Published in Nat Genet on December 05, 2010
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer (2011) 6.32
Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene. Cancer Discov (2011) 3.45
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet (2011) 3.37
Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet (2012) 3.20
Single nucleotide polymorphisms and risk of recurrence of renal-cell carcinoma: a cohort study. Lancet Oncol (2012) 2.44
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression. Nat Genet (2012) 2.25
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet (2013) 2.24
Genome-wide association study identifies two susceptibility loci for osteosarcoma. Nat Genet (2013) 2.21
Current status of genome-wide association studies in cancer. Hum Genet (2011) 2.14
Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1. Nat Genet (2011) 2.00
Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. J Natl Cancer Inst (2012) 1.99
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Nat Genet (2011) 1.98
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet (2011) 1.97
Defining early-onset kidney cancer: implications for germline and somatic mutation testing and clinical management. J Clin Oncol (2013) 1.96
The VHL/HIF axis in clear cell renal carcinoma. Semin Cancer Biol (2012) 1.90
A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. Cancer Prev Res (Phila) (2011) 1.86
Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harb Symp Quant Biol (2011) 1.81
HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma. Cancer Discov (2015) 1.62
State of the science: an update on renal cell carcinoma. Mol Cancer Res (2012) 1.58
A subset-based approach improves power and interpretation for the combined analysis of genetic association studies of heterogeneous traits. Am J Hum Genet (2012) 1.57
Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer. Eur Urol (2015) 1.56
Genetic basis of kidney cancer: role of genomics for the development of disease-based therapeutics. Genome Res (2012) 1.49
Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival. J Natl Cancer Inst (2014) 1.47
Joint association of genome-wide association study-identified susceptibility loci and dietary patterns in risk of renal cell carcinoma among non-Hispanic whites. Am J Epidemiol (2014) 1.46
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer. J Physiol (2013) 1.35
A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23. Hum Mol Genet (2011) 1.34
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia. Nat Genet (2011) 1.33
New insights into the biology of renal cell carcinoma. Hematol Oncol Clin North Am (2011) 1.31
Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer. Hum Mol Genet (2011) 1.17
Genome-wide association study identifies common variants associated with circulating vitamin E levels. Hum Mol Genet (2011) 1.14
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. Hum Mol Genet (2014) 1.09
Renal cancer biomarkers: the promise of personalized care. BMC Med (2012) 1.08
The chromosome 2p21 region harbors a complex genetic architecture for association with risk for renal cell carcinoma. Hum Mol Genet (2011) 1.08
Most common 'sporadic' cancers have a significant germline genetic component. Hum Mol Genet (2014) 1.03
Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer. Hum Mol Genet (2012) 1.02
Renal cell cancer among African Americans: an epidemiologic review. BMC Cancer (2011) 1.01
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol (2017) 1.00
Variation at HLA-DRB1 is associated with resistance to enteric fever. Nat Genet (2014) 0.99
A functional variant in the MTOR promoter modulates its expression and is associated with renal cell cancer risk. PLoS One (2012) 0.98
New strategies in renal cell carcinoma: targeting the genetic and metabolic basis of disease. Clin Cancer Res (2015) 0.98
MicroRNA sequence polymorphisms and the risk of different types of cancer. Sci Rep (2014) 0.97
Biomarkers for anti-angiogenic therapy in cancer. Int J Mol Sci (2013) 0.96
Genome-wide association study of endometrial cancer in E2C2. Hum Genet (2013) 0.93
Genetic polymorphisms in the 9p21 region associated with risk of multiple cancers. Carcinogenesis (2014) 0.90
Anti-vascular endothelial growth factor therapy in breast cancer. Int J Mol Sci (2014) 0.89
Comprehensive evaluation of one-carbon metabolism pathway gene variants and renal cell cancer risk. PLoS One (2011) 0.86
Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer. PLoS One (2015) 0.85
Genomic Analysis as the First Step toward Personalized Treatment in Renal Cell Carcinoma. Front Oncol (2014) 0.85
A genome-wide association study of renal cell carcinoma among African Americans. Cancer Epidemiol Biomarkers Prev (2013) 0.85
Common genetic variants in miR-1206 (8q24.2) and miR-612 (11q13.3) affect biogenesis of mature miRNA forms. PLoS One (2012) 0.83
A vitamin D receptor-alkylating derivative of 1α,25-dihydroxyvitamin D3 inhibits growth of human kidney cancer cells and suppresses tumor growth. Cancer Prev Res (Phila) (2010) 0.83
Untuning the tumor metabolic machine: HIF-α: pro- and antitumorigenic? Nat Med (2012) 0.82
Rare variants in BRCA2 and CHEK2 are associated with the risk of urinary tract cancers. Sci Rep (2016) 0.81
A GWAS-identified susceptibility locus on chromosome 11q13.3 and its putative molecular target for prediction of postoperative prognosis of human renal cell carcinoma. Oncol Lett (2013) 0.81
Intermittent induction of HIF-1α produces lasting effects on malignant progression independent of its continued expression. PLoS One (2015) 0.80
Common variation at 1q24.1 (ALDH9A1) is a potential risk factor for renal cancer. PLoS One (2015) 0.80
The role of PHD2 mutations in the pathogenesis of erythrocytosis. Hypoxia (Auckl) (2014) 0.80
Assessing disease risk in genome-wide association studies using family history. Epidemiology (2012) 0.80
Genetic variants in the inositol phosphate metabolism pathway and risk of different types of cancer. Sci Rep (2015) 0.79
miR-490-5p suppresses tumour growth in renal cell carcinoma through targeting PIK3CA. Biol Cell (2015) 0.79
Genetic variation in the GSTM3 promoter confer risk and prognosis of renal cell carcinoma by reducing gene expression. Br J Cancer (2013) 0.79
Functional promoter -31G>C variant in survivin gene is associated with risk and progression of renal cell cancer in a Chinese population. PLoS One (2012) 0.79
A genetic polymorphism affects the risk and prognosis of renal cell carcinoma: association with follistatin-like protein 1 expression. Sci Rep (2016) 0.78
Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nat Genet (2016) 0.78
ADIPOQ polymorphism rs182052 is associated with clear cell renal cell carcinoma. Cancer Sci (2015) 0.78
Application of multi-SNP approaches Bayesian LASSO and AUC-RF to detect main effects of inflammatory-gene variants associated with bladder cancer risk. PLoS One (2013) 0.78
Tumour and patient factors in renal cell carcinoma-towards personalized therapy. Nat Rev Urol (2015) 0.78
Gene-environment interaction of genome-wide association study-identified susceptibility loci and meat-cooking mutagens in the etiology of renal cell carcinoma. Cancer (2015) 0.78
Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41. Nat Commun (2016) 0.77
Comprehensive resequence analysis of a 123-kb region of chromosome 11q13 associated with prostate cancer. Prostate (2012) 0.77
The eGenVar data management system--cataloguing and sharing sensitive data and metadata for the life sciences. Database (Oxford) (2014) 0.77
Zinc transporter genes and urological cancers: integrated analysis suggests a role for ZIP11 in bladder cancer. Tumour Biol (2015) 0.77
Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis). Int J Mol Med (2015) 0.76
The A Allele at rs13419896 of EPAS1 Is Associated with Enhanced Expression and Poor Prognosis for Non-Small Cell Lung Cancer. PLoS One (2015) 0.76
Genetic control of renal tumorigenesis by the mouse Rtm1 locus. BMC Genomics (2013) 0.76
Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer. Nat Commun (2016) 0.75
Multilevel-analysis identify a cis-expression quantitative trait locus associated with risk of renal cell carcinoma. Oncotarget (2015) 0.75
A susceptibility locus rs7099208 is associated with non-obstructive azoospermia via reduction in the expression of FAM160B1. J Biomed Res (2015) 0.75
Chromosomal imbalances revealed in primary renal cell carcinomas by comparative genomic hybridization. Int J Clin Exp Pathol (2015) 0.75
Variants of SCARB1 and VDR Involved in Complex Genetic Interactions May Be Implicated in the Genetic Susceptibility to Clear Cell Renal Cell Carcinoma. Biomed Res Int (2015) 0.75
Potential role of gene-environment interactions in ion transport mechanisms in the etiology of renal cell cancer. Sci Rep (2016) 0.75
Synthetic high-density lipoproteins as targeted monotherapy for chronic lymphocytic leukemia. Oncotarget (2017) 0.75
Genetic variation in IGF1 predicts renal cell carcinoma susceptibility and prognosis in Chinese population. Sci Rep (2016) 0.75
Molecular profiling of renal cell carcinoma: building a bridge toward clinical impact. Curr Opin Urol (2016) 0.75
International cancer seminars: a focus on kidney cancer. Ann Oncol (2016) 0.75
Association of Hypoxia-Inducible Factor-2 Alpha Gene Polymorphisms with the Risk of Hepatitis B Virus-Related Liver Disease in Guangxi Chinese: A Case-Control Study. PLoS One (2016) 0.75
Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway. PLoS Genet (2017) 0.75
Logistic Bayesian LASSO for genetic association analysis of data from complex sampling designs. J Hum Genet (2017) 0.75
IL1 genes polymorphism and the risk of renal cell carcinoma in Chinese Han population. Oncotarget (2017) 0.75
Renal cell cancers: unveiling the hereditary ones and saving lives-a tailored diagnostic approach. Int Urol Nephrol (2017) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet (2006) 17.36
Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet (2008) 15.43
Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum Mol Genet (2008) 13.26
Inference of population structure using multilocus genotype data: dominant markers and null alleles. Mol Ecol Notes (2007) 10.11
Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet (2010) 7.62
ProbABEL package for genome-wide association analysis of imputed data. BMC Bioinformatics (2010) 6.46
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet (2009) 5.62
Epidemiology and risk factors for kidney cancer. Nat Rev Urol (2010) 5.25
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14
Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol (2003) 5.14
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes. Nucleic Acids Res (2006) 4.63
A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc Natl Acad Sci U S A (1997) 4.17
Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels. Nature (1997) 3.47
Population substructure and control selection in genome-wide association studies. PLoS One (2008) 3.44
Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. Cancer Res (2003) 2.93
Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray. Am J Pathol (2003) 2.59
The 1000 Genomes Project: new opportunities for research and social challenges. Genome Med (2010) 2.43
Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol Cancer Res (2004) 2.27
A population--based case--control study of renal cell carcinoma. J Natl Cancer Inst (1984) 2.17
The epidemiology of bladder and kidney cancer. Nat Clin Pract Urol (2007) 1.87
Lower plasma levels and accelerated clearance of high density lipoprotein (HDL) and non-HDL cholesterol in scavenger receptor class B type I transgenic mice. J Biol Chem (1999) 1.85
Hereditary kidney cancer: unique opportunity for disease-based therapy. Cancer (2009) 1.32
HIF in kidney disease and development. J Am Soc Nephrol (2008) 1.28
Genetics and the common cancers. Eur J Cancer (2001) 1.27
International renal-cell-cancer study. VI. the role of medical and family history. Int J Cancer (1996) 1.22
Family history and the risk of kidney cancer: a multicenter case-control study in Central Europe. Cancer Epidemiol Biomarkers Prev (2007) 1.14
Family history and risk of renal cell carcinoma. Cancer Epidemiol Biomarkers Prev (2001) 1.01
High marks for GWAS. Nat Genet (2009) 1.00
Cancer statistics, 2008. CA Cancer J Clin (2008) 86.74
Cancer statistics, 2009. CA Cancer J Clin (2009) 83.57
Cancer statistics, 2007. CA Cancer J Clin (2007) 53.49
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med (2003) 35.39
Cancer statistics, 2006. CA Cancer J Clin (2006) 30.71
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Mortality results from a randomized prostate-cancer screening trial. N Engl J Med (2009) 30.05
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA (2002) 28.72
Cancer statistics, 2005. CA Cancer J Clin (2005) 25.65
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
International network of cancer genome projects. Nature (2010) 20.35
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet (2007) 19.18
Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst (2004) 19.00
Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet (2008) 16.17
Replicating genotype-phenotype associations. Nature (2007) 16.11
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Cancer statistics, 2004. CA Cancer J Clin (2004) 15.72
Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet (2008) 15.43
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet (2009) 14.86
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
A human genome diversity cell line panel. Science (2002) 14.11
Cancer statistics, 2003. CA Cancer J Clin (2003) 13.46
Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA (2008) 13.35
Body-mass index and mortality among 1.46 million white adults. N Engl J Med (2010) 13.34
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Many sequence variants affecting diversity of adult human height. Nat Genet (2008) 12.80
Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation (2003) 12.78
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet (2008) 12.43
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Prostate cancer screening in the randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: mortality results after 13 years of follow-up. J Natl Cancer Inst (2012) 11.91
Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med (2003) 11.58
The landscape of cancer genes and mutational processes in breast cancer. Nature (2012) 11.24
Mutational processes molding the genomes of 21 breast cancers. Cell (2012) 11.22
Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet (2007) 10.81
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem (2003) 10.79
The life history of 21 breast cancers. Cell (2012) 10.59
Common variants conferring risk of schizophrenia. Nature (2009) 10.37
Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet (2007) 9.88
Polygenes, risk prediction, and targeted prevention of breast cancer. N Engl J Med (2008) 9.64
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. Lancet (2011) 9.49
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23