Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.

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Published in N Engl J Med on October 28, 2010

Authors

Eunice L Kwak1, Yung-Jue Bang, D Ross Camidge, Alice T Shaw, Benjamin Solomon, Robert G Maki, Sai-Hong I Ou, Bruce J Dezube, Pasi A Jänne, Daniel B Costa, Marileila Varella-Garcia, Woo-Ho Kim, Thomas J Lynch, Panos Fidias, Hannah Stubbs, Jeffrey A Engelman, Lecia V Sequist, WeiWei Tan, Leena Gandhi, Mari Mino-Kenudson, Greg C Wei, S Martin Shreeve, Mark J Ratain, Jeffrey Settleman, James G Christensen, Daniel A Haber, Keith Wilner, Ravi Salgia, Geoffrey I Shapiro, Jeffrey W Clark, A John Iafrate

Author Affiliations

1: Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA. ekwak@partners.org

Associated clinical trials:

A Study Of Oral PF-02341066, A C-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer (PROFILE 1001) | NCT00585195

Program to Establish the Genetic and Immunologic Profile of Patient's Tumor for All Types of Advanced Cancer (PROFILER) | NCT01774409

Study to Evaluate Resistance Mechanisms and Real-world Pharmacoeconomics of Crizotinib in NSCLC Patients | NCT02041468

A Phase I/Ib Study of MEK162, a MEK Inhibitor, in Combination With Carboplatin and Pemetrexed in Patients With Non-squamous Carcinoma of the Lung (MEK162) | NCT02185690

Matching Patients With Hematologic Malignancy to Adequate Clinical Trials | NCT02758080

Nimotuzumab Combined With Chemoradiotherapy for Unresectable Locally Advanced Squamous Cell Lung Cancer | NCT02577341

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