Published in Oncogene on August 16, 2010
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet (2012) 7.00
Lifetime cancer risks in individuals with germline PTEN mutations. Clin Cancer Res (2012) 3.33
Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma. J Clin Invest (2013) 1.12
PTEN regulation of ERK1/2 signaling in cancer. J Recept Signal Transduct Res (2012) 1.05
The evolving role of radiation therapy in the management of malignant melanoma. Int J Radiat Oncol Biol Phys (2011) 1.04
Decoding melanoma metastasis. Cancers (Basel) (2010) 1.02
AKT1 Activation Promotes Development of Melanoma Metastases. Cell Rep (2015) 1.00
A tumor suppressor function for the lipid phosphatase INPP4B in melanocytic neoplasms. J Invest Dermatol (2013) 0.97
A phosphatidylinositol 3-kinase-Pax3 axis regulates Brn-2 expression in melanoma. Mol Cell Biol (2012) 0.95
N-cadherin regulates mammary tumor cell migration through Akt3 suppression. Oncogene (2012) 0.93
Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma. Clin Cancer Res (2013) 0.93
Genetics of melanoma. Front Genet (2013) 0.91
Functional effects of GRM1 suppression in human melanoma cells. Mol Cancer Res (2012) 0.91
The Akt signaling pathway: an emerging therapeutic target in malignant melanoma. Cancer Biol Ther (2011) 0.89
Future of radiation therapy for malignant melanoma in an era of newer, more effective biological agents. Onco Targets Ther (2011) 0.88
RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression. Mol Cancer (2015) 0.87
Metabotropic glutamate receptor 1 mediates melanocyte transformation via transactivation of insulin-like growth factor 1 receptor. Pigment Cell Melanoma Res (2014) 0.85
Therapeutic Implications of Targeting AKT Signaling in Melanoma. Enzyme Res (2011) 0.85
Targeting sphingosine kinase-1 to inhibit melanoma. Pigment Cell Melanoma Res (2012) 0.85
High-expression of DJ-1 and loss of PTEN associated with tumor metastasis and correlated with poor prognosis of gastric carcinoma. Int J Med Sci (2013) 0.84
mGlu Receptors and Cancerous Growth. Wiley Interdiscip Rev Membr Transp Signal (2011) 0.84
The transcription factor ATF2 promotes melanoma metastasis by suppressing protein fucosylation. Sci Signal (2015) 0.80
Chromosome 10, frequently lost in human melanoma, encodes multiple tumor-suppressive functions. Cancer Res (2014) 0.80
A majority of human melanoma cell lines exhibits an S phase-specific defect in excision of UV-induced DNA photoproducts. PLoS One (2014) 0.80
Animal models of melanoma: a somatic cell gene delivery mouse model allows rapid evaluation of genes implicated in human melanoma. Chin J Cancer (2011) 0.79
The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations. Pigment Cell Melanoma Res (2016) 0.79
Directed migration of cancer cells guided by the graded texture of the underlying matrix. Nat Mater (2016) 0.78
The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma. Oncotarget (2016) 0.78
Phytochemicals for the Management of Melanoma. Mini Rev Med Chem (2016) 0.77
Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers. Cell Adh Migr (2016) 0.77
Activating PIK3CA mutations coexist with BRAF or NRAS mutations in a limited fraction of melanomas. J Transl Med (2015) 0.77
WNT/β-catenin signaling regulates mitochondrial activity to alter the oncogenic potential of melanoma in a PTEN-dependent manner. Oncogene (2017) 0.77
Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis. Small GTPases (2010) 0.76
Active β-catenin is regulated by the PTEN/PI3 kinase pathway: a role for protein phosphatase PP2A. Genes Cancer (2016) 0.75
Mutations of the BRAF gene in human cancer. Nature (2002) 65.42
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (1997) 29.34
The Catalogue of Somatic Mutations in Cancer (COSMIC). Curr Protoc Hum Genet (2008) 16.09
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet (1997) 15.38
Pten is essential for embryonic development and tumour suppression. Nat Genet (1998) 13.41
Role of the INK4a locus in tumor suppression and cell mortality. Cell (1996) 11.41
High frequency of BRAF mutations in nevi. Nat Genet (2002) 9.95
Tenets of PTEN tumor suppression. Cell (2008) 8.61
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell (2003) 8.11
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A (1999) 7.88
Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet (2009) 7.81
Pten dose dictates cancer progression in the prostate. PLoS Biol (2003) 7.62
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer (2006) 7.53
Essential role for oncogenic Ras in tumour maintenance. Nature (1999) 6.51
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell (2007) 6.44
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol (1998) 6.38
Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer Res (2008) 5.95
Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nat Med (2004) 4.98
Oncogenic Braf induces melanocyte senescence and melanoma in mice. Cancer Cell (2009) 4.76
Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell (2006) 4.68
Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev (2006) 4.24
Deregulated Akt3 activity promotes development of malignant melanoma. Cancer Res (2004) 3.80
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. J Invest Dermatol (2004) 3.80
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci U S A (2003) 3.34
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice. Cancer Res (2000) 3.24
Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res (1997) 2.98
PTEN, more than the AKT pathway. Carcinogenesis (2007) 2.70
A novel AKT3 mutation in melanoma tumours and cell lines. Br J Cancer (2008) 2.63
The Akt kinases: isoform specificity in metabolism and cancer. Cell Cycle (2009) 2.62
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev (1997) 2.47
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci U S A (2006) 2.41
MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal (2009) 2.38
Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. Cancer Res (2002) 2.19
Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. Cancer Res (2005) 2.19
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem (1999) 2.07
Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. Cancer Res (2000) 1.96
Use of human tissue to assess the oncogenic activity of melanoma-associated mutations. Nat Genet (2005) 1.90
Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background. Cancer Res (2005) 1.84
Dual inactivation of RB and p53 pathways in RAS-induced melanomas. Mol Cell Biol (2001) 1.73
Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice. Oncogene (2009) 1.66
TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN. J Cell Sci (2005) 1.63
Implication of the MAGI-1b/PTEN signalosome in stabilization of adherens junctions and suppression of invasiveness. FASEB J (2004) 1.61
Epigenetic silencing of the PTEN gene in melanoma. Cancer Res (2006) 1.58
Loss of PTEN promotes tumor development in malignant melanoma. Cancer Res (2003) 1.58
Retracted AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. J Biol Chem (2003) 1.49
Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. Proc Natl Acad Sci U S A (2002) 1.30
Complementation of hypopigmentation in p-mutant (pink-eyed dilution) mouse melanocytes by normal human P cDNA, and defective complementation by OCA2 mutant sequences. J Invest Dermatol (1997) 1.29
Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo. Oncogene (2003) 1.29
Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies. J Invest Dermatol (2000) 1.12
Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer. Oncol Rep (2000) 1.05
Analysis of ras mutations in human melanocytic lesions: activation of the ras gene seems to be associated with the nodular type of human malignant melanoma. J Cancer Res Clin Oncol (1995) 1.02
Methylation of PTEN as a prognostic factor in malignant melanoma of the skin. J Invest Dermatol (2009) 0.99
Role of epidermal growth factor receptor signaling in RAS-driven melanoma. Mol Cell Biol (2005) 0.90
Role of the INK4a locus in tumor suppression and cell mortality. Cell (1996) 11.41
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell (1998) 8.33
Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature (1997) 7.66
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature (2000) 7.28
Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain. Genes Dev (2001) 4.64
CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am J Respir Cell Mol Biol (1994) 4.62
Roles for Nkx3.1 in prostate development and cancer. Genes Dev (1999) 4.30
The public versus the World Health Organization on health system performance. Health Aff (Millwood) (2001) 3.96
An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell (1995) 3.68
"Occult" hepatitis B virus as source of infection in liver transplant recipients. Lancet (1994) 3.33
Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. J Neurosci (2000) 3.16
HCV-related fibrosis progression following liver transplantation: increase in recent years. J Hepatol (2000) 2.60
Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc. J Biol Chem (1999) 2.51
Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene (1998) 2.49
Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell (1999) 2.46
Decreased number and function of endothelial progenitor cells in patients with migraine. Neurology (2008) 2.44
Fear-potentiated startle: a neural and pharmacological analysis. Behav Brain Res (1993) 2.43
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet (2000) 2.34
Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. J Biol Chem (1997) 2.34
Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene (1999) 2.34
Nanoscale nuclear magnetic resonance with a nitrogen-vacancy spin sensor. Science (2013) 2.33
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery. Br J Anaesth (2010) 2.32
lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H). Development (1996) 2.20
Recurrent and acquired hepatitis C viral infection in liver transplant recipients. Gastroenterology (1992) 2.09
Classification and definition of major flares in SLE clinical trials. Lupus (1999) 2.02
Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Obstet Gynecol (2001) 1.95
HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. Proc Natl Acad Sci U S A (2001) 1.89
Telomere dysfunction triggers developmentally regulated germ cell apoptosis. Mol Biol Cell (2001) 1.85
Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways. Exp Neurol (1998) 1.85
Serotyping of primary human immunodeficiency virus type 1 isolates from diverse geographic locations by flow cytometry. J Virol (1995) 1.80
Hereditary adult-onset Alexander's disease with palatal myoclonus, spastic paraparesis, and cerebellar ataxia. Neurology (1995) 1.79
Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection. Mucosal Immunol (2010) 1.78
Liquid water in frozen tissue: study by nuclear magnetic resonance. Science (1966) 1.77
Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors. Cell (1999) 1.75
The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. Am J Obstet Gynecol (2000) 1.74
Dual inactivation of RB and p53 pathways in RAS-induced melanomas. Mol Cell Biol (2001) 1.73
Dominant mobility modulation by the electric field effect at the LaAlO3/SrTiO3 interface. Phys Rev Lett (2009) 1.72
DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status. Leukemia (2008) 1.70
Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Mol Cell (2001) 1.68
Determinants of patient satisfaction in postmastectomy breast reconstruction. Plast Reconstr Surg (2000) 1.67
Effect of influenza viral infection on the ingestion and killing of bacteria by alveolar macrophages. Am Rev Respir Dis (1977) 1.64
Hepatitis B virus and apparent fulminant non-A, non-B hepatitis. Lancet (1992) 1.63
Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma. Br J Cancer (2008) 1.59
A nested case-control study of mammographic patterns, breast volume, and breast cancer (New York City, NY, United States). Cancer Causes Control (1995) 1.59
Host cell-dependent alterations in envelope components of human immunodeficiency virus type 1 virions. J Virol (1997) 1.59
Comparative study of Contour Transtar and STARR procedure for the treatment of obstructed defecation syndrome (ODS)--feasibility, morbidity and early functional results. Colorectal Dis (2009) 1.58
Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology. Diabetes (2007) 1.57
Clinical implications of detection of Ureaplasma urealyticum in the amniotic cavity with the polymerase chain reaction. Am J Obstet Gynecol (2000) 1.57
Meeting report from the 7th International Melanoma Congress, Sydney, November, 2010. Pigment Cell Melanoma Res (2010) 1.55
A mutation of the Wilson disease protein, ATP7B, is degraded in the proteasomes and forms protein aggregates. Gastroenterology (2001) 1.53
Enterococcus avium bacteremia: a 12-year clinical experience with 53 patients. Eur J Clin Microbiol Infect Dis (2011) 1.53
Seroprevalence of herpes simplex virus infections in a family medicine clinic. Arch Fam Med (1995) 1.52
Reduced circulating angiogenic cells in Alzheimer disease. Neurology (2009) 1.52
Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27. Cancer Res (1997) 1.50
Patient-specific computational hemodynamics of intracranial aneurysms from 3D rotational angiography and CT angiography: an in vivo reproducibility study. AJNR Am J Neuroradiol (2010) 1.49
Evolution of hepatitis C virus quasispecies in patients with severe cholestatic hepatitis after liver transplantation. Hepatology (1999) 1.48
Two-dimensional normal-state quantum oscillations in a superconducting heterostructure. Nature (2009) 1.47
In situ observation of filamentary conducting channels in an asymmetric Ta₂O5-x/TaO2-x bilayer structure. Nat Commun (2013) 1.46
Full-thickness burn to the hand from an automobile airbag. J Burn Care Rehabil (1999) 1.46
Recurrent focal segmental glomerulosclerosis following renal transplantation in Korean pediatric patients. Pediatr Transplant (2001) 1.45
Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure. Kidney Int (1999) 1.45
Does birthweight predict bone mass in adulthood? A systematic review and meta-analysis. Osteoporos Int (2010) 1.44
Mathematical description of a bursting pacemaker neuron by a modification of the Hodgkin-Huxley equations. Biophys J (1976) 1.42
A system for the propagation of adenoviral vectors with genetically modified receptor specificities. Nat Biotechnol (1999) 1.39
Determination of homocysteine and its related compounds by solid-phase microextraction-gas chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl (1999) 1.38
A 50-year-old male with diabetes mellitus, peripheral neuropathy, hypothyroidism, obesity, sleep disorder, pickwickian syndrome, and heart failure. Mt Sinai J Med (1998) 1.38
Quantitation of hepatitis C virus RNA in liver transplant recipients. Gastroenterology (1994) 1.37
A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells. Oncogene (1997) 1.36
Expression and activity of L-Myc in normal mouse development. Mol Cell Biol (1996) 1.36
Fluid shear stress activation of IkappaB kinase is integrin-dependent. J Biol Chem (1998) 1.33
Lytic anti-endothelial cell antibodies in haemolytic-uraemic syndrome. Lancet (1988) 1.33
A novel light-regulated promoter is conserved in cereal and dicot chloroplasts. Plant Cell (1992) 1.31
Characteristics of the binding of labeled fluoromisonidazole in cells in vitro. Radiat Res (1990) 1.29
Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma. Cold Spring Harb Symp Quant Biol (2009) 1.29
Dlk1 in normal and abnormal hematopoiesis. Leukemia (2005) 1.28
Expression, purification, and characterization of gp160e, the soluble, trimeric ectodomain of the simian immunodeficiency virus envelope glycoprotein, gp160. J Biol Chem (2000) 1.26
Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome. Proc Natl Acad Sci U S A (2001) 1.24
Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor. EMBO J (1996) 1.23
Microsatellite instability occurs in distinct subtypes of pediatric but not adult central nervous system tumors. Cancer Res (2001) 1.23
Myxoma virus targets primary human leukemic stem and progenitor cells while sparing normal hematopoietic stem and progenitor cells. Leukemia (2009) 1.22
Saccular aneurysms on straight and curved vessels are subject to different hemodynamics: implications of intravascular stenting. AJNR Am J Neuroradiol (2006) 1.22
Inhibitory effects of green tea polyphenols on growth and cellular adherence of an oral bacterium, Porphyromonas gingivalis. Biosci Biotechnol Biochem (1996) 1.20
Efficient oncolysis by a replicating adenovirus (ad) in vivo is critically dependent on tumor expression of primary ad receptors. Cancer Res (2001) 1.20
Renal tubule necrosis and apoptosis modulation by A1 adenosine receptor expression. Kidney Int (2007) 1.20
Optimal antidotal dose of activated charcoal. Toxicol Appl Pharmacol (1973) 1.20
Efficacy of primary chemoprophylaxis against Pneumocystis carinii pneumonia during the first year of life in infants infected with human immunodeficiency virus type 1. J Pediatr (1994) 1.20
Occurence of a sialylglycopeptide and free sialylglycans in hen's egg yolk. Biochim Biophys Acta (1997) 1.18
Successful orthotopic liver transplantation for lamivudine-associated YMDD mutant hepatitis B virus. Gastroenterology (2000) 1.17
Chronic ethanol causes heterologous desensitization of receptors by reducing alpha s messenger RNA. Nature (1988) 1.17
Low-temperature synthesis of graphene on nickel foil by microwave plasma chemical vapor deposition. Appl Phys Lett (2011) 1.16
Augmentation of lower esophageal sphincter pressure and gastric yield pressure after radiofrequency energy delivery to the gastroesophageal junction: a porcine model. Gastrointest Endosc (2000) 1.16
Bleach use and HIV seroconversion among New York City injection drug users. J Acquir Immune Defic Syndr (1994) 1.15
The pattern and prevalence of hypodontia in Koreans. Oral Dis (2008) 1.14
The treatment of attention-deficit hyperactivity disorder: an annotated bibliography and critical appraisal of published systematic reviews and metaanalyses. Can J Psychiatry (1999) 1.13
Giant flexoelectric effect in ferroelectric epitaxial thin films. Phys Rev Lett (2011) 1.13
Reduction of cardiac volume in left-breast treatment fields by respiratory maneuvers: a CT study. Int J Radiat Oncol Biol Phys (2000) 1.13
Molecular sorting in polarized and non-polarized cells: common problems, common solutions. J Cell Sci Suppl (1993) 1.12
Murine pulmonary alveolar macrophages: rates of bacterial ingestion, inactivation, and destruction. J Infect Dis (1976) 1.12
Elliptic flow of charged particles in Pb-Pb collisions at sqrt[S(NN)] = 2.76 TeV. Phys Rev Lett (2010) 1.12