One (2012) 0.90
Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging. Genome Biol (2015) 0.89
Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand. Neurobiol Aging (2013) 0.88
Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation. Elife (2014) 0.88
RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis. Aging Cell (2014) 0.88
Annotation of primate miRNAs by high throughput sequencing of small RNA libraries. BMC Genomics (2012) 0.88
deepBlockAlign: a tool for aligning RNA-seq profiles of read block patterns. Bioinformatics (2011) 0.87
MicroRNAs in the aging female brain: a putative mechanism for age-specific estrogen effects. Endocrinology (2013) 0.87
An emerging role for microRNAs in sexually dimorphic neurobiological systems. Pflugers Arch (2013) 0.86
Evolutionary Divergence of Gene and Protein Expression in the Brains of Humans and Chimpanzees. Genome Biol Evol (2015) 0.85
Maturation of the human dorsolateral prefrontal cortex coincides with a dynamic shift in microRNA expression. Schizophr Bull (2013) 0.84
Upregulation of a small vault RNA (svtRNA2-1a) is an early event in Parkinson disease and induces neuronal dysfunction. RNA Biol (2013) 0.83
Conserved microRNA editing in mammalian evolution, development and disease. Genome Biol (2014) 0.83
Modulated expression of human peripheral blood microRNAs from infancy to adulthood and its role in aging. Aging Cell (2014) 0.83
Heritable changes in regional cortical thickness with age. Brain Imaging Behav (2014) 0.82
Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases. Sci Rep (2015) 0.82
Development and application of a modified dynamic time warping algorithm (DTW-S) to analyses of primate brain expression time series. BMC Bioinformatics (2011) 0.82
Dynamic and differential regulation in the microRNA expression in the developing and mature cataractous rat lens. J Cell Mol Med (2013) 0.81
Deep sequencing reveals a novel class of bidirectional promoters associated with neuronal genes. BMC Genomics (2014) 0.81
General hallmarks of microRNAs in brain evolution and development. RNA Biol (2015) 0.81
Coordinated gene expression of neuroinflammatory and cell signaling markers in dorsolateral prefrontal cortex during human brain development and aging. PLoS One (2014) 0.81
Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism. PLoS Biol (2016) 0.81
Cortical Tubers: Windows into Dysregulation of Epilepsy Risk and Synaptic Signaling Genes by MicroRNAs. Cereb Cortex (2014) 0.80
Unraveling the characteristics of microRNA regulation in the developmental and aging process of the human brain. BMC Med Genomics (2013) 0.80
A Parallel Study of mRNA and microRNA Profiling of Peripheral Blood in Young Adult Women. Front Genet (2011) 0.80
Gene expression in the human brain: the current state of the study of specificity and spatiotemporal dynamics. Child Dev (2012) 0.80
Specific Regional and Age-Related Small Noncoding RNA Expression Patterns Within Superior Temporal Gyrus of Typical Human Brains Are Less Distinct in Autism Brains. J Child Neurol (2015) 0.80
Shared Pathways Among Autism Candidate Genes Determined by Co-expression Network Analysis of the Developing Human Brain Transcriptome. J Mol Neurosci (2015) 0.79
Dumbbell-PCR: a method to quantify specific small RNA variants with a single nucleotide resolution at terminal sequences. Nucleic Acids Res (2015) 0.79
Identification and characterization of novel and conserved microRNAs in several tissues of the Chinese rare minnow (Gobiocypris rarus) based on illumina deep sequencing technology. BMC Genomics (2016) 0.78
Coordination of gene expression of arachidonic and docosahexaenoic acid cascade enzymes during human brain development and aging. PLoS One (2014) 0.78
Age-related changes of gene expression in the neocortex: preliminary data on RNA-Seq of the transcriptome in three functionally distinct cortical areas. Dev Psychopathol (2012) 0.78
MicroRNA-181c Ameliorates Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats. Mol Neurobiol (2016) 0.78
isomiR-SEA: an RNA-Seq analysis tool for miRNAs/isomiRs expression level profiling and miRNA-mRNA interaction sites evaluation. BMC Bioinformatics (2016) 0.78
Integromics network meta-analysis on cardiac aging offers robust multi-layer modular signatures and reveals micronome synergism. BMC Genomics (2015) 0.77
Extensive ceRNA-ceRNA interaction networks mediated by miRNAs regulate development in multiple rhesus tissues. Nucleic Acids Res (2016) 0.77
Evolution of human longevity uncoupled from caloric restriction mechanisms. PLoS One (2014) 0.76
Functional genomics of human brain development and implications for autism spectrum disorders. Transl Psychiatry (2015) 0.76
Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue. Transl Psychiatry (2016) 0.76
Prolonged ovarian hormone deprivation alters the effects of 17β-estradiol on microRNA expression in the aged female rat hypothalamus. Oncotarget (2015) 0.76
Decoding human gene expression signatures in the brain. Transcription (2013) 0.76
Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. PLoS One (2015) 0.76
Accelerated aging-related transcriptome changes in the female prefrontal cortex. Aging Cell (2012) 0.76
Shared signatures of social stress and aging in peripheral blood mononuclear cell gene expression profiles. Aging Cell (2014) 0.75
Absence of mutation in miR-34a gene in a Chinese longevity population. Dongwuxue Yanjiu (2015) 0.75
MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging. BMC Biol (2017) 0.75
Mechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional content. PLoS One (2012) 0.75
A nutrigenomics approach for the study of anti-aging interventions: olive oil phenols and the modulation of gene and microRNA expression profiles in mouse brain. Eur J Nutr (2015) 0.75
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
KEGG for linking genomes to life and the environment. Nucleic Acids Res (2007) 49.37
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res (2005) 44.08
miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res (2006) 39.25
The impact of microRNAs on protein output. Nature (2008) 32.39
affy--analysis of Affymetrix GeneChip data at the probe level. Bioinformatics (2004) 32.08
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci (2008) 17.27
Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature (2009) 14.07
Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol (2008) 12.35
MATCH: A tool for searching transcription factor binding sites in DNA sequences. Nucleic Acids Res (2003) 11.82
A brain-specific microRNA regulates dendritic spine development. Nature (2006) 10.18
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A (2007) 9.82
Regional differences in synaptogenesis in human cerebral cortex. J Comp Neurol (1997) 9.09
Gene regulation and DNA damage in the ageing human brain. Nature (2004) 9.01
Comparison of label-free methods for quantifying human proteins by shotgun proteomics. Mol Cell Proteomics (2005) 8.14
Mass spectrometry and protein analysis. Science (2006) 8.05
When does age-related cognitive decline begin? Neurobiol Aging (2009) 7.85
miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A (2008) 6.24
Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees. Science (2005) 5.68
The database of experimentally supported targets: a functional update of TarBase. Nucleic Acids Res (2008) 5.65
Gene-expression profile of the ageing brain in mice. Nat Genet (2000) 5.46
Regulation of miRNA expression during neural cell specification. Eur J Neurosci (2005) 5.27
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A (2008) 5.24
Analysis and validation of proteomic data generated by tandem mass spectrometry. Nat Methods (2007) 5.10
An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell (2008) 4.72
Determinants of substitution rates in mammalian genes: expression pattern affects selection intensity but not mutation rate. Mol Biol Evol (2000) 4.70
NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell (2008) 4.57
Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. Radiology (2000) 4.31
A developmental timing microRNA and its target regulate life span in C. elegans. Science (2005) 4.24
Estimating accuracy of RNA-Seq and microarrays with proteomics. BMC Genomics (2009) 3.87
A transcriptional profile of aging in the human kidney. PLoS Biol (2004) 3.69
Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nat Biotechnol (2009) 3.66
Mapping brain maturation. Trends Neurosci (2006) 3.60
Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics (2009) 3.50
Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet (2006) 3.34
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
A database of vertebrate longevity records and their relation to other life-history traits. J Evol Biol (2009) 2.93
Mapping changes in the human cortex throughout the span of life. Neuroscientist (2004) 2.86
A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. Mol Cancer Res (2008) 2.77
microRNAs at the synapse. Nat Rev Neurosci (2009) 2.66
Growth rates and life histories in twenty-two small-scale societies. Am J Hum Biol (2006) 2.37
Evolution of the aging brain transcriptome and synaptic regulation. PLoS One (2008) 2.23
The human REV1 gene codes for a DNA template-dependent dCMP transferase. Nucleic Acids Res (1999) 2.10
Molecular aging in human prefrontal cortex is selective and continuous throughout adult life. Biol Psychiatry (2005) 2.06
Ontogeny of the human central nervous system: what is happening when? Early Hum Dev (2005) 1.85
Transcriptional neoteny in the human brain. Proc Natl Acad Sci U S A (2009) 1.78
Sequence features associated with microRNA strand selection in humans and flies. BMC Genomics (2009) 1.76
Transcriptional regulation of vertebrate axon guidance and synapse formation. Nat Rev Neurosci (2007) 1.69
A modular network model of aging. Mol Syst Biol (2007) 1.68
miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Res Bull (2009) 1.66
Synaptophysin and postsynaptic density protein 95 in the human prefrontal cortex from mid-gestation into early adulthood. Neuroscience (2007) 1.56
Synapses are lost during aging in the primate prefrontal cortex. Neuroscience (2007) 1.50
Neuroimaging studies of normal brain development and their relevance for understanding childhood neuropsychiatric disorders. J Am Acad Child Adolesc Psychiatry (2008) 1.36
Functional maturation of excitatory synapses in layer 3 pyramidal neurons during postnatal development of the primate prefrontal cortex. Cereb Cortex (2007) 1.27
Abnormal sympathetic nervous system development and physiological dysautonomia in Egr3-deficient mice. Development (2008) 1.19
Genomes optimize reproduction: aging as a consequence of the developmental program. Physiology (Bethesda) (2005) 1.16
The regulation of physiological changes during mammalian aging. Q Rev Biol (1976) 0.99
Evolution of brain size and juvenile periods in primates. J Hum Evol (2006) 0.92
MicroRNA expression profile in murine central nervous system development. J Mol Neurosci (2008) 0.92
Comparative proteomic profiling of membrane proteins in rat cerebellum, spinal cord, and sciatic nerve. J Proteome Res (2009) 0.90
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
A genome-wide association study of global gene expression. Nat Genet (2007) 22.98
Global quantification of mammalian gene expression control. Nature (2011) 22.36
The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data. Nat Biotechnol (2004) 16.08
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature (2004) 12.72
Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet (2012) 10.53
Discovering microRNAs from deep sequencing data using miRDeep. Nat Biotechnol (2008) 10.17
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
Multiscale mobility networks and the spatial spreading of infectious diseases. Proc Natl Acad Sci U S A (2009) 8.88
Intra- and interspecific variation in primate gene expression patterns. Science (2002) 7.92
Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: who benefits and by how much? J Clin Oncol (2004) 7.36
CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature (2006) 7.17
The evolution of gene expression levels in mammalian organs. Nature (2011) 7.16
Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med (2011) 7.16
Cubic AgPb(m)SbTe(2+m): bulk thermoelectric materials with high figure of merit. Science (2004) 7.07
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev (2007) 6.71
Altered histone acetylation is associated with age-dependent memory impairment in mice. Science (2010) 6.38
Patterns of damage in genomic DNA sequences from a Neandertal. Proc Natl Acad Sci U S A (2007) 6.12
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science (2010) 6.04
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science (2007) 6.04
A human snoRNA with microRNA-like functions. Mol Cell (2008) 5.84
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83
Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees. Science (2005) 5.68
A genome-wide comparison of recent chimpanzee and human segmental duplications. Nature (2005) 5.51
Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science (2005) 5.50
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet (2002) 5.38
Clinical findings in 111 cases of influenza A (H7N9) virus infection. N Engl J Med (2013) 5.38
Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. Hum Mol Genet (2007) 5.28
Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum (2005) 5.18
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature (2003) 5.04
dbCAN: a web resource for automated carbohydrate-active enzyme annotation. Nucleic Acids Res (2012) 4.91
Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study. JAMA (2003) 4.88
Deep sequencing reveals 50 novel genes for recessive cognitive disorders. Nature (2011) 4.85
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell (2005) 4.83
Regulation of PTEN by Rho small GTPases. Nat Cell Biol (2005) 4.51
Seasonal transmission potential and activity peaks of the new influenza A(H1N1): a Monte Carlo likelihood analysis based on human mobility. BMC Med (2009) 4.47
Operon prediction using both genome-specific and general genomic information. Nucleic Acids Res (2006) 4.41
Sequence and analysis of rice chromosome 4. Nature (2002) 4.39
Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy. Hum Mol Genet (2006) 4.35
Ligand configurational entropy and protein binding. Proc Natl Acad Sci U S A (2007) 4.33
Transmit and receive transmission line arrays for 7 Tesla parallel imaging. Magn Reson Med (2005) 4.25
Fast mapping of short sequences with mismatches, insertions and deletions using index structures. PLoS Comput Biol (2009) 4.24
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16
Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann Neurol (2011) 4.09
Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres. Nature (2012) 4.00
Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity (2004) 4.00
Estimating accuracy of RNA-Seq and microarrays with proteomics. BMC Genomics (2009) 3.87
Regional patterns of gene expression in human and chimpanzee brains. Genome Res (2004) 3.84
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet (2008) 3.71
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat Immunol (2004) 3.65
Intradiscal injection therapy for degenerative chronic discogenic low back pain with end plate Modic changes. Spine J (2010) 3.55
Array CGH identifies reciprocal 16p13.1 duplications and deletions that predispose to autism and/or mental retardation. Hum Mutat (2007) 3.52
DOOR: a database for prokaryotic operons. Nucleic Acids Res (2008) 3.50
A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A (2007) 3.50
A neutral model of transcriptome evolution. PLoS Biol (2004) 3.44
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet (2007) 3.39
The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex. Nat Genet (2013) 3.39
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
E2-2 protein and Fuchs's corneal dystrophy. N Engl J Med (2010) 3.31
Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals. Am J Hum Genet (2010) 3.28
Rise in insulin resistance is associated with escalated telomere attrition. Circulation (2005) 3.27
Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase. Proc Natl Acad Sci U S A (2007) 3.27
Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells. Cell (2012) 3.26
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. Nat Genet (2010) 3.24
Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study. Aging Cell (2008) 3.24
A probabilistic disease-gene finder for personal genomes. Genome Res (2011) 3.23
The transcriptional repressor DEC2 regulates sleep length in mammals. Science (2009) 3.12
Beta-arrestin-mediated localization of smoothened to the primary cilium. Science (2008) 3.10
Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. J Immunol (2004) 3.10
Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy. Proc Natl Acad Sci U S A (2006) 3.09
Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis. J Mol Biol (2004) 3.05
Evolution of primate gene expression. Nat Rev Genet (2006) 3.04
Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells (2007) 3.04
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature (2013) 3.00
Aligned single-crystalline Si nanowire arrays for photovoltaic applications. Small (2005) 2.98
Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell (2007) 2.96
Great ape genetic diversity and population history. Nature (2013) 2.95
Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol (2008) 2.86
Racial diversity of actionable mutations in non-small cell lung cancer. J Thorac Oncol (2015) 2.80
Preperitoneal single-port transvesical enucleation of the prostate (STEP) for large-volume BPH: one-year follow-up of Qmax, IPSS, and QoL. Urology (2012) 2.78
Atrial Fibrillation Is an Independent Predictor of Mortality in Critically Ill Patients. Crit Care Med (2015) 2.77
PatMaN: rapid alignment of short sequences to large databases. Bioinformatics (2008) 2.77
Single-incision transaxillary robotic thyroidectomy: challenges and limitations in a North American population. Otolaryngol Head Neck Surg (2012) 2.76
Mapping translocation breakpoints by next-generation sequencing. Genome Res (2008) 2.73
Prognostic and predictive value of a microRNA signature in stage II colon cancer: a microRNA expression analysis. Lancet Oncol (2013) 2.67
A maximum entropy model applied to spatial and temporal correlations from cortical networks in vitro. J Neurosci (2008) 2.65
PRIMEGENS: robust and efficient design of gene-specific probes for microarray analysis. Bioinformatics (2002) 2.65