Published in J Alzheimers Dis on January 01, 2010
Oral delivery of bioencapsulated proteins across blood-brain and blood-retinal barriers. Mol Ther (2013) 1.15
The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. J Neuroimmune Pharmacol (2012) 1.13
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. J Biol Chem (2011) 1.04
Treatment with 670 nm light up regulates cytochrome C oxidase expression and reduces inflammation in an age-related macular degeneration model. PLoS One (2013) 1.03
Amyloid-β Peptides and Tau Protein as Biomarkers in Cerebrospinal and Interstitial Fluid Following Traumatic Brain Injury: A Review of Experimental and Clinical Studies. Front Neurol (2013) 1.00
EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques. Nat Commun (2015) 0.89
Amyloid accumulation is a late event in sporadic Alzheimer's disease-like pathology in nontransgenic rats. Oncotarget (2015) 0.89
Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model. Neurosci Lett (2011) 0.87
Neuropathological approaches to cerebral aging and neuroplasticity. Dialogues Clin Neurosci (2013) 0.87
Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease. Cell Cycle (2014) 0.85
Synapse stability in the precuneus early in the progression of Alzheimer's disease. J Alzheimers Dis (2013) 0.85
Virchow-Robin space and aquaporin-4: new insights on an old friend. Croat Med J (2014) 0.84
Imaging the Alzheimer brain. J Alzheimers Dis (2011) 0.83
Behaviorally activated mRNA expression profiles produce signatures of learning and enhanced inhibition in aged rats with preserved memory. PLoS One (2013) 0.83
Emerging Link between Alzheimer's Disease and Homeostatic Synaptic Plasticity. Neural Plast (2016) 0.80
Functional MRI and neural responses in a rat model of Alzheimer's disease. Neuroimage (2013) 0.80
Effect of synthetic aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance. PLoS One (2012) 0.80
Multiple effects of β-amyloid on single excitatory synaptic connections in the PFC. Front Cell Neurosci (2013) 0.80
The Molecular Mechanisms of Neural Flow Coupling: A New Concept. J Neuroimaging (2015) 0.80
Proteomic analysis of lymphoblastoid cells from Nasu-Hakola patients: a step forward in our understanding of this neurodegenerative disorder. PLoS One (2014) 0.79
Biochemical assessment of precuneus and posterior cingulate gyrus in the context of brain aging and Alzheimer's disease. PLoS One (2014) 0.78
Investigating interventions in Alzheimer's disease with computer simulation models. PLoS One (2013) 0.77
Is PrP the road to ruin? EMBO J (2011) 0.77
PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments. Proc Natl Acad Sci U S A (2016) 0.76
The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease. Mol Med (2017) 0.75
Using Drugs as Molecular Probes: A Computational Chemical Biology Approach in Neurodegenerative Diseases. J Alzheimers Dis (2016) 0.75
Localization of heat shock proteins in cerebral cortical cultures following induction by celastrol. Cell Stress Chaperones (2014) 0.75
Neuropsychiatric Disturbances in Alzheimer's Disease: What Have We Learned from Neuropathological Studies? Curr Alzheimer Res (2016) 0.75
Reduced CSF Water Influx in Alzheimer's Disease Supporting the β-Amyloid Clearance Hypothesis. PLoS One (2015) 0.75
Ion channel regulation by β-secretase BACE1 - enzymatic and non-enzymatic effects beyond Alzheimer's disease. Channels (Austin) (2016) 0.75
Active duty service members who sustain a traumatic brain injury have chronically elevated peripheral concentrations of Aβ40 and lower ratios of Aβ42/40. Brain Inj (2016) 0.75
Effects of soluble β-amyloid on the release of neurotransmitters from rat brain synaptosomes. Front Aging Neurosci (2014) 0.75
Genetic epistasis regulates amyloid deposition in resilient aging. Alzheimers Dement (2017) 0.75
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature (1996) 26.30
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun (1984) 20.07
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature (2002) 19.36
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol (2007) 17.69
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med (2008) 17.09
Short-term synaptic plasticity. Annu Rev Physiol (2002) 16.67
A specific amyloid-beta protein assembly in the brain impairs memory. Nature (2006) 16.19
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A (1998) 16.04
Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol (1991) 14.25
Alzheimer's disease is a synaptic failure. Science (2002) 13.82
Alzheimer's disease: the amyloid cascade hypothesis. Science (1992) 13.80
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science (1988) 13.54
Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci (2005) 12.85
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science (1992) 12.18
Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature (1993) 11.54
The MAPK signaling cascade. FASEB J (1995) 10.81
Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci (2005) 9.17
A beta oligomers - a decade of discovery. J Neurochem (2007) 8.88
APP processing and synaptic function. Neuron (2003) 8.37
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci (2007) 8.27
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol (2000) 8.07
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem (1999) 7.94
Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction. Science (2000) 7.86
PI3K: downstream AKTion blocks apoptosis. Cell (1997) 7.73
Dendritic spine changes associated with hippocampal long-term synaptic plasticity. Nature (1999) 7.72
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci (2002) 7.57
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron (2005) 7.53
The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry (1993) 7.26
Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature (1992) 7.16
Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature (1992) 7.02
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature (2008) 6.89
Insights into the ageing mind: a view from cognitive neuroscience. Nat Rev Neurosci (2004) 6.62
Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci (2001) 6.32
Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci (2007) 6.27
Signal transduction via the MAP kinases: proceed at your own RSK. Proc Natl Acad Sci U S A (1993) 6.19
Structure and function of dendritic spines. Annu Rev Physiol (2002) 6.17
Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet (1976) 6.09
Glutamine repeats and neurodegeneration. Annu Rev Neurosci (2000) 6.06
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science (1990) 6.03
Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron (2004) 5.95
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci U S A (1999) 5.75
Statins and the risk of dementia. Lancet (2000) 5.65
Signal transduction through MAP kinase cascades. Adv Cancer Res (1998) 5.65
Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proc Natl Acad Sci U S A (2002) 5.46
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A (2003) 5.44
Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res (2008) 5.29
Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem (2009) 5.23
Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science (1992) 5.22
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution. J Mol Med (Berl) (2003) 5.15
Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci (2004) 5.10
Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet (1997) 5.04
In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life. J Neurosci (2003) 5.00
GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature (2003) 4.97
Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science (1996) 4.96
Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium. J Neurosci (1993) 4.90
Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron (2004) 4.88
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science (2004) 4.81
Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci (2005) 4.71
Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. J Biol Chem (1999) 4.64
Mitogen-activated protein kinases in synaptic plasticity and memory. Curr Opin Neurobiol (2004) 4.59
CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science (1991) 4.53
AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem (1999) 4.49
Metabolic regulation of brain Abeta by neprilysin. Science (2001) 4.47
Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol (2001) 4.43
Mitochondrial abnormalities in Alzheimer's disease. J Neurosci (2001) 4.39
Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. J Biol Chem (2004) 4.33
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron (2004) 4.21
Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function. Annu Rev Neurosci (1994) 4.15
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann Intern Med (2008) 4.03
Different modes of expression of AMPA and NMDA receptors in hippocampal synapses. Nat Neurosci (1999) 3.99
Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron (2008) 3.98
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet (2006) 3.94
Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron (2009) 3.94
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc Natl Acad Sci U S A (2009) 3.86
Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat Rev Neurosci (2002) 3.84
Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation. J Neurosci (2006) 3.84
The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem (2001) 3.81
Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature (1996) 3.79
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med (2008) 3.69
Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol (2004) 3.67
Beta-catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev (1998) 3.65
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 3.61
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat Neurosci (2004) 3.59
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci U S A (2001) 3.50
Postsynaptic signaling and plasticity mechanisms. Science (2002) 3.46
Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage. Learn Mem (2005) 3.37
Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J Biol Chem (2007) 3.35
Internalization of ionotropic glutamate receptors in response to mGluR activation. Nat Neurosci (2001) 3.34
A network dysfunction perspective on neurodegenerative diseases. Nature (2006) 3.33
Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2009) 3.31
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci (2005) 3.23
Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J (2001) 3.22
Genesis of dendritic spines: insights from ultrastructural and imaging studies. Nat Rev Neurosci (2004) 3.22
Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J Neurosci (2008) 3.21
Neuronal activity-dependent cell survival mediated by transcription factor MEF2. Science (1999) 3.19
MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol (2002) 3.17
Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease. J Neurochem (2005) 3.06
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature (2002) 3.05
Mitoenergetic failure in Alzheimer disease. Am J Physiol Cell Physiol (2006) 1.22
A modified microstamping technique enhances polylysine transfer and neuronal cell patterning. Biomaterials (2003) 1.20
Designing Neural Networks in Culture: Experiments are described for controlled growth, of nerve cells taken from rats, in predesigned geometrical patterns on laboratory culture dishes. Proc IEEE Inst Electr Electron Eng (2010) 1.16
Added astroglia promote greater synapse density and higher activity in neuronal networks. Neuron Glia Biol (2007) 1.16
Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells. Int J Biochem Cell Biol (2009) 1.15
Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. Brain Res (2002) 1.09
Age-related changes in neuronal glucose uptake in response to glutamate and beta-amyloid. J Neurosci Res (2003) 1.06
Active 3-D microscaffold system with fluid perfusion for culturing in vitro neuronal networks. Lab Chip (2007) 1.03
Propagation of action potential activity in a predefined microtunnel neural network. J Neural Eng (2011) 1.00
Simultaneous age-related depolarization of mitochondrial membrane potential and increased mitochondrial reactive oxygen species production correlate with age-related glutamate excitotoxicity in rat hippocampal neurons. J Neurosci Res (2007) 1.00
Age-related decreases in NAD(P)H and glutathione cause redox declines before ATP loss during glutamate treatment of hippocampal neurons. J Neurosci Res (2008) 0.99
Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L). Cancer Biol Ther (2010) 0.98
Age-related differences in NFkappaB translocation and Bcl-2/Bax ratio caused by TNFalpha and Abeta42 promote survival in middle-age neurons and death in old neurons. Exp Neurol (2008) 0.96
A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons. J Neurosci (2012) 0.95
Gold-coated microelectrode array with thiol linked self-assembled monolayers for engineering neuronal cultures. IEEE Trans Biomed Eng (2004) 0.94
Development of astroglial cells in patterned neuronal cultures. J Biomater Sci Polym Ed (2007) 0.92
Is brain amyloid production a cause or a result of dementia of the Alzheimer's type? J Alzheimers Dis (2010) 0.92
Hippocampal networks on reliable patterned substrates. J Neurosci Methods (2011) 0.91
Neuronal network structuring induces greater neuronal activity through enhanced astroglial development. J Neural Eng (2006) 0.90
Autophagy in aging and Alzheimer's disease: pathologic or protective? J Alzheimers Dis (2011) 0.89
Critical age-related loss of cofactors of neuron cytochrome C oxidase reversed by estrogen. Exp Neurol (2008) 0.89
Age-related deficiencies in complex I endogenous substrate availability and reserve capacity of complex IV in cortical neuron electron transport. Biochim Biophys Acta (2009) 0.85
Differential protection among fractionated blueberry polyphenolic families against DA-, Abeta(42)- and LPS-induced decrements in Ca(2+) buffering in primary hippocampal cells. J Agric Food Chem (2010) 0.84
Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons. Aging Cell (2014) 0.84
Large extracellular spikes recordable from axons in microtunnels. IEEE Trans Neural Syst Rehabil Eng (2013) 0.83
Chronic stimulation of cultured neuronal networks boosts low-frequency oscillatory activity at theta and gamma with spikes phase-locked to gamma frequencies. J Neural Eng (2012) 0.83
Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease. Age (Dordr) (2012) 0.83
Age-related changes to tumor necrosis factor receptors affect neuron survival in the presence of beta-amyloid. J Neurosci Res (2008) 0.83
Dual-energy precursor and nuclear erythroid-related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species. Neurobiol Aging (2013) 0.83
SU-8 2000 rendered cytocompatible for neuronal bioMEMS applications. J Biomed Mater Res A (2009) 0.77
Patterning to influence in vitro neuronal interfaces. Conf Proc IEEE Eng Med Biol Soc (2004) 0.76
Specific CA3 neurons decode neural information of dentate granule cells evoked by paired-pulse stimulation in co-cultured networks. Conf Proc IEEE Eng Med Biol Soc (2017) 0.75
Postmortem effect of pentobarbital anesthetic on survival of adult cortical neurons in primary culture. Brain Res (2004) 0.75