Published in Aging Cell on February 23, 2011
mTOR is a key modulator of ageing and age-related disease. Nature (2013) 5.40
The temporal scaling of Caenorhabditis elegans ageing. Nature (2016) 1.63
Why is aging conserved and what can we do about it? PLoS Biol (2015) 1.50
Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proc Natl Acad Sci U S A (2015) 1.21
Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2014) 1.17
Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans. Nat Commun (2014) 1.11
Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection. Aging (Albany NY) (2011) 1.09
Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1. J Gerontol A Biol Sci Med Sci (2013) 1.01
Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans. Longev Healthspan (2012) 1.00
Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans. PLoS Genet (2012) 0.96
Counterbalance between BAG and URX neurons via guanylate cyclases controls lifespan homeostasis in C. elegans. EMBO J (2013) 0.93
Mitochondria and organismal longevity. Curr Genomics (2012) 0.93
Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans. Curr Genomics (2012) 0.93
Neuronal responses to physiological stress. Front Genet (2012) 0.92
Malate and fumarate extend lifespan in Caenorhabditis elegans. PLoS One (2013) 0.91
Neuronal inputs and outputs of aging and longevity. Front Genet (2013) 0.90
Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans. Front Genet (2015) 0.88
The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation? Exp Gerontol (2014) 0.88
Inhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans. Aging Cell (2015) 0.86
The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons. Elife (2016) 0.85
Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans. Free Radic Biol Med (2014) 0.85
Longevity GWAS Using the Drosophila Genetic Reference Panel. J Gerontol A Biol Sci Med Sci (2015) 0.84
Elucidating the Mechanism of Weissella-dependent Lifespan Extension in Caenorhabditis elegans. Sci Rep (2015) 0.84
Interactions between oxygen homeostasis, food availability, and hydrogen sulfide signaling. Front Genet (2012) 0.82
Biochemical Genetic Pathways that Modulate Aging in Multiple Species. Cold Spring Harb Perspect Med (2015) 0.81
Being cool: how body temperature influences ageing and longevity. Biogerontology (2015) 0.81
Transcriptional feedback in the insulin signalling pathway modulates ageing in both Caenorhabditis elegans and Drosophila melanogaster. Mol Biosyst (2013) 0.80
Searching for the elusive mitochondrial longevity signal in C. elegans. Worm (2014) 0.79
The red death meets the abdominal bristle: polygenic mutation for susceptibility to a bacterial pathogen in Caenorhabditis elegans. Evolution (2015) 0.78
Moderately lower temperatures greatly extend the lifespan of Brachionus manjavacas (Rotifera): Thermodynamics or gene regulation? Exp Gerontol (2016) 0.77
Increased hypoxia-inducible factor 1alpha expression in rat brain tissues in response to aging. Neural Regen Res (2012) 0.77
The MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegans. PLoS One (2011) 0.77
UV-photoconversion of ethosuximide from a longevity-promoting compound to a potent toxin. PLoS One (2013) 0.77
Age-associated vulval integrity is an important marker of nematode healthspan. Age (Dordr) (2016) 0.77
Dietary restriction and lifespan: Lessons from invertebrate models. Ageing Res Rev (2016) 0.77
Loss of hif-1 promotes resistance to the exogenous mitochondrial stressor ethidium bromide in Caenorhabditis elegans. BMC Cell Biol (2016) 0.75
MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans. Sci Rep (2016) 0.75
Uncovering the mechanisms of Caenorhabditis elegans ageing from global quantification of the underlying landscape. J R Soc Interface (2016) 0.75
New insights into cell non-autonomous mechanisms of the C. elegans hypoxic response. Worm (2016) 0.75
Expression of lymphocyte-derived growth hormone (GH) and GH-releasing hormone receptors in aging rats. Cell Immunol (2013) 0.75
Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans. PLoS Genet (2017) 0.75
Life(span) in balance: oxygen fuels a sophisticated neural network for lifespan homeostasis in C. elegans. EMBO J (2013) 0.75
Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity. Aging Cell (2017) 0.75
HIF-1-dependent regulation of lifespan in Caenorhabditis elegans by the acyl-CoA-binding protein MAA-1. Aging (Albany NY) (2017) 0.75
Genetic interaction with temperature is an important determinant of nematode longevity. Aging Cell (2017) 0.75
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A (1995) 24.77
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature (1999) 23.45
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell (2001) 19.75
The FoxO code. Oncogene (2008) 6.22
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol (2001) 5.81
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 5.51
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol (2007) 5.48
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell (2006) 5.36
WormBase: a comprehensive resource for nematode research. Nucleic Acids Res (2009) 5.20
Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science (2009) 3.64
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell (2010) 3.33
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell (2006) 3.26
Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell (2006) 2.95
Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans. Proc Natl Acad Sci U S A (2004) 2.84
Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2. Science (2002) 2.71
Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science (2009) 2.62
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet (2009) 2.60
The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia. Proc Natl Acad Sci U S A (2001) 2.45
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell (2008) 2.32
In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans. Aging Cell (2005) 2.15
Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans. J Biol Chem (2005) 2.07
The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS One (2009) 1.81
Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC Dev Biol (2008) 1.75
Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. PLoS Biol (2004) 1.72
Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. Cell Mol Life Sci (2009) 1.71
Worming pathways to and from DAF-16/FOXO. Exp Gerontol (2006) 1.56
The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer. Curr Opin Genet Dev (2003) 1.56
RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination. Dev Cell (2007) 1.45
C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech Ageing Dev (2006) 1.44
Measuring Caenorhabditis elegans life span on solid media. J Vis Exp (2009) 1.39
Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans. PLoS Pathog (2009) 1.35
Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Exp Gerontol (2007) 1.31
The pVHL-hIF-1 system. A key mediator of oxygen homeostasis. Adv Exp Med Biol (2001) 1.29
Can we develop genetically tractable models to assess healthspan (rather than life span) in animal models? J Gerontol A Biol Sci Med Sci (2009) 1.28
The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging. Biol Chem (2010) 1.12
Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity. Genetics (2008) 1.09
Genetic analysis of hypoxia signaling and response in C elegans. Ann N Y Acad Sci (2003) 1.06
Systematic identification of gene activities promoting hypoxic death. Genetics (2008) 1.00
The hypoxic response and aging. Cell Cycle (2009) 1.00
The von Hippel Lindau tumor suppressor limits longevity. J Am Soc Nephrol (2009) 1.00
The molecular basis of von Hippel-Lindau disease. Mol Med (1997) 0.95
Divergent mechanisms controlling hypoxic sensitivity and lifespan by the DAF-2/insulin/IGF-receptor pathway. PLoS One (2009) 0.90
FOXO4 induces human plasminogen activator inhibitor-1 gene expression via an indirect mechanism by modulating HIF-1alpha and CREB levels. Antioxid Redox Signal (2010) 0.88
Effects of acute hypoxia tests on blood markers in high-level endurance athletes. Eur J Appl Physiol (2009) 0.85
A role for SIRT1 in the hypoxic response. Mol Cell (2010) 0.84
Effect of HIF1A gene polymorphism on human muscle performance. Bull Exp Biol Med (2008) 0.83
Oxidative stress and HIF-1 alpha modulate hypoxic ventilatory responses after hypoxic training on athletes. Respir Physiol Neurobiol (2009) 0.83
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature (2002) 8.45
Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev (2006) 6.62
mTOR is a key modulator of ageing and age-related disease. Nature (2013) 5.40
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011) 4.48
Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell (2008) 3.58
mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. Science (2013) 3.41
A molecular mechanism of chronological aging in yeast. Cell Cycle (2009) 3.12
Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell (2006) 2.95
The TOR pathway comes of age. Biochim Biophys Acta (2009) 2.83
Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science (2009) 2.62
Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab (2012) 2.56
Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res (2008) 2.32
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell (2008) 2.32
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci Transl Med (2012) 1.98
A method for high-throughput quantitative analysis of yeast chronological life span. J Gerontol A Biol Sci Med Sci (2008) 1.76
Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC Dev Biol (2008) 1.75
Measuring replicative life span in the budding yeast. J Vis Exp (2009) 1.68
Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. PLoS Genet (2011) 1.52
Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. PLoS One (2008) 1.45
Measuring Caenorhabditis elegans life span on solid media. J Vis Exp (2009) 1.39
The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics (2006) 1.36
Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. Aging Cell (2006) 1.32
Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Exp Gerontol (2007) 1.31
Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell (2013) 1.31
Ageing: A midlife longevity drug? Nature (2009) 1.25
Hot topics in aging research: protein translation, 2009. Aging Cell (2009) 1.24
Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. Mol Biol Cell (2002) 1.24
Hypertrophy and senescence factors in yeast aging. A reply to Bilinski et al. FEMS Yeast Res (2012) 1.23
Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae. Genetics (2012) 1.23
A genomic analysis of chronological longevity factors in budding yeast. Cell Cycle (2011) 1.22
pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast. Cell Cycle (2012) 1.21
Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. Cell Metab (2012) 1.18
Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast. PLoS One (2011) 1.16
Quantifying yeast chronological life span by outgrowth of aged cells. J Vis Exp (2009) 1.14
Genome-wide identification of conserved longevity genes in yeast and worms. Mech Ageing Dev (2006) 1.13
Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. Cell Cycle (2011) 1.13
The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging. Biol Chem (2010) 1.12
YODA: software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast. BMC Bioinformatics (2010) 1.03
Spermidine surprise for a long life. Nat Cell Biol (2009) 1.03
The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1. PLoS Genet (2013) 1.02
A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS Genet (2013) 1.02
Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1. J Gerontol A Biol Sci Med Sci (2013) 1.01
Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell (2011) 1.01
Midlife gene expressions identify modulators of aging through dietary interventions. Proc Natl Acad Sci U S A (2012) 1.00
Regulation of mRNA translation as a conserved mechanism of longevity control. Adv Exp Med Biol (2010) 0.99
A genomic approach to yeast chronological aging. Methods Mol Biol (2009) 0.99
The enigmatic role of Sir2 in aging. Cell (2005) 0.99
WormFarm: a quantitative control and measurement device toward automated Caenorhabditis elegans aging analysis. Aging Cell (2013) 0.98
Preserving youth: does rapamycin deliver? Sci Transl Med (2013) 0.97
Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell (2012) 0.94
Yeast replicative aging: a paradigm for defining conserved longevity interventions. FEMS Yeast Res (2013) 0.94
Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans. Curr Genomics (2012) 0.93
Does resveratrol activate yeast Sir2 in vivo? Aging Cell (2007) 0.92
Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae. Exp Gerontol (2012) 0.91
Modulating mTOR in aging and health. Interdiscip Top Gerontol (2014) 0.90
Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix. Aging Cell (2011) 0.89
Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span. Science (2015) 0.88
Medicine: grapes versus gluttony. Nature (2006) 0.87
Yeast as a model to understand the interaction between genotype and the response to calorie restriction. FEBS Lett (2012) 0.86
Genome-wide analysis of yeast aging. Subcell Biochem (2012) 0.85
End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging. FEMS Yeast Res (2013) 0.84
A role for SIRT1 in the hypoxic response. Mol Cell (2010) 0.84
Ageing: A healthy diet for stem cells. Nature (2012) 0.82
Single-gene deletions that restore mating competence to diploid yeast. FEMS Yeast Res (2007) 0.81
The biological sciences section program at the 60th Annual Meeting of the Gerontological Society of America. J Gerontol A Biol Sci Med Sci (2008) 0.81
PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae. Age (Dordr) (2015) 0.79
UV-photoconversion of ethosuximide from a longevity-promoting compound to a potent toxin. PLoS One (2013) 0.77
Cell biology: A molecular age barrier. Nature (2008) 0.77
The MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegans. PLoS One (2011) 0.77
Corrigendum: Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nat Commun (2015) 0.76
Elevated MTORC1 signaling and impaired autophagy. Autophagy (2012) 0.76
Correction: Why Is Aging Conserved and What Can We Do about it? PLoS Biol (2015) 0.75
Development. Chemical warfare in the battle of the sexes. Science (2014) 0.75
Replicative life span analysis in budding yeast. Methods Mol Biol (2014) 0.75
Genomics and genetics of aging. Curr Genomics (2012) 0.75