Published in J Clin Invest on October 01, 2010
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Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes Dev (2011) 3.04
Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation. Immunity (2013) 2.19
CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest (2011) 1.49
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Cathepsin K knockout mitigates high-fat diet-induced cardiac hypertrophy and contractile dysfunction. Diabetes (2012) 1.02
Activation of the Nipah virus fusion protein in MDCK cells is mediated by cathepsin B within the endosome-recycling compartment. J Virol (2012) 1.00
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A multifunctional protease inhibitor to regulate endolysosomal function. ACS Chem Biol (2011) 0.79
Internalization of exogenous cystatin F supresses cysteine proteases and induces the accumulation of single-chain cathepsin L by multiple mechanisms. J Biol Chem (2011) 0.79
Coexpression of heparanase activity, cathepsin L, tissue factor, tissue factor pathway inhibitor, and MMP-9 in proliferative diabetic retinopathy. Mol Vis (2016) 0.79
Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis. Am J Respir Cell Mol Biol (2013) 0.79
Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon. Biol Chem (2012) 0.79
Processing of CXCL12 by different osteoblast-secreted cathepsins. Stem Cells Dev (2012) 0.79
Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes. J Biol Chem (2012) 0.79
Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells. Oncotarget (2015) 0.79
Molecular dynamics simulation of halogen bonding mimics experimental data for cathepsin L inhibition. J Comput Aided Mol Des (2014) 0.78
Pro-atherogenic shear stress and HIV proteins synergistically upregulate cathepsin K in endothelial cells. Ann Biomed Eng (2014) 0.78
Endothelial cells and cathepsins: Biochemical and biomechanical regulation. Biochimie (2015) 0.78
A snapshot of the Ixodes scapularis degradome. Gene (2011) 0.78
Monocyte-derived macrophage assisted breast cancer cell invasion as a personalized, predictive metric to score metastatic risk. Sci Rep (2015) 0.78
Microscopic detection of quenched activity-based optical imaging probes using an antibody detection system: localizing protease activity. Mol Imaging Biol (2014) 0.78
Interaction of protein C inhibitor with the type II transmembrane serine protease enteropeptidase. PLoS One (2012) 0.78
Cathepsin Gene Family Reveals Transcriptome Patterns Related to the Infective Stages of the Salmon Louse Caligus rogercresseyi. PLoS One (2015) 0.78
Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer. BMC Cancer (2016) 0.78
Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K-Akt/p-HDAC6 Signaling Pathway. Arterioscler Thromb Vasc Biol (2016) 0.77
Synthesis of dehydrodipeptide esters and their evaluation as inhibitors of cathepsin C. Med Chem Res (2015) 0.77
The protease degrading sperm histones post-fertilization in sea urchin eggs is a nuclear cathepsin L that is further required for embryo development. PLoS One (2012) 0.77
Intracellular killing of bacteria: is Dictyostelium a model macrophage or an alien? Cell Microbiol (2014) 0.77
Increased Circulating Cathepsin K in Patients with Chronic Heart Failure. PLoS One (2015) 0.77
Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry (2012) 0.77
The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans. Mol Biol Cell (2014) 0.77
The protease cathepsin L regulates Th17 cell differentiation. J Autoimmun (2015) 0.76
Interactions of human MSC with head and neck squamous cell carcinoma cell line PCI-13 reduce markers of epithelia-mesenchymal transition. Clin Oral Investig (2014) 0.76
Isolation and characterization of chicken bile matrix metalloproteinase. Poult Sci (2014) 0.76
Cystatin D Locates in the Nucleus at Sites of Active Transcription and Modulates Gene and Protein Expression. J Biol Chem (2015) 0.76
Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation. FASEB J (2013) 0.76
Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells. Mol Cancer (2015) 0.76
Bifunctional Probes of Cathepsin Protease Activity and pH Reveal Alterations in Endolysosomal pH during Bacterial Infection. Cell Chem Biol (2016) 0.75
Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans. Sci Rep (2017) 0.75
The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development. Curr Mol Med (2016) 0.75
Lactobacillus-derived extracellular vesicles enhance host immune responses against vancomycin-resistant enterococci. BMC Microbiol (2017) 0.75
Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies. Biol Chem (2015) 0.75
Heterozygous Ile453Val codon mutation in exon 7, homozygous single nucleotide polymorphisms in intron 2 and 5 of cathepsin C are associated with Haim-Munk syndrome. Eur J Dent (2014) 0.75
Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis. Parasit Vectors (2015) 0.75
New cancer therapies and jaw necrosis. Br Dent J (2015) 0.75
Effect of poloxamer 407 administration on the serum lipids profile, anxiety level and protease activity in the heart and liver of mice. Interdiscip Toxicol (2013) 0.75
Cathepsin B Inhibitors: Combining Dipeptide Nitriles with an Occluding Loop Recognition Element by Click Chemistry. ACS Med Chem Lett (2015) 0.75
IGF-1 promotes the growth and metastasis of hepatocellular carcinoma via the inhibition of proteasome-mediated cathepsin B degradation. World J Gastroenterol (2015) 0.75
In vivo imaging of tissue-remodeling activity involving infiltration of macrophages by a systemically administered protease-activatable probe in colon cancer tissues. Transl Oncol (2013) 0.75
Detection of Plasma Protease Activity Using Microsphere-Cytometry Assays with E. coli Derived Substrates: VWF Proteolysis by ADAMTS13. PLoS One (2015) 0.75
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Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res (2006) 2.20
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A (2003) 1.83
Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat Med (2005) 1.69
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci U S A (2010) 1.60
Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice. Gut (2011) 1.58
CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest (2011) 1.49
Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nat Nanotechnol (2011) 1.41
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation. J Exp Med (2008) 1.38
Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc Natl Acad Sci U S A (2002) 1.37
Thyroid functions of mouse cathepsins B, K, and L. J Clin Invest (2003) 1.33
Toward computer-based cleavage site prediction of cysteine endopeptidases. Biol Chem (2003) 1.27
Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone. J Bone Miner Res (2006) 1.21
The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling. Am J Pathol (2002) 1.11
Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression. J Biol Chem (2008) 1.10
Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem (2006) 1.10
Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol (2011) 1.09
Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice. Gastroenterology (2009) 1.07
Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer. Biol Chem (2010) 1.06
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Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression. J Neurochem (2008) 1.03
Cathepsin B & L are not required for ebola virus replication. PLoS Negl Trop Dis (2012) 1.02
Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein. Biochem Biophys Res Commun (2009) 1.00
Activation of the Nipah virus fusion protein in MDCK cells is mediated by cathepsin B within the endosome-recycling compartment. J Virol (2012) 1.00
Cathepsin H is an additional convertase of pro-granzyme B. J Biol Chem (2010) 0.99
Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biol Chem (2004) 0.98
Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model. Biol Chem (2008) 0.98
Impaired turnover of autophagolysosomes in cathepsin L deficiency. Biol Chem (2010) 0.98
Specific functions of lysosomal proteases in endocytic and autophagic pathways. Biochim Biophys Acta (2011) 0.97
Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression. Mol Cell Neurosci (2009) 0.96
Mutations in LRPAP1 are associated with severe myopia in humans. Am J Hum Genet (2013) 0.96
Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. PLoS One (2011) 0.95
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice. FASEB J (2006) 0.94
LIMP-2 links late phagosomal trafficking with the onset of the innate immune response to Listeria monocytogenes: a role in macrophage activation. J Biol Chem (2010) 0.92
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Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L. Biochem J (2011) 0.91
Nitric oxide produced in rat liver mitochondria causes oxidative stress and impairment of respiration after transient hypoxia. FASEB J (2003) 0.91
Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies. Peptides (2009) 0.91
A role for cathepsin E in the processing of mast-cell carboxypeptidase A. J Cell Sci (2005) 0.90
Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in mice. PLoS One (2011) 0.90
Isolation in cell cultures and initial characterisation of two novel bocavirus species from swine in Northern Ireland. Vet Microbiol (2011) 0.89
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The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles. Eur J Cell Biol (2004) 0.89
Cellular senescence induced by cathepsin X downregulation. Eur J Cell Biol (2011) 0.89
Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice. Biol Chem (2006) 0.88
A transporter associated with antigen-processing independent vacuolar pathway for the MHC class I-mediated presentation of endogenous transmembrane proteins. J Immunol (2007) 0.88
Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins. Free Radic Res (2010) 0.88
Asparagine endopeptidase is required for normal kidney physiology and homeostasis. FASEB J (2011) 0.88
Cell type-specific functions of the lysosomal protease cathepsin L in the heart. J Biol Chem (2007) 0.87
The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length. Biol Chem (2014) 0.87
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Cardiac and ocular pathologies in a mouse model of mucopolysaccharidosis type VI. Pediatr Res (2003) 0.86
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Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology (2010) 0.85
Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters. J Neurochem (2012) 0.85
The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea. FASEB J (2010) 0.85
Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases. Biol Chem (2009) 0.84
Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters. J Biol Chem (2012) 0.84
The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction. FASEB J (2013) 0.84
Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts. Biol Chem (2011) 0.83
Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor. Int J Cancer (2010) 0.83
Cathepsins D and L reduce the toxicity of advanced glycation end products. Free Radic Biol Med (2012) 0.82
Reproduction of postweaning multisystemic wasting syndrome in pigs experimentally inoculated with a Swedish porcine circovirus 2 isolate. J Vet Diagn Invest (2003) 0.82
Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis. Cell Mol Life Sci (2013) 0.81
Proteolytic cleavage of the disease-related lysosomal membrane glycoprotein CLN7. Biochim Biophys Acta (2012) 0.80
Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery. Biol Chem (2009) 0.80
Cysteine cathepsins are not involved in Fas/CD95 signalling in primary skin fibroblasts. FEBS Lett (2007) 0.79
Cathepsin X-deficient gastric epithelial cells in co-culture with macrophages: characterization of cytokine response and migration capability after Helicobacter pylori infection. J Biol Chem (2010) 0.79
Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP. Biol Chem (2011) 0.78
Allergic airway inflammation in mice deficient for the antigen-processing protease cathepsin E. Int Arch Allergy Immunol (2012) 0.78
Induction of premalignant host responses by cathepsin x/z-deficiency in Helicobacter pylori-infected mice. PLoS One (2013) 0.77
Reduced neutrophil sequestration in lung tissue after laparoscopic lavage in a rat peritonitis model. World J Surg (2001) 0.77
Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice. Biochimie (2010) 0.77
Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment. Inflamm Res (2012) 0.76
Sensitive detection of African swine fever virus using real-time PCR with a 5' conjugated minor groove binder probe. J Virol Methods (2010) 0.75
Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies. Biol Chem (2015) 0.75
Molecular beacon real-time PCR detection of swine viruses. J Virol Methods (2006) 0.75
CA/C1 peptidases of the malaria parasites Plasmodium falciparum and P. berghei and their mammalian hosts--a bioinformatical analysis. Biol Chem (2009) 0.75
An open source protein gel documentation system for proteome analyses. J Chem Inf Comput Sci (2004) 0.75