Published in J Lipid Res on September 24, 2010
Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis. Cell Metab (2015) 1.88
Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. Structure (2015) 1.45
Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1. Am J Hum Genet (2012) 1.11
Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation. Circ Res (2014) 0.92
Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine. J Biol Chem (2011) 0.91
Acid ceramidase as a therapeutic target in metastatic prostate cancer. J Lipid Res (2013) 0.84
Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols. J Lipid Res (2015) 0.75
Regulation of lysosomal ion homeostasis by channels and transporters. Sci China Life Sci (2016) 0.75
Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. Sci Rep (2017) 0.75
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim Biophys Acta (2008) 2.25
Purification, characterization, and biosynthesis of human acid ceramidase. J Biol Chem (1995) 1.23
The presence of spingomyelin- and ceramide-cleaving enzymes in the small intestinal tract. Biochim Biophys Acta (1969) 1.23
Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase. Biochim Biophys Acta (1975) 1.15
Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney. J Biol Chem (2001) 1.06
Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide. J Biochem (1999) 0.99
Stimulation of acid ceramidase activity by saposin D. Arch Biochem Biophys (1994) 0.99
Diagnosis of metachromatic leukodystrophy, Krabbe disease, and Farber disease after uptake of fatty acid-labeled cerebroside sulfate into cultured skin fibroblasts. J Clin Invest (1982) 0.96
Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases. Chembiochem (2007) 0.96
A fluorescence-based high-performance liquid chromatographic assay to determine acid ceramidase activity. Anal Biochem (1999) 0.95
Model SV40-transformed fibroblast lines for metabolic studies of human prosaposin and acid ceramidase deficiencies. Clin Chim Acta (1997) 0.95
Retrovirus-mediated correction of the metabolic defect in cultured Farber disease cells. Hum Gene Ther (1999) 0.94
Role of lysosomal acid ceramidase in the metabolism of ceramide in human skin fibroblasts. Arch Biochem Biophys (1981) 0.91
Ceramidase activity in porcine epidermis. FEBS Lett (1990) 0.91
Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls. Biochem J (1982) 0.90
Acid and alkaline ceramidases of rat tissues. Biochem Cell Biol (1986) 0.89
High performance liquid chromatography of ceramides: application to analysis in human tissues and demonstration of ceramide excess in Farber's disease. J Lipid Res (1974) 0.88
Leukocyte and plasma N-laurylsphingosine deacylase (ceramidase) in Farber disease. Clin Genet (1989) 0.84
A case of combined Farber and Sandhoff disease. Eur J Pediatr (1989) 0.83
Metabolism of ceramide-containing endocytotic vesicles in human diploid fibroblasts. J Biol Chem (1982) 0.82
Metabolism of cerebroside sulphate and subcellular distribution of its metabolites in cultured skin fibroblasts derived from controls, metachromatic leukodystrophy, globoid cell leukodystrophy and Farber disease. J Inherit Metab Dis (1987) 0.81
Identification and quantitation of free ceramides in human platelets. J Lipid Res (1972) 0.80
A simple method for screening for Farber disease on cultured skin fibroblasts. Clin Chim Acta (1996) 0.79
Sulfatide and sphingomyelin loading of living cells as tools for the study of ceramide turnover by lysosomal ceramidase--implications for the diagnosis of Farber disease. Biochem Mol Med (1995) 0.78
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem (2006) 2.96
Recommendations on the diagnosis and management of Niemann-Pick disease type C. Mol Genet Metab (2009) 2.78
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem (2008) 2.31
Sialyllactose in viral membrane gangliosides is a novel molecular recognition pattern for mature dendritic cell capture of HIV-1. PLoS Biol (2012) 1.79
Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells. Cancer Lett (2009) 1.35
Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease. Prog Lipid Res (2010) 1.28
Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision? Autophagy (2007) 1.28
Sphingomyelin hydrolysis during apoptosis. Biochim Biophys Acta (2002) 1.27
Incidence and natural history of mucopolysaccharidosis type III in France and comparison with United Kingdom and Greece. Am J Med Genet A (2011) 1.26
The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing. FASEB J (2007) 1.25
Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis. Proc Natl Acad Sci U S A (2002) 1.23
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression. Blood (2005) 1.20
Inhibitors of sphingolipid metabolism enzymes. Biochim Biophys Acta (2006) 1.14
Danon's disease (X-linked vacuolar cardiomyopathy and myopathy): a case with a novel Lamp-2 gene mutation. Neuromuscul Disord (2002) 1.13
Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1. Am J Hum Genet (2012) 1.11
Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation. Cancer Res (2009) 1.11
Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways. Arterioscler Thromb Vasc Biol (2002) 1.11
Ceramide-induced autophagy: to junk or to protect cells? Autophagy (2009) 1.09
Striking phenotypic variability in two familial cases of myosin storage myopathy with a MYH7 Leu1793pro mutation. Neuromuscul Disord (2009) 1.07
Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes (2011) 1.05
Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis. J Biol Chem (2012) 1.05
Lysosomes and lysosomal proteins in cancer cell death (new players of an old struggle). Biochim Biophys Acta (2005) 1.04
Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase. ChemMedChem (2008) 1.03
Glutathione peroxidase-1 protects from CD95-induced apoptosis. J Biol Chem (2002) 1.03
Functions of sphingolipid metabolism in mammals--lessons from genetic defects. Biochim Biophys Acta (2008) 1.03
Synthesis of cyclopropene analogues of ceramide and their effect on dihydroceramide desaturase. J Org Chem (2003) 1.01
IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. PLoS One (2009) 1.01
Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis. J Biol Chem (2005) 1.00
Sphingolipids as modulators of cancer cell death: potential therapeutic targets. Biochim Biophys Acta (2006) 0.98
Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines. Bioorg Med Chem (2008) 0.98
N-acetylcysteine prevents the deleterious effect of tumor necrosis factor-(alpha) on calcium transients and contraction in adult rat cardiomyocytes. Circulation (2004) 0.98
Cellular changes that accompany shedding of human corneocytes. J Invest Dermatol (2012) 0.97
Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues. Chem Phys Lipids (2006) 0.96
Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases. Chembiochem (2007) 0.96
FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response. J Immunol (2009) 0.96
Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23. PLoS One (2012) 0.95
On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem (2014) 0.94
Systemic ceramide accumulation leads to severe and varied pathological consequences. EMBO Mol Med (2013) 0.94
A multifunctional desaturase involved in the biosynthesis of the processionary moth sex pheromone. Proc Natl Acad Sci U S A (2007) 0.93
Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage. Hum Mol Genet (2008) 0.93
Potential roles of membrane fluidity and ceramide in hyperthermia and alcohol stimulation of TRAIL apoptosis. Apoptosis (2007) 0.93
The natural marine anhydrophytosphingosine, Jaspine B, induces apoptosis in melanoma cells by interfering with ceramide metabolism. Biochem Pharmacol (2009) 0.93
Neutral sphingomyelinase inhibition participates to the benefits of N-acetylcysteine treatment in post-myocardial infarction failing heart rats. J Mol Cell Cardiol (2007) 0.93
Ceramide production associated with retinal apoptosis after retinal detachment. Graefes Arch Clin Exp Ophthalmol (2008) 0.92
A MANBA mutation resulting in residual beta-mannosidase activity associated with severe leukoencephalopathy: a possible pseudodeficiency variant. BMC Med Genet (2009) 0.91
Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine. J Biol Chem (2011) 0.91
Regulation of autophagy by sphingolipids. Anticancer Agents Med Chem (2011) 0.91
Sphingolipids in macroautophagy. Methods Mol Biol (2008) 0.90
Role of FAN in tumor necrosis factor-alpha and lipopolysaccharide-induced interleukin-6 secretion and lethality in D-galactosamine-sensitized mice. J Biol Chem (2004) 0.89
The French Gaucher's disease registry: clinical characteristics, complications and treatment of 562 patients. Orphanet J Rare Dis (2012) 0.89
Synthesis of cytotoxic aza analogues of jaspine B. J Org Chem (2010) 0.89
CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation. Proc Natl Acad Sci U S A (2011) 0.88
Autologous transplantation of lentivector/acid ceramidase-transduced hematopoietic cells in nonhuman primates. Hum Gene Ther (2011) 0.88
Beta-mannosidosis: a new cause of spinocerebellar ataxia. Clin Neurol Neurosurg (2008) 0.88
Expression and evolution of delta9 and delta11 desaturase genes in the moth Spodoptera littoralis. Insect Biochem Mol Biol (2004) 0.87
Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia. J Lipid Res (2010) 0.87
Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells. J Lipid Res (2012) 0.87
Analogs of the dihydroceramide desaturase inhibitor GT11 modified at the amide function: synthesis and biological activities. Org Biomol Chem (2005) 0.87
Abnormal iron metabolism in fibroblasts from a patient with the neurodegenerative disease hereditary ferritinopathy. Mol Neurodegener (2010) 0.87
The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior. Psychopharmacology (Berl) (2008) 0.87
Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss. PLoS Genet (2010) 0.87
The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells. FASEB J (2012) 0.87
Anti-inflammatory action of lipid nanocarrier-delivered myriocin: therapeutic potential in cystic fibrosis. Biochim Biophys Acta (2013) 0.86
Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity. Chembiochem (2009) 0.86
Specific sphingolipid content decrease in Cerkl knockdown mouse retinas. Exp Eye Res (2013) 0.86
Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk. PLoS One (2010) 0.85
FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling. J Leukoc Biol (2010) 0.84
Biosynthesis of 10,12-dienoic fatty acids by a bifunctional Delta11 desaturase in Spodoptera littoralis. Insect Biochem Mol Biol (2006) 0.84
Acid ceramidase as a therapeutic target in metastatic prostate cancer. J Lipid Res (2013) 0.84
Palmitoyl protein thioesterase 1 modulates tumor necrosis factor alpha-induced apoptosis. Biochim Biophys Acta (2009) 0.84
Lysosomal storage diseases: is impaired apoptosis a pathogenic mechanism? Neurochem Res (2004) 0.83
Lethal toxin from Clostridium sordellii induces apoptotic cell death by disruption of mitochondrial homeostasis in HL-60 cells. Cell Microbiol (2003) 0.83
Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer. Pharmacol Res (2003) 0.83
Sphingolipid signalling: molecular basis and role in TNF-alpha-induced cell death. Expert Rev Mol Med (2002) 0.83
In vivo delivery of human acid ceramidase via cord blood transplantation and direct injection of lentivirus as novel treatment approaches for Farber disease. Mol Genet Metab (2008) 0.83
Ara-C- and daunorubicin-induced recruitment of Lyn in sphingomyelinase-enriched membrane rafts. FASEB J (2002) 0.83
Expression of p27(Kip1) in bladder cancers: immunohistochemical study and prognostic value in a series of 95 cases. Cancer Lett (2002) 0.82
Regulation of cell death by sphingosine 1-phosphate lyase. Autophagy (2010) 0.82
The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs. FASEB J (2003) 0.82
Danon disease: further clinical and molecular heterogeneity. Muscle Nerve (2009) 0.81
Substrate-dependent stereochemical course of the (Z)-13-desaturation catalyzed by the processionary moth multifunctional desaturase. J Am Chem Soc (2007) 0.81
Human genetic disorders of sphingolipid biosynthesis. J Inherit Metab Dis (2014) 0.81
Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1. Toxicol Appl Pharmacol (2004) 0.81
Fat necrosis generates proinflammatory halogenated lipids during acute pancreatitis. Ann Surg (2013) 0.81
A new member of the PBAN family in Spodoptera littoralis: molecular cloning and immunovisualisation in scotophase hemolymph. Insect Biochem Mol Biol (2002) 0.80
Enhanced skeletal muscle lipid oxidative efficiency in insulin-resistant vs insulin-sensitive nondiabetic, nonobese humans. J Clin Endocrinol Metab (2013) 0.80
Phosphatidylcholine-derived phosphatidic acid and diacylglycerol are involved in the signaling pathways activated by docetaxel. J Exp Ther Oncol (2003) 0.80
Ceramide in regulation of apoptosis. Implication in multitoxicant resistance. Subcell Biochem (2002) 0.80
Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry. Chem Phys Lipids (2012) 0.80
Mannose 6-phosphorylated proteins are required for tumor necrosis factor-induced apoptosis: defective response in I-cell disease fibroblasts. J Biol Chem (2004) 0.80
Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner. J Biol Chem (2009) 0.80
Straightforward access to spisulosine and 4,5-dehydrospisulosine stereoisomers: probes for profiling ceramide synthase activities in intact cells. J Org Chem (2013) 0.79
Host cell P-glycoprotein is essential for cholesterol uptake and replication of Toxoplasma gondii. J Biol Chem (2009) 0.79
Natural products as platforms for the design of sphingolipid-related anticancer agents. Adv Cancer Res (2013) 0.79
Detection of an intragenic deletion expands the spectrum of CTSC mutations in Papillon-Lefèvre syndrome. J Invest Dermatol (2007) 0.79