Published in Microbiol Mol Biol Rev on December 01, 2010
Human genetic susceptibility to infectious disease. Nat Rev Genet (2012) 2.25
Genetic variants of complement genes ficolin-2, mannose-binding lectin and complement factor H are associated with leprosy in Han Chinese from Southwest China. Hum Genet (2013) 0.99
Animal models and conserved processes. Theor Biol Med Model (2012) 0.99
Serum metabolomics reveals higher levels of polyunsaturated fatty acids in lepromatous leprosy: potential markers for susceptibility and pathogenesis. PLoS Negl Trop Dis (2011) 0.96
Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China. PLoS One (2012) 0.88
Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China. Hum Genet (2012) 0.85
The armadillo: a model for the neuropathy of leprosy and potentially other neurodegenerative diseases. Dis Model Mech (2012) 0.84
Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China. Genes Immun (2014) 0.82
Infection with Mycobacterium lepromatosis. Am J Trop Med Hyg (2016) 0.81
Differential dermal expression of CCL17 and CCL18 in tuberculoid and lepromatous leprosy. PLoS Negl Trop Dis (2014) 0.81
Role of toll-interacting protein gene polymorphisms in leprosy Mexican patients. Biomed Res Int (2013) 0.81
Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls. J Trop Med (2012) 0.80
Modulation of the cytokine response in human monocytes by mycobacterium leprae phenolic glycolipid-1. J Interferon Cytokine Res (2011) 0.80
Genetic Variation in Toll-Interacting Protein Is Associated With Leprosy Susceptibility and Cutaneous Expression of Interleukin 1 Receptor Antagonist. J Infect Dis (2015) 0.78
Human polymorphisms as clinical predictors in leprosy. J Trop Med (2011) 0.78
Association of genetic polymorphism of HLA-DRB1 antigens with the susceptibility to lepromatous leprosy. Biomed Rep (2013) 0.78
An association study of TOLL and CARD with leprosy susceptibility in Chinese population. Hum Mol Genet (2013) 0.78
Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil. BMC Infect Dis (2014) 0.77
The influence of innate and adaptative immune responses on the differential clinical outcomes of leprosy. Infect Dis Poverty (2017) 0.76
Human Genetic Ancestral Composition Correlates with the Origin of Mycobacterium leprae Strains in a Leprosy Endemic Population. PLoS Negl Trop Dis (2015) 0.76
Pre-miR-146a (rs2910164 G>C) single nucleotide polymorphism is genetically and functionally associated with leprosy. PLoS Negl Trop Dis (2014) 0.76
ML1419c peptide immunization induces Mycobacterium leprae-specific HLA-A*0201-restricted CTL in vivo with potential to kill live mycobacteria. J Immunol (2011) 0.76
Pauci- and Multibacillary Leprosy: Two Distinct, Genetically Neglected Diseases. PLoS Negl Trop Dis (2016) 0.76
CUBN and NEBL common variants in the chromosome 10p13 linkage region are associated with multibacillary leprosy in Vietnam. Hum Genet (2014) 0.76
Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes. BMC Genomics (2017) 0.76
Leprosy in a texan. Proc (Bayl Univ Med Cent) (2015) 0.75
Influence of Genetic Ancestry on INDEL Markers of NFKβ1, CASP8, PAR1, IL4 and CYP19A1 Genes in Leprosy Patients. PLoS Negl Trop Dis (2015) 0.75
Induction and treatment of anergy in murine leprosy. Int J Exp Pathol (2014) 0.75
Association of a new FCN3 haplotype with high ficolin-3 levels in leprosy. PLoS Negl Trop Dis (2017) 0.75
Association of the solute carrier family 11 member 1 gene polymorphisms with susceptibility to leprosy in a Brazilian sample. Mem Inst Oswaldo Cruz (2016) 0.75
Common variants in the PARL and PINK1 genes increase the risk to leprosy in Han Chinese from South China. Sci Rep (2016) 0.75
First genetic evidence of leprosy in early medieval Austria. Wien Med Wochenschr (2014) 0.75
The future of genetic studies of complex human diseases. Science (1996) 64.76
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet (1995) 49.77
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15
Toll-like receptor signalling. Nat Rev Immunol (2004) 34.74
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12
Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 22.57
Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis (1966) 22.28
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science (1993) 19.80
Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science (2006) 18.74
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med (1993) 18.56
Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med (1993) 17.01
A whole-genome association study of major determinants for host control of HIV-1. Science (2007) 15.19
Immunology of tuberculosis. Annu Rev Immunol (2001) 14.26
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol (1991) 11.04
Interleukin-10. Annu Rev Immunol (1993) 10.14
Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science (1991) 8.85
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet (2000) 8.79
Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell (2000) 8.34
Genomewide association study of leprosy. N Engl J Med (2009) 8.17
Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology (2010) 7.86
Inferences, questions and possibilities in Toll-like receptor signalling. Nature (2004) 7.57
Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med (2003) 7.38
Patterns of linkage disequilibrium in the human genome. Nat Rev Genet (2002) 7.09
Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A (1997) 6.99
Genetic dissection of immunity to mycobacteria: the human model. Annu Rev Immunol (2001) 6.92
Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. N Engl J Med (1998) 6.14
Genetics of resistance to infection with Salmonella typhimurium in mice. J Infect Dis (1976) 5.92
CARD15 mutations in Blau syndrome. Nat Genet (2001) 5.79
An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet (1997) 5.65
Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system. Proc Natl Acad Sci U S A (1992) 5.55
Interleukin-12 and its role in the generation of TH1 cells. Immunol Today (1993) 5.55
Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol (2008) 5.37
Leprosy. Lancet (2004) 5.37
Prediction of bone density from vitamin D receptor alleles. Nature (1994) 5.36
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet (2009) 5.29
Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Res (1985) 5.22
In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading. Nat Genet (2003) 5.10
Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J Immunol (1999) 4.77
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet (2005) 4.45
Genetic regulation of resistance to intracellular pathogens. Nature (1982) 4.45
Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. Nature (1994) 4.37
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
Herpes simplex virus encephalitis in human UNC-93B deficiency. Science (2006) 4.26
Natural resistance to Salmonella infection, delayed hypersensitivity and Ir genes in different strains of mice. Nature (1974) 4.19
Regulation of Leishmania populations within the host. II. genetic control of acute susceptibility of mice to Leishmania donovani infection. Clin Exp Immunol (1977) 4.10
The continuing challenges of leprosy. Clin Microbiol Rev (2006) 4.09
DC-SIGN: escape mechanism for pathogens. Nat Rev Immunol (2003) 4.04
1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol (2000) 3.82
Genomewide scans of complex human diseases: true linkage is hard to find. Am J Hum Genet (2001) 3.70
Primary immunodeficiencies: 2009 update. J Allergy Clin Immunol (2009) 3.70
The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. Cell (2010) 3.64
TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. J Exp Med (2005) 3.44
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis (2005) 3.39
The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription. Mol Immunol (1997) 3.36
DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. J Exp Med (2003) 3.32
Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev (2009) 3.20
Association of low levels of mannan-binding protein with a common defect of opsonisation. Lancet (1989) 3.12
Susceptibility to leprosy is associated with PARK2 and PACRG. Nature (2004) 3.07
Letter: Genetic control of natural resistance to Leishmania donovani. Nature (1974) 2.85
Acid-fast bacilli in nasal excretions in leprosy, and results of inoculation of mice. Am J Hyg (1960) 2.83
Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J Clin Invest (1998) 2.78
Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis (2002) 2.76
Cytokine patterns of immunologically mediated tissue damage. J Immunol (1992) 2.72
A common human TLR1 polymorphism regulates the innate immune response to lipopeptides. Eur J Immunol (2007) 2.71
Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med (2008) 2.64
TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med (2005) 2.62
Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. Eur J Immunol (2008) 2.62
Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies. Nat Genet (2009) 2.51
Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol). J Clin Invest (1984) 2.43
1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. J Clin Invest (1984) 2.39
Cutting edge: carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells. J Immunol (2003) 2.39
Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol (2010) 2.38
Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair. Nat Immunol (2009) 2.37
Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense. PLoS Genet (2009) 2.35
Mannose-binding lectin and its genetic variants. Genes Immun (2006) 2.35
NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. PLoS Pathog (2009) 2.31
Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. J Exp Med (1995) 2.30
Aspects of genetic susceptibility to human infectious diseases. Annu Rev Genet (2006) 2.23
Physical distance, genetic relationship, age, and leprosy classification are independent risk factors for leprosy in contacts of patients with leprosy. J Infect Dis (2005) 2.21
Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans. Clin Exp Immunol (1998) 2.20
T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection. J Immunol (1997) 2.18
Interferon-gamma receptor-1 gene polymorphism in tuberculosis patients from Croatia. Scand J Immunol (2003) 2.17
Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death. J Exp Med (2008) 2.17
Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. J Immunol (2007) 2.14
NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2. J Biol Chem (2007) 2.13
A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children. J Allergy Clin Immunol (2004) 2.12
Impact of mannose-binding lectin on susceptibility to infectious diseases. Clin Infect Dis (2003) 2.08
Mannose-binding lectin and innate immunity. Immunol Rev (2009) 2.08
Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat Med (2003) 2.08
Relevance of the tumor necrosis factor alpha (TNF alpha) -308 promoter polymorphism in TNF alpha gene regulation. J Inflamm (1997) 2.05
NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis. PLoS Pathog (2005) 2.04
Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. J Immunol (2003) 2.02
BCG vaccination of children against leprosy in Uganda: final results. J Hyg (Lond) (1981) 2.02
Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae. Science (1998) 2.02
Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases. Nat Immunol (2007) 1.96
Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study. Lancet Neurol (2009) 1.94
Toll-like receptor pathways in the immune responses to mycobacteria. Microbes Infect (2004) 1.94
Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res (2007) 4.92
Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science (2003) 4.80
The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. PLoS Pathog (2008) 3.79
The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. Cell (2010) 3.64
Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell (2012) 3.54
Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. J Immunol (2003) 2.02
Toll-like receptor polymorphisms and susceptibility to human disease. Clin Sci (Lond) (2008) 1.94
Mycobacterium tuberculosis, macrophages, and the innate immune response: does common variation matter? Immunol Rev (2007) 1.88
Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection. J Immunol (2007) 1.57
Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl Trop Dis (2008) 1.56
Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles. PLoS Pathog (2008) 1.41
Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy. J Infect Dis (2008) 1.34
Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila. J Immunol (2007) 1.28
Differential constitutive and cytokine-modulated expression of human Toll-like receptors in primary neutrophils, monocytes, and macrophages. Int J Med Sci (2008) 1.24
Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis. J Immunol (2012) 1.21
Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants. PLoS Pathog (2011) 1.13
Towards subtlety: understanding the role of Toll-like receptor signaling in susceptibility to human infections. Clin Immunol (2006) 1.12
Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens. Infect Immun (2003) 1.11
Genetic variants associated with susceptibility to Helicobacter pylori. JAMA (2013) 1.11
Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes. Hum Immunol (2010) 1.09
NOD1 and NOD2 regulation of pulmonary innate immunity to Legionella pneumophila. Eur J Immunol (2010) 1.09
The dynamics of QuantiFERON-TB gold in-tube conversion and reversion in a cohort of South African adolescents. Am J Respir Crit Care Med (2015) 1.08
Role of Toll-like receptor 5 in the innate immune response to acute P. aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol (2009) 1.07
Fas (CD95) induces macrophage proinflammatory chemokine production via a MyD88-dependent, caspase-independent pathway. J Leukoc Biol (2007) 1.06
Impaired TLR5 functionality is associated with survival in melioidosis. J Immunol (2013) 0.96
Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam. J Infect Dis (2005) 0.96
Toll-like receptor signaling in airborne Burkholderia thailandensis infection. Infect Immun (2009) 0.96
Common polymorphisms in the PKP3-SIGIRR-TMEM16J gene region are associated with susceptibility to tuberculosis. J Infect Dis (2012) 0.94
Family history and risk of recurrent cystitis and pyelonephritis in women. J Urol (2010) 0.92
Tuberculosis Infection: Insight from Immunogenomics. Drug Discov Today Dis Mech (2007) 0.92
Human CD1a deficiency is common and genetically regulated. J Immunol (2013) 0.92
The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury. PLoS One (2009) 0.90
Maturation of innate responses to mycobacteria over the first nine months of life. J Immunol (2014) 0.85
Toll-like receptors: their roles in bacterial recognition and respiratory infections. Expert Rev Anti Infect Ther (2008) 0.82
Common polymorphisms in the CD43 gene region are associated with tuberculosis disease and mortality. Am J Respir Cell Mol Biol (2015) 0.79
The role of NOD2 in murine and human melioidosis. J Immunol (2013) 0.79
Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome. Int Arch Allergy Immunol (2008) 0.78
Toll-like receptor polymorphisms are associated with increased neurosyphilis risk. Sex Transm Dis (2014) 0.78
Nucleotide-binding oligomerization domain containing-like receptor family, caspase recruitment domain (CARD) containing 4 (NLRC4) regulates intrapulmonary replication of aerosolized Legionella pneumophila. BMC Infect Dis (2013) 0.77
Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap data. PLoS One (2012) 0.76
Role of oral antibiotics in treatment of breastfeeding women with chronic breast pain who fail conservative therapy. Breastfeed Med (2014) 0.75
Human susceptibility to legionnaires' disease. Methods Mol Biol (2013) 0.75