Published in Proc Natl Acad Sci U S A on November 22, 2010
NCI's provocative questions on cancer: some answers to ignite discussion. Oncotarget (2011) 1.42
Impact of genomic damage and ageing on stem cell function. Nat Cell Biol (2014) 1.33
Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age? Oncogene (2012) 1.29
Molecular damage in cancer: an argument for mTOR-driven aging. Aging (Albany NY) (2011) 1.29
Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer. Cell Stem Cell (2015) 1.11
Stochastic modeling indicates that aging and somatic evolution in the hematopoetic system are driven by non-cell-autonomous processes. Aging (Albany NY) (2014) 1.08
Evolved tumor suppression: why are we so good at not getting cancer? Cancer Res (2011) 1.05
Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection? Aging (Albany NY) (2011) 1.04
The age of the target cell affects B-cell leukaemia malignancy. Aging (Albany NY) (2010) 1.04
Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression? Aging (Albany NY) (2012) 1.02
Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations. Proc Natl Acad Sci U S A (2015) 0.99
What can ecology teach us about cancer? Transl Oncol (2011) 0.93
Contribution of an aged microenvironment to aging-associated myeloproliferative disease. PLoS One (2012) 0.91
Extracellular cyclophilin-A stimulates ERK1/2 phosphorylation in a cell-dependent manner but broadly stimulates nuclear factor kappa B. Cancer Cell Int (2012) 0.89
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. J Clin Invest (2015) 0.88
Population dynamics of normal and leukaemia stem cells in the haematopoietic stem cell niche show distinct regimes where leukaemia will be controlled. J R Soc Interface (2013) 0.87
Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment. Front Immunol (2016) 0.86
Leukemogenesis and ageing: 'fit for transformation'? Aging (Albany NY) (2011) 0.82
Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia. Proc Natl Acad Sci U S A (2016) 0.81
Clearance of senescent hepatocytes in a neoplastic-prone microenvironment delays the emergence of hepatocellular carcinoma. Aging (Albany NY) (2014) 0.81
Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis. Oncotarget (2015) 0.80
Acute lymphoblastic leukemia and developmental biology: a crucial interrelationship. Cell Cycle (2011) 0.79
STAT5 activation in B-cell acute lymphoblastic leukemia: damned if you do, damned if you don't. Cancer Cell Microenviron (2016) 0.76
The evolution of lifespan and age-dependent cancer risk. Trends Cancer (2016) 0.75
Aging promotes neoplastic disease through effects on the tissue microenvironment. Aging (Albany NY) (2016) 0.75
Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations. Oncotarget (2017) 0.75
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
Paradoxical roles of the immune system during cancer development. Nat Rev Cancer (2006) 10.57
Acute lymphoblastic leukemia. N Engl J Med (2004) 7.83
Age-related changes in lymphocyte development and function. Nat Immunol (2004) 6.16
The age of cancer. Nature (2000) 4.32
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer (2005) 4.30
The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med (1999) 4.06
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci (2005) 3.96
Observation of antigen-dependent CD8+ T-cell/ dendritic cell interactions in vivo. Cell Immunol (2001) 3.91
Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol (2007) 3.53
Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow. J Exp Med (2005) 3.21
Radiation and the microenvironment - tumorigenesis and therapy. Nat Rev Cancer (2005) 2.65
p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell (2010) 2.65
Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. Immunity (1997) 2.35
The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors. J Immunol (2003) 2.17
The role of stem cells in aging. Exp Hematol (2003) 2.13
Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes Dev (2008) 1.79
Irradiation selects for p53-deficient hematopoietic progenitors. PLoS Biol (2010) 1.65
Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1. Proc Natl Acad Sci U S A (1998) 1.60
Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation. J Immunol (2004) 1.57
Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging. Proc Natl Acad Sci U S A (2008) 1.25
Impaired DNA replication within progenitor cell pools promotes leukemogenesis. PLoS Biol (2005) 1.25
Tissue, cell and stage specificity of (epi)mutations in cancers. Nat Rev Cancer (2005) 1.24
Studying the pathogenesis of BCR-ABL+ leukemia in mice. Oncogene (2002) 1.22
Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations. Biochim Biophys Acta (2007) 1.21
Cancer and age in the USA. Crit Rev Oncol Hematol (2001) 1.17
Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors. J Immunol (1997) 1.15
Irradiation alters selection for oncogenic mutations in hematopoietic progenitors. Cancer Res (2009) 1.09
Senescent BALB/c mice exhibit decreased expression of lambda5 surrogate light chains and reduced development within the pre-B cell compartment. J Immunol (1998) 1.04
Reduced EBF expression underlies loss of B-cell potential of hematopoietic progenitors with age. Aging Cell (2010) 1.02
Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood (2007) 1.01
B cells, E2A, and aging. Immunol Rev (2005) 0.95
The aging of early B-cell precursors. Immunol Rev (2005) 0.89
Estimation of the number of mutations necessary to cause chronic myeloid leukaemia from epidemiological data. Br J Haematol (1996) 0.88
The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. J Clin Invest (2011) 4.41
Grb2 regulates internalization of EGF receptors through clathrin-coated pits. Mol Biol Cell (2003) 2.58
Cellular heterogeneity and molecular evolution in cancer. Annu Rev Pathol (2012) 2.56
Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2. Nat Med (2011) 2.12
Irradiation selects for p53-deficient hematopoietic progenitors. PLoS Biol (2010) 1.65
Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl. Cancer Cell (2010) 1.64
Defective gene expression, S phase progression, and maturation during hematopoiesis in E2F1/E2F2 mutant mice. Mol Cell Biol (2003) 1.56
Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Proc Natl Acad Sci U S A (2002) 1.51
Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell (2010) 1.43
Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J Biol Chem (2004) 1.33
The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss. Proc Natl Acad Sci U S A (2003) 1.27
ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nat Chem Biol (2012) 1.26
Impaired DNA replication within progenitor cell pools promotes leukemogenesis. PLoS Biol (2005) 1.25
Solution characterization of the extracellular region of CD147 and its interaction with its enzyme ligand cyclophilin A. J Mol Biol (2009) 1.21
Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations. Biochim Biophys Acta (2007) 1.21
Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. J Biol Chem (2005) 1.17
Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition. Cancer Res (2012) 1.16
p53 mediates senescence-like arrest induced by chronic replicational stress. Mol Cell Biol (2007) 1.11
The survival of antigen-stimulated T cells requires NFkappaB-mediated inhibition of p73 expression. Immunity (2003) 1.11
Irradiation alters selection for oncogenic mutations in hematopoietic progenitors. Cancer Res (2009) 1.09
Targeting Akt3 signaling in triple-negative breast cancer. Cancer Res (2013) 1.06
Interfering RNA-mediated purine analog resistance for in vitro and in vivo cell selection. Blood (2008) 1.04
Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection? Aging (Albany NY) (2011) 1.04
Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation. Mol Cell Biol (2004) 1.00
Critical roles for macrophages in islet angiogenesis and maintenance during pancreatic degeneration. Diabetes (2008) 0.99
Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape. Cell Cycle (2010) 0.91
Active RB elicits late G1/S inhibition. Exp Cell Res (2002) 0.89
Replicational stress selects for p53 mutation. Cell Cycle (2007) 0.89
Identification of gene function by cyclical packaging rescue of retroviral cDNA libraries. Proc Natl Acad Sci U S A (2002) 0.88
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. J Clin Invest (2015) 0.88
Characterization of transcriptional regulation during negative selection in vivo. J Immunol (2003) 0.88
Identification and characterization of transcription factor target genes using gene-targeted mice. Methods (2002) 0.85
E2F1 and E2F2 are differentially required for homeostasis-driven and antigen-induced T cell proliferation in vivo. J Immunol (2005) 0.83
Targeting developmental pathways in children with cancer: what price success? Lancet Oncol (2013) 0.82
Inhibiting tyrosine phosphorylation of protein kinase Cδ (PKCδ) protects the salivary gland from radiation damage. J Biol Chem (2014) 0.81
Recombinant adenoviral vectors can induce expression of p73 via the E4-orf6/7 protein. J Virol (2006) 0.80
Contrasting roles for C/EBPα and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects. Stem Cells (2015) 0.79
The CUSP DeltaNp63alpha isoform of human p63 is downregulated by solar-simulated ultraviolet radiation. J Dermatol Sci (2003) 0.79
Using functional genomics to overcome therapeutic resistance in hematological malignancies. Immunol Res (2013) 0.78
Strong foreign promoters contribute to innate inflammatory responses induced by adenovirus transducing vectors. Virology (2011) 0.78
Mutation-specific control of BCR-ABL T315I positive leukemia with a recombinant yeast-based therapeutic vaccine in a murine model. Vaccine (2010) 0.78
Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration. Int Immunol (2005) 0.77
Roles for bone-marrow-derived cells in beta-cell maintenance. Trends Mol Med (2004) 0.76
CUSP/p63 expression in basal cell carcinoma. Exp Dermatol (2002) 0.76
Building a better model of cancer. Cell Div (2006) 0.75
Rational design of a parthenolide-based drug regimen that selectively eradicates acute myelogenous leukemia stem cells. J Biol Chem (2016) 0.75