Ferroportin and erythroid cells: an update.

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Published in Adv Hematol on August 11, 2010

Authors

Luciano Cianetti1, Marco Gabbianelli, Nadia Maria Sposi

Author Affiliations

1: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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TGF-beta signal transduction. Annu Rev Biochem (1998) 17.83

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Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans (2006) 7.69

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature (2000) 7.46

Stem cells: units of development, units of regeneration, and units in evolution. Cell (2000) 7.36

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem (2000) 5.75

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LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett (2000) 5.22

A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem (2000) 5.21

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med (2007) 5.18

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab (2005) 4.79

Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem (1999) 4.77

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. Nature (1989) 4.43

Hereditary hemochromatosis--a new look at an old disease. N Engl J Med (2004) 4.42

Erythropoietin. Blood (1991) 4.37

Beta-thalassemia. N Engl J Med (2005) 4.22

Forging a field: the golden age of iron biology. Blood (2008) 3.83

Control of globin gene expression during development and erythroid differentiation. Exp Hematol (2005) 3.47

Suppression of hepcidin during anemia requires erythropoietic activity. Blood (2006) 3.32

Granulocyte colony-stimulating factor and its receptor. Blood (1991) 3.24

Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias. Nat Rev Genet (2001) 3.15

Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci U S A (2006) 3.13

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature (1994) 2.99

Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells. Blood (1997) 2.93

Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nat Rev Mol Cell Biol (2008) 2.92

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Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood (2009) 2.65

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Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. J Clin Invest (2001) 2.49

Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias. Blood (2007) 2.33

Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1. EMBO J (2001) 2.32

Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res (2006) 2.16

The transforming growth factor-beta superfamily of receptors. Cytokine Growth Factor Rev (2004) 2.15

Hematopoietic regulators: redundancy or subtlety? Blood (1993) 2.13

The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A (2005) 2.10

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Colony-stimulating factor-1 receptor. Blood (1990) 2.10

Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin. Blood (2005) 2.02

Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology (2002) 1.97

In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations. Blood (2005) 1.96

Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha. Blood (2008) 1.88

Regulation of iron acquisition and iron distribution in mammals. Biochim Biophys Acta (2006) 1.72

Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease. Proc Natl Acad Sci U S A (2001) 1.71

Functional consequences of ferroportin 1 mutations. Blood Cells Mol Dis (2005) 1.70

Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor. Blood (1991) 1.70

Iron regulation and erythropoiesis. Curr Opin Hematol (2008) 1.70

New insights into erythropoiesis. Curr Opin Hematol (2002) 1.69

Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload. Gastroenterology (2001) 1.68

Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1. Nucleic Acids Res (2007) 1.67

Iron uptake and metabolism in the new millennium. Trends Cell Biol (2006) 1.66

Multivalent DNA binding complex generated by small Maf and Bach1 as a possible biochemical basis for beta-globin locus control region complex. J Biol Chem (1998) 1.64

Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3). Blood (2002) 1.62

Erythropoiesis: model systems, molecular regulators, and developmental programs. IUBMB Life (2009) 1.61

Regulation of human fetal hemoglobin: new players, new complexities. Blood (2005) 1.60

Regulation of hepcidin and iron-overload disease. Annu Rev Pathol (2009) 1.58

Expression of alternative transcripts of ferroportin-1 during human erythroid differentiation. Haematologica (2005) 1.53

Transcription. Gene expression--where to start? Science (2008) 1.50

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Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I. Blood (2008) 1.43

A cell stress signaling model of fetal hemoglobin induction: what doesn't kill red blood cells may make them stronger. Exp Hematol (2008) 1.42

Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells. Blood (1994) 1.41

Ontogeny of erythropoiesis. Curr Opin Hematol (2008) 1.40

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Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: comparison with interleukin-1 alpha. Blood (1988) 1.35

Ineffective erythropoiesis and thalassemias. Curr Opin Hematol (2009) 1.34

The mitochondrial protein frataxin prevents nuclear damage. Hum Mol Genet (2002) 1.33

Development of the hematopoietic system. Curr Opin Genet Dev (1996) 1.33

Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesis. Haematologica (2009) 1.32

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Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1). Gene (1999) 1.25

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"Pure" human hematopoietic progenitors: permissive action of basic fibroblast growth factor. Science (1990) 1.17

Non-HFE hemochromatosis. Hepatology (2004) 1.16

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Multi-level effects of flt3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors. Blood (1995) 1.13

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Iron regulatory proteins in pathobiology. Biochem J (2000) 1.12

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Role of the ferroportin iron-responsive element in iron and nitric oxide dependent gene regulation. Blood Cells Mol Dis (2003) 1.11

Hepcidin modulation in human diseases: from research to clinic. World J Gastroenterol (2009) 1.09

Iron increases expression of iron-export protein MTP1 in lung cells. Am J Physiol Lung Cell Mol Physiol (2002) 1.08

Current approach to hemochromatosis. Blood Rev (2008) 1.07

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