Peptide signaling in the staphylococci.

PubWeight™: 1.89‹?› | Rank: Top 3%

🔗 View Article (PMC 3086461)

Published in Chem Rev on December 21, 2010

Authors

Matthew Thoendel1, Jeffrey S Kavanaugh, Caralyn E Flack, Alexander R Horswill

Author Affiliations

1: Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.

Articles citing this

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38

Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harb Perspect Med (2012) 3.65

Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev (2013) 1.64

Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance. PLoS One (2015) 1.47

Staphylococcal biofilm disassembly. Trends Microbiol (2011) 1.44

Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. PLoS Pathog (2014) 1.39

The bicomponent pore-forming leucocidins of Staphylococcus aureus. Microbiol Mol Biol Rev (2014) 1.32

Staphylococcus aureus biofilms: recent developments in biofilm dispersal. Front Cell Infect Microbiol (2014) 1.27

PSMs of hypervirulent Staphylococcus aureus act as intracellular toxins that kill infected osteoblasts. PLoS One (2013) 1.26

Peptide pheromone signaling in Streptococcus and Enterococcus. FEMS Microbiol Rev (2013) 1.25

Virulence strategies of the dominant USA300 lineage of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). FEMS Immunol Med Microbiol (2012) 1.19

The formation of Staphylococcus aureus enterotoxin in food environments and advances in risk assessment. Virulence (2011) 1.19

Rot and SaeRS cooperate to activate expression of the staphylococcal superantigen-like exoproteins. J Bacteriol (2012) 1.06

Staphylococcus epidermidis agr quorum-sensing system: signal identification, cross talk, and importance in colonization. J Bacteriol (2014) 1.04

Identification of ligand specificity determinants in lantibiotic bovicin HJ50 and the receptor BovK, a multitransmembrane histidine kinase. J Biol Chem (2014) 1.04

Characterization of structural elements in native autoinducing peptides and non-native analogues that permit the differential modulation of AgrC-type quorum sensing receptors in Staphylococcus aureus. Org Biomol Chem (2015) 1.03

Evolution of resistance to a last-resort antibiotic in Staphylococcus aureus via bacterial competition. Cell (2014) 1.01

Activation and inhibition of the receptor histidine kinase AgrC occurs through opposite helical transduction motions. Mol Cell (2014) 1.01

Filaments in curved streamlines: Rapid formation of Staphylococcus aureus biofilm streamers. New J Phys (2014) 1.01

Targeting agr- and agr-Like quorum sensing systems for development of common therapeutics to treat multiple gram-positive bacterial infections. Sensors (Basel) (2013) 1.01

Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry. J Nat Prod (2014) 1.01

Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor. Infect Immun (2013) 1.01

Accumulation-associated protein enhances Staphylococcus epidermidis biofilm formation under dynamic conditions and is required for infection in a rat catheter model. Infect Immun (2014) 1.00

Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner. Mol Microbiol (2011) 0.99

Cooperation, quorum sensing, and evolution of virulence in Staphylococcus aureus. Infect Immun (2013) 0.99

Regulated proteolysis in bacterial development. FEMS Microbiol Rev (2013) 0.93

Detection of Staphylococcus aureus delta-toxin production by whole-cell MALDI-TOF mass spectrometry. PLoS One (2012) 0.93

Identification of four new agr quorum sensing-interfering cyclodepsipeptides from a marine Photobacterium. Mar Drugs (2013) 0.92

Impact of Environmental Cues on Staphylococcal Quorum Sensing and Biofilm Development. J Biol Chem (2016) 0.90

Quantitative analysis of autoinducing peptide I (AIP-I) from Staphylococcus aureus cultures using ultrahigh performance liquid chromatography-high resolving power mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2013) 0.89

Structural characterization of native autoinducing peptides and abiotic analogues reveals key features essential for activation and inhibition of an AgrC quorum sensing receptor in Staphylococcus aureus. J Am Chem Soc (2013) 0.89

Rot is a key regulator of Staphylococcus aureus biofilm formation. Mol Microbiol (2015) 0.87

Host cell-induced signaling causes Clostridium perfringens to upregulate production of toxins important for intestinal infections. Gut Microbes (2013) 0.87

Molecular characterisation of methicillin-sensitive Staphylococcus aureus from deep surgical site infections in orthopaedic patients. Eur J Clin Microbiol Infect Dis (2012) 0.87

Trapping and identification of cellular substrates of the Staphylococcus aureus ClpC chaperone. J Bacteriol (2013) 0.86

ω-Hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation. Antimicrob Agents Chemother (2015) 0.85

Streptomycin-induced expression in Bacillus subtilis of YtnP, a lactonase-homologous protein that inhibits development and streptomycin production in Streptomyces griseus. Appl Environ Microbiol (2011) 0.85

Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA). Planta Med (2012) 0.85

The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis. PLoS Pathog (2013) 0.84

Flipping the switch: tools for detecting small molecule inhibitors of staphylococcal virulence. Front Microbiol (2014) 0.83

Versatility of Biofilm Matrix Molecules in Staphylococcus epidermidis Clinical Isolates and Importance of Polysaccharide Intercellular Adhesin Expression during High Shear Stress. mSphere (2016) 0.82

Random mutagenesis and topology analysis of the autoinducing peptide biosynthesis proteins in Staphylococcus aureus. Mol Microbiol (2012) 0.82

N-acyl homoserine lactone-producing Pseudomonas putida strain T2-2 from human tongue surface. Sensors (Basel) (2013) 0.82

Chemical probes of quorum sensing: from compound development to biological discovery. FEMS Microbiol Rev (2016) 0.82

Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles. Cell Chem Biol (2016) 0.82

Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing in Staphylococcus aureus. ACS Biomater Sci Eng (2015) 0.82

Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non-native Ligands: An Emerging Target for Virulence Control in Pseudomonas aeruginosa. Chembiochem (2015) 0.82

Highly Stable, Amide-Bridged Autoinducing Peptide Analogues that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus. Angew Chem Int Ed Engl (2016) 0.81

RovS and its associated signaling peptide form a cell-to-cell communication system required for Streptococcus agalactiae pathogenesis. MBio (2015) 0.81

Structural Mechanisms of Peptide Recognition and Allosteric Modulation of Gene Regulation by the RRNPP Family of Quorum-Sensing Regulators. J Mol Biol (2016) 0.81

Serum Lipoproteins Are Critical for Pulmonary Innate Defense against Staphylococcus aureus Quorum Sensing. J Immunol (2015) 0.81

Influence of the AgrC-AgrA complex on the response time of Staphylococcus aureus quorum sensing. J Bacteriol (2014) 0.80

Structure-function analysis of peptide signaling in the Clostridium perfringens Agr-like quorum sensing system. J Bacteriol (2015) 0.80

Increasing AIP Macrocycle Size Reveals Key Features of agr Activation in Staphylococcus aureus. Chembiochem (2015) 0.80

Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation. ACS Chem Biol (2016) 0.80

Staphylococcus aureus Alpha-Toxin Is Conserved among Diverse Hospital Respiratory Isolates Collected from a Global Surveillance Study and Is Neutralized by Monoclonal Antibody MEDI4893. Antimicrob Agents Chemother (2016) 0.80

Prevention and treatment of Staphylococcus aureus biofilms. Expert Rev Anti Infect Ther (2015) 0.79

Insights into alpha-hemolysin (Hla) evolution and expression among Staphylococcus aureus clones with hospital and community origin. PLoS One (2014) 0.79

The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response. Microbiol Spectr (2016) 0.79

Apolipoprotein B48, the Structural Component of Chylomicrons, Is Sufficient to Antagonize Staphylococcus aureus Quorum-Sensing. PLoS One (2015) 0.78

Identification of the agr Peptide of Listeria monocytogenes. Front Microbiol (2016) 0.77

Resistance to Acute Macrophage Killing Promotes Airway Fitness of Prevalent Community-Acquired Staphylococcus aureus Strains. J Immunol (2016) 0.77

Exploiting Quorum Sensing Interfering Strategies in Gram-Negative Bacteria for the Enhancement of Environmental Applications. Front Microbiol (2016) 0.77

Key driving forces in the biosynthesis of autoinducing peptides required for staphylococcal virulence. Proc Natl Acad Sci U S A (2015) 0.77

Staphylococcus aureus Shifts toward Commensalism in Response to Corynebacterium Species. Front Microbiol (2016) 0.77

Functional reconstitution of Staphylococcus aureus truncated AgrC histidine kinase in a model membrane system. PLoS One (2013) 0.76

Identification of a peptide-pheromone that enhances Listeria monocytogenes escape from host cell vacuoles. PLoS Pathog (2015) 0.76

Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR. Org Biomol Chem (2015) 0.76

Development of an in vitro colonization model to investigate Staphylococcus aureus interactions with airway epithelia. Cell Microbiol (2016) 0.76

The Staphylococcus aureus Global Regulator MgrA Modulates Clumping and Virulence by Controlling Surface Protein Expression. PLoS Pathog (2016) 0.76

When being alone is enough: noncanonical functions of canonical bacterial quorum-sensing systems. Future Microbiol (2016) 0.75

Structure-Activity Relationships of the Competence Stimulating Peptides (CSPs) in Streptococcus pneumoniae Reveal Motifs Critical for Intra-group and Cross-group ComD Receptor Activation. ACS Chem Biol (2017) 0.75

Non-Woven Polymer Nanofiber Coatings that Inhibit Quorum Sensing in Staphylococcus aureus: Toward New Non-Bactericidal Approaches to Infection Control. ACS Infect Dis (2017) 0.75

The Active Component of Aspirin, Salicylic Acid, Promotes Staphylococcus aureus Biofilm Formation in a PIA-dependent Manner. Front Microbiol (2017) 0.75

The Spl Serine Proteases Modulate Staphylococcus aureus Protein Production and Virulence in a Rabbit Model of Pneumonia. mSphere (2016) 0.75

Hybrid Quadrupole-Orbitrap mass spectrometry for quantitative measurement of quorum sensing inhibition. J Microbiol Methods (2016) 0.75

Truncated Autoinducing Peptides as Antagonists of Staphylococcus lugdunensis Quorum Sensing. J Med Chem (2016) 0.75

Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models. Sci Rep (2017) 0.75

Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System. Front Microbiol (2016) 0.75

Multi-virulence-locus sequence typing of Staphylococcus lugdunensis generates results consistent with a clonal population structure and is reliable for epidemiological typing. J Clin Microbiol (2014) 0.75

Green fluorescent protein (GFP)-based overexpression screening and characterization of AgrC, a Receptor protein of quorum sensing in Staphylococcus aureus. Int J Mol Sci (2013) 0.75

Small proteins in cyanobacteria provide a paradigm for the functional analysis of the bacterial micro-proteome. BMC Microbiol (2016) 0.75

Reduced Enterotoxin D Formation on Boiled Ham in Staphylococcus Aureus Δagr Mutant. Toxins (Basel) (2017) 0.75

Transcriptomic and metabolic responses of Staphylococcus aureus in mixed culture with Lactobacillus plantarum, Streptococcus thermophilus and Enterococcus durans in milk. J Ind Microbiol Biotechnol (2016) 0.75

Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen. Proc Natl Acad Sci U S A (2017) 0.75

Targeting quorum sensing signal biosynthesis to fight antibiotic resistant infections: Ambuic acid as a model inhibitor. Antimicrob Agents Chemother (2017) 0.75

Attenuating Staphylococcus aureus Virulence by Targeting Flotillin Protein Scaffold Activity. Cell Chem Biol (2017) 0.75

Articles cited by this

(truncated to the top 100)

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res (1994) 392.47

The Protein Data Bank. Nucleic Acids Res (2000) 187.10

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis (1997) 57.27

Bacterial biofilms: a common cause of persistent infections. Science (1999) 40.82

Staphylococcus aureus infections. N Engl J Med (1998) 36.39

Protein structure prediction on the Web: a case study using the Phyre server. Nat Protoc (2009) 32.64

The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science (1998) 19.92

Bacterial biofilms: from the natural environment to infectious diseases. Nat Rev Microbiol (2004) 18.85

Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med (2006) 18.83

The HMMTOP transmembrane topology prediction server. Bioinformatics (2001) 12.57

Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J (1993) 11.30

Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol Microbiol (2003) 10.68

Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol (2009) 10.42

Census and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulators. Annu Rev Microbiol (1996) 10.26

Microbial biofilms: from ecology to molecular genetics. Microbiol Mol Biol Rev (2000) 9.83

Regulation of exoprotein gene expression in Staphylococcus aureus by agar. Mol Gen Genet (1986) 9.54

Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain. J Bacteriol (2005) 8.72

Cloning, characterization, and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus. J Bacteriol (1988) 8.18

Bacterial interference caused by autoinducing peptide variants. Science (1997) 7.96

Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med (2007) 7.75

Principles governing amino acid composition of integral membrane proteins: application to topology prediction. J Mol Biol (1998) 7.72

Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing. Annu Rev Genet (2001) 7.63

Staphylococcus aureus endocarditis: a consequence of medical progress. JAMA (2005) 7.41

Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease. Infect Immun (2002) 7.34

Bacterial biofilms: an emerging link to disease pathogenesis. Annu Rev Microbiol (2003) 7.29

An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae. Proc Natl Acad Sci U S A (1995) 7.29

The intercellular adhesion (ica) locus is present in Staphylococcus aureus and is required for biofilm formation. Infect Immun (1999) 7.22

Regulation of exoprotein expression in Staphylococcus aureus by a locus (sar) distinct from agr. Proc Natl Acad Sci U S A (1992) 6.95

sigmaB modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4. J Bacteriol (2002) 6.71

Cell density control of staphylococcal virulence mediated by an octapeptide pheromone. Proc Natl Acad Sci U S A (1995) 6.13

Listening in on bacteria: acyl-homoserine lactone signalling. Nat Rev Mol Cell Biol (2002) 6.01

Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med (2007) 5.95

Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections. Clin Infect Dis (2006) 5.92

Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia. Chest (2005) 5.91

Prediction and analysis of coiled-coil structures. Methods Enzymol (1996) 5.74

Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections. Nat Rev Microbiol (2006) 5.73

Improving the accuracy of transmembrane protein topology prediction using evolutionary information. Bioinformatics (2007) 5.68

Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci. J Bacteriol (2001) 5.57

The role of the delta-lysin gene (hld) in the regulation of virulence genes by the accessory gene regulator (agr) in Staphylococcus aureus. EMBO J (1990) 5.55

Understanding biofilm resistance to antibacterial agents. Nat Rev Drug Discov (2003) 5.48

Staphylococcus epidermidis--the 'accidental' pathogen. Nat Rev Microbiol (2009) 5.34

The bacterial Sm-like protein Hfq: a key player in RNA transactions. Mol Microbiol (2004) 4.88

COBALT: constraint-based alignment tool for multiple protein sequences. Bioinformatics (2007) 4.83

The agr P2 operon: an autocatalytic sensory transduction system in Staphylococcus aureus. Mol Gen Genet (1995) 4.63

Role of the accessory gene regulator (agr) in pathogenesis of staphylococcal osteomyelitis. Infect Immun (1995) 4.58

Quorum sensing in staphylococci. Annu Rev Genet (2008) 4.58

Biological insights from structures of two-component proteins. Annu Rev Microbiol (2009) 4.47

Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis. J Clin Invest (1994) 4.39

The HAMP domain structure implies helix rotation in transmembrane signaling. Cell (2006) 4.34

Impact of the agr quorum-sensing system on adherence to polystyrene in Staphylococcus aureus. J Infect Dis (2000) 4.19

Deletion of the alternative sigma factor sigmaB in Staphylococcus aureus reveals its function as a global regulator of virulence genes. J Bacteriol (1998) 4.18

Sociomicrobiology: the connections between quorum sensing and biofilms. Trends Microbiol (2005) 4.12

Stimulus perception in bacterial signal-transducing histidine kinases. Microbiol Mol Biol Rev (2006) 4.12

How human neutrophils kill and degrade microbes: an integrated view. Immunol Rev (2007) 3.97

Agr-mediated dispersal of Staphylococcus aureus biofilms. PLoS Pathog (2008) 3.91

Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci U S A (2009) 3.89

Pathogenesis of methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis (2008) 3.88

Identification and nucleotide sequence of the delta-lysin gene, hld, adjacent to the accessory gene regulator (agr) of Staphylococcus aureus. Mol Gen Genet (1989) 3.80

Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence. Proc Natl Acad Sci U S A (1999) 3.79

Mutation of sarA in Staphylococcus aureus limits biofilm formation. Infect Immun (2003) 3.77

Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus. J Bacteriol (2000) 3.70

Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium. Genome Biol (2009) 3.66

Activation of alpha-toxin translation in Staphylococcus aureus by the trans-encoded antisense RNA, RNAIII. EMBO J (1995) 3.64

Coagulase-negative staphylococci: role as pathogens. Annu Rev Med (1999) 3.59

Quorum sensing in Staphylococcus aureus biofilms. J Bacteriol (2004) 3.58

Cloning and sequencing of sarA of Staphylococcus aureus, a gene required for the expression of agr. J Bacteriol (1994) 3.54

National trends in ambulatory visits and antibiotic prescribing for skin and soft-tissue infections. Arch Intern Med (2008) 3.46

Staphylococcus epidermidis infections. Microbes Infect (2002) 3.45

Microarray-based analysis of the Staphylococcus aureus sigmaB regulon. J Bacteriol (2004) 3.45

TOPCONS: consensus prediction of membrane protein topology. Nucleic Acids Res (2009) 3.45

RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus. Mol Cell (2008) 3.44

Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia. Infect Immun (2006) 3.41

Rhamnolipid surfactant production affects biofilm architecture in Pseudomonas aeruginosa PAO1. J Bacteriol (2003) 3.37

Clinical isolates of Staphylococcus lugdunensis and S. schleiferi: bacteriological characteristics and susceptibility to antimicrobial agents. Res Microbiol (1989) 3.29

The histidine protein kinase superfamily. Adv Microb Physiol (1999) 3.29

Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era. J Clin Invest (2009) 3.24

Clinical practice. Skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus. N Engl J Med (2007) 3.16

Effects of Enterococcus faecalis fsr genes on production of gelatinase and a serine protease and virulence. Infect Immun (2000) 3.15

Signal peptidases. Chem Rev (2002) 3.12

SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation. J Biol Chem (1999) 3.11

Molecular interactions between two global regulators, sar and agr, in Staphylococcus aureus. J Biol Chem (1998) 3.09

Characterization of the sar locus and its interaction with agr in Staphylococcus aureus. J Bacteriol (1996) 3.05

Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc Natl Acad Sci U S A (2010) 3.05

Global regulation of Staphylococcus aureus genes by Rot. J Bacteriol (2003) 3.02

ica and beyond: biofilm mechanisms and regulation in Staphylococcus epidermidis and Staphylococcus aureus. FEMS Microbiol Lett (2007) 3.01

The Staphylococcus aureus alternative sigma factor sigmaB controls the environmental stress response but not starvation survival or pathogenicity in a mouse abscess model. J Bacteriol (1998) 2.99

Biofilm theory can guide the treatment of device-related orthopaedic infections. Clin Orthop Relat Res (2005) 2.99

Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus. J Bacteriol (2001) 2.97

Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression. EMBO J (2005) 2.95

Structural insight into partner specificity and phosphoryl transfer in two-component signal transduction. Cell (2009) 2.94

Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism. Genes Dev (2007) 2.86

Structure of the entire cytoplasmic portion of a sensor histidine-kinase protein. EMBO J (2005) 2.85

Identification of the streptococcal competence-pheromone receptor. Mol Microbiol (1996) 2.85

Quorum-sensing control of biofilm factors in Staphylococcus epidermidis. J Infect Dis (2003) 2.82

Transmembrane topology and histidine protein kinase activity of AgrC, the agr signal receptor in Staphylococcus aureus. Mol Microbiol (1998) 2.77

Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ. Nat Struct Biol (1999) 2.72

Glucose and nonmaintained pH decrease expression of the accessory gene regulator (agr) in Staphylococcus aureus. Infect Immun (1992) 2.70

Transcriptional control of the agr-dependent virulence gene regulator, RNAIII, in Staphylococcus aureus. Mol Microbiol (1996) 2.69

A cell-cell signaling peptide activates the PlcR virulence regulon in bacteria of the Bacillus cereus group. EMBO J (2002) 2.66

The sae locus of Staphylococcus aureus controls exoprotein synthesis at the transcriptional level. Arch Microbiol (1997) 2.65

Articles by these authors

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38

Agr-mediated dispersal of Staphylococcus aureus biofilms. PLoS Pathog (2008) 3.91

Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med (2010) 3.36

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature (2012) 2.94

Modulation of eDNA release and degradation affects Staphylococcus aureus biofilm maturation. PLoS One (2009) 2.84

Bacteria activate sensory neurons that modulate pain and inflammation. Nature (2013) 2.56

Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps. J Innate Immun (2010) 2.34

Identification of genes involved in polysaccharide-independent Staphylococcus aureus biofilm formation. PLoS One (2010) 2.27

Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo. J Immunol (2011) 2.16

The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A. Biochemistry (2003) 1.97

Interconnections between Sigma B, agr, and proteolytic activity in Staphylococcus aureus biofilm maturation. Infect Immun (2009) 1.86

Biofilm dispersal of community-associated methicillin-resistant Staphylococcus aureus on orthopedic implant material. J Orthop Res (2010) 1.81

agr-Dependent interactions of Staphylococcus aureus USA300 with human polymorphonuclear neutrophils. J Innate Immun (2010) 1.77

Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. PLoS One (2011) 1.71

Fluorescent reporters for Staphylococcus aureus. J Microbiol Methods (2009) 1.65

An in vitro biofilm model to examine the effect of antibiotic ointments on biofilms produced by burn wound bacterial isolates. Burns (2010) 1.64

Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation. PLoS One (2010) 1.60

New approaches for treating staphylococcal biofilm infections. Ann N Y Acad Sci (2011) 1.56

Low levels of β-lactam antibiotics induce extracellular DNA release and biofilm formation in Staphylococcus aureus. MBio (2012) 1.51

Staphylococcal and streptococcal superantigen exotoxins. Clin Microbiol Rev (2013) 1.48

Staphylococcal biofilm disassembly. Trends Microbiol (2011) 1.44

A role for type I signal peptidase in Staphylococcus aureus quorum sensing. Mol Microbiol (2007) 1.35

Proteolytic cleavage inactivates the Staphylococcus aureus lipoteichoic acid synthase. J Bacteriol (2011) 1.22

Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin. Biochemistry (2004) 1.22

Pentaerythritol propoxylate: a new crystallization agent and cryoprotectant induces crystal growth of 2-methylcitrate dehydratase. Acta Crystallogr D Biol Crystallogr (2002) 1.20

Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion. J Immunol (2011) 1.20

Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury. MBio (2013) 1.19

Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection. PLoS One (2012) 1.18

Extracellular proteases are key mediators of Staphylococcus aureus virulence via the global modulation of virulence-determinant stability. Microbiologyopen (2012) 1.13

Structural basis for ligand recognition and discrimination of a quorum-quenching antibody. J Biol Chem (2011) 1.13

Biosynthesis of peptide signals in gram-positive bacteria. Adv Appl Microbiol (2010) 1.10

Proinflammatory exoprotein characterization of toxic shock syndrome Staphylococcus aureus. Biochemistry (2011) 1.10

Biosynthesis of Staphylococcus aureus autoinducing peptides by using the synechocystis DnaB mini-intein. Appl Environ Microbiol (2007) 1.08

Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. J Biol Chem (2012) 1.08

sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates. Mol Microbiol (2012) 1.08

Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis. EMBO J (2012) 1.06

FamClash: a method for ranking the activity of engineered enzymes. Proc Natl Acad Sci U S A (2004) 1.06

Identification of Staphylococcus aureus AgrD residues required for autoinducing peptide biosynthesis. J Biol Chem (2009) 1.06

Reduced vancomycin susceptibility in an in vitro catheter-related biofilm model correlates with poor therapeutic outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2013) 1.02

The Tricarballylate utilization (tcuRABC) genes of Salmonella enterica serovar Typhimurium LT2. J Bacteriol (2004) 1.02

Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry. J Nat Prod (2014) 1.01

Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor. Infect Immun (2013) 1.01

Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease. Protein Sci (2007) 1.00

Use of microfluidic technology to analyze gene expression during Staphylococcus aureus biofilm formation reveals distinct physiological niches. Appl Environ Microbiol (2013) 1.00

Sialic acid catabolism in Staphylococcus aureus. J Bacteriol (2013) 1.00

Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner. Mol Microbiol (2011) 0.99

Staphopains modulate Staphylococcus aureus biofilm integrity. Infect Immun (2013) 0.97

Nox2 modification of LDL is essential for optimal apolipoprotein B-mediated control of agr type III Staphylococcus aureus quorum-sensing. PLoS Pathog (2013) 0.96

The ATP:Co(I)rrinoid adenosyltransferase (CobA) enzyme of Salmonella enterica requires the 2'-OH group of ATP for function and yields inorganic triphosphate as its reaction byproduct. J Biol Chem (2002) 0.95

Degradation of nuclease-stabilized RNA oligonucleotides in Mycoplasma-contaminated cell culture media. Nucleic Acid Ther (2012) 0.92

Phosphatidylinositol-specific phospholipase C contributes to survival of Staphylococcus aureus USA300 in human blood and neutrophils. Infect Immun (2014) 0.91

A coverslip-based technique for evaluating Staphylococcus aureus biofilm formation on human plasma. Front Cell Infect Microbiol (2012) 0.90

The role of innate immunity in promoting SaeR/S-mediated virulence in Staphylococcus aureus. J Innate Immun (2013) 0.89

Quantitative analysis of autoinducing peptide I (AIP-I) from Staphylococcus aureus cultures using ultrahigh performance liquid chromatography-high resolving power mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2013) 0.89

Rot is a key regulator of Staphylococcus aureus biofilm formation. Mol Microbiol (2015) 0.87

The structure of LsrB from Yersinia pestis complexed with autoinducer-2. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.86

Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA). Planta Med (2012) 0.85

Methionine sulfoxide reductases protect against oxidative stress in Staphylococcus aureus encountering exogenous oxidants and human neutrophils. J Innate Immun (2013) 0.84

Small-molecule quorum quenchers to prevent Staphylococcus aureus infection. Future Microbiol (2013) 0.83

Random mutagenesis and topology analysis of the autoinducing peptide biosynthesis proteins in Staphylococcus aureus. Mol Microbiol (2012) 0.82

Transcriptome analysis of acyl-homoserine lactone-based quorum sensing regulation in Yersinia pestis [corrected]. PLoS One (2013) 0.81

Analysis of autoinducer-2 quorum sensing in Yersinia pestis. Infect Immun (2013) 0.79

The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response. Microbiol Spectr (2016) 0.79

Staphylococcus aureus osteomyelitis: bad to the bone. Cell Host Microbe (2013) 0.78

Swimming cells promote a dynamic environment within biofilms. Proc Natl Acad Sci U S A (2012) 0.77

Bacteriophage Transduction in Staphylococcus epidermidis. Methods Mol Biol (2014) 0.76