Published in PLoS Genet on August 12, 2010
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Genetic studies of body mass index yield new insights for obesity biology. Nature (2015) 8.27
Discovery and refinement of loci associated with lipid levels. Nat Genet (2013) 7.86
Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature (2013) 6.57
Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet (2014) 5.78
The Lin28/let-7 axis regulates glucose metabolism. Cell (2011) 4.65
New genetic loci link adipose and insulin biology to body fat distribution. Nature (2015) 3.38
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Interpreting noncoding genetic variation in complex traits and human disease. Nat Biotechnol (2012) 3.01
JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity (2012) 2.85
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat Neurosci (2015) 2.43
Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet (2013) 2.43
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Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab (2012) 2.22
Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun (2015) 2.16
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature (2014) 1.88
Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease. PLoS Genet (2014) 1.88
Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height. Hum Mol Genet (2012) 1.87
Pathway analysis of genomic data: concepts, methods, and prospects for future development. Trends Genet (2012) 1.86
New susceptibility loci associated with kidney disease in type 1 diabetes. PLoS Genet (2012) 1.79
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Comprehensive literature review and statistical considerations for GWAS meta-analysis. Nucleic Acids Res (2012) 1.75
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
Boosting signal-to-noise in complex biology: prior knowledge is power. Cell (2011) 1.71
Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity. Neuron (2014) 1.70
Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. PLoS Genet (2010) 1.56
Protein interaction-based genome-wide analysis of incident coronary heart disease. Circ Cardiovasc Genet (2011) 1.54
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nat Genet (2013) 1.54
A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet (2013) 1.50
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Nat Genet (2013) 1.49
The Genetic Landscape of Renal Complications in Type 1 Diabetes. J Am Soc Nephrol (2016) 1.44
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet (2017) 1.44
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Hum Mol Genet (2014) 1.39
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genet (2011) 1.30
Discovery and fine mapping of serum protein loci through transethnic meta-analysis. Am J Hum Genet (2012) 1.29
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nat Commun (2015) 1.27
The cerebellum ages slowly according to the epigenetic clock. Aging (Albany NY) (2015) 1.26
The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue. PLoS One (2013) 1.25
The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis. PLoS One (2013) 1.25
MAGMA: generalized gene-set analysis of GWAS data. PLoS Comput Biol (2015) 1.25
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet (2016) 1.24
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet (2016) 1.22
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Hum Mol Genet (2013) 1.19
Functional and genomic context in pathway analysis of GWAS data. Trends Genet (2014) 1.18
A systems biology framework identifies molecular underpinnings of coronary heart disease. Arterioscler Thromb Vasc Biol (2013) 1.18
From SNPs to genes: disease association at the gene level. PLoS One (2011) 1.18
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat Genet (2014) 1.17
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet (2012) 1.14
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. PLoS Genet (2013) 1.12
Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'. Trends Genet (2014) 1.10
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. Hum Mol Genet (2014) 1.10
Linkage-disequilibrium-based binning affects the interpretation of GWASs. Am J Hum Genet (2012) 1.07
Using the gene ontology to scan multilevel gene sets for associations in genome wide association studies. Genet Epidemiol (2011) 1.06
A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A. Hum Mol Genet (2013) 1.05
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nat Genet (2015) 1.05
GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person. Nat Commun (2016) 1.04
The statistical properties of gene-set analysis. Nat Rev Genet (2016) 1.04
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat Genet (2015) 1.02
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry (2014) 1.01
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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nat Commun (2015) 1.01
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A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation. J Med Genet (2011) 0.96
Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder. Transl Psychiatry (2012) 0.94
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill. PLoS Genet (2013) 0.94
Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Hum Mol Genet (2014) 0.94
Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets. Eur J Hum Genet (2012) 0.93
The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study. Hum Mol Genet (2013) 0.92
Integration of biological networks and pathways with genetic association studies. Hum Genet (2012) 0.92
Integrative pathway analysis of a genome-wide association study of (V)O(2max) response to exercise training. J Appl Physiol (1985) (2013) 0.91
The Missing lnc(RNA) between the pancreatic β-cell and diabetes. Front Genet (2014) 0.91
Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction. PLoS Genet (2014) 0.91
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Pathway analyses implicate glial cells in schizophrenia. PLoS One (2014) 0.90
Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. Neurology (2016) 0.90
The genetic relationship between handedness and neurodevelopmental disorders. Trends Mol Med (2013) 0.89
Gene-based analysis of regionally enriched cortical genes in GWAS data sets of cognitive traits and psychiatric disorders. PLoS One (2012) 0.88
Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat Neurosci (2016) 0.87
Chronic periodontitis genome-wide association studies: gene-centric and gene set enrichment analyses. J Dent Res (2014) 0.87
A meta-analysis of gene expression quantitative trait loci in brain. Transl Psychiatry (2014) 0.87
Genome-wide associations for birth weight and correlations with adult disease. Nature (2016) 0.87
Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics. PLoS Comput Biol (2016) 0.86
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Hum Mol Genet (2014) 0.86
An Integrative Genomic Study Implicates the Postsynaptic Density in the Pathogenesis of Bipolar Disorder. Neuropsychopharmacology (2015) 0.85
Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network. Nutr Metab Cardiovasc Dis (2012) 0.85
A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia. Nat Commun (2015) 0.85
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No large-effect low-frequency coding variation found for myocardial infarction. Hum Mol Genet (2014) 0.84
Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. Am J Med Genet B Neuropsychiatr Genet (2013) 0.84
Meta gene set enrichment analyses link miR-137-regulated pathways with schizophrenia risk. Front Genet (2015) 0.84
Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols. Pharmacogenet Genomics (2015) 0.84
Genetic Moderation of Stress Effects on Corticolimbic Circuitry. Neuropsychopharmacology (2015) 0.84
Pathways targeted by antidiabetes drugs are enriched for multiple genes associated with type 2 diabetes risk. Diabetes (2014) 0.83
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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature (2009) 33.26
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
A fine-scale map of recombination rates and hotspots across the human genome. Science (2005) 26.82
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Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med (2004) 18.86
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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
A mitochondrial protein compendium elucidates complex I disease biology. Cell (2008) 13.51
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet (2006) 13.16
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Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes (2002) 10.49
Mitochondrial dysfunction and type 2 diabetes. Science (2005) 10.25
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab (2008) 9.74
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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A (2004) 6.53
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Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet (2009) 3.92
Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet (2009) 3.19
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Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS One (2009) 2.03
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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
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Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73
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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
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A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet (2004) 10.87
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet (2008) 10.49
Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci U S A (2006) 10.32
Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med (2008) 9.83
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet (2008) 9.52
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