Published in Proc Natl Acad Sci U S A on January 10, 2011
The expanding significance of keratin intermediate filaments in normal and diseased epithelia. Curr Opin Cell Biol (2012) 1.36
Wnt/β-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3. J Biol Chem (2013) 1.00
Keratins in colorectal epithelial function and disease. Int J Exp Pathol (2012) 0.89
The correlation between the expression of differentiation markers in rat small intestinal mucosa and the transcript levels of schlafen 3. JAMA Surg (2013) 0.83
Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism. Mol Biol Cell (2015) 0.82
Antibiotics increase gut metabolism and antioxidant proteins and decrease acute phase response and necrotizing enterocolitis in preterm neonates. PLoS One (2012) 0.81
The amount of keratins matters for stress protection of the colonic epithelium. PLoS One (2015) 0.80
Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease. PLoS One (2014) 0.79
Hemidesmosome integrity protects the colon against colitis and colorectal cancer. Gut (2016) 0.78
Inflammation decreases keratin level in ulcerative colitis; inadequate restoration associates with increased risk of colitis-associated cancer. BMJ Open Gastroenterol (2015) 0.78
Epithelial Intermediate Filaments: Guardians against Microbial Infection? Cells (2016) 0.77
Altered Protein Expression in the Ileum of Mice Associated with the Development of Chronic Infections with Echinostoma caproni (Trematoda). PLoS Negl Trop Dis (2015) 0.77
Intermediate Filaments and Polarization in the Intestinal Epithelium. Cells (2016) 0.77
Keratin 8 knockdown leads to loss of the chloride transporter DRA in the colon. Am J Physiol Gastrointest Liver Physiol (2016) 0.76
Keratin 8 is required for the maintenance of architectural structure in thymus epithelium. PLoS One (2013) 0.76
Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice. FASEB J (2015) 0.76
Keratins Are Altered in Intestinal Disease-Related Stress Responses. Cells (2016) 0.76
Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway. Cell Death Differ (2017) 0.75
Multiple roles for keratin intermediate filaments in the regulation of epithelial barrier function and apico-basal polarity. Tissue Barriers (2016) 0.75
Intermediate filament proteins of digestive organs: Physiology and pathophysiology. Am J Physiol Gastrointest Liver Physiol (2017) 0.75
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32
The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell (1982) 19.91
Development of the human infant intestinal microbiota. PLoS Biol (2007) 18.91
Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell (1993) 5.99
Survivin, cancer networks and pathway-directed drug discovery. Nat Rev Cancer (2008) 5.65
Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol (1996) 5.62
Integrins and anoikis. Curr Opin Cell Biol (1997) 5.38
Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol Rev (2005) 4.08
New consensus nomenclature for mammalian keratins. J Cell Biol (2006) 3.27
'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments. Curr Opin Cell Biol (2002) 3.00
Structure and function of hemidesmosomes: more than simple adhesion complexes. J Invest Dermatol (1999) 2.64
Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. Genes Dev (1994) 2.51
Toward unraveling the complexity of simple epithelial keratins in human disease. J Clin Invest (2009) 2.34
Structure and assembly of hemidesmosomes. Bioessays (1998) 1.91
Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential. Cancer Res (2007) 1.87
Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis. J Cell Biol (2000) 1.80
Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation. J Cell Biol (2001) 1.73
Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality. EMBO J (2000) 1.70
A disease- and phosphorylation-related nonmechanical function for keratin 8. J Cell Biol (2006) 1.68
Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates. J Cell Biol (1998) 1.65
PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways. Hum Mol Genet (2001) 1.56
Keratin 8 mutations in patients with cryptogenic liver disease. N Engl J Med (2001) 1.55
Cytokeratins 8 and 19 in the mouse placental development. J Cell Biol (2000) 1.49
No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammation. Mol Med (2008) 1.46
Characterization of epithelial cell shedding from human small intestine. Lab Invest (2006) 1.45
Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant. J Clin Invest (1996) 1.43
Studying simple epithelial keratins in cells and tissues. Methods Cell Biol (2004) 1.43
Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment. J Cell Sci (2005) 1.39
Survivin as a global target of intrinsic tumor suppression networks. Cell Cycle (2009) 1.36
Simple epithelium keratins are required for maintenance of hepatocyte integrity. Am J Pathol (1997) 1.36
Microflora of the gastrointestinal tract: a review. Methods Mol Biol (2004) 1.36
Keratin 20 helps maintain intermediate filament organization in intestinal epithelia. Mol Biol Cell (2003) 1.29
Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations. Gastroenterology (2010) 1.28
Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form Mallory bodies. Am J Pathol (2000) 1.21
Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury. Hepatology (2003) 1.21
Integrins and human intestinal cell functions. Front Biosci (1999) 1.19
Keratins modulate colonocyte electrolyte transport via protein mistargeting. J Cell Biol (2004) 1.18
Anomalous apical plasma membrane phenotype in CK8-deficient mice indicates a novel role for intermediate filaments in the polarization of simple epithelia. J Cell Sci (2001) 1.18
Keratin variants associate with progression of fibrosis during chronic hepatitis C infection. Hepatology (2006) 1.14
Survivin identifies keratinocyte stem cells and is downregulated by anti-beta1 integrin during anoikis. Stem Cells (2006) 1.10
Dual roles of intermediate filaments in apoptosis. Exp Cell Res (2007) 1.06
Keratin 8 overexpression promotes mouse Mallory body formation. J Cell Biol (2005) 1.04
Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation. J Cell Sci (2004) 1.04
Protein phosphatase inhibition in normal and keratin 8/18 assembly-incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity. Hepatology (1998) 1.04
Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease. Clin Gastroenterol Hepatol (2007) 1.00
Human keratin 8 mutations that disturb filament assembly observed in inflammatory bowel disease patients. J Cell Sci (2004) 0.99
A mutation of keratin 18 within the coil 1A consensus motif causes widespread keratin aggregation but cell type-restricted lethality in mice. Exp Cell Res (2007) 0.96
Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formation. J Pathol (2008) 0.94
The beta4 integrin subunit rescues A431 cells from apoptosis through a PI3K/Akt kinase signaling pathway. Biochem Biophys Res Commun (1999) 0.87
Adhesion-independent alpha6beta4 integrin clustering is mediated by phosphatidylinositol 3-kinase. Cancer Res (2004) 0.86
Keratin 18 provides resistance to Fas-mediated liver failure in mice. Eur J Clin Invest (2009) 0.81
Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nat Immunol (2005) 4.26
Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues. J Exp Med (2002) 4.18
Dynamic T cell migration program provides resident memory within intestinal epithelium. J Exp Med (2010) 4.09
DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Nat Immunol (2007) 3.96
Chemokines and the tissue-specific migration of lymphocytes. Immunity (2002) 3.58
New consensus nomenclature for mammalian keratins. J Cell Biol (2006) 3.27
A role for leukocyte-endothelial adhesion mechanisms in epilepsy. Nat Med (2008) 3.16
'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments. Curr Opin Cell Biol (2002) 3.00
Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med (2002) 2.96
Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem (2007) 2.85
Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking. Nat Immunol (2008) 2.83
Plasma-cell homing. Nat Rev Immunol (2003) 2.74
From Mallory to Mallory-Denk bodies: what, how and why? Exp Cell Res (2007) 2.61
Unique gene expression program of human germinal center T helper cells. Blood (2004) 2.40
Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes. Am J Pathol (2002) 2.28
CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat Immunol (2008) 2.26
Chemokines in the systemic organization of immunity. Immunol Rev (2003) 2.25
Panhematin provides a therapeutic benefit in experimental pancreatitis. Gut (2010) 2.23
CD73 (ecto-5'-nucleotidase) hepatocyte levels differ across mouse strains and contribute to mallory-denk body formation. Hepatology (2013) 2.04
Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. J Biol Chem (2005) 2.03
"Heads and tails" of intermediate filament phosphorylation: multiple sites and functional insights. Trends Biochem Sci (2006) 1.97
CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J Clin Invest (2003) 1.93
Underrepresentation of underrepresented minorities in academic medicine: the need to enhance the pipeline and the pipe. Gastroenterology (2009) 1.91
Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments. Trends Cell Biol (2005) 1.89
Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors. J Immunol (2002) 1.88
Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells. Nat Cell Biol (2003) 1.84
Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsets. J Immunol (2003) 1.75
Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. J Exp Med (2008) 1.74
Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation. J Cell Biol (2011) 1.72
A common mucosal chemokine (mucosae-associated epithelial chemokine/CCL28) selectively attracts IgA plasmablasts. J Immunol (2003) 1.71
A disease- and phosphorylation-related nonmechanical function for keratin 8. J Cell Biol (2006) 1.68
Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury. PLoS One (2008) 1.67
IL-17 regulates adipogenesis, glucose homeostasis, and obesity. J Immunol (2010) 1.67
Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood. J Immunol (2005) 1.63
Chemokines in lymphocyte trafficking and intestinal immunity. Microcirculation (2003) 1.60
Epidemiology of alcohol-related liver and pancreatic disease in the United States. Arch Intern Med (2008) 1.59
The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells. J Exp Med (2002) 1.59
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance. Immunity (2012) 1.57
Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinoma. Gastroenterology (2006) 1.54
Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers. J Virol (2002) 1.53
A cell-surface molecule involved in organ-specific homing of lymphocytes. 1983. J Immunol (2006) 1.51
Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathways. J Exp Med (2003) 1.50
Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs. Blood (2007) 1.48
Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver. J Immunol (2005) 1.48
Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. 1982. J Immunol (2005) 1.45
Studying simple epithelial keratins in cells and tissues. Methods Cell Biol (2004) 1.43
RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing. Immunity (2004) 1.42
CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium. Nat Immunol (2006) 1.42
Keratin 8/18 breakdown and reorganization during apoptosis. Exp Cell Res (2004) 1.42
Critical role for the chemokine receptor CXCR6 in homeostasis and activation of CD1d-restricted NKT cells. J Immunol (2008) 1.40
T cell chemotaxis in a simple microfluidic device. Lab Chip (2006) 1.40
Liver-infiltrating lymphocytes in end-stage hepatitis C virus: subsets, activation status, and chemokine receptor phenotypes. J Hepatol (2003) 1.39
Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment. J Cell Sci (2005) 1.39
Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells. J Biol Chem (2005) 1.38
Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies. Hepatology (2007) 1.37
Chemoattractants, extracellular proteases, and the integrated host defense response. Exp Hematol (2006) 1.37
Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands. Exp Hematol (2006) 1.36
Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization. J Cell Sci (2007) 1.34
Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression. Proc Natl Acad Sci U S A (2002) 1.32
Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction. J Clin Invest (2005) 1.31
Chemokines in rapid leukocyte adhesion triggering and migration. Semin Immunol (2002) 1.31
CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate. J Exp Med (2004) 1.30
Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation. Proc Natl Acad Sci U S A (2003) 1.29
Keratin 20 helps maintain intermediate filament organization in intestinal epithelia. Mol Biol Cell (2003) 1.29
Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation. Hepatology (2008) 1.29
Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations. Gastroenterology (2010) 1.28
Distinct subsets of human Valpha24-invariant NKT cells: cytokine responses and chemokine receptor expression. Trends Immunol (2002) 1.27
Targeting T cell responses by selective chemokine receptor expression. Semin Immunol (2003) 1.25
Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation. J Biol Chem (2002) 1.25
Keratins as susceptibility genes for end-stage liver disease. Gastroenterology (2005) 1.24
The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase. J Biol Chem (2002) 1.23
Dendritic cells support sequential reprogramming of chemoattractant receptor profiles during naive to effector T cell differentiation. J Immunol (2003) 1.22
Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury. Hepatology (2003) 1.21
The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur J Immunol (2007) 1.20
Acknowledging joint first authors of published work: the time has come. Gastroenterology (2012) 1.19
Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease. Hepatology (2004) 1.19
Keratins: guardians of the liver. Hepatology (2002) 1.19
Keratins modulate colonocyte electrolyte transport via protein mistargeting. J Cell Biol (2004) 1.18
Cytoskeletal keratin glycosylation protects epithelial tissue from injury. Nat Cell Biol (2010) 1.18
Maturation and trafficking markers on rotavirus-specific B cells during acute infection and convalescence in children. J Virol (2004) 1.16
Chemoattractant receptors and lymphocyte egress from extralymphoid tissue: changing requirements during the course of inflammation. J Immunol (2010) 1.14
Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress. Gastroenterology (2010) 1.14
Keratin variants associate with progression of fibrosis during chronic hepatitis C infection. Hepatology (2006) 1.14
iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity. J Immunol (2007) 1.13
Redundant role of chemokines CCL25/TECK and CCL28/MEC in IgA+ plasmablast recruitment to the intestinal lamina propria after rotavirus infection. J Immunol (2006) 1.11
Lymphocyte electrotaxis in vitro and in vivo. J Immunol (2008) 1.10
RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells. Proc Natl Acad Sci U S A (2006) 1.10
Functional analysis of the human papillomavirus type 16 E1=E4 protein provides a mechanism for in vivo and in vitro keratin filament reorganization. J Virol (2004) 1.10