Published in J Antibiot (Tokyo) on January 01, 1990
Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci U S A (1999) 5.28
The ubiquitin-proteasome pathway and proteasome inhibitors. Med Res Rev (2001) 2.18
Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system. Angew Chem Int Ed Engl (2014) 1.18
From bortezomib to other inhibitors of the proteasome and beyond. Curr Pharm Des (2013) 1.04
The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium. Chembiochem (2012) 0.95
Development and characterization of proteasome inhibitors. Methods Enzymol (2005) 0.87
Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. ACS Chem Biol (2013) 0.86
The UPS: a promising target for breast cancer treatment. BMC Biochem (2008) 0.85
Chemical genetics: exploring the role of the proteasome in cell biology using natural products and other small molecule proteasome inhibitors. J Med Chem (2008) 0.85
Nocardia asteroides strain GUH-2 induces proteasome inhibition and apoptotic death of cultured cells. Res Microbiol (2006) 0.83
Combined 3D-QSAR, molecular docking and molecular dynamics study on derivatives of peptide epoxyketone and tyropeptin-boronic acid as inhibitors against the β5 subunit of human 20S proteasome. Int J Mol Sci (2011) 0.78
Peptide and Peptide-Like Modulators of 20S Proteasome Enzymatic Activity in Cancer Cells. Int J Pept Res Ther (2006) 0.77
Identifying the Minimal Enzymes Required for Biosynthesis of Epoxyketone Proteasome Inhibitors. Chembiochem (2015) 0.75
Thermostabilization and thermoactivation of thermolabile enzymes by trehalose and its application for the synthesis of full length cDNA. Proc Natl Acad Sci U S A (1998) 4.95
Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta (2000) 4.19
The role of auditory feedback in the control of vocalization in the white-crowned sparrow. Z Tierpsychol (1965) 3.86
A circuit for detection of interaural time differences in the brain stem of the barn owl. J Neurosci (1990) 3.81
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer. Nat Genet (1997) 3.34
Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res (1994) 2.61
A radiation hybrid map of the rat genome containing 5,255 markers. Nat Genet (1999) 2.54
An extracellular poly(3-hydroxybutyrate) depolymerase from Alcaligenes faecalis. Eur J Biochem (1982) 2.49
High-efficiency cloning of Arabidopsis full-length cDNA by biotinylated CAP trapper. Plant J (1998) 2.45
Auditory spatial receptive fields created by multiplication. Science (2001) 2.44
Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. J Cell Biol (2000) 2.36
Decrystallization of adult birdsong by perturbation of auditory feedback. Nature (1999) 2.29
A cytotoxic ribonuclease targeting specific transfer RNA anticodons. Science (1999) 2.29
Hepatitis C virus particle detected by immunoelectron microscopic study. J Gen Virol (1994) 2.28
Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II. Nature (1986) 2.28
Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab Invest (1997) 2.25
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene (1999) 2.22
Interaction between auditory and motor activities in an avian song control nucleus. Proc Natl Acad Sci U S A (1981) 2.20
Late radiographic findings after anterior cervical fusion for spondylotic myeloradiculopathy. Spine (Phila Pa 1976) (1993) 2.17
Expression of adult and fetal natural killer cell markers in sinonasal lymphomas. Blood (1994) 2.16
High efficiency selection of full-length cDNA by improved biotinylated cap trapper. DNA Res (1997) 2.11
Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue. Nucleic Acids Res (1986) 2.04
Trends for coronary heart disease and stroke and their risk factors in Japan. Circulation (1989) 2.01
p300 gene alterations in colorectal and gastric carcinomas. Oncogene (1996) 2.01
Campylobacter fetus subspecies fetus cellulitis associated with bacteremia in debilitated hosts. Clin Infect Dis (1998) 2.01
Ionic and osmotic effects of NaCl-induced inactivation of photosystems I and II in Synechococcus sp. Plant Physiol (2000) 2.01
Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration. Biochem Biophys Res Commun (2004) 1.98
Role of the putative membrane-bound endo-1,4-beta-glucanase KORRIGAN in cell elongation and cellulose synthesis in Arabidopsis thaliana. Plant Cell Physiol (2001) 1.97
Song-selective auditory circuits in the vocal control system of the zebra finch. Proc Natl Acad Sci U S A (1991) 1.95
Inhibition of prostasin-induced ENaC activities by PN-1 and regulation of PN-1 expression by TGF-beta1 and aldosterone. Kidney Int (2006) 1.94
Roles of homeobox and bHLH genes in specification of a retinal cell type. Development (2001) 1.93
Closing-opening wedge osteotomy to correct angular kyphotic deformity by a single posterior approach. Spine (Phila Pa 1976) (2001) 1.93
Neuronal growth, atrophy and death in a sexually dimorphic song nucleus in the zebra finch brain. Nature (1985) 1.92
Mechanism of action of 2, 3-butanedione 2-monoxime on contraction of frog skeletal muscle fibres. J Muscle Res Cell Motil (1988) 1.88
PCR localization of angiotensin II receptor and angiotensinogen mRNAs in rat kidney. Kidney Int (1993) 1.86
Nocturnal intermittent hypoxia and the development of type 2 diabetes: the Circulatory Risk in Communities Study (CIRCS). Diabetologia (2009) 1.85
Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties. J Biol Chem (1992) 1.82
Birdsong: from behavior to neuron. Annu Rev Neurosci (1985) 1.82
Control of sodium and potassium transport in the cortical collecting duct of the rat. Effects of bradykinin, vasopressin, and deoxycorticosterone. J Clin Invest (1985) 1.82
Segregation of stimulus phase and intensity coding in the cochlear nucleus of the barn owl. J Neurosci (1984) 1.81
Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis. J Clin Invest (1997) 1.79
Cross-cultural comparison of the sleep-disordered breathing prevalence among Americans and Japanese. Eur Respir J (2010) 1.79
Neuronal and behavioral sensitivity to binaural time differences in the owl. J Neurosci (1981) 1.78
Hepatocellular carcinoma with portal vein tumor thrombus: embolization of arterioportal shunts. Radiology (1997) 1.74
Immunolocalization of matrix metalloproteinase 3 (stromelysin) in rheumatoid synovioblasts (B cells): correlation with rheumatoid arthritis. Ann Rheum Dis (1989) 1.71
Axonal delay lines for time measurement in the owl's brainstem. Proc Natl Acad Sci U S A (1988) 1.70
Role of endothelium in dilator responses of spontaneously hypertensive rat arteries. Hypertension (1984) 1.63
Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma. Am J Respir Crit Care Med (2001) 1.63
A neural map of auditory space in the owl. Science (1978) 1.63
Limb salvage using distraction osteogenesis. A classification of the technique. J Bone Joint Surg Br (1997) 1.59
Purification and properties of extracellular poly(3-hydroxybutyrate) depolymerases from Pseudomonas lemoignei. Biochim Biophys Acta (1985) 1.58
Nucleotide sequence of the DNA polymerase gene of herpes simplex virus type 2 and comparison with the type 1 counterpart. Gene (1987) 1.56
The epiconus syndrome presenting with radicular-type neurological features. Spinal Cord (1997) 1.55
Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimurium. Cell Prolif (2009) 1.55
Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts. Oncogene (1999) 1.55
Time and intensity cues are processed independently in the auditory system of the owl. J Neurosci (1984) 1.55
Hormone-induced sexual differentiation of brain and behavior in zebra finches. Science (1980) 1.54
Gating of auditory responses in the vocal control system of awake songbirds. Nat Neurosci (1998) 1.54
Cloning, nucleotide sequence, and expression in Escherichia coli of the gene for poly(3-hydroxybutyrate) depolymerase from Alcaligenes faecalis. J Bacteriol (1989) 1.54
A severe outbreak of haemorrhagic colitis and haemolytic uraemic syndrome associated with Escherichia coli O157:H7 in Japan. Eur J Pediatr (1994) 1.52
Orthopedic symptoms in pustular bacterid (pustulosis palmaris et plantaris): Tietze's syndrome and arthritis of manubriosternal joint due to focal infection. J Dermatol (1977) 1.51
Dietary intake and serum total cholesterol level: their relationship to different lifestyles in several Japanese populations. Circulation (1982) 1.51
Evaluating benign and malignant bone and soft-tissue lesions with technetium-99m-MIBI scintigraphy. J Nucl Med (1997) 1.51
Production of lesions similar to naturally occurring swine atrophic rhinitis by cell-free sonicated extract of Bordetella bronchiseptica. Nihon Juigaku Zasshi (1979) 1.50
Binaural characteristics of units in the owl's brainstem auditory pathway: precursors of restricted spatial receptive fields. J Neurosci (1983) 1.50
Coexistence of somatic and germ-line mutations of APC gene in desmoid tumors from patients with familial adenomatous polyposis. Cancer Res (1993) 1.49
Revision surgery for lumbar disc herniation. An analysis of 45 patients. Int Orthop (1995) 1.48
Purification and properties of beta-ketothiolase from Zoogloea ramigera. Arch Microbiol (1978) 1.48
Herpes simplex virus type 2 UL34 protein requires UL31 protein for its relocation to the internal nuclear membrane in transfected cells. J Gen Virol (2001) 1.47
Detection and direct typing of herpes simplex virus by polymerase chain reaction. Med Microbiol Immunol (1990) 1.47
The bHLH gene Hes1 regulates differentiation of multiple cell types. Mol Cells (2000) 1.47
Tolerance to sound intensity of binaural coincidence detection in the nucleus laminaris of the owl. J Neurosci (1996) 1.47
Real-time measurement of human optic nerve head and choroid circulation, using the laser speckle phenomenon. Jpn J Ophthalmol (1997) 1.47
11C-acetate PET in the evaluation of brain glioma: comparison with 11C-methionine and 18F-FDG-PET. Mol Imaging Biol (2008) 1.46
The UL34 gene product of herpes simplex virus type 2 is a tail-anchored type II membrane protein that is significant for virus envelopment. J Gen Virol (2000) 1.45
Biosynthetic thiolase from zoogloea ramigera. I. Preliminary characterization and analysis of proton transfer reaction. J Biol Chem (1987) 1.44
4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer. J Biol Chem (1999) 1.44
A monoclonal antibody specific to a song system nuclear antigen in estrildine finches. Neuron (2001) 1.44
Neurons selective for orientation and binocular disparity in the visual Wulst of the barn owl (Tyto alba). Science (1976) 1.44
Three cases of malignant hypertension: the roles of endothelin-1 and the renin-angiotensin-aldosterone system. Clin Nephrol (1994) 1.44
Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo) (1992) 1.44
Production and biological activity of rebeccamycin, a novel antitumor agent. J Antibiot (Tokyo) (1987) 1.43
Three-dimensional structure of a DNA repair enzyme, 3-methyladenine DNA glycosylase II, from Escherichia coli. Cell (1996) 1.43
Excitation-contraction coupling in intact frog skeletal muscle fibers injected with mmolar concentrations of fura-2. Biophys J (1992) 1.43
Neural map of interaural phase difference in the owl's brainstem. Proc Natl Acad Sci U S A (1986) 1.42
The role of the UL41 gene of herpes simplex virus type 1 in evasion of non-specific host defence mechanisms during primary infection. J Gen Virol (2000) 1.42
Effects of patent ductus arteriosus on left ventricular output and organ blood flows in preterm infants with respiratory distress syndrome treated with surfactant. J Pediatr (1994) 1.42
Characterization of human cytomegalovirus-induced DNA polymerase and the associated 3'-to-5', exonuclease. Virology (1983) 1.42
Smt3, a SUMO-1 homolog, is conjugated to Cdc3, a component of septin rings at the mother-bud neck in budding yeast. Biochem Biophys Res Commun (1999) 1.41
Projections of the cochlear nuclei and nucleus laminaris to the inferior colliculus of the barn owl. J Comp Neurol (1988) 1.41
Marginal excision for osteosarcoma with caffeine assisted chemotherapy. Clin Orthop Relat Res (1999) 1.41
A new technique for one-stage radical eradication of long-standing chronic thoracic empyema. J Thorac Cardiovasc Surg (1990) 1.39
Relationship between left atrial function and plasma level of atrial natriuretic peptide in patients with heart disease. Cardiology (1998) 1.39
A single-base change within the DNA polymerase locus of herpes simplex virus type 2 can confer resistance to aphidicolin. J Virol (1987) 1.39
Molecular cloning and sequence determination of the tuf gene coding for the elongation factor Tu of Thermus thermophilus HB8. Eur J Biochem (1987) 1.38
Schmorl's nodes and low-back pain. Analysis of magnetic resonance imaging findings in symptomatic and asymptomatic individuals. Eur Spine J (1995) 1.38