Published in PLoS One on October 13, 2010
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Longitudinal data analysis for discrete and continuous outcomes. Biometrics (1986) 60.93
Molecular basis of human hypertension: role of angiotensinogen. Cell (1992) 6.07
Epistasis and its implications for personal genetics. Am J Hum Genet (2009) 3.52
Psychological predictors of hypertension in the Framingham Study. Is there tension in hypertension? JAMA (1993) 3.42
Detection of gene x gene interactions in genome-wide association studies of human population data. Hum Hered (2007) 2.97
Are symptoms of anxiety and depression risk factors for hypertension? Longitudinal evidence from the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. Arch Fam Med (1997) 2.38
NHLBI family blood pressure program: methodology and recruitment in the HyperGEN network. Hypertension genetic epidemiology network. Ann Epidemiol (2000) 2.28
Genes, environment, and cardiovascular disease. Arterioscler Thromb Vasc Biol (2003) 2.04
Associations between anxiety disorders and physical illness. Eur Arch Psychiatry Clin Neurosci (2003) 1.46
Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease: a meta-analysis. Arterioscler Thromb Vasc Biol (2003) 1.17
Polymorphisms of the insertion / deletion ACE and M235T AGT genes and hypertension: surprising new findings and meta-analysis of data. BMC Nephrol (2005) 1.13
Using endophenotypes for pathway clusters to map complex disease genes. Genet Epidemiol (2006) 1.04
From 'omics' to complex disease: a systems biology approach to gene-environment interactions in cancer. Cancer Cell Int (2010) 1.02
Genetic influence on electrocardiogram time intervals and heart rate in aging mice. Am J Physiol Heart Circ Physiol (2009) 1.02
Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study. Ann Hum Genet (2006) 1.01
A gene-environment interaction model of stress-induced hypertension. Cardiovasc Toxicol (2005) 0.94
M235T angiotensinogen gene polymorphism and cardiovascular renal risk. J Hypertens (1999) 0.93
Angiotensinogen M235T polymorphism is associated with coronary artery disease severity. Clin Chim Acta (2005) 0.92
Association between the angiotensinogen 235T-variant and essential hypertension in whites: a systematic review and methodological appraisal. Hypertension (1997) 0.91
The prognostic significance of heart rate for cardiovascular disease and hypertension. Curr Hypertens Rep (2010) 0.89
Angiotensin II--an important stress hormone. Biol Signals (1996) 0.87
Worldwide genetic variation in dopamine and serotonin pathway genes: implications for association studies. Am J Med Genet B Neuropsychiatr Genet (2008) 0.86
Essential hypertension: abnormal renal vascular and endocrine responses to a mild psychological stimulus. Hypertension (1981) 0.86
Genetic polymorphisms of angiotensin-2 type 1 receptor and angiotensinogen and risk of renal dysfunction and coronary heart disease in type 2 diabetes mellitus. BMC Nephrol (2009) 0.82
Renin correlates with blood pressure reactivity to stressors. Neuropsychopharmacology (1990) 0.81
Cardiovascular phenotype of young adults and angiotensinogen alleles. J Hypertens (2001) 0.79
Heart rhythm genomic fabric in hypoxia. Biochem Biophys Res Commun (2009) 0.79
Hemodynamic and endocrine effects of mental stress in untreated borderline hypertension. Am J Hypertens (1990) 0.77
Genome-wide patterns of population structure and admixture in West Africans and African Americans. Proc Natl Acad Sci U S A (2009) 5.39
BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies. Nucleic Acids Res (2006) 4.93
European Society of Hypertension position paper on ambulatory blood pressure monitoring. J Hypertens (2013) 4.28
Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies. BMJ (2009) 3.99
Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y. Am J Clin Nutr (2004) 3.76
Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data. Ann Intern Med (2011) 3.65
Comparative efficacy, acceptability, and tolerability of augmentation agents in treatment-resistant depression: systematic review and network meta-analysis. J Clin Psychiatry (2015) 3.46
The Felodipine Event Reduction (FEVER) Study: a randomized long-term placebo-controlled trial in Chinese hypertensive patients. J Hypertens (2005) 3.27
Alcohol consumption and risk for congestive heart failure in the Framingham Heart Study. Ann Intern Med (2002) 3.12
Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis. Arthritis Rheum (2006) 2.81
Risk for cardiovascular disease early and late after a diagnosis of giant-cell arteritis: a cohort study. Ann Intern Med (2014) 2.76
Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease. Gastroenterology (2008) 2.70
A new approach yields high rates of radiographic progression in knee osteoarthritis. J Rheumatol (2008) 2.63
The effect of body weight on progression of knee osteoarthritis is dependent on alignment. Arthritis Rheum (2004) 2.58
Body weight and psychological distress in NHANES I. Int J Obes Relat Metab Disord (1992) 2.47
Chocolate consumption is inversely associated with prevalent coronary heart disease: the National Heart, Lung, and Blood Institute Family Heart Study. Clin Nutr (2010) 2.40
Antihypertensive drugs and risk of incident gout among patients with hypertension: population based case-control study. BMJ (2012) 2.39
Increasing incidence of shoulder arthroplasty in the United States. J Bone Joint Surg Am (2011) 2.15
Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: the Framingham Study. Arthritis Rheum (2007) 2.12
Knee alignment does not predict incident osteoarthritis: the Framingham osteoarthritis study. Arthritis Rheum (2007) 2.11
Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study. Circulation (2005) 2.03
Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos. Nat Med (2010) 2.01
Alcohol consumption and risk of ischemic stroke: The Framingham Study. Stroke (2002) 1.97
The Longitudinal Examination of Arthritis Pain (LEAP) study: relationships between weekly fluctuations in patient-rated joint pain and other health outcomes. J Rheumatol (2007) 1.95
Tibiofemoral joint osteoarthritis: risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis study. Radiology (2009) 1.95
Frequency and predictors of inappropriate management of recurrent gout attacks in a longitudinal study. J Rheumatol (2005) 1.93
Structural factors associated with malalignment in knee osteoarthritis: the Boston osteoarthritis knee study. J Rheumatol (2005) 1.93
Weight loss in overweight adults and the long-term risk of hypertension: the Framingham study. Arch Intern Med (2005) 1.91
Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci U S A (2007) 1.81
Recent diuretic use and the risk of recurrent gout attacks: the online case-crossover gout study. J Rheumatol (2006) 1.79
Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta. J Biol Chem (2005) 1.75
A case-control study of oral contraceptive use and incident breast cancer. Am J Epidemiol (2008) 1.72
Does early physical activity predict body fat change throughout childhood? Prev Med (2003) 1.68
Genome scans for blood pressure and hypertension: the National Heart, Lung, and Blood Institute Family Heart Study. Hypertension (2002) 1.66
Bone marrow lesions in the knee are associated with increased local bone density. Arthritis Rheum (2005) 1.64
Blood pressure reduction for the secondary prevention of stroke: a Chinese trial and a systematic review of the literature. Hypertens Res (2009) 1.63
Obesity and the risk of psoriatic arthritis: a population-based study. Ann Rheum Dis (2012) 1.63
Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study. Ann Rheum Dis (2011) 1.63
Epidemiology of osteoarthritis. Rheum Dis Clin North Am (2012) 1.61
Use of a DASH food group score to predict excess weight gain in adolescent girls in the National Growth and Health Study. Arch Pediatr Adolesc Med (2011) 1.60
Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes. J Biol Chem (2003) 1.60
MicroRNA-196: critical roles and clinical applications in development and cancer. J Cell Mol Med (2011) 1.59
European Society of Hypertension practice guidelines for ambulatory blood pressure monitoring. J Hypertens (2014) 1.58
PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J (2008) 1.58
A summary of the effects of antihypertensive medications on measured blood pressure. Am J Hypertens (2005) 1.55
Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling. J Biol Chem (2004) 1.52
Effect of birth cohort on risk of hip fracture: age-specific incidence rates in the Framingham Study. Am J Public Health (2002) 1.50
Daily walking and the risk of incident functional limitation in knee osteoarthritis: an observational study. Arthritis Care Res (Hoboken) (2014) 1.50
Nocturnal risk of gout attacks. Arthritis Rheumatol (2015) 1.46
Midlife psychological stress and risk of dementia: a 35-year longitudinal population study. Brain (2010) 1.45
Commentary: effect of obesity on mortality: comment on article by Banack and Kaufman. Epidemiology (2014) 1.45
Coronary artery disease risk in familial combined hyperlipidemia and familial hypertriglyceridemia: a case-control comparison from the National Heart, Lung, and Blood Institute Family Heart Study. Circulation (2003) 1.44
Breath malodor reduction with use of a stannous-containing sodium fluoride dentifrice: a meta-analysis of four randomized and controlled clinical trials. Am J Dent (2010) 1.44
Sex differences in musculoskeletal pain in older adults. Pain (2005) 1.44
Risk of cardiac arrhythmias during hypoglycemia in patients with type 2 diabetes and cardiovascular risk. Diabetes (2014) 1.42
Lifestyle determinants of high-density lipoprotein cholesterol: the National Heart, Lung, and Blood Institute Family Heart Study. Am Heart J (2004) 1.41
Long-term alcohol consumption and the risk of atrial fibrillation in the Framingham Study. Am J Cardiol (2004) 1.41
Hoffa's Fat Pad: Evaluation on Unenhanced MR Images as a Measure of Patellofemoral Synovitis in Osteoarthritis. AJR Am J Roentgenol (2009) 1.39
Alcohol consumption and metabolic syndrome: does the type of beverage matter? Obes Res (2004) 1.38
Real-time individual predictions of prostate cancer recurrence using joint models. Biometrics (2013) 1.38
Meniscal pathology on MRI increases the risk for both incident and enlarging subchondral bone marrow lesions of the knee: the MOST Study. Ann Rheum Dis (2010) 1.36
Overcoming drug resistance in pancreatic cancer. Expert Opin Ther Targets (2011) 1.36
Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: the Beijing osteoarthritis study. Arthritis Rheum (2002) 1.36
Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes. J Mol Cell Cardiol (2006) 1.35
Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study. Ann Rheum Dis (2010) 1.35
Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH. J Biol Chem (2003) 1.34
Role of mast cells in acupuncture effect: a pilot study. Explore (NY) (2008) 1.32
Quadriceps weakness and its relationship to tibiofemoral and patellofemoral knee osteoarthritis in Chinese: the Beijing osteoarthritis study. Arthritis Rheum (2004) 1.32
Serum albumin and risk of myocardial infarction and all-cause mortality in the Framingham Offspring Study. Circulation (2002) 1.32
Association of lifestyle factors with abdominal subcutaneous and visceral adiposity: the Framingham Heart Study. Diabetes Care (2008) 1.31
Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts. Clin Cancer Res (2009) 1.30
Trajectories of gait speed predict mortality in well-functioning older adults: the Health, Aging and Body Composition study. J Gerontol A Biol Sci Med Sci (2012) 1.29
High prevalence of lateral knee osteoarthritis in Beijing Chinese compared with Framingham Caucasian subjects. Arthritis Rheum (2002) 1.27
An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study. BMC Genet (2007) 1.27
Positional identification of hypertension susceptibility genes on chromosome 2. Hypertension (2004) 1.25
Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation. J Immunol (2002) 1.23
Fruit and vegetable consumption and LDL cholesterol: the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr (2004) 1.23
Differential phosphorylation of NG2 proteoglycan by ERK and PKCalpha helps balance cell proliferation and migration. J Cell Biol (2007) 1.22
Migraine, fibromyalgia, and depression among people with IBS: a prevalence study. BMC Gastroenterol (2006) 1.21
Incidence and risk factors for vertebral fracture in women and men: 25-year follow-up results from the population-based Framingham study. J Bone Miner Res (2006) 1.21
Intake of fruits, vegetables, and dairy products in early childhood and subsequent blood pressure change. Epidemiology (2005) 1.21
Control of vesicle fusion by a tyrosine phosphatase. Nat Cell Biol (2004) 1.21
Secular trends in alcohol consumption over 50 years: the Framingham Study. Am J Med (2008) 1.20
Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location. Biochem J (2004) 1.20
Patterns of compartment involvement in tibiofemoral osteoarthritis in men and women and in whites and African Americans. Arthritis Care Res (Hoboken) (2012) 1.20
Symptoms of posttraumatic stress disorder among adult survivors three months after the Sichuan earthquake in China. J Trauma Stress (2009) 1.19
KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases. FEBS J (2008) 1.18
Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia. J Cereb Blood Flow Metab (2006) 1.18
Tyrosine phosphorylation of VHR phosphatase by ZAP-70. Nat Immunol (2002) 1.16
Blood pressure trajectories from midlife to late life in relation to dementia in women followed for 37 years. Hypertension (2012) 1.16
Positive association between serum 25-hydroxyvitamin D level and bone density in osteoarthritis. Arthritis Rheum (2005) 1.15
Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells. Blood (2008) 1.15
Confirmation of a low α/β ratio for prostate cancer treated by external beam radiation therapy alone using a post-treatment repeated-measures model for PSA dynamics. Int J Radiat Oncol Biol Phys (2010) 1.15
Parental obesity and offspring serum alanine and aspartate aminotransferase levels: the Framingham heart study. Gastroenterology (2008) 1.15
Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR). J Biol Chem (2001) 1.14
Online adaptive radiotherapy for muscle-invasive bladder cancer: results of a pilot study. Int J Radiat Oncol Biol Phys (2010) 1.13
Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes. J Biol Chem (2005) 1.13
Magnetic resonance imaging-based three-dimensional bone shape of the knee predicts onset of knee osteoarthritis: data from the osteoarthritis initiative. Arthritis Rheum (2013) 1.13
Serum uric acid is associated with carotid plaques: the National Heart, Lung, and Blood Institute Family Heart Study. J Rheumatol (2009) 1.11