Published in J Antibiot (Tokyo) on November 10, 2010
Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis. Proc Natl Acad Sci U S A (2012) 1.26
A taxonomic and phylogenetic revision of the Penicillium sclerotiorum complex. Stud Mycol (2011) 1.19
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Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity. Antimicrob Agents Chemother (2014) 0.97
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The biology and synthesis of α-hydroxytropolones. Medchemcomm (2014) 0.89
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Sloth hair as a novel source of fungi with potent anti-parasitic, anti-cancer and anti-bacterial bioactivity. PLoS One (2014) 0.80
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Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol (2003) 7.84
Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics. J Leukoc Biol (2008) 2.76
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proc Natl Acad Sci U S A (2010) 2.29
Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol. Proc Natl Acad Sci U S A (2008) 1.88
Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase. J Antibiot (Tokyo) (2006) 1.84
Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases. Chem Biol (2005) 1.80
ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver. Circulation (2004) 1.76
A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis. Biochemistry (2006) 1.67
Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). Biochem Biophys Res Commun (2003) 1.52
Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase). Proc Natl Acad Sci U S A (2003) 1.44
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Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. ACS Synth Biol (2013) 1.40
Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction. J Biol Chem (2005) 1.38
Blue flower color development by anthocyanins: from chemical structure to cell physiology. Nat Prod Rep (2009) 1.30
The onchocerciasis chronicle: from the beginning to the end? Trends Parasitol (2012) 1.28
Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine. J Antibiot (Tokyo) (2009) 1.22
High-resolution structures of a chitinase complexed with natural product cyclopentapeptide inhibitors: mimicry of carbohydrate substrate. Proc Natl Acad Sci U S A (2002) 1.20
Retracted Aberrant methylation of heparan sulfate glucosamine 3-O-sulfotransferase 2 genes as a biomarker in colorectal cancer. Anticancer Res (2010) 1.18
Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness. J Lipid Res (2003) 1.17
Hyper-inducible expression system for streptomycetes. Proc Natl Acad Sci U S A (2004) 1.14
Isolation of new actinomycete strains for the screening of new bioactive compounds. J Gen Appl Microbiol (2003) 1.14
Mechanism by which the lectin actinohivin blocks HIV infection of target cells. Proc Natl Acad Sci U S A (2009) 1.12
Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization. Biochim Biophys Acta (2004) 1.12
Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlH, a non-heme iron dioxygenase of Streptomyces avermitilis. J Am Chem Soc (2006) 1.10
Lariatins, antimycobacterial peptides produced by Rhodococcus sp. K01-B0171, have a lasso structure. J Am Chem Soc (2006) 1.09
Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters. J Ind Microbiol Biotechnol (2013) 1.07
Guadinomines, Type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. I: taxonomy, fermentation, isolation and biological properties. J Antibiot (Tokyo) (2008) 1.07
Enhancement of metabolites productivity of Penicillium pinophilum FKI-5653, by co-culture with Trichoderma harzianum FKI-5655. J Antibiot (Tokyo) (2011) 1.07
Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlI, a cytochrome P450 of Streptomyces avermitilis. J Am Chem Soc (2006) 1.07
Serum cytokine levels in response to hepatic cryoablation. J Surg Oncol (2007) 1.07
Volvulus of the gall bladder diagnosed by ultrasonography, computed tomography, coronal magnetic resonance imaging and magnetic resonance cholangio-pancreatography. World J Gastroenterol (2006) 1.06
Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Arterioscler Thromb Vasc Biol (2011) 1.06
Depletion of CD4+CD25+ regulatory T cells enhances interleukin-2-induced antitumor immunity in a mouse model of colon adenocarcinoma. Cancer Sci (2007) 1.05
Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis. Proc Natl Acad Sci U S A (2011) 1.04
Promising lead compounds for novel antiprotozoals. J Antibiot (Tokyo) (2010) 1.01
Nonomuraea maheshkhaliensis sp. nov., a novel actinomycete isolated from mangrove rhizosphere mud. J Gen Appl Microbiol (2007) 1.00
A new antibiotic, antimycin Ag, produced by Streptomyces sp. K01-0031. J Antibiot (Tokyo) (2005) 0.99
Crystal structure of the non-heme iron dioxygenase PtlH in pentalenolactone biosynthesis. J Biol Chem (2007) 0.99
Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kappaB activation. Antimicrob Agents Chemother (2004) 0.99
Isolation and identification of three new 5-alkenyl-3,3(2H)-furanones from two streptomyces species using a genomic screening approach. J Antibiot (Tokyo) (2006) 0.98
A concise stereoselective route to the indoline spiroaminal framework of neoxaline and oxaline. Org Lett (2005) 0.97
Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate. Arch Biochem Biophys (2006) 0.96
Bottromycin derivatives: efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities. Bioorg Med Chem Lett (2010) 0.95
Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes. J Antibiot (Tokyo) (2007) 0.95
EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-beta signaling in lung fibroblasts. Respir Res (2006) 0.95
Novel mitochondrial complex II isolated from Trypanosoma cruzi is composed of 12 peptides including a heterodimeric Ip subunit. J Biol Chem (2009) 0.94
Structure determination and total synthesis of bottromycin A2: a potent antibiotic against MRSA and VRE. Angew Chem Int Ed Engl (2009) 0.93
Avermectin Biosynthesis. Chem Rev (1997) 0.93
Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages. Proc Natl Acad Sci U S A (2004) 0.93
Epi-trichosetin, a new undecaprenyl pyrophosphate synthase inhibitor, produced by Fusarium oxysporum FKI-4553. J Antibiot (Tokyo) (2013) 0.93
Actinohivin, a novel anti-human immunodeficiency virus protein from an actinomycete, inhibits viral entry to cells by binding high-mannose type sugar chains of gp120. Biochem Biophys Res Commun (2004) 0.93
Aranorosin circumvents arbekacin-resistance in MRSA by inhibiting the bifunctional enzyme AAC(6')/APH(2″). J Antibiot (Tokyo) (2012) 0.92
In vitro antimalarial activity of biflavonoids from Wikstroemia indica. Planta Med (2004) 0.92
Nosokomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. I: Fermentation, isolation and biological properties. J Antibiot (Tokyo) (2010) 0.92
Advances in drug discovery and biochemical studies. Trends Parasitol (2007) 0.91
Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells. Biol Pharm Bull (2007) 0.91
Verticipyrone, a new NADH-fumarate reductase inhibitor, produced by Verticillium sp. FKI-1083. J Antibiot (Tokyo) (2006) 0.91
Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms. Pharmacol Ther (2007) 0.91
Funicone-related compounds, potentiators of antifungal miconazole activity, produced by Talaromycesflavus FKI-0076. J Antibiot (Tokyo) (2002) 0.90
Tensidols, new potentiators of antifungal miconazole activity, produced by Aspergillus niger FKI-2342. J Antibiot (Tokyo) (2006) 0.90
Jogyamycin, a new antiprotozoal aminocyclopentitol antibiotic, produced by Streptomyces sp. a-WM-JG-16.2. J Antibiot (Tokyo) (2012) 0.90
A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium. J Antibiot (Tokyo) (2010) 0.90
Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp. K04-0144. II. Biological activities. J Antibiot (Tokyo) (2008) 0.90
Total synthesis of (-)-borrelidin. Org Lett (2004) 0.89
Antiplasmodial and antitrypanosomal activity of plants from the Kingdom of Saudi Arabia. J Nat Med (2008) 0.89
Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry. J Antibiot (Tokyo) (2009) 0.89
Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550. J Antibiot (Tokyo) (2006) 0.89