Published in Gastroenterology on September 15, 2010
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Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism. PLoS Genet (2014) 1.57
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Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis. Hepatology (2014) 1.15
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PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes. Free Radic Biol Med (2013) 0.87
Akt and mTORC1 have different roles during liver tumorigenesis in mice. Gastroenterology (2013) 0.86
Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes. Mol Cancer Res (2011) 0.86
Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice. PLoS One (2014) 0.81
Activation of hepatic stellate cell in Pten null liver injury model. Fibrogenesis Tissue Repair (2016) 0.80
TGF-β signaling alters the pattern of liver tumorigenesis induced by Pten inactivation. Oncogene (2014) 0.80
Isolation of CD133+ liver stem cells for clonal expansion. J Vis Exp (2011) 0.79
Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-related Hepatocellular Carcinoma in Mice. J Biol Chem (2016) 0.78
Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade. Liver Int (2016) 0.77
Evaluation of the medicinal herb Graptopetalum paraguayense as a treatment for liver cancer. PLoS One (2015) 0.75
Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription. J Clin Invest (2017) 0.75
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The C-terminus domain of the hepatitis B virus x protein stimulates the proliferation of mouse foetal hepatic progenitor cells, although it is not required for the formation of spheroids. Int J Mol Med (2017) 0.75
Akt2-Dependent Phosphorylation of Radixin in Regulation of Mrp-2 Trafficking in WIF-B Cells. Dig Dis Sci (2016) 0.75
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A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med (2006) 6.31
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EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology (2008) 5.53
EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res (2008) 4.17
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med (2001) 4.07
Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol (2005) 4.00
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest (2004) 3.92
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The origin and liver repopulating capacity of murine oval cells. Proc Natl Acad Sci U S A (2003) 2.99
Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis (2008) 2.89
Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes (2005) 2.88
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Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene (2006) 2.65
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Liver stem cells and hepatocellular carcinoma. Hepatology (2009) 2.27
Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease. Am J Pathol (2003) 2.27
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Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma. Cancer (2003) 2.09
Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest (2006) 2.03
Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity. Gut (2007) 1.99
Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Cancer Res (2008) 1.98
Progenitor cells in diseased human liver. Semin Liver Dis (2003) 1.93
A CD133-expressing murine liver oval cell population with bilineage potential. Stem Cells (2007) 1.87
Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells. Gastroenterology (2007) 1.66
Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. Hepatology (2010) 1.63
Liver stem cells: implications for hepatocarcinogenesis. Stem Cell Rev (2005) 1.62
Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling. Gut (2009) 1.44
CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis. Hepatology (2009) 1.40
Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice. Stem Cells (2009) 1.33
The critical role of AKT2 in hepatic steatosis induced by PTEN loss. Am J Pathol (2010) 1.27
Different lineages of chemically induced hepatocellular carcinoma in rats defined by monoclonal antibodies. Cancer Res (1989) 1.23
Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer. Mol Cancer Ther (2007) 1.22
Comparison of liver progenitor cells in human atypical ductular reactions with those seen in experimental models of liver injury. Hepatology (1998) 1.21
Exogenous thioredoxin prevents ethanol-induced oxidative damage and apoptosis in mouse liver. Hepatology (2009) 1.14
Differential cytokeratin and alpha-fetoprotein expression in morphologically distinct epithelial cells emerging at the early stage of rat hepatocarcinogenesis. Cancer Res (1985) 1.12
Akt2 expression correlates with prognosis of human hepatocellular carcinoma. Oncol Rep (2004) 1.12
Liver specific overexpression of platelet-derived growth factor-B accelerates liver cancer development in chemically induced liver carcinogenesis. Int J Cancer (2011) 1.12
Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1. Blood (2005) 1.05
Inducible expression of Wnt genes during adult hepatic stem/progenitor cell response. FEBS Lett (2009) 0.94
Expression and significance of new tumor suppressor gene PTEN in primary liver cancer. J Cell Mol Med (2003) 0.89
PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors. Jpn J Cancer Res (1999) 0.88
Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients. Oncol Rep (2007) 0.82
Oxidative damage and gene expression profile of antioxidant enzymes after T-2 toxin exposure in mice. J Biochem Mol Toxicol (2009) 0.80
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell (2005) 11.19
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature (2004) 7.64
In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat Nanotechnol (2006) 6.93
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab (2007) 6.83
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci U S A (2002) 5.93
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat Med (2010) 4.96
Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Proc Natl Acad Sci U S A (2008) 4.89
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet (2004) 4.71
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell (2010) 4.62
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest (2004) 4.54
The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. J Clin Invest (2003) 4.11
Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol (2005) 4.00
Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J Clin Invest (2005) 3.95
Role of Akt/protein kinase B in metabolism. Trends Endocrinol Metab (2002) 3.87
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature (2013) 3.72
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature (2007) 3.57
Identification of a proline-rich Akt substrate as a 14-3-3 binding partner. J Biol Chem (2003) 2.94
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat Med (2012) 2.86
Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum Mol Genet (2009) 2.85
Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. J Biol Chem (2003) 2.76
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival. Cell (2012) 2.75
Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. Nat Genet (2005) 2.63
Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab (2007) 2.53
(64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression. J Nucl Med (2007) 2.50
Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody. Eur J Nucl Med Mol Imaging (2007) 2.31
Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metab (2009) 2.23
Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes. Mol Cell Biol (2006) 2.12
Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival. Blood (2005) 2.09
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. FASEB J (2002) 2.04
Cerebral microbleeds in the elderly: a pathological analysis. Stroke (2010) 2.04
Tracheobronchomalacia and tracheal hemorrhage in patients with Duchenne muscular dystrophy receiving long-term ventilation with uncuffed tracheostomies. Chest (2003) 1.99
Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration. J Biol Chem (2006) 1.94
Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation. Mol Cell Biol (2002) 1.90
Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis In 3T3-L1 adipocytes. J Biol Chem (2003) 1.90
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat Med (2012) 1.87
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). J Biol Chem (2004) 1.85
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. Am J Physiol Endocrinol Metab (2002) 1.82
The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis. Science (2004) 1.80
Extrahepatic anomalies in infants with biliary atresia: results of a large prospective North American multicenter study. Hepatology (2013) 1.80
Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression. Oncogene (2003) 1.79
The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling. Proc Natl Acad Sci U S A (2009) 1.79
Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proc Natl Acad Sci U S A (2007) 1.77
Gastrointestinal stromal tumors: clinical profile, pathogenesis, treatment strategies and prognosis. J Gastroenterol Hepatol (2005) 1.76
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Blood (2010) 1.75
The role of FOXO in the regulation of metabolism. Curr Diab Rep (2009) 1.73
Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation. Blood (2004) 1.73
Pregnancies and births achieved from in vitro matured oocytes retrieved from poor responders undergoing stimulation in in vitro fertilization cycles. Fertil Steril (2003) 1.67
Do type and duration of antiretroviral therapy attenuate liver fibrosis in HIV-hepatitis C virus-coinfected patients? Clin Infect Dis (2005) 1.66
Akt and CHIP coregulate tau degradation through coordinated interactions. Proc Natl Acad Sci U S A (2008) 1.66
Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron (2002) 1.65
Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. Hepatology (2010) 1.63
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. J Biol Chem (2007) 1.62
c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma. Hepatology (2011) 1.61
Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression. Blood (2009) 1.61
SALL4 is a key regulator of survival and apoptosis in human leukemic cells. Blood (2008) 1.61
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Natl Acad Sci U S A (2007) 1.61
Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circ Res (2009) 1.60
Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-beta. Hepatology (2010) 1.60
Construction of human activity-based phosphorylation networks. Mol Syst Biol (2013) 1.59
Acute liver injury induced by weight-loss herbal supplements. World J Hepatol (2010) 1.57
Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metab (2011) 1.55
Electron paramagnetic resonance-guided normobaric hyperoxia treatment protects the brain by maintaining penumbral oxygenation in a rat model of transient focal cerebral ischemia. J Cereb Blood Flow Metab (2006) 1.54
Interobserver agreement in hepatitis C grading and staging and in the Banff grading schema for acute cellular rejection: the "hepatitis C 3" multi-institutional trial experience. Arch Pathol Lab Med (2006) 1.49
Concern Concomitant targeting of multiple key transcription factors effectively disrupts cancer stem cells enriched in side population of human pancreatic cancer cells. PLoS One (2013) 1.49
Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. Exp Mol Pathol (2008) 1.48
Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. J Clin Invest (2011) 1.46
microPET of tumor integrin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4). J Nucl Med (2007) 1.46
Insulin signaling to hepatic lipid metabolism in health and disease. Crit Rev Biochem Mol Biol (2011) 1.45
Oocyte vitrification technology has made egg-sharing donation easier in China. Reprod Biomed Online (2011) 1.45
Hypervitaminosis A inducing intra-hepatic cholestasis--a rare case report. Exp Mol Pathol (2009) 1.43
A new PET tracer specific for vascular endothelial growth factor receptor 2. Eur J Nucl Med Mol Imaging (2007) 1.43
A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab (2007) 1.42
Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40. J Biol Chem (2005) 1.42
Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines. Cancer Res (2005) 1.41
Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A(H7N9) virus. Clin Infect Dis (2013) 1.40
CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis. Hepatology (2009) 1.40
Preservation of extracorporeal tissue in closing gastroschisis augments intestinal length. J Pediatr Surg (2008) 1.39
Arsenite causes DNA damage in keratinocytes via generation of hydroxyl radicals. Chem Res Toxicol (2004) 1.37
ibeA, a virulence factor of avian pathogenic Escherichia coli. Microbiology (2005) 1.37
Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Alcohol Clin Exp Res (2004) 1.37
Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell Metab (2006) 1.36
Gene expression patterns of the liver in response to alcohol: in vivo and in vitro models compared. Exp Mol Pathol (2006) 1.36
An energetic tale of AMPK-independent effects of metformin. J Clin Invest (2010) 1.35
Diffuse large B-cell lymphoma (Richter syndrome) in patients with chronic lymphocytic leukaemia (CLL): a cohort study of newly diagnosed patients. Br J Haematol (2013) 1.34
Hypothermia and neonatal encephalopathy. Pediatrics (2014) 1.34
Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice. Stem Cells (2009) 1.33
Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest (2008) 1.33
S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model. Hepatology (2009) 1.32
CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation. Exp Mol Pathol (2006) 1.31
ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2003) 1.31
Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation. Hepatology (2007) 1.30