The BioPAX community standard for pathway data sharing.

PubWeight™: 9.19‹?› | Rank: Top 0.1%

🔗 View Article (PMC 3001121)

Published in Nat Biotechnol on September 09, 2010

Authors

Emek Demir1, Michael P Cary, Suzanne Paley, Ken Fukuda, Christian Lemer, Imre Vastrik, Guanming Wu, Peter D'Eustachio, Carl Schaefer, Joanne Luciano, Frank Schacherer, Irma Martinez-Flores, Zhenjun Hu, Veronica Jimenez-Jacinto, Geeta Joshi-Tope, Kumaran Kandasamy, Alejandra C Lopez-Fuentes, Huaiyu Mi, Elgar Pichler, Igor Rodchenkov, Andrea Splendiani, Sasha Tkachev, Jeremy Zucker, Gopal Gopinath, Harsha Rajasimha, Ranjani Ramakrishnan, Imran Shah, Mustafa Syed, Nadia Anwar, Ozgün Babur, Michael Blinov, Erik Brauner, Dan Corwin, Sylva Donaldson, Frank Gibbons, Robert Goldberg, Peter Hornbeck, Augustin Luna, Peter Murray-Rust, Eric Neumann, Oliver Ruebenacker, Oliver Reubenacker, Matthias Samwald, Martijn van Iersel, Sarala Wimalaratne, Keith Allen, Burk Braun, Michelle Whirl-Carrillo, Kei-Hoi Cheung, Kam Dahlquist, Andrew Finney, Marc Gillespie, Elizabeth Glass, Li Gong, Robin Haw, Michael Honig, Olivier Hubaut, David Kane, Shiva Krupa, Martina Kutmon, Julie Leonard, Debbie Marks, David Merberg, Victoria Petri, Alex Pico, Dean Ravenscroft, Liya Ren, Nigam Shah, Margot Sunshine, Rebecca Tang, Ryan Whaley, Stan Letovksy, Kenneth H Buetow, Andrey Rzhetsky, Vincent Schachter, Bruno S Sobral, Ugur Dogrusoz, Shannon McWeeney, Mirit Aladjem, Ewan Birney, Julio Collado-Vides, Susumu Goto, Michael Hucka, Nicolas Le Novère, Natalia Maltsev, Akhilesh Pandey, Paul Thomas, Edgar Wingender, Peter D Karp, Chris Sander, Gary D Bader

Author Affiliations

1: Computational Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

Articles citing this

(truncated to the top 100)

Reactome: a database of reactions, pathways and biological processes. Nucleic Acids Res (2010) 11.23

The Reactome pathway knowledgebase. Nucleic Acids Res (2013) 8.56

PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees. Nucleic Acids Res (2012) 8.54

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res (2011) 7.84

The IntAct molecular interaction database in 2012. Nucleic Acids Res (2011) 7.49

Enrichment map: a network-based method for gene-set enrichment visualization and interpretation. PLoS One (2010) 6.61

A travel guide to Cytoscape plugins. Nat Methods (2012) 6.53

Large-scale gene function analysis with the PANTHER classification system. Nat Protoc (2013) 6.41

WikiPathways: building research communities on biological pathways. Nucleic Acids Res (2011) 4.78

Toward interoperable bioscience data. Nat Genet (2012) 4.72

EcoCyc: a comprehensive database of Escherichia coli biology. Nucleic Acids Res (2010) 4.68

From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource. Biomark Med (2011) 4.05

RegulonDB version 7.0: transcriptional regulation of Escherichia coli K-12 integrated within genetic sensory response units (Gensor Units). Nucleic Acids Res (2010) 3.76

The ConsensusPathDB interaction database: 2013 update. Nucleic Acids Res (2012) 2.94

Rhea--a manually curated resource of biochemical reactions. Nucleic Acids Res (2011) 2.87

Controlled vocabularies and semantics in systems biology. Mol Syst Biol (2011) 2.79

Gramene database in 2010: updates and extensions. Nucleic Acids Res (2010) 2.70

The Synthetic Biology Open Language (SBOL) provides a community standard for communicating designs in synthetic biology. Nat Biotechnol (2014) 2.63

The Comparative Toxicogenomics Database's 10th year anniversary: update 2015. Nucleic Acids Res (2014) 2.55

Software for systems biology: from tools to integrated platforms. Nat Rev Genet (2011) 2.42

EDAM: an ontology of bioinformatics operations, types of data and identifiers, topics and formats. Bioinformatics (2013) 2.02

PharmGKB: the Pharmacogenomics Knowledge Base. Methods Mol Biol (2013) 1.81

ISA-TAB-Nano: a specification for sharing nanomaterial research data in spreadsheet-based format. BMC Biotechnol (2013) 1.80

Software support for SBGN maps: SBGN-ML and LibSBGN. Bioinformatics (2012) 1.69

The Reactome BioMart. Database (Oxford) (2011) 1.66

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res (2016) 1.52

Using biological pathway data with paxtools. PLoS Comput Biol (2013) 1.50

VANTED v2: a framework for systems biology applications. BMC Syst Biol (2012) 1.49

Perturbation biology nominates upstream-downstream drug combinations in RAF inhibitor resistant melanoma cells. Elife (2015) 1.46

graphite - a Bioconductor package to convert pathway topology to gene network. BMC Bioinformatics (2012) 1.44

The 3rd DBCLS BioHackathon: improving life science data integration with Semantic Web technologies. J Biomed Semantics (2013) 1.44

Getting more out of biomedical documents with GATE's full lifecycle open source text analytics. PLoS Comput Biol (2013) 1.38

The Translational Medicine Ontology and Knowledge Base: driving personalized medicine by bridging the gap between bench and bedside. J Biomed Semantics (2011) 1.37

WikiPathways: capturing the full diversity of pathway knowledge. Nucleic Acids Res (2015) 1.35

The Biomolecular Interaction Network Database in PSI-MI 2.5. Database (Oxford) (2011) 1.34

Large-scale event extraction from literature with multi-level gene normalization. PLoS One (2013) 1.30

Path2Models: large-scale generation of computational models from biochemical pathway maps. BMC Syst Biol (2013) 1.29

Pathway Tools version 19.0 update: software for pathway/genome informatics and systems biology. Brief Bioinform (2015) 1.29

Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks. BMC Syst Biol (2012) 1.28

IntPath--an integrated pathway gene relationship database for model organisms and important pathogens. BMC Syst Biol (2012) 1.28

PathVisio 3: an extendable pathway analysis toolbox. PLoS Comput Biol (2015) 1.27

Identifying aberrant pathways through integrated analysis of knowledge in pharmacogenomics. Bioinformatics (2012) 1.27

A formal MIM specification and tools for the common exchange of MIM diagrams: an XML-Based format, an API, and a validation method. BMC Bioinformatics (2011) 1.25

SPIKE: a database of highly curated human signaling pathways. Nucleic Acids Res (2010) 1.23

Systems toxicology: from basic research to risk assessment. Chem Res Toxicol (2014) 1.23

Functional and genomic context in pathway analysis of GWAS data. Trends Genet (2014) 1.18

Integrating systems biology models and biomedical ontologies. BMC Syst Biol (2011) 1.16

Comparative analysis and assessment of M. tuberculosis H37Rv protein-protein interaction datasets. BMC Genomics (2011) 1.14

Bioinformatics and systems biology of the lipidome. Chem Rev (2011) 1.14

Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease. PLoS Genet (2013) 1.14

Evaluation of research in biomedical ontologies. Brief Bioinform (2012) 1.12

Improving collaboration by standardization efforts in systems biology. Front Bioeng Biotechnol (2014) 1.12

BioHackathon series in 2011 and 2012: penetration of ontology and linked data in life science domains. J Biomed Semantics (2014) 1.12

Precise generation of systems biology models from KEGG pathways. BMC Syst Biol (2013) 1.11

Critical assessment of human metabolic pathway databases: a stepping stone for future integration. BMC Syst Biol (2011) 1.10

CellBase, a comprehensive collection of RESTful web services for retrieving relevant biological information from heterogeneous sources. Nucleic Acids Res (2012) 1.09

NetSlim: high-confidence curated signaling maps. Database (Oxford) (2011) 1.09

hiPathDB: a human-integrated pathway database with facile visualization. Nucleic Acids Res (2011) 1.08

CMLLite: a design philosophy for CML. J Cheminform (2011) 1.08

A mathematical methodology for determining the temporal order of pathway alterations arising during gliomagenesis. PLoS Comput Biol (2012) 1.07

Leveling the playing field: bringing development of biomarkers and molecular diagnostics up to the standards for drug development. Clin Cancer Res (2012) 1.07

Promoting Coordinated Development of Community-Based Information Standards for Modeling in Biology: The COMBINE Initiative. Front Bioeng Biotechnol (2015) 1.07

Comparison of human cell signaling pathway databases--evolution, drawbacks and challenges. Database (Oxford) (2015) 1.06

Semantically enabling pharmacogenomic data for the realization of personalized medicine. Pharmacogenomics (2012) 1.05

Pathway-based drug repositioning using causal inference. BMC Bioinformatics (2013) 1.04

NDEx, the Network Data Exchange. Cell Syst (2015) 1.03

Overview of the Cancer Genetics and Pathway Curation tasks of BioNLP Shared Task 2013. BMC Bioinformatics (2015) 1.03

BiNoM 2.0, a Cytoscape plugin for accessing and analyzing pathways using standard systems biology formats. BMC Syst Biol (2013) 1.02

Bioinformatic approaches for functional annotation and pathway inference in metagenomics data. Brief Bioinform (2012) 1.02

R-based software for the integration of pathway data into bioinformatic algorithms. Biology (Basel) (2014) 1.01

Knowledge management for systems biology a general and visually driven framework applied to translational medicine. BMC Syst Biol (2011) 1.01

Prediction of individualized therapeutic vulnerabilities in cancer from genomic profiles. Bioinformatics (2014) 0.99

A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway. Database (Oxford) (2011) 0.99

Qualitative translation of relations from BioPAX to SBML qual. Bioinformatics (2012) 0.98

Updates in Rhea--a manually curated resource of biochemical reactions. Nucleic Acids Res (2014) 0.98

ReactionFlow: an interactive visualization tool for causality analysis in biological pathways. BMC Proc (2015) 0.97

NaviCell: a web-based environment for navigation, curation and maintenance of large molecular interaction maps. BMC Syst Biol (2013) 0.96

The role of ontologies in biological and biomedical research: a functional perspective. Brief Bioinform (2015) 0.96

Centrality-based pathway enrichment: a systematic approach for finding significant pathways dominated by key genes. BMC Syst Biol (2012) 0.95

CySBGN: a Cytoscape plug-in to integrate SBGN maps. BMC Bioinformatics (2013) 0.94

Computational tools for metabolic engineering. Metab Eng (2012) 0.94

Integrating biological pathways and genomic profiles with ChiBE 2. BMC Genomics (2014) 0.94

Pattern search in BioPAX models. Bioinformatics (2013) 0.93

TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling. Database (Oxford) (2014) 0.93

BioPAX support in CellDesigner. Bioinformatics (2011) 0.93

Representing physiological processes and their participants with PhysioMaps. J Biomed Semantics (2013) 0.92

Dupuytren's: a systems biology disease. Arthritis Res Ther (2011) 0.91

Data management strategies for multinational large-scale systems biology projects. Brief Bioinform (2012) 0.91

KaBOB: ontology-based semantic integration of biomedical databases. BMC Bioinformatics (2015) 0.91

Integrated network analysis and effective tools in plant systems biology. Front Plant Sci (2014) 0.90

GLAMM: Genome-Linked Application for Metabolic Maps. Nucleic Acids Res (2011) 0.90

Automatically visualise and analyse data on pathways using PathVisioRPC from any programming environment. BMC Bioinformatics (2015) 0.90

A network map of BDNF/TRKB and BDNF/p75NTR signaling system. J Cell Commun Signal (2013) 0.90

ANAP: an integrated knowledge base for Arabidopsis protein interaction network analysis. Plant Physiol (2012) 0.90

Combining computational models, semantic annotations and simulation experiments in a graph database. Database (Oxford) (2015) 0.89

Improving integrative searching of systems chemical biology data using semantic annotation. J Cheminform (2012) 0.89

Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis. Nucleic Acids Res (2016) 0.89

Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems. Database (Oxford) (2015) 0.89

PathVisio-Validator: a rule-based validation plugin for graphical pathway notations. Bioinformatics (2011) 0.89

Systems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis. Nucleic Acids Res (2013) 0.89

Articles cited by this

Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52

Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res (2003) 103.76

Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature (2008) 75.40

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res (2008) 54.83

The KEGG resource for deciphering the genome. Nucleic Acids Res (2004) 53.05

The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics (2003) 32.92

The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer (2002) 28.11

Integration of biological networks and gene expression data using Cytoscape. Nat Protoc (2007) 27.10

The Database of Interacting Proteins: 2004 update. Nucleic Acids Res (2004) 23.67

BioGRID: a general repository for interaction datasets. Nucleic Acids Res (2006) 22.41

TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes. Nucleic Acids Res (2006) 22.20

Reactome: a knowledgebase of biological pathways. Nucleic Acids Res (2005) 20.05

Database resources of the National Center for Biotechnology Information. Nucleic Acids Res (2006) 18.84

BIND: the Biomolecular Interaction Network Database. Nucleic Acids Res (2003) 18.75

The Sequence Ontology: a tool for the unification of genome annotations. Genome Biol (2005) 18.20

ExPASy: The proteomics server for in-depth protein knowledge and analysis. Nucleic Acids Res (2003) 17.39

MINT: a Molecular INTeraction database. FEBS Lett (2002) 17.21

The genetic landscape of a cell. Science (2010) 16.52

The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data. Nat Biotechnol (2004) 16.08

DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions. Nucleic Acids Res (2002) 15.70

Reactome knowledgebase of human biological pathways and processes. Nucleic Acids Res (2008) 15.69

IntAct: an open source molecular interaction database. Nucleic Acids Res (2004) 15.02

Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79

Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66

IntAct--open source resource for molecular interaction data. Nucleic Acids Res (2006) 13.82

The PANTHER database of protein families, subfamilies, functions and pathways. Nucleic Acids Res (2005) 13.37

PID: the Pathway Interaction Database. Nucleic Acids Res (2008) 12.92

Discovering regulatory and signalling circuits in molecular interaction networks. Bioinformatics (2002) 12.88

Network-based classification of breast cancer metastasis. Mol Syst Biol (2007) 12.18

MINT: the Molecular INTeraction database. Nucleic Acids Res (2006) 11.90

A genomic regulatory network for development. Science (2002) 9.67

BioModels Database: a free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systems. Nucleic Acids Res (2006) 9.49

The Systems Biology Graphical Notation. Nat Biotechnol (2009) 8.53

WikiPathways: pathway editing for the people. PLoS Biol (2008) 8.13

Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions. BMC Biol (2007) 8.03

MPact: the MIPS protein interaction resource on yeast. Nucleic Acids Res (2006) 7.75

RegulonDB (version 6.0): gene regulation model of Escherichia coli K-12 beyond transcription, active (experimental) annotated promoters and Textpresso navigation. Nucleic Acids Res (2007) 7.64

Computational prediction of human metabolic pathways from the complete human genome. Genome Biol (2004) 7.52

The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases. Nucleic Acids Res (2009) 7.33

Expansion of the BioCyc collection of pathway/genome databases to 160 genomes. Nucleic Acids Res (2005) 7.13

EcoCyc: a comprehensive view of Escherichia coli biology. Nucleic Acids Res (2008) 7.05

Online predicted human interaction database. Bioinformatics (2005) 6.83

CellML: its future, present and past. Prog Biophys Mol Biol (2004) 6.28

PANTHER version 6: protein sequence and function evolution data with expanded representation of biological pathways. Nucleic Acids Res (2006) 6.20

Pathguide: a pathway resource list. Nucleic Acids Res (2006) 6.05

Using process diagrams for the graphical representation of biological networks. Nat Biotechnol (2005) 5.75

Pathway Tools version 13.0: integrated software for pathway/genome informatics and systems biology. Brief Bioinform (2009) 5.44

A human functional protein interaction network and its application to cancer data analysis. Genome Biol (2010) 4.73

BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bioinformatics (2000) 4.40

The GRID: the General Repository for Interaction Datasets. Genome Biol (2003) 4.09

Rules for modeling signal-transduction systems. Sci STKE (2006) 3.86

Molecular interaction map of the mammalian cell cycle control and DNA repair systems. Mol Biol Cell (1999) 3.41

An ontology for biological function based on molecular interactions. Bioinformatics (2000) 3.40

Next generation simulation tools: the Systems Biology Workbench and BioSPICE integration. OMICS (2003) 3.38

cPath: open source software for collecting, storing, and querying biological pathways. BMC Bioinformatics (2006) 3.24

Pathway information for systems biology. FEBS Lett (2005) 2.97

PATIKA: an integrated visual environment for collaborative construction and analysis of cellular pathways. Bioinformatics (2002) 2.93

VisANT: an online visualization and analysis tool for biological interaction data. BMC Bioinformatics (2004) 2.88

An ontology for collaborative construction and analysis of cellular pathways. Bioinformatics (2004) 2.66

NetPath: a public resource of curated signal transduction pathways. Genome Biol (2010) 2.62

MIRIAM Resources: tools to generate and resolve robust cross-references in Systems Biology. BMC Syst Biol (2007) 2.56

TRANSPATH: an information resource for storing and visualizing signaling pathways and their pathological aberrations. Nucleic Acids Res (2006) 2.55

Virtual Cell modelling and simulation software environment. IET Syst Biol (2008) 2.43

NAViGaTOR: Network Analysis, Visualization and Graphing Toronto. Bioinformatics (2009) 2.34

metaSHARK: software for automated metabolic network prediction from DNA sequence and its application to the genomes of Plasmodium falciparum and Eimeria tenella. Nucleic Acids Res (2005) 2.21

VisANT 3.0: new modules for pathway visualization, editing, prediction and construction. Nucleic Acids Res (2007) 2.17

Publishing on the semantic web. Nature (2001) 1.88

ChiBE: interactive visualization and manipulation of BioPAX pathway models. Bioinformatics (2009) 1.76

Text mining for metabolic pathways, signaling cascades, and protein networks. Sci STKE (2005) 1.71

BiNoM: a Cytoscape plugin for manipulating and analyzing biological networks. Bioinformatics (2007) 1.65

Knowledge representation of signal transduction pathways. Bioinformatics (2001) 1.63

HyBrow: a prototype system for computer-aided hypothesis evaluation. Bioinformatics (2004) 1.50

A decompositional approach to parameter estimation in pathway modeling: a case study of the Akt and MAPK pathways and their crosstalk. Bioinformatics (2006) 1.44

Pathway analysis of dilated cardiomyopathy using global proteomic profiling and enrichment maps. Proteomics (2010) 1.29

A case study in pathway knowledgebase verification. BMC Bioinformatics (2006) 1.18

Pathway recognition and augmentation by computational analysis of microarray expression data. Bioinformatics (2005) 1.12

The molecule role ontology: an ontology for annotation of signal transduction pathway molecules in the scientific literature. Comp Funct Genomics (2004) 1.01

Superposition of transcriptional behaviors determines gene state. PLoS One (2008) 0.91

The evolution of the IUBMB-Nicholson maps. IUBMB Life (2000) 0.85

Articles by these authors

Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Genome Res (2008) 151.16

Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09

The Bioperl toolkit: Perl modules for the life sciences. Genome Res (2002) 58.63

The KEGG resource for deciphering the genome. Nucleic Acids Res (2004) 53.05

The Pfam protein families database. Nucleic Acids Res (2002) 51.34

KEGG for linking genomes to life and the environment. Nucleic Acids Res (2007) 49.37

From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res (2006) 44.35

Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66

The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration. Nat Biotechnol (2007) 35.41

Human MicroRNA targets. PLoS Biol (2004) 34.51

A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03

The KEGG databases at GenomeNet. Nucleic Acids Res (2002) 33.68

The minimum information about a genome sequence (MIGS) specification. Nat Biotechnol (2008) 31.04

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics (2002) 30.58

KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res (2011) 30.20

KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res (2009) 28.60

Integration of biological networks and gene expression data using Cytoscape. Nat Protoc (2007) 27.10

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov (2012) 26.98

Automated generation of heuristics for biological sequence comparison. BMC Bioinformatics (2005) 24.54

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29

Integrative genomic profiling of human prostate cancer. Cancer Cell (2010) 23.61

MicroRNA targets in Drosophila. Genome Biol (2003) 23.59

GoMiner: a resource for biological interpretation of genomic and proteomic data. Genome Biol (2003) 22.63

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72

PANTHER: a library of protein families and subfamilies indexed by function. Genome Res (2003) 21.64

Global mapping of the yeast genetic interaction network. Science (2004) 21.34

Human Protein Reference Database--2009 update. Nucleic Acids Res (2008) 21.25

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A (2002) 20.48

The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36

International network of cancer genome projects. Nature (2010) 20.35

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal (2013) 19.54

The B73 maize genome: complexity, diversity, and dynamics. Science (2009) 18.73

A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature (2009) 18.39

EnsMart: a generic system for fast and flexible access to biological data. Genome Res (2004) 17.64

ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia (2004) 17.08

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96

The genetic landscape of a cell. Science (2010) 16.52

The microRNA.org resource: targets and expression. Nucleic Acids Res (2007) 16.26

Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21

The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data. Nat Biotechnol (2004) 16.08

Reactome knowledgebase of human biological pathways and processes. Nucleic Acids Res (2008) 15.69

Development of a chemical structure comparison method for integrated analysis of chemical and genomic information in the metabolic pathways. J Am Chem Soc (2003) 15.30

Data, information, knowledge and principle: back to metabolism in KEGG. Nucleic Acids Res (2013) 15.13

The consensus coding sequence (CCDS) project: Identifying a common protein-coding gene set for the human and mouse genomes. Genome Res (2009) 14.90

The Pathway Tools software. Bioinformatics (2002) 14.89

Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79

Ensembl 2011. Nucleic Acids Res (2010) 14.68

The International Protein Index: an integrated database for proteomics experiments. Proteomics (2004) 14.67

Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66

Ensembl 2012. Nucleic Acids Res (2011) 14.55

Characterizing gene sets with FuncAssociate. Bioinformatics (2003) 14.10

High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID). BMC Bioinformatics (2005) 14.02

InterPro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res (2011) 13.45

Reactome: a knowledge base of biologic pathways and processes. Genome Biol (2007) 13.36

The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biol (2003) 13.32

Identification of microRNAs of the herpesvirus family. Nat Methods (2005) 12.98

Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project. Nat Biotechnol (2008) 12.96

PID: the Pathway Interaction Database. Nucleic Acids Res (2008) 12.92

EnsemblCompara GeneTrees: Complete, duplication-aware phylogenetic trees in vertebrates. Genome Res (2008) 12.72

Ensembl 2014. Nucleic Acids Res (2013) 12.62

Identification of virus-encoded microRNAs. Science (2004) 12.56

Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell (2012) 12.32

Prepublication data sharing. Nature (2009) 12.24

Human protein reference database--2006 update. Nucleic Acids Res (2006) 12.16

The somatic genomic landscape of glioblastoma. Cell (2013) 11.73

Ensembl 2013. Nucleic Acids Res (2012) 11.70

Computational assignment of the EC numbers for genomic-scale analysis of enzymatic reactions. J Am Chem Soc (2004) 11.50

Optimized design and assessment of whole genome tiling arrays. Bioinformatics (2007) 11.38

The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet (2013) 11.29

Reactome: a database of reactions, pathways and biological processes. Nucleic Acids Res (2010) 11.23

KEGG as a glycome informatics resource. Glycobiology (2005) 11.05