Published in Science on December 03, 2010
Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy. Sci Transl Med (2013) 2.31
Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy. Sci Transl Med (2015) 1.63
Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy. Nat Chem Biol (2011) 1.58
Quantitative chemical imaging with multiplex stimulated Raman scattering microscopy. J Am Chem Soc (2012) 1.51
Advances in fluorescence labeling strategies for dynamic cellular imaging. Nat Chem Biol (2014) 1.47
Quantitative vibrational imaging by hyperspectral stimulated Raman scattering microscopy and multivariate curve resolution analysis. Anal Chem (2012) 1.46
Coherent Raman spectro-imaging with laser frequency combs. Nature (2013) 1.37
High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues. Nat Photonics (2015) 1.37
Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy. Proc Natl Acad Sci U S A (2013) 1.36
Highly specific label-free molecular imaging with spectrally tailored excitation stimulated Raman scattering (STE-SRS) microscopy. Nat Photonics (2011) 1.32
Hyperspectral imaging with stimulated Raman scattering by chirped femtosecond lasers. J Phys Chem B (2013) 1.30
Coherent Raman scanning fiber endoscopy. Opt Lett (2011) 1.28
Multicolored stain-free histopathology with coherent Raman imaging. Lab Invest (2012) 1.22
Label-free live-cell imaging of nucleic acids using stimulated Raman scattering microscopy. Chemphyschem (2012) 1.20
Diagnosis of tumors during tissue-conserving surgery with integrated autofluorescence and Raman scattering microscopy. Proc Natl Acad Sci U S A (2013) 1.17
Raman and SERS microscopy for molecular imaging of live cells. Nat Protoc (2013) 1.15
Imaging drug delivery to skin with stimulated Raman scattering microscopy. Mol Pharm (2011) 1.15
Biomolecular imaging with coherent nonlinear vibrational microscopy. Annu Rev Phys Chem (2012) 1.12
Stimulated Raman Scattering Microscopy with a Robust Fibre Laser Source. Nat Photonics (2014) 1.10
Raman spectroscopy and CARS microscopy of stem cells and their derivatives. J Raman Spectrosc (2011) 1.05
Multicolor stimulated Raman scattering microscopy with a rapidly tunable optical parametric oscillator. Opt Lett (2013) 1.03
Single cell optical imaging and spectroscopy. Chem Rev (2013) 1.03
Synchronous digitization for high dynamic range lock-in amplification in beam-scanning microscopy. Rev Sci Instrum (2014) 1.02
Multicolor stimulated Raman scattering (SRS) microscopy. Mol Phys (2012) 1.02
Label-free imaging of lipid dynamics using Coherent Anti-stokes Raman Scattering (CARS) and Stimulated Raman Scattering (SRS) microscopy. Curr Opin Genet Dev (2011) 1.00
Small molecule perimeter defense in entomopathogenic bacteria. Proc Natl Acad Sci U S A (2012) 0.99
Effect of desiccating stress on mouse meibomian gland function. Ocul Surf (2013) 0.99
In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy. J Am Chem Soc (2014) 0.99
The need for speed. J Biophotonics (2012) 0.97
Imaging beyond the proteome. Chem Commun (Camb) (2012) 0.95
Comparing in vivo pump-probe and multiphoton fluorescence microscopy of melanoma and pigmented lesions. J Biomed Opt (2015) 0.94
Biological imaging with coherent Raman scattering microscopy: a tutorial. J Biomed Opt (2014) 0.94
Laser spectrometry for multi-elemental imaging of biological tissues. Sci Rep (2014) 0.93
Label-free quantitative imaging of cholesterol in intact tissues by hyperspectral stimulated Raman scattering microscopy. Angew Chem Int Ed Engl (2013) 0.93
Multicolor live-cell chemical imaging by isotopically edited alkyne vibrational palette. J Am Chem Soc (2014) 0.92
Label-free imaging of lipid-droplet intracellular motion in early Drosophila embryos using femtosecond-stimulated Raman loss microscopy. Biophys J (2012) 0.92
Shedding new light on lipid functions with CARS and SRS microscopy. Biochim Biophys Acta (2014) 0.92
Microsecond Scale Vibrational Spectroscopic Imaging by Multiplex Stimulated Raman Scattering Microscopy. Light Sci Appl (2015) 0.91
Identification of a protein-containing enamel matrix layer which bridges with the dentine-enamel junction of adult human teeth. Arch Oral Biol (2012) 0.91
Advances in multiphoton microscopy for imaging embryos. Curr Opin Genet Dev (2011) 0.91
Direct visualization of de novo lipogenesis in single living cells. Sci Rep (2014) 0.88
Label-free DNA imaging in vivo with stimulated Raman scattering microscopy. Proc Natl Acad Sci U S A (2015) 0.88
Fast vibrational imaging of single cells and tissues by stimulated Raman scattering microscopy. Acc Chem Res (2014) 0.88
Vibrational spectroscopic imaging for the evaluation of matrix and mineral chemistry. Curr Osteoporos Rep (2014) 0.87
Label-Free, Longitudinal Visualization of PDT Response In Vitro with Optical Coherence Tomography. Isr J Chem (2012) 0.87
Time-domain spectroscopy in the mid-infrared. Sci Rep (2014) 0.87
Time-lens based hyperspectral stimulated Raman scattering imaging and quantitative spectral analysis. J Biophotonics (2013) 0.87
Longitudinal, 3D in vivo imaging of sebaceous glands by coherent anti-stokes Raman scattering microscopy: normal function and response to cryotherapy. J Invest Dermatol (2014) 0.87
Pump-probe imaging of pigmented cutaneous melanoma primary lesions gives insight into metastatic potential. Biomed Opt Express (2015) 0.86
Evaluation of stimulated Raman scattering microscopy for identifying squamous cell carcinoma in human skin. Lasers Surg Med (2013) 0.85
Spectrometer-free vibrational imaging by retrieving stimulated Raman signal from highly scattered photons. Sci Adv (2015) 0.84
Invited Review Article: Pump-probe microscopy. Rev Sci Instrum (2016) 0.84
A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy. Nat Commun (2015) 0.84
Personalized nanomedicine advancements for stem cell tracking. Adv Drug Deliv Rev (2012) 0.84
High-throughput nonlinear optical microscopy. Biophys J (2013) 0.84
Coherent Raman Scattering Microscopy in Biology and Medicine. Annu Rev Biomed Eng (2015) 0.84
Clinical instrumentation and applications of Raman spectroscopy. Chem Soc Rev (2016) 0.84
Automated identification of subcellular organelles by coherent anti-stokes Raman scattering. Biophys J (2014) 0.83
Optical heterodyne-detected Raman-induced Kerr effect (OHD-RIKE) microscopy. J Phys Chem B (2011) 0.83
Coherent anti-Stokes Raman scattering and spontaneous Raman spectroscopy and microscopy of microalgae with nitrogen depletion. Biomed Opt Express (2012) 0.83
Live-cell vibrational imaging of choline metabolites by stimulated Raman scattering coupled with isotope-based metabolic labeling. Analyst (2014) 0.83
Vibrational Imaging of Glucose Uptake Activity in Live Cells and Tissues by Stimulated Raman Scattering. Angew Chem Int Ed Engl (2015) 0.83
Imaging morphodynamics of human blood cells in vivo with video-rate third harmonic generation microscopy. Biomed Opt Express (2012) 0.82
Imaging complex protein metabolism in live organisms by stimulated Raman scattering microscopy with isotope labeling. ACS Chem Biol (2015) 0.81
Compact non-contact total emission detection for in vivo multiphoton excitation microscopy. J Microsc (2013) 0.81
Molecular imaging with surface-enhanced Raman spectroscopy nanoparticle reporters. MRS Bull (2013) 0.81
Label-free biomedical imaging of lipids by stimulated Raman scattering microscopy. Curr Protoc Mol Biol (2015) 0.81
Label-free nanometer-resolution imaging of biological architectures through surface enhanced Raman scattering. Sci Rep (2013) 0.80
Femtosecond pulse shaping enables detection of optical Kerr-effect (OKE) dynamics for molecular imaging. Opt Lett (2014) 0.80
Live-cell quantitative imaging of proteome degradation by stimulated Raman scattering. Angew Chem Int Ed Engl (2014) 0.79
Stimulated Raman scattering microscopy: an emerging tool for drug discovery. Chem Soc Rev (2016) 0.78
Beam scanning for rapid coherent Raman hyperspectral imaging. Opt Lett (2015) 0.78
Broadband coherent Raman spectroscopy running at 24,000 spectra per second. Sci Rep (2016) 0.78
Deciphering single cell metabolism by coherent Raman scattering microscopy. Curr Opin Chem Biol (2016) 0.78
In Situ and In Vivo Molecular Analysis by Coherent Raman Scattering Microscopy. Annu Rev Anal Chem (Palo Alto Calif) (2016) 0.77
Molecular diffusion in the human nail measured by stimulated Raman scattering microscopy. Proc Natl Acad Sci U S A (2015) 0.77
Continuous-Wave Stimulated Raman Scattering (cwSRS) Microscopy. Appl Phys B (2013) 0.77
Molecular imaging with CARS micro-spectroscopy. Curr Opin Chem Biol (2016) 0.77
Quantitative chemical imaging with background-free multiplex coherent anti-Stokes Raman scattering by dual-soliton Stokes pulses. Biomed Opt Express (2016) 0.77
Application of Multiphoton Microscopy in Dermatological Studies: a Mini-Review. J Innov Opt Health Sci (2014) 0.76
Denoising Stimulated Raman Spectroscopic Images by Total Variation Minimization. J Phys Chem C Nanomater Interfaces (2015) 0.76
In situ visualization of intracellular morphology of epidermal cells using stimulated Raman scattering microscopy. J Biomed Opt (2016) 0.75
Pure electrical, highly-efficient and sidelobe free coherent Raman spectroscopy using acousto-optics tunable filter (AOTF). Sci Rep (2016) 0.75
Flexible digital signal processing architecture for narrowband and spread-spectrum lock-in detection in multiphoton microscopy and time-resolved spectroscopy. Rev Sci Instrum (2015) 0.75
Improving the accuracy of brain tumor surgery via Raman-based technology. Neurosurg Focus (2016) 0.75
Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography. Opt Express (2016) 0.75
Optical diagnosis and characterization of dental caries with polarization-resolved hyperspectral stimulated Raman scattering microscopy. Biomed Opt Express (2016) 0.75
Wide-Field Detected Fourier Transform CARS Microscopy. Sci Rep (2016) 0.75
New insights into the intracellular distribution pattern of cationic amphiphilic drugs. Sci Rep (2017) 0.75
Coherent anti-Stokes Raman scattering imaging under ambient light. Opt Lett (2016) 0.75
Achromatic miniature lens system for coherent Raman scattering microscopy. Biomed Opt Express (2013) 0.75
Light in diagnosis, therapy and surgery. Nat Biomed Eng (2017) 0.75
Coherent Raman Scattering Microscopy for Evaluation of Head and Neck Carcinoma. Otolaryngol Head Neck Surg (2017) 0.75
A machine learning framework to analyze hyperspectral stimulated Raman scattering microscopy images of expressed human meibum. J Raman Spectrosc (2017) 0.75
Cancer imaging using surface-enhanced resonance Raman scattering nanoparticles. Nat Protoc (2017) 0.75
Vibrational spectroscopic techniques to assess bone quality. Osteoporos Int (2017) 0.75
Label-free pathology by spectrally sliced femtosecond stimulated Raman scattering (SRS) microscopy. PLoS One (2017) 0.75
Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy. Science (2008) 10.19
In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature (2005) 6.60
Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy. Proc Natl Acad Sci U S A (2005) 5.96
Coherent anti-stokes Raman scattering microscopy: chemical imaging for biology and medicine. Annu Rev Anal Chem (Palo Alto Calif) (2008) 5.13
Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov (2004) 3.41
Monitoring of lipid storage in Caenorhabditis elegans using coherent anti-Stokes Raman scattering (CARS) microscopy. Proc Natl Acad Sci U S A (2007) 2.65
Minimally invasive high-speed imaging of sarcomere contractile dynamics in mice and humans. Nature (2008) 2.56
Analysis and experimental assessment of the sensitivity of stimulated Raman scattering microscopy. Opt Express (2009) 2.33
High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy. Opt Lett (2006) 2.27
Moisturization and skin barrier function. Dermatol Ther (2004) 2.09
Multiphoton excitation fluorescence microscopy and spectroscopy of in vivo human skin. Biophys J (1997) 1.91
In vivo coherent anti-Stokes Raman scattering imaging of sciatic nerve tissue. J Microsc (2007) 1.74
Quantitative coherent anti-Stokes Raman scattering imaging of lipid distribution in coexisting domains. Biophys J (2005) 1.68
Quantitative multiplex CARS spectroscopy in congested spectral regions. J Phys Chem B (2006) 1.39
Label-free, real-time monitoring of biomass processing with stimulated Raman scattering microscopy. Angew Chem Int Ed Engl (2010) 1.30
Vibrational imaging of tablets by epi-detected stimulated Raman scattering microscopy. Analyst (2010) 1.26
Hair follicles--an efficient storage and penetration pathway for topically applied substances. Summary of recent results obtained at the Center of Experimental and Applied Cutaneous Physiology, Charité -Universitätsmedizin Berlin, Germany. Skin Pharmacol Physiol (2008) 1.12
Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells. Science (2010) 11.37
Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy. Science (2008) 10.19
Stochastic protein expression in individual cells at the single molecule level. Nature (2006) 8.00
Probing gene expression in live cells, one protein molecule at a time. Science (2006) 7.21
Probing transcription factor dynamics at the single-molecule level in a living cell. Science (2007) 6.85
Protein conformational dynamics probed by single-molecule electron transfer. Science (2003) 6.48
Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy. Proc Natl Acad Sci U S A (2005) 5.96
Genome-wide detection of single-nucleotide and copy-number variations of a single human cell. Science (2012) 5.50
Coherent anti-stokes Raman scattering microscopy: chemical imaging for biology and medicine. Annu Rev Anal Chem (Palo Alto Calif) (2008) 5.13
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. Proc Natl Acad Sci U S A (2006) 4.60
Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited. Nat Chem Biol (2005) 4.24
Linking stochastic dynamics to population distribution: an analytical framework of gene expression. Phys Rev Lett (2006) 4.06
DNA primase acts as a molecular brake in DNA replication. Nature (2006) 3.66
A stochastic single-molecule event triggers phenotype switching of a bacterial cell. Science (2008) 3.46
Single-molecule kinetics of lambda exonuclease reveal base dependence and dynamic disorder. Science (2003) 3.22
Central dogma at the single-molecule level in living cells. Nature (2011) 3.00
Probing allostery through DNA. Science (2013) 2.92
Imaging chromophores with undetectable fluorescence by stimulated emission microscopy. Nature (2009) 2.74
Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy. J Lipid Res (2003) 2.59
Digital RNA sequencing minimizes sequence-dependent bias and amplification noise with optimized single-molecule barcodes. Proc Natl Acad Sci U S A (2012) 2.59
Observation of individual microtubule motor steps in living cells with endocytosed quantum dots. J Phys Chem B (2005) 2.55
Nonspecifically bound proteins spin while diffusing along DNA. Nat Struct Mol Biol (2009) 2.43
Chromosome organization by a nucleoid-associated protein in live bacteria. Science (2011) 2.41
Fluctuating enzymes: lessons from single-molecule studies. Acc Chem Res (2005) 2.33
Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy. Sci Transl Med (2013) 2.31
High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy. Opt Lett (2006) 2.27
Laser-scanning coherent anti-Stokes Raman scattering microscopy and applications to cell biology. Biophys J (2002) 2.26
Single-molecule imaging of transcription factor binding to DNA in live mammalian cells. Nat Methods (2013) 2.22
Coherent nonlinear optical imaging: beyond fluorescence microscopy. Annu Rev Phys Chem (2011) 2.22
Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing. Science (2012) 2.14
Fluorogenic DNA sequencing in PDMS microreactors. Nat Methods (2011) 2.13
Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients. Proc Natl Acad Sci U S A (2013) 2.09
Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase. Proc Natl Acad Sci U S A (2007) 2.06
Heterodyne coherent anti-Stokes Raman scattering (CARS) imaging. Opt Lett (2006) 1.96
Observation of a power-law memory kernel for fluctuations within a single protein molecule. Phys Rev Lett (2005) 1.91
RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods (2011) 1.82
Single-molecule Michaelis-Menten equations. J Phys Chem B (2005) 1.80
Nonperturbative chemical imaging of organelle transport in living cells with coherent anti-stokes Raman scattering microscopy. Biophys J (2006) 1.75
Generalized Langevin equation with fractional Gaussian noise: subdiffusion within a single protein molecule. Phys Rev Lett (2004) 1.70
Chemically-selective imaging of brain structures with CARS microscopy. Opt Express (2007) 1.62
High-resolution near-field Raman microscopy of single-walled carbon nanotubes. Phys Rev Lett (2003) 1.55
Organelle tracking in a living cell with microsecond time resolution and nanometer spatial precision. Chemphyschem (2008) 1.41
Coherent anti-stokes raman scattering spectral interferometry: determination of the real and imaginary components of nonlinear susceptibility chi(3) for vibrational microscopy. Opt Lett (2004) 1.40
Diffusion constant of a nonspecifically bound protein undergoing curvilinear motion along DNA. J Phys Chem B (2008) 1.33
Ordering of water molecules between phospholipid bilayers visualized by coherent anti-Stokes Raman scattering microscopy. Proc Natl Acad Sci U S A (2003) 1.33
Highly specific label-free molecular imaging with spectrally tailored excitation stimulated Raman scattering (STE-SRS) microscopy. Nat Photonics (2011) 1.32
Label-free, real-time monitoring of biomass processing with stimulated Raman scattering microscopy. Angew Chem Int Ed Engl (2010) 1.30
Multiplexed single-molecule assay for enzymatic activity on flow-stretched DNA. Nat Methods (2007) 1.29
Coherent Raman scanning fiber endoscopy. Opt Lett (2011) 1.28
Direct visualization of lipid phase segregation in single lipid bilayers with coherent anti-Stokes Raman scattering microscopy. Chemphyschem (2005) 1.27
Two-dimensional reaction free energy surfaces of catalytic reaction: effects of protein conformational dynamics on enzyme catalysis. J Phys Chem B (2007) 1.25
Probing dynein and kinesin stepping with mechanical manipulation in a living cell. Chemphyschem (2009) 1.24
Multicolored stain-free histopathology with coherent Raman imaging. Lab Invest (2012) 1.22
Coordinated production and utilization of FADH2 by NAD(P)H-flavin oxidoreductase and 4-hydroxyphenylacetate 3-monooxygenase. Biochemistry (2003) 1.21
Label-free live-cell imaging of nucleic acids using stimulated Raman scattering microscopy. Chemphyschem (2012) 1.20
Coherent anti-stokes Raman scattering microscopy: a biological review. Cytometry A (2006) 1.17
When does the Michaelis-Menten equation hold for fluctuating enzymes? J Phys Chem B (2006) 1.15
Imaging drug delivery to skin with stimulated Raman scattering microscopy. Mol Pharm (2011) 1.15
High-power picosecond fiber source for coherent Raman microscopy. Opt Lett (2009) 1.12
Dynamic distance disorder in proteins is caused by trapping. J Phys Chem B (2006) 1.10
Spatial organization of RNA polymerase II inside a mammalian cell nucleus revealed by reflected light-sheet superresolution microscopy. Proc Natl Acad Sci U S A (2013) 1.09
Generalized Haldane equation and fluctuation theorem in the steady-state cycle kinetics of single enzymes. Phys Rev E Stat Nonlin Soft Matter Phys (2006) 1.07
Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism. Virology (2009) 1.05
Peroxisome proliferator-activated receptor alpha antagonism inhibits hepatitis C virus replication. Chem Biol (2006) 1.04
Single-molecule study of DNA polymerization activity of HIV-1 reverse transcriptase on DNA templates. J Mol Biol (2009) 1.03
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: IV. viral proteinase slides along DNA to locate and process its substrates. J Biol Chem (2012) 1.03
Multicolor stimulated Raman scattering microscopy with a rapidly tunable optical parametric oscillator. Opt Lett (2013) 1.03
Multicolor stimulated Raman scattering (SRS) microscopy. Mol Phys (2012) 1.02
Fiber four-wave mixing source for coherent anti-Stokes Raman scattering microscopy. Opt Lett (2012) 1.02
Synchronized time-lens source for coherent Raman scattering microscopy. Opt Express (2010) 1.02
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: II. adenovirus proteinase is activated in an unusual one-dimensional biochemical reaction. J Biol Chem (2012) 1.00
Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice. J Biomed Opt (2011) 0.99
Reliable cell segmentation based on spectral phasor analysis of hyperspectral stimulated Raman scattering imaging data. Anal Chem (2014) 0.99
Intracavity wavelength modulation of an optical parametric oscillator for coherent Raman microscopy. Opt Express (2009) 0.96
Intracellular imaging of HCV RNA and cellular lipids by using simultaneous two-photon fluorescence and coherent anti-Stokes Raman scattering microscopies. Chembiochem (2006) 0.92
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: I. binding to DNA AND to hexon of the precursor to protein VI, pVI, of human adenovirus. J Biol Chem (2012) 0.90
Rare event of histone demethylation can initiate singular gene expression of olfactory receptors. Proc Natl Acad Sci U S A (2013) 0.89
Nonequilibrium steady state of a nanometric biochemical system: determining the thermodynamic driving force from single enzyme turnover time traces. Nano Lett (2005) 0.89
Role of conformational dynamics in kinetics of an enzymatic cycle in a nonequilibrium steady state. J Chem Phys (2009) 0.86
FAD is a preferred substrate and an inhibitor of Escherichia coli general NAD(P)H:flavin oxidoreductase. J Biol Chem (2002) 0.86
Near-degenerate four-wave-mixing microscopy. Nano Lett (2009) 0.85