Published in Curr Opin Pharmacol on October 14, 2010
Development of subtype-selective oestrogen receptor-based therapeutics. Nat Rev Drug Discov (2011) 1.39
Estrogen receptors regulate an inflammatory pathway of dendritic cell differentiation: mechanisms and implications for immunity. Horm Behav (2012) 1.12
Estrogen receptors regulate innate immune cells and signaling pathways. Cell Immunol (2015) 1.12
Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential. Steroids (2014) 1.07
Estrogen negatively regulates epithelial wound healing and protective lipid mediator circuits in the cornea. FASEB J (2011) 1.06
Estrogen Induces Metastatic Potential of Papillary Thyroid Cancer Cells through Estrogen Receptor α and β. Int J Endocrinol (2013) 0.93
Understanding nuclear receptor form and function using structural biology. J Mol Endocrinol (2013) 0.91
Estrogen protects against intracranial aneurysm rupture in ovariectomized mice. Hypertension (2014) 0.89
Selective oestrogen receptor modulators differentially potentiate brain mitochondrial function. J Neuroendocrinol (2012) 0.86
Estrogenic plant consumption predicts red colobus monkey (Procolobus rufomitratus) hormonal state and behavior. Horm Behav (2012) 0.83
ERβ-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1. Hum Reprod (2013) 0.83
Selective insulin receptor modulators (SIRM): a new class of antidiabetes drugs? Diabetes (2012) 0.83
The sulfatase pathway for estrogen formation: targets for the treatment and diagnosis of hormone-associated tumors. J Drug Deliv (2013) 0.82
Estrogens and stem cells in thyroid cancer. Front Endocrinol (Lausanne) (2014) 0.82
Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice. Neurosurgery (2014) 0.80
Estrogenic plant extracts reverse weight gain and fat accumulation without causing mammary gland or uterine proliferation. PLoS One (2011) 0.80
Estrogen and thyroid cancer is a stem affair: A preliminary study. Biomed Pharmacother (2016) 0.77
Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α. Drug Des Devel Ther (2015) 0.77
Development of a recombinant human ovarian (BG1) cell line containing estrogen receptor α and β for improved detection of estrogenic/antiestrogenic chemicals. Environ Toxicol Chem (2015) 0.76
Effects of ospemifene on the female reproductive and urinary tracts: translation from preclinical models into clinical evidence. Menopause (2015) 0.75
Estrogen Receptor β in Melanoma: From Molecular Insights to Potential Clinical Utility. Front Endocrinol (Lausanne) (2016) 0.75
Dose- and Time-Dependent Transcriptional Response of Ishikawa Cells Exposed to Genistein. Toxicol Sci (2016) 0.75
Estrogen stabilizes hypoxia-inducible factor 1α through G protein-coupled estrogen receptor 1 in eutopic endometrium of endometriosis. Fertil Steril (2016) 0.75
Effects of selective and combined activation of estrogen receptor α and β on reproductive organ development and sexual behaviour in Japanese quail (Coturnix japonica). PLoS One (2017) 0.75
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA (2002) 80.37
Genome-wide analysis of estrogen receptor binding sites. Nat Genet (2006) 18.63
Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell (2005) 14.32
FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell (2008) 14.18
Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell (2003) 10.42
Whole-genome cartography of estrogen receptor alpha binding sites. PLoS Genet (2007) 5.85
Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc Natl Acad Sci U S A (2000) 5.47
ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands. EMBO J (2009) 5.36
Estrogen receptors: how do they signal and what are their targets. Physiol Rev (2007) 5.27
The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology (1999) 3.67
Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem (2000) 3.34
Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem (2001) 3.24
Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res (2004) 2.67
Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D. Proc Natl Acad Sci U S A (2004) 2.64
Evaluation of an estrogen receptor-beta agonist in animal models of human disease. Endocrinology (2003) 2.63
Unique ERalpha cistromes control cell type-specific gene regulation. Mol Endocrinol (2008) 2.19
Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors. Endocrinology (2004) 2.10
Estrogen: consequences and implications of human mutations in synthesis and action. J Clin Endocrinol Metab (1999) 1.90
Plasma membrane estrogen receptors. Trends Endocrinol Metab (2009) 1.85
Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta. J Cell Biochem (2003) 1.76
Characterization of the biological roles of the estrogen receptors, ERalpha and ERbeta, in estrogen target tissues in vivo through the use of an ERalpha-selective ligand. Endocrinology (2002) 1.74
Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis. Nat Rev Cancer (2006) 1.72
Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell (2003) 1.70
Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene (2005) 1.65
MF101, a selective estrogen receptor beta modulator for the treatment of menopausal hot flushes: a phase II clinical trial. Menopause (2009) 1.63
Estrogen receptor-beta activation results in S-nitrosylation of proteins involved in cardioprotection. Circulation (2009) 1.56
Estrogen receptor alpha and beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells. Mol Endocrinol (2005) 1.48
Estrogen receptor β ligands: recent advances and biomedical applications. Med Res Rev (2011) 1.38
Genome-wide dynamics of chromatin binding of estrogen receptors alpha and beta: mutual restriction and competitive site selection. Mol Endocrinol (2009) 1.34
The SWI/SNF chromatin remodeling subunit BAF57 is a critical regulator of estrogen receptor function in breast cancer cells. J Biol Chem (2006) 1.32
Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem (2004) 1.30
Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol Cell Endocrinol (2007) 1.30
Structure-based design of estrogen receptor-beta selective ligands. J Am Chem Soc (2004) 1.29
The genome landscape of ERalpha- and ERbeta-binding DNA regions. Proc Natl Acad Sci U S A (2008) 1.27
Selective estrogen receptor-beta agonists repress transcription of proinflammatory genes. J Immunol (2008) 1.26
Estrogen receptor beta binds to and regulates three distinct classes of target genes. J Biol Chem (2010) 1.21
A selective estrogen receptor-beta agonist causes lesion regression in an experimentally induced model of endometriosis. Hum Reprod (2004) 1.10
The estrogen receptor {alpha}-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms. J Endocrinol (2008) 1.09
Modulation of steroid hormone receptor activity. Prog Brain Res (2010) 1.07
Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology (2006) 1.04
The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes. J Endocrinol (2006) 1.04
Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists. PLoS One (2009) 0.99
Multiple transcription factor elements collaborate with estrogen receptor alpha to activate an inducible estrogen response element in the NKG2E gene. Endocrinology (2007) 0.96
WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock. Crit Care Med (2006) 0.94
Retracted Coactivation of estrogen receptor beta by gonadotropin-induced cofactor GIOT-4. Mol Cell Biol (2008) 0.91
Unliganded estrogen receptor-beta regulation of genes is inhibited by tamoxifen. Mol Cell Endocrinol (2009) 0.89
Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics (2003) 100.88
Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res (2003) 52.74
Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res (2002) 40.03
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell (2010) 39.09
GOstat: find statistically overrepresented Gene Ontologies within a group of genes. Bioinformatics (2004) 30.14
International network of cancer genome projects. Nature (2010) 20.35
A genotype calling algorithm for affymetrix SNP arrays. Bioinformatics (2005) 10.43
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature (2007) 7.91
Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm. PLoS Biol (2008) 6.30
A benchmark for Affymetrix GeneChip expression measures. Bioinformatics (2004) 5.99
Exploration, normalization, and genotype calls of high-density oligonucleotide SNP array data. Biostatistics (2006) 5.20
Summarizing and correcting the GC content bias in high-throughput sequencing. Nucleic Acids Res (2012) 4.94
Subtype and pathway specific responses to anticancer compounds in breast cancer. Proc Natl Acad Sci U S A (2011) 4.55
Expression profiling in primates reveals a rapid evolution of human transcription factors. Nature (2006) 4.26
Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites. Genome Biol (2006) 3.45
Spotted long oligonucleotide arrays for human gene expression analysis. Genome Res (2003) 2.95
A single-array preprocessing method for estimating full-resolution raw copy numbers from all Affymetrix genotyping arrays including GenomeWideSNP 5 & 6. Bioinformatics (2009) 2.90
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer. Proc Natl Acad Sci U S A (2010) 2.79
Using control genes to correct for unwanted variation in microarray data. Biostatistics (2011) 2.70
Functional genomic analysis of oligodendrocyte differentiation. J Neurosci (2006) 2.64
Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity. Nat Cell Biol (2010) 2.38
Mining a tandem mass spectrometry database to determine the trends and global factors influencing peptide fragmentation. Anal Chem (2003) 2.28
Statistical modeling of sequencing errors in SAGE libraries. Bioinformatics (2004) 2.25
Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development. Genome Biol (2011) 2.18
Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex. PLoS Biol (2006) 2.17
Integrative analysis of RUNX1 downstream pathways and target genes. BMC Genomics (2008) 2.14
Network inference using informative priors. Proc Natl Acad Sci U S A (2008) 1.96
Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum. Mol Cell Proteomics (2006) 1.86
Gene set enrichment analysis made simple. Stat Methods Med Res (2009) 1.79
Regulation of apicomplexan actin-based motility. Nat Rev Microbiol (2006) 1.78
Evaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias, and copy number variation. Genome Res (2010) 1.77
A quartet of PIF bHLH factors provides a transcriptionally centered signaling hub that regulates seedling morphogenesis through differential expression-patterning of shared target genes in Arabidopsis. PLoS Genet (2013) 1.73
Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol (2009) 1.72
A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle. J Biol Chem (2002) 1.71
TumorBoost: normalization of allele-specific tumor copy numbers from a single pair of tumor-normal genotyping microarrays. BMC Bioinformatics (2010) 1.70
A Tetrahymena Piwi bound to mature tRNA 3' fragments activates the exonuclease Xrn2 for RNA processing in the nucleus. Mol Cell (2012) 1.65
MF101, a selective estrogen receptor beta modulator for the treatment of menopausal hot flushes: a phase II clinical trial. Menopause (2009) 1.63
Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression. Mol Cell (2006) 1.63
A new rodent model to assess blood stage immunity to the Plasmodium falciparum antigen merozoite surface protein 119 reveals a protective role for invasion inhibitory antibodies. J Exp Med (2003) 1.61
Identification of candidate growth promoting genes in ovarian cancer through integrated copy number and expression analysis. PLoS One (2010) 1.60
A single-sample method for normalizing and combining full-resolution copy numbers from multiple platforms, labs and analysis methods. Bioinformatics (2009) 1.53
A comparison of Affymetrix gene expression arrays. BMC Bioinformatics (2007) 1.53
Reticulocyte and erythrocyte binding-like proteins function cooperatively in invasion of human erythrocytes by malaria parasites. Infect Immun (2010) 1.52
The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling. J Biol Chem (2006) 1.45
High-quality DNA sequence capture of 524 disease candidate genes. Proc Natl Acad Sci U S A (2011) 1.41
Molecular analysis of gene expression in the developing pontocerebellar projection system. Neuron (2002) 1.37
Protocol matters: which methylome are you actually studying? Epigenomics (2010) 1.37
The type I TGF-beta receptor is covalently modified and regulated by sumoylation. Nat Cell Biol (2008) 1.37
Genome-wide analysis of glucocorticoid receptor binding regions in adipocytes reveal gene network involved in triglyceride homeostasis. PLoS One (2010) 1.36
SNPs on chips: the hidden genetic code in expression arrays. Biol Psychiatry (2006) 1.36
Comparing somatic mutation-callers: beyond Venn diagrams. BMC Bioinformatics (2013) 1.35
Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. Proc Natl Acad Sci U S A (2012) 1.33
In vitro anticancer activity of twelve Chinese medicinal herbs. Phytother Res (2005) 1.32
Global analyses of mRNA translational control during early Drosophila embryogenesis. Genome Biol (2007) 1.30
Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population. Mol Endocrinol (2004) 1.30
Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol Cell Endocrinol (2007) 1.30
A dynamic programming approach for the alignment of signal peaks in multiple gas chromatography-mass spectrometry experiments. BMC Bioinformatics (2007) 1.29
Frequency and severity of hot flashes and sleep disturbance in postmenopausal women with hot flashes. Menopause (2009) 1.23
Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases: implications for vaccine and drug design. Infect Immun (2007) 1.23
Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system. Genome Res (2007) 1.21
On gene ranking using replicated microarray time course data. Biometrics (2008) 1.21
Estrogen receptor beta binds to and regulates three distinct classes of target genes. J Biol Chem (2010) 1.21
Genetic dissection of the human leukocyte antigen region by use of haplotypes of Tasmanians with multiple sclerosis. Am J Hum Genet (2002) 1.21
A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife (2013) 1.20
Evolution of the relaxin-like peptide family. BMC Evol Biol (2005) 1.20
Traditional Chinese medicine in the treatment of breast cancer. Semin Oncol (2002) 1.19
Bayesian inference of signaling network topology in a cancer cell line. Bioinformatics (2012) 1.17
Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5. J Biol Chem (2003) 1.17
Identifying nineteenth century genealogical links from genotypes. Hum Genet (2005) 1.17
Finding short DNA motifs using permuted Markov models. J Comput Biol (2005) 1.13
Genome-wide analysis of glucocorticoid receptor-binding sites in myotubes identifies gene networks modulating insulin signaling. Proc Natl Acad Sci U S A (2012) 1.12
Copy-number-aware differential analysis of quantitative DNA sequencing data. Genome Res (2012) 1.12
Fibronectin- and protein kinase C-mediated activation of ERK/MAPK are essential for proplateletlike formation. Blood (2002) 1.11
Multiple testing and its applications to microarrays. Stat Methods Med Res (2009) 1.10
Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancer. BMC Med Genomics (2009) 1.09
Analysis of gene expression in the developing mouse retina. Proc Natl Acad Sci U S A (2003) 1.09
Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes. Proc Natl Acad Sci U S A (2011) 1.09
Normalizing and integrating metabolomics data. Anal Chem (2012) 1.08
Unifying gene expression measures from multiple platforms using factor analysis. PLoS One (2011) 1.06
The wound repair response controls outcome to cutaneous leishmaniasis. Proc Natl Acad Sci U S A (2005) 1.06
Evidence for a novel glaucoma locus at chromosome 3p21-22. Hum Genet (2005) 1.06
Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology (2006) 1.04
A high force of plasmodium vivax blood-stage infection drives the rapid acquisition of immunity in papua new guinean children. PLoS Negl Trop Dis (2013) 1.04
A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer. Breast Cancer Res Treat (2010) 1.03
Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing. Nucleic Acids Res (2010) 1.03
Estrogen receptor β causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2. Breast Cancer Res Treat (2010) 1.02
Differential splicing using whole-transcript microarrays. BMC Bioinformatics (2009) 1.02
Mind the gap: analysis of marker-assisted breeding strategies for inbred mouse strains. Mamm Genome (2006) 1.02
An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. Hum Mutat (2008) 1.02
Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer. Breast Cancer Res Treat (2006) 1.02