Published in BMJ on January 27, 1990
Psychological outcomes of different treatment policies in women with early breast cancer outside a clinical trial. BMJ (1990) 10.93
Mobilisation with movement and exercise, corticosteroid injection, or wait and see for tennis elbow: randomised trial. BMJ (2006) 4.52
Psychological support for patients undergoing breast cancer surgery: a randomised study. BMJ (1996) 4.11
Cost effectiveness of community leg ulcer clinics: randomised controlled trial. BMJ (1998) 4.10
Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial). Ann Rheum Dis (2007) 3.89
The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study. BMC Med Res Methodol (2001) 3.54
The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J Clin Invest (2005) 3.22
Independent association between rate of clearance of infection and clinical outcome of HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients. Clin Infect Dis (2009) 3.05
Larval therapy for leg ulcers (VenUS II): randomised controlled trial. BMJ (2009) 2.45
The window of therapeutic opportunity in multiple sclerosis: evidence from monoclonal antibody therapy. J Neurol (2005) 2.44
Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits. Curr Biol (2008) 2.27
Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J Clin Invest (1992) 2.26
Afferent and efferent components of the cardiovascular reflex responses to acute hypoxia in term fetal sheep. J Physiol (1993) 2.16
The problem of pseudoreplication in neuroscientific studies: is it affecting your analysis? BMC Neurosci (2010) 2.13
Time course of recovery of health status following an infective exacerbation of chronic bronchitis. Thorax (2003) 2.11
Venous occlusion plethysmography in cardiovascular research: methodology and clinical applications. Br J Clin Pharmacol (2001) 1.97
Intra-articular distension and steroids in the management of capsulitis of the shoulder. BMJ (1991) 1.93
Double-blind, placebo-controlled, randomized clinical trial of homoeopathic arnica C30 for pain and infection after total abdominal hysterectomy. J R Soc Med (1997) 1.80
Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis. Ann Rheum Dis (2005) 1.77
Randomised double blind placebo controlled trial of prednisolone in children admitted to hospital with respiratory syncytial virus bronchiolitis. Thorax (1997) 1.69
Management of feverish children at home. BMJ (1992) 1.69
A randomised clinical trial of subgrouping and targeted treatment for low back pain compared with best current care. The STarT Back Trial Study Protocol. BMC Musculoskelet Disord (2008) 1.65
A randomised controlled trial of acupuncture care for persistent low back pain: cost effectiveness analysis. BMJ (2006) 1.65
Cost effectiveness of a community based exercise programme in over 65 year olds: cluster randomised trial. J Epidemiol Community Health (2004) 1.63
Comparison of Bobath based and movement science based treatment for stroke: a randomised controlled trial. J Neurol Neurosurg Psychiatry (2005) 1.63
How many repeated measures in repeated measures designs? Statistical issues for comparative trials. BMC Med Res Methodol (2003) 1.62
Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Gut (2001) 1.61
Cognitive behavioural therapy (CBT) for carers of patients with Parkinson's disease: a preliminary randomised controlled trial. J Neurol Neurosurg Psychiatry (2005) 1.59
Bone turnover during high dose inhaled corticosteroid treatment. Thorax (1991) 1.59
Explaining variability in sodium intake through oral sensory phenotype, salt sensation and liking. Physiol Behav (2010) 1.57
"Summary measure" statistic for assessing the outcome of treatment trials in relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry (1998) 1.56
The α₂β₁ integrin is a metastasis suppressor in mouse models and human cancer. J Clin Invest (2010) 1.55
Systemic cytokine response after laparoscopic-assisted resection of rectosigmoid carcinoma: A prospective randomized trial. Ann Surg (2000) 1.53
Fasting and postprandial markers of inflammation in lean and overweight children. Am J Clin Nutr (2009) 1.51
Evidence for a signaling axis by which intestinal phosphate rapidly modulates renal phosphate reabsorption. Proc Natl Acad Sci U S A (2007) 1.50
Suprascapular nerve block for the treatment of frozen shoulder in primary care: a randomized trial. Br J Gen Pract (1999) 1.50
The MS Symptom and Impact Diary (MSSID): psychometric evaluation of a new instrument to measure the day to day impact of multiple sclerosis. J Neurol Neurosurg Psychiatry (2004) 1.48
Cost-utility estimation of surgical treatment of pancreatic carcinoma aimed at cure. World J Surg (2011) 1.47
Effectiveness of intra-articular injections of sodium bicarbonate and calcium gluconate in the treatment of osteoarthritis of the knee: a randomized double-blind clinical trial. BMC Musculoskelet Disord (2015) 1.41
Cost-utility of a walking programme for moderately depressed, obese, or overweight elderly women in primary care: a randomised controlled trial. BMC Public Health (2008) 1.41
Activation of the L-arginine nitric oxide pathway in severe sepsis. Arch Dis Child (1997) 1.37
Pitfalls in the interpretation of studies: I. J R Soc Med (1995) 1.37
In vivo effects of amphetamine analogs reveal evidence for serotonergic inhibition of mesolimbic dopamine transmission in the rat. J Pharmacol Exp Ther (2011) 1.37
Activation of normal neutrophils by anti-neutrophil cytoplasm antibodies. Clin Exp Immunol (1992) 1.37
Childhood trauma is associated with hypothalamic-pituitary-adrenal axis responsiveness in irritable bowel syndrome. Gastroenterology (2009) 1.33
Longitudinal study of grass pollen exposure, symptoms, and exhaled nitric oxide in childhood seasonal allergic asthma. Thorax (2004) 1.31
Threshold for effects of vitamin D deficiency on glucose metabolism in obese female African-American adolescents. J Clin Endocrinol Metab (2009) 1.31
Cost effectiveness analysis of laparoscopic hysterectomy compared with standard hysterectomy: results from a randomised trial. BMJ (2004) 1.30
Long-term survival of nonhuman primate islets implanted in an omental pouch on a biodegradable scaffold. Am J Transplant (2009) 1.29
Bone loss in unclassified polyarthritis and early rheumatoid arthritis is better detected by digital x ray radiogrammetry than dual x ray absorptiometry: relationship with disease activity and radiographic outcome. Ann Rheum Dis (2004) 1.28
Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma. Thorax (2002) 1.28
Faster absorption of ethanol and higher peak concentration in women after gastric bypass surgery. Br J Clin Pharmacol (2002) 1.28
Effect of salcatonin given intranasally on bone mass and fracture rates in established osteoporosis: a dose-response study. BMJ (1992) 1.27
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nat Commun (2015) 1.27
A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache. J Neurol Neurosurg Psychiatry (1996) 1.27
Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes (2012) 1.27
IMPaCT Back study protocol. Implementation of subgrouping for targeted treatment systems for low back pain patients in primary care: a prospective population-based sequential comparison. BMC Musculoskelet Disord (2010) 1.25
A comparison of missing data methods for hypothesis tests of the treatment effect in substance abuse clinical trials: a Monte-Carlo simulation study. Subst Abuse Treat Prev Policy (2008) 1.23
No benefit from chronic lithium dosing in a sibling-matched, gender balanced, investigator-blinded trial using a standard mouse model of familial ALS. PLoS One (2009) 1.23
The contribution of social networks to the health and self-management of patients with long-term conditions: a longitudinal study. PLoS One (2014) 1.21
Stearic acid-rich interesterified fat and trans-rich fat raise the LDL/HDL ratio and plasma glucose relative to palm olein in humans. Nutr Metab (Lond) (2007) 1.21
Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. J Biol Chem (2010) 1.18
A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep. J Physiol (1997) 1.18
Synthetic glycovaccine protects against the bite of leishmania-infected sand flies. J Infect Dis (2006) 1.18
Lower bone mass in prepubertal overweight children with prediabetes. J Bone Miner Res (2010) 1.17
Medication persistence over 2 years of follow-up in a cohort of early rheumatoid arthritis patients: associated factors and relationship with disease activity and with disability. Arthritis Res Ther (2009) 1.17
Partial remission phase of diabetes in children younger than age 10 years. Arch Dis Child (1999) 1.16
Prior endurance exercise prevents postprandial lipaemia-induced increases in reactive oxygen species in circulating CD31+ cells. J Physiol (2011) 1.16
Determinants of direct costs in Dutch rheumatoid arthritis patients. Ann Rheum Dis (2004) 1.14
Psychological treatment for insomnia in the management of long-term hypnotic drug use: a pragmatic randomised controlled trial. Br J Gen Pract (2003) 1.13
Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress. Aging Cell (2011) 1.13
Cost effectiveness of nurse delivered endoscopy: findings from randomised multi-institution nurse endoscopy trial (MINuET). BMJ (2009) 1.12
Astigmatism and the analysis of its surgical correction. Br J Ophthalmol (2001) 1.11
Catechol-O-methyltransferase val158met genotype modulates sustained attention in both the drug-free state and in response to amphetamine. Psychiatr Genet (2010) 1.11
Control of viremia and prevention of AIDS following immunotherapy of SIV-infected macaques with peptide-pulsed blood. PLoS Pathog (2008) 1.10
Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment. Antimicrob Agents Chemother (2006) 1.10
Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. BMJ (2000) 1.09
GAD65 antibody isotypes and epitope recognition during the prediabetic process in siblings of children with type I diabetes. Clin Exp Immunol (2004) 1.09
The impact of loss to follow-up on hypothesis tests of the treatment effect for several statistical methods in substance abuse clinical trials. J Subst Abuse Treat (2008) 1.09
Reduction in renal blood flow following acute increase in the portal pressure: evidence for the existence of a hepatorenal reflex in man? Gut (1997) 1.09
Outcome of Burkholderia cepacia colonisation in an adult cystic fibrosis centre. Thorax (2002) 1.08
A possible role of the L-arginine-nitric oxide pathway in the modulation of cholinergic transmission in the guinea-pig taenia coli. Br J Pharmacol (1992) 1.07
The role of nitric oxide synthesis in cardiovascular responses to acute hypoxia in the late gestation sheep fetus. J Physiol (1996) 1.07
Stabilization of costal cartilage graft warping using infrared laser irradiation in a porcine model. Arch Facial Plast Surg (2010) 1.07
Effects of prevailing hypoxaemia, acidaemia or hypoglycaemia upon the cardiovascular, endocrine and metabolic responses to acute hypoxaemia in the ovine fetus. J Physiol (2002) 1.06
A role for xanthine oxidase in the control of fetal cardiovascular function in late gestation sheep. J Physiol (2012) 1.06
Substantial improvements in performance indicators achieved in a peripheral blood mononuclear cell cryopreservation quality assurance program using single donor samples. Clin Vaccine Immunol (2006) 1.05
Power Doppler ultrasonography is useful for assessing disease activity and predicting joint destruction in rheumatoid arthritis patients receiving tocilizumab--preliminary data. Rheumatol Int (2011) 1.05
Determination of thymic function directly from peripheral blood: a validated modification to an established method. J Immunol Methods (2008) 1.05
A cluster-randomized trial of insecticide-treated curtains for dengue vector control in Thailand. Am J Trop Med Hyg (2012) 1.05
The adaptive response of the reticuloendothelial system to major liver resection in humans. Ann Surg (2006) 1.05
Confidence intervals rather than P values: estimation rather than hypothesis testing. Br Med J (Clin Res Ed) (1986) 18.51
A note on the analysis of repeated measurements of the same subjects. J Chronic Dis (1962) 6.18
Is dialysis hypotension caused by an abnormality of venous tone? Br Med J (Clin Res Ed) (1988) 3.48
Repeated warnings re repeated measures. Aust N Z J Med (1986) 3.15
Reduction in postprandial energy expenditure during pregnancy. Br Med J (Clin Res Ed) (1987) 3.12
VARCOV II: a computer program for the multivariate analysis of growth and response curves. Comput Methods Programs Biomed (1988) 3.10
Statistical methods for assessing agreement between two methods of clinical measurement. Lancet (1986) 211.50
The sequence of the human genome. Science (2001) 101.55
Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA (1995) 45.41
The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet (2001) 31.74
Measuring agreement in method comparison studies. Stat Methods Med Res (1999) 31.11
Systematic determination of genetic network architecture. Nat Genet (1999) 25.45
Multiple significance tests: the Bonferroni method. BMJ (1995) 23.46
Systematic reviews in health care: Assessing the quality of controlled clinical trials. BMJ (2001) 20.65
A genome-wide transcriptional analysis of the mitotic cell cycle. Mol Cell (1998) 19.67
Confidence intervals rather than P values: estimation rather than hypothesis testing. Br Med J (Clin Res Ed) (1986) 18.51
Cronbach's alpha. BMJ (1997) 13.79
The scandal of poor medical research. BMJ (1994) 11.58
The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. Ann Intern Med (2001) 11.48
Statistical guidelines for contributors to medical journals. Br Med J (Clin Res Ed) (1983) 10.90
Statistics notes. Logarithms. BMJ (1996) 10.56
Statistics in medical journals. Stat Med (1983) 9.80
Evaluating non-randomised intervention studies. Health Technol Assess (2003) 9.69
What do we mean by validating a prognostic model? Stat Med (2000) 9.18
Comparing methods of measurement: why plotting difference against standard method is misleading. Lancet (1995) 9.14
Statistics notes: Analysing controlled trials with baseline and follow up measurements. BMJ (2001) 8.98
Statistics and ethics in medical research: III How large a sample? Br Med J (1980) 8.78
Maternal serum screening for Down's syndrome in early pregnancy. BMJ (1988) 8.65
Better reporting of randomised controlled trials: the CONSORT statement. BMJ (1996) 8.39
More informative abstracts revisited. Ann Intern Med (1990) 8.26
Use of check lists in assessing the statistical content of medical studies. Br Med J (Clin Res Ed) (1986) 7.42
Transforming data. BMJ (1996) 6.78
Regression towards the mean. BMJ (1994) 6.57
Measurement error. BMJ (1996) 6.18
Transcriptional regulation and function during the human cell cycle. Nat Genet (2001) 5.89
Assessing the quality of randomization from reports of controlled trials published in obstetrics and gynecology journals. JAMA (1994) 5.80
Risk of bacterial infection associated with allogeneic blood transfusion among patients undergoing hip fracture repair. Transfusion (1999) 5.67
Statistics notes. The odds ratio. BMJ (2000) 5.61
The CONSORT statement: revised recommendations for improving the quality of reports of parallel group randomized trials. BMC Med Res Methodol (2001) 5.43
Applying the right statistics: analyses of measurement studies. Ultrasound Obstet Gynecol (2003) 5.40
How can medical journals help prevent poor medical research? Some opportunities presented by electronic publishing. Lancet (1999) 5.27
Statistics notes. Interaction 2: Compare effect sizes not P values. BMJ (1996) 5.18
Correlation, regression, and repeated data. BMJ (1994) 4.88
Calculating correlation coefficients with repeated observations: Part 1--Correlation within subjects. BMJ (1995) 4.87
REporting recommendations for tumour MARKer prognostic studies (REMARK). Br J Cancer (2005) 4.85
Social factors and height of primary schoolchildren in England and Scotland. J Epidemiol Community Health (1978) 4.73
Electrophysiological estimation of the number of motor units within a human muscle. J Neurol Neurosurg Psychiatry (1971) 4.70
Randomisation. BMJ (1991) 4.66
Patients' preferences and randomised trials. Lancet (1996) 4.64
Red blood cell magnesium and chronic fatigue syndrome. Lancet (1991) 4.48
Measurement error and correlation coefficients. BMJ (1996) 4.38
Indirect comparisons of competing interventions. Health Technol Assess (2005) 4.33
Statistical aspects of prognostic factor studies in oncology. Br J Cancer (1994) 4.22
Measurement error. BMJ (1996) 4.13
Survival analysis part I: basic concepts and first analyses. Br J Cancer (2003) 4.08
Some examples of regression towards the mean. BMJ (1994) 4.01
Survival probabilities (the Kaplan-Meier method). BMJ (1998) 3.98
Public knowledge of AIDS and the DHSS advertisement campaign. Br Med J (Clin Res Ed) (1986) 3.92
Impact of allocation concealment on conclusions drawn from meta-analyses of randomized trials. Int J Epidemiol (2007) 3.84
A catalogue of reporting guidelines for health research. Eur J Clin Invest (2010) 3.83
Effects of a drug overdose in a television drama on presentations to hospital for self poisoning: time series and questionnaire study. BMJ (1999) 3.52
Frequency and reasons for outcome reporting bias in clinical trials: interviews with trialists. BMJ (2011) 3.50
The benefits and harms of breast cancer screening: an independent review. Br J Cancer (2013) 3.43
Transformations, means, and confidence intervals. BMJ (1996) 3.42
Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices. J Neurosci (1987) 3.39
Estimating sample sizes for binary, ordered categorical, and continuous outcomes in two group comparisons. BMJ (1995) 3.35
Measurement error proportional to the mean. BMJ (1996) 3.34
National study of health and growth: standards of attained height, weight and triceps skinfold in English children 5 to 11 years old. Ann Hum Biol (1977) 3.23
The use of transformation when comparing two means. BMJ (1996) 3.22
A note on the use of the intraclass correlation coefficient in the evaluation of agreement between two methods of measurement. Comput Biol Med (1990) 3.18
Interaction 3: How to examine heterogeneity. BMJ (1996) 3.17
Missing covariate data within cancer prognostic studies: a review of current reporting and proposed guidelines. Br J Cancer (2004) 3.15
The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med (1996) 3.10
Survival analysis part II: multivariate data analysis--an introduction to concepts and methods. Br J Cancer (2003) 3.06
Calculating correlation coefficients with repeated observations: Part 2--Correlation between subjects. BMJ (1995) 2.94
Randomised trial of educational visits to enhance use of systematic reviews in 25 obstetric units. BMJ (1998) 2.94
Transcription, genomes, function. Trends Genet (2000) 2.86
Outcome selection bias in meta-analysis. Stat Methods Med Res (2005) 2.86
Statistics and ethics in medical research. VI--Presentation of results. Br Med J (1980) 2.85
Physiological changes in ageing muscles. J Neurol Neurosurg Psychiatry (1973) 2.84
The effects of combining education and enforcement to reduce tobacco sales to minors. A study of four northern California communities. JAMA (1991) 2.77
A prognostic model for ovarian cancer. Br J Cancer (2001) 2.77
Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors. N Engl J Med (1992) 2.73
The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. J Am Podiatr Med Assoc (2001) 2.71
Survival analysis Part III: multivariate data analysis -- choosing a model and assessing its adequacy and fit. Br J Cancer (2003) 2.71
Baseline comparisons in randomized clinical trials. Stat Med (1991) 2.69
Predictors of physician's smoking cessation advice. JAMA (1991) 2.66
Randomised controlled trial of a short course of traditional acupuncture compared with usual care for persistent non-specific low back pain. BMJ (2006) 2.63
Recurrent brachial plexus neuropathy. Brain (1975) 2.63
More informative abstracts. Ann Intern Med (1987) 2.63
Effect of arterial revascularisation on survival: a systematic review of studies comparing bilateral and single internal mammary arteries. Lancet (2001) 2.61
One and two sided tests of significance. BMJ (1994) 2.61
Diabetes care from diagnosis: effects of training in patient-centred care on beliefs, attitudes and behaviour of primary care professionals. Patient Educ Couns (1999) 2.57
Monitoring of large randomised clinical trials: a new approach with Bayesian methods. Lancet (2001) 2.35
Can general practitioners influence exercise habits? Controlled trial. Br Med J (Clin Res Ed) (1985) 2.29
c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes. Br J Cancer (1991) 2.29
Evaluation of sample size and power for multi-arm survival trials allowing for non-uniform accrual, non-proportional hazards, loss to follow-up and cross-over. Stat Med (2006) 2.23
The efficacy of problem-solving treatments after deliberate self-harm: meta-analysis of randomized controlled trials with respect to depression, hopelessness and improvement in problems. Psychol Med (2001) 2.22
Electrophysiological study of dystrophia myotonica. J Neurol Neurosurg Psychiatry (1971) 2.20
Transabdominal ultrasound screening for early ovarian cancer. BMJ (1989) 2.20
Ultrasound screening for familial ovarian cancer. Gynecol Oncol (1991) 2.19