Published in Proc Natl Acad Sci U S A on October 04, 2010
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C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival. Genes Dev (2006) 1.15
C. elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5. Development (2009) 1.10
Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in Caenorhabditis elegans. Mol Biol Cell (2008) 1.01
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Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron (2007) 2.55
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Rapid development of colitis in NSAID-treated IL-10-deficient mice. Gastroenterology (2002) 2.27
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Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci U S A (2012) 2.10
MicroRNA 23b regulates autophagy associated with radioresistance of pancreatic cancer cells. Gastroenterology (2013) 2.00
Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. J Biol Chem (2008) 1.95
Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nat Chem Biol (2010) 1.94
Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Science (2008) 1.93
TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation. Immunity (2012) 1.75
AtbHLH29 of Arabidopsis thaliana is a functional ortholog of tomato FER involved in controlling iron acquisition in strategy I plants. Cell Res (2005) 1.66
Depletion of neutrophils in IL-10(-/-) mice delays clearance of gastric Helicobacter infection and decreases the Th1 immune response to Helicobacter. J Immunol (2003) 1.51
Overprescribing in China, driven by financial incentives, results in very high use of antibiotics, injections, and corticosteroids. Health Aff (Millwood) (2012) 1.48
An in vivo human-plasmablast enrichment technique allows rapid identification of therapeutic influenza A antibodies. Cell Host Microbe (2013) 1.46
Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation. Trends Cell Biol (2012) 1.39
Comparisons of three methods for organic and inorganic carbon in calcareous soils of northwestern China. PLoS One (2012) 1.38
Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. J Neurosci (2010) 1.38
Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo. Nanoscale (2011) 1.32
Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake. J Neurosci (2011) 1.28
Protein tyrosine kinase Syk in mast cell signaling. Mol Immunol (2002) 1.28
M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth. Proc Natl Acad Sci U S A (2012) 1.21
Autophagy as an immune effector against tuberculosis. Curr Opin Microbiol (2013) 1.19
LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis. Science (2012) 1.18
Biliverdin reductase mediates hypoxia-induced EMT via PI3-kinase and Akt. J Am Soc Nephrol (2008) 1.18
C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells. Development (2008) 1.18
Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking. PLoS One (2010) 1.17
Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. J Biol Chem (2009) 1.16
Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling. J Biol Chem (2010) 1.15
Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis. Mol Cancer (2009) 1.14
Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1/CHAT-1. PLoS Genet (2010) 1.14
Regulation of growth response to water stress in the soybean primary root. I. Proteomic analysis reveals region-specific regulation of phenylpropanoid metabolism and control of free iron in the elongation zone. Plant Cell Environ (2009) 1.13
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Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. EMBO J (2013) 1.12
The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by targeting FasL. Mol Oncol (2012) 1.11
Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biol (2011) 1.11
A splice site mutation in CRYBA1/A3 causing autosomal dominant posterior polar cataract in a Chinese pedigree. Mol Vis (2010) 1.10
C. elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5. Development (2009) 1.10
Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal cancers. Clin Sci (Lond) (2013) 1.08
Gold-nanoparticle-based multicolor nanobeacons for sequence-specific DNA analysis. Angew Chem Int Ed Engl (2009) 1.08
Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer. Cancer Res (2011) 1.08
Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells. PLoS Genet (2009) 1.07
Diminazene aceturate enhances angiotensin-converting enzyme 2 activity and attenuates ischemia-induced cardiac pathophysiology. Hypertension (2013) 1.07
Imbalance of Hsp70 family variants fosters tau accumulation. FASEB J (2012) 1.07
The role of N-methyl-D-aspartate receptor subunit NR2B in spinal cord in cancer pain. Eur J Pain (2009) 1.07
Down-regulation of miR-126 expression in colorectal cancer and its clinical significance. Med Oncol (2010) 1.05
HULC and Linc00152 Act as Novel Biomarkers in Predicting Diagnosis of Hepatocellular Carcinoma. Cell Physiol Biochem (2015) 1.05
Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells. J Biol Chem (2002) 1.05
The 2.1-A crystal structure of native neuroserpin reveals unique structural elements that contribute to conformational instability. J Mol Biol (2009) 1.04
Apoptosis and proinflammatory cytokine responses of primary mouse microglia and astrocytes induced by human H1N1 and avian H5N1 influenza viruses. Cell Mol Immunol (2008) 1.04
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biol Psychiatry (2013) 1.03
Analysis of factors influencing the outpatient workload at Chinese health centres. BMC Health Serv Res (2010) 1.02
Preparation of MPEG-PLA nanoparticle for honokiol delivery in vitro. Int J Pharm (2009) 1.02
Phycourobilin in trichromatic phycocyanin from oceanic cyanobacteria is formed post-translationally by a phycoerythrobilin lyase-isomerase. J Biol Chem (2009) 1.01
Actin-bundling protein L-plastin regulates T cell activation. J Immunol (2010) 1.01
HCV core protein interacts with Dicer to antagonize RNA silencing. Virus Res (2008) 1.01
The Th17/Treg imbalance exists in patients with heart failure with normal ejection fraction and heart failure with reduced ejection fraction. Clin Chim Acta (2010) 1.00
Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations. J Neurosci Methods (2011) 1.00
Overexpression of the tonoplast aquaporin AtTIP5;1 conferred tolerance to boron toxicity in Arabidopsis. J Genet Genomics (2010) 1.00
Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. Arthritis Res Ther (2008) 1.00
Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation. Mol Biol Cell (2011) 1.00
Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1alpha-activated and VEGF-mediated pathway. Eur J Pharmacol (2009) 0.99
p53R2 inhibits the proliferation of human cancer cells in association with cell-cycle arrest. Mol Cancer Ther (2011) 0.99
LRP1 shedding in human brain: roles of ADAM10 and ADAM17. Mol Neurodegener (2009) 0.98
Modeling the transmission dynamics of sheep brucellosis in Inner Mongolia Autonomous Region, China. Math Biosci (2013) 0.97
Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling. PLoS One (2013) 0.97
Hypnotic effect of jujubosides from Semen Ziziphi Spinosae. J Ethnopharmacol (2010) 0.97
ERG-SOX4 interaction promotes epithelial-mesenchymal transition in prostate cancer cells. Prostate (2014) 0.97
Efficient inhibition of C-26 colon carcinoma by VSVMP gene delivered by biodegradable cationic nanogel derived from polyethyleneimine. ACS Nano (2010) 0.97
Photophysical diversity of two novel cyanobacteriochromes with phycocyanobilin chromophores: photochemistry and dark reversion kinetics. FEBS J (2011) 0.96
The NorR regulon is critical for Vibrio cholerae resistance to nitric oxide and sustained colonization of the intestines. MBio (2012) 0.96
Transcriptomic analysis reveals new regulatory roles of Clp signaling in secondary metabolite biosynthesis and surface motility in Lysobacter enzymogenes OH11. Appl Microbiol Biotechnol (2014) 0.96
Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells. Toxicol In Vitro (2011) 0.95
UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination. Cell Res (2013) 0.95
RAD51C germline mutations in Chinese women with familial breast cancer. Breast Cancer Res Treat (2011) 0.95
Rhodium(II)- and copper(II)-catalyzed reactions of enol diazoacetates with nitrones: metal carbene versus Lewis acid directed pathways. Angew Chem Int Ed Engl (2012) 0.94
Self-assembled hydrophobic honokiol loaded MPEG-PCL diblock copolymer micelles. Pharm Res (2009) 0.94
Lyase activities of CpcS- and CpcT-like proteins from Nostoc PCC7120 and sequential reconstitution of binding sites of phycoerythrocyanin and phycocyanin beta-subunits. J Biol Chem (2007) 0.94
Effects of subchronic exposure to multi-walled carbon nanotubes on mice. J Toxicol Environ Health A (2010) 0.94
Transmission dynamics and control for a brucellosis model in Hinggan League of Inner Mongolia, China. Math Biosci Eng (2014) 0.94
Polymeric matrix for drug delivery: honokiol-loaded PCL-PEG-PCL nanoparticles in PEG-PCL-PEG thermosensitive hydrogel. J Biomed Mater Res A (2010) 0.94
Genetic control of soybean seed isoflavone content: importance of statistical model and epistasis in complex traits. Theor Appl Genet (2009) 0.93
Nonparametric methods for measurements below detection limit. Stat Med (2009) 0.92
The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells. J Biol Chem (2010) 0.92
Dexmedetomidine prevents remifentanil-induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl-d-aspartate receptor 2B subunit. Brain Res Bull (2012) 0.92
Molecular and functional characterization of sulfiredoxin homologs from higher plants. Cell Res (2006) 0.92
Catalases promote resistance of oxidative stress in Vibrio cholerae. PLoS One (2012) 0.92
Protective effect of glutamine-enriched early enteral nutrition on intestinal mucosal barrier injury after liver transplantation in rats. Am J Surg (2010) 0.92
Poly(epsilon-caprolactone)/poly(ethylene glycol)/poly(epsilon-caprolactone) nanoparticles: preparation, characterization, and application in doxorubicin delivery. J Phys Chem B (2009) 0.92
Tyrosines in the carboxyl terminus regulate Syk kinase activity and function. J Biol Chem (2010) 0.92
Black and green teas equally inhibit diabetic cataracts in a streptozotocin-induced rat model of diabetes. J Agric Food Chem (2005) 0.91
Guidelines for monitoring autophagy in Caenorhabditis elegans. Autophagy (2015) 0.91
Phospholipase D1 regulates high-affinity IgE receptor-induced mast cell degranulation. Blood (2004) 0.91
CyclinD1, a prominent prognostic marker for endometrial diseases. Diagn Pathol (2013) 0.91
Evidence for oxidative stress in NSAID-induced colitis in IL10-/- mice. Free Radic Biol Med (2003) 0.91
Lactobacillus casei combats acid stress by maintaining cell membrane functionality. J Ind Microbiol Biotechnol (2012) 0.90