Vaccines delivered by integration-deficient lentiviral vectors targeting dendritic cells induces strong antigen-specific immunity.

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Published in Vaccine on August 13, 2010

Authors

Biliang Hu1, Bingbing Dai, Pin Wang

Author Affiliations

1: Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089, USA.

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Dendritic cells and the control of immunity. Nature (1998) 56.54

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