Published in Antioxid Redox Signal on October 25, 2010
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat Med (2012) 2.86
FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol (2013) 2.83
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy. Nat Cell Biol (2012) 1.63
FOXO transcription factors throughout T cell biology. Nat Rev Immunol (2012) 1.60
Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS One (2010) 1.41
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control. Genes Cancer (2010) 1.38
Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol (2013) 1.24
Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. J Biol Chem (2011) 1.23
FOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms. PLoS Pathog (2012) 1.22
FOXO transcription factors: their clinical significance and regulation. Biomed Res Int (2014) 1.14
Retracted Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nat Immunol (2013) 1.09
FOXO1, TGF-β regulation and wound healing. Int J Mol Sci (2014) 1.07
Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor. PLoS One (2010) 1.04
Isotretinoin and FoxO1: A scientific hypothesis. Dermatoendocrinol (2011) 1.02
Proline oxidase-adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation. Cell Death Differ (2013) 0.99
Aging and dry eye disease. Exp Gerontol (2012) 0.97
Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne. Exp Dermatol (2013) 0.95
FoxO transcription factors support oxidative stress resistance in human chondrocytes. Arthritis Rheumatol (2014) 0.92
A genome-wide RNAi screen identifies FOXO4 as a metastasis-suppressor through counteracting PI3K/AKT signal pathway in prostate cancer. PLoS One (2014) 0.91
Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients. Oncotarget (2014) 0.90
Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1? Exp Dermatol (2013) 0.88
Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase. Arthritis Rheumatol (2014) 0.87
Delineation of the key aspects in the regulation of epithelial monolayer formation. Mol Cell Biol (2013) 0.87
AKT/PKB Signaling: Navigating the Network. Cell (2017) 0.87
Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay. EMBO Mol Med (2013) 0.85
A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes. Breast Cancer Res (2014) 0.85
A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. Aging Cell (2013) 0.84
FoxO4 inhibits atherosclerosis through its function in bone marrow derived cells. Atherosclerosis (2011) 0.83
The redox biology network in cancer pathophysiology and therapeutics. Redox Biol (2015) 0.83
Selective insulin resistance in adipocytes. J Biol Chem (2015) 0.83
FOXO1 mediates RANKL-induced osteoclast formation and activity. J Immunol (2015) 0.81
Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy. J Cell Sci (2015) 0.81
Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes. Cell Physiol Biochem (2015) 0.80
Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo. J Exp Clin Cancer Res (2015) 0.80
FOXO3a and the MAPK p38 are activated by cetuximab to induce cell death and inhibit cell proliferation and their expression predicts cetuximab efficacy in colorectal cancer. Br J Cancer (2016) 0.79
Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. J Clin Invest (2016) 0.79
Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. PLoS One (2014) 0.78
UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation. Cancer Biol Ther (2015) 0.78
FoxO3a is an antimelanogenic factor that mediates antioxidant-induced depigmentation. J Invest Dermatol (2013) 0.78
A Genome-Wide mRNA Screen and Functional Analysis Reveal FOXO3 as a Candidate Gene for Chicken Growth. PLoS One (2015) 0.77
Towards understanding the lifespan extension by reduced insulin signaling: bioinformatics analysis of DAF-16/FOXO direct targets in Caenorhabditis elegans. Oncotarget (2016) 0.77
The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia. Curr Gerontol Geriatr Res (2012) 0.77
GABARAPL1 suppresses metastasis by counteracting PI3K/Akt pathway in prostate cancer. Oncotarget (2016) 0.77
Signaling via PI3K/FOXO1A pathway modulates formation and survival of human embryonic stem cell-derived endothelial cells. Stem Cells Dev (2014) 0.77
Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy. Cardiovasc Diabetol (2016) 0.77
Global identification of genes and pathways regulated by Akt during activation of T helper cells. F1000Res (2013) 0.77
Transcription-Factor-Dependent Control of Adult Hippocampal Neurogenesis. Cold Spring Harb Perspect Biol (2015) 0.76
Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium. Nat Commun (2016) 0.76
Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes. Immunity (2016) 0.76
IGF-1-induced enhancement of PRNP expression depends on the negative regulation of transcription factor FOXO3a. PLoS One (2013) 0.76
Tanshinone IIA Modulates Low Density Lipoprotein Uptake via Down-Regulation of PCSK9 Gene Expression in HepG2 Cells. PLoS One (2016) 0.75
Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a. Intrinsically Disord Proteins (2015) 0.75
Novel effects of Brefeldin A (BFA) in signaling through the insulin receptor (IR) pathway and regulating FoxO1-mediated transcription. Cell Logist (2014) 0.75
Spatiotemporal expression of foxo4, foxo6a, and foxo6b in the developing brain and retina are transcriptionally regulated by PI3K signaling in zebrafish. Dev Genes Evol (2017) 0.75
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature (2002) 7.88
The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol (2002) 4.85
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol (2003) 4.31
FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem (2003) 3.41
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J Cell Biol (2002) 2.86
Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol Cell Biol (2002) 2.84
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood (2009) 2.49
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity (2013) 2.05
The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. J Biol Chem (2009) 2.05
Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. Immunity (2013) 1.75
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy. Nat Cell Biol (2012) 1.63
FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. Mol Cell Biol (2004) 1.63
Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy. Blood (2012) 1.61
MAPK signaling pathways in the regulation of hematopoiesis. J Leukoc Biol (2009) 1.60
The role of the PI3K-PKB signaling module in regulation of hematopoiesis. Cell Cycle (2009) 1.55
HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation. Blood (2008) 1.54
FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. J Cell Biol (2004) 1.51
FOXO transcription factors as regulators of immune homeostasis: molecules to die for? J Immunol (2003) 1.44
FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1. J Biol Chem (2006) 1.40
Respiratory syncytial virus inhibits granulocyte apoptosis through a phosphatidylinositol 3-kinase and NF-kappaB-dependent mechanism. J Immunol (2006) 1.40
Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complex. Mol Biol Cell (2004) 1.39
The ins and outs of syntenin, a multifunctional intracellular adaptor protein. J Cell Sci (2008) 1.38
Rapid temporal control of Foxp3 protein degradation by sirtuin-1. PLoS One (2011) 1.31
Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression. Blood (2002) 1.26
Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells. Blood (2011) 1.24
Induction of prosurvival molecules by apoptotic stimuli: involvement of FOXO3a and ROS. Oncogene (2005) 1.23
Statin synergizes with LPS to induce IL-1beta release by THP-1 cells through activation of caspase-1. Mol Immunol (2008) 1.22
Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation. Cancer Res (2007) 1.15
Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion. J Biol Chem (2013) 1.15
Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2. Blood (2005) 1.13
Canonical Wnt signaling negatively modulates regulatory T cell function. Immunity (2013) 1.13
Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis. Blood (2007) 1.11
Chronic protein kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation. Cancer Res (2006) 1.10
Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function. Blood (2005) 1.07
Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells. Blood (2002) 1.06
Signal inhibitory receptor on leukocytes-1 is a novel functional inhibitory immune receptor expressed on human phagocytes. J Immunol (2010) 1.01
Src kinases regulate PKB activation and modulate cytokine and chemoattractant-controlled neutrophil functioning. J Leukoc Biol (2002) 1.01
Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes. J Immunol (2004) 1.00
Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors. Blood (2009) 1.00
Differential expression of leukocyte-associated Ig-like receptor-1 during neutrophil differentiation and activation. J Leukoc Biol (2006) 1.00
SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition. PLoS One (2013) 1.00
Signal transducer and activator of transcription 5 (STAT5). Int J Biochem Cell Biol (2004) 0.96
Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60. Nat Commun (2013) 0.94
Stressed marrow: FoxOs stem tumour growth. Nat Cell Biol (2007) 0.94
Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions. Comparison with the role of phosphotidylinositol-3 kinase. Eur J Biochem (2002) 0.93
Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum (2009) 0.92
p38 MAP kinase inhibits neutrophil development through phosphorylation of C/EBPalpha on serine 21. Stem Cells (2009) 0.92
Signal inhibitory receptor on leukocytes-1 (SIRL-1) negatively regulates the oxidative burst in human phagocytes. Eur J Immunol (2013) 0.92
IL-5-mediated eosinophil survival requires inhibition of GSK-3 and correlates with beta-catenin relocalization. J Leukoc Biol (2006) 0.91
STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass. PLoS One (2012) 0.91
PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function. Blood (2012) 0.91
The reduced GM-CSF priming of ROS production in granulocytes from patients with myelodysplasia is associated with an impaired lipid raft formation. J Leukoc Biol (2006) 0.88
Glutamine metabolism links growth factor signaling to the regulation of autophagy. Autophagy (2012) 0.86
The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity. Biochem J (2013) 0.85
Regulation of autophagy by Forkhead box (FOX) O transcription factors. Adv Biol Regul (2012) 0.84
Protein kinase B (PKB/c-akt) regulates homing of hematopoietic progenitors through modulation of their adhesive and migratory properties. Blood (2010) 0.83
Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling. J Immunol (2010) 0.83
Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation. Haematologica (2010) 0.83
A nonredundant role for canonical NF-κB in human myeloid dendritic cell development and function. J Immunol (2010) 0.83
Cytokine mediated suppression of TF-1 apoptosis requires PI3K activation and inhibition of Bim expression. FEBS Lett (2005) 0.82
Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output. Blood (2009) 0.81
Mammalian target of rapamycin activity is required for expansion of CD34+ hematopoietic progenitor cells. Haematologica (2009) 0.81
Tight control of STAT5 activity determines human CD34-derived interstitial dendritic cell and langerhans cell development. J Immunol (2011) 0.80
Survival, but not maturation, is affected in neutrophil progenitors from GSD-1b patients. J Inherit Metab Dis (2011) 0.80
Transcriptional regulation of lymphocyte quiescence: as cunning as a FOX. Trends Immunol (2003) 0.78
Ectopic expression of C/EBPalpha and ID1 is sufficient to restore defective neutrophil development in low-risk myelodysplasia. Haematologica (2009) 0.78
Hepatic autophagy is differentially regulated in periportal and pericentral zones - a general mechanism relevant for other tissues? Cell Commun Signal (2013) 0.78
Co-expression of the collagen receptors leukocyte-associated immunoglobulin-like receptor-1 and glycoprotein VI on a subset of megakaryoblasts. Haematologica (2010) 0.76
c-Jun activating binding protein 1 binds to the IgA receptor and modulates protein levels of FcalphaRI and FcRgamma-chain. Eur J Immunol (2010) 0.76
Valproic acid treatment is associated with altered leukocyte subset development. J Clin Psychopharmacol (2012) 0.75
Functional analysis of the interleukin-5 receptor antagonist peptide, AF18748. Cytokine (2004) 0.75